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The map label for this gene is uppS [H]

Identifier: 193213406

GI number: 193213406

Start: 1937345

End: 1938151

Strand: Direct

Name: uppS [H]

Synonym: Cpar_1767

Alternate gene names: 193213406

Gene position: 1937345-1938151 (Clockwise)

Preceding gene: 193213402

Following gene: 193213407

Centisome position: 84.63

GC content: 53.16

Gene sequence:

>807_bases
ATGCCCCAGTGGTTCAAATCAACGATCGATCCTGAAGACGCCCTGCTGCAGGATGAGCTGAAATCTACATGCGTATTTCC
ACGGCACATCGGGATCATCATGGATGGAAACGGCCGGTGGGCCAAACAGAAAGGCAAGTCGCGCATCGAAGGACATATCG
CTGGCGTTGATTCGGTTCAGGATATCGTCGAAGCATGCTCCCAGCTCGGCATCAGTGCCCTGACGCTTTTCACTTTTTCT
ATCGAAAACTGGCGGAGGCCGAAACCTGAAATTTCAGCCCTGATGAAGCTGCTGATCAAGGTGCTCAAAAAAGAGACCCC
CCAGCTTTGCGAAAATAATATCAGGCTCGAGGTCATTGGCGATTTGAATCTGGTCAGCAGCACCGTACGGAAAACGCTCG
AAGAAACGATAGAGCAGACCAGAAACAACCATGAGCTGACCCTGACCATCGCCTTGAGCTACAGCGGCAAGTGGGACATC
ACCAACGCCTGCCGCACCATTGCCGAACAGGTGGCGAACGGAACGATCGCCCCCGAGCAGATCGACGAAAACCTTTTTGC
CGCGAACTTGTCAACGGCTTCGCTCCCGGATCCGGAGCTTCTGATCCGAACCAGCGGAGAGTTCCGCATCAGCAATTTCA
TGCTTTGGCAAATCGCCTATTCTGAAATCTTTTTCACGGAGACGTACTGGCCCGATTTCCGACGCGACAAGCTCTACGAC
GCACTCCGGGAGTATCAGAACCGGGAAAGGCGCTTTGGCCAGACAAGCGAACAACTCAAAGCCGAAACCTTGAGAAAACA
GGCCTAA

Upstream 100 bases:

>100_bases
ATTTCATGGATATTGCGGGTACAGTCACCTATGAACGGTTCAGATTGGAAAGCTCAACTTCCGAACAAAAGCGTTAACCT
CTCGTTTTTCATCTAGTTAC

Downstream 100 bases:

>100_bases
CTCACCGAATCATTCAGGTTTTTCATGAATACAACACCCTTTTCGCCAGACAAGCTCTCAGCACTTCTGATTGGCCTGGC
ACTGCTTAACGGTCCGATAT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPQWFKSTIDPEDALLQDELKSTCVFPRHIGIIMDGNGRWAKQKGKSRIEGHIAGVDSVQDIVEACSQLGISALTLFTFS
IENWRRPKPEISALMKLLIKVLKKETPQLCENNIRLEVIGDLNLVSSTVRKTLEETIEQTRNNHELTLTIALSYSGKWDI
TNACRTIAEQVANGTIAPEQIDENLFAANLSTASLPDPELLIRTSGEFRISNFMLWQIAYSEIFFTETYWPDFRRDKLYD
ALREYQNRERRFGQTSEQLKAETLRKQA

Sequences:

>Translated_268_residues
MPQWFKSTIDPEDALLQDELKSTCVFPRHIGIIMDGNGRWAKQKGKSRIEGHIAGVDSVQDIVEACSQLGISALTLFTFS
IENWRRPKPEISALMKLLIKVLKKETPQLCENNIRLEVIGDLNLVSSTVRKTLEETIEQTRNNHELTLTIALSYSGKWDI
TNACRTIAEQVANGTIAPEQIDENLFAANLSTASLPDPELLIRTSGEFRISNFMLWQIAYSEIFFTETYWPDFRRDKLYD
ALREYQNRERRFGQTSEQLKAETLRKQA
>Mature_267_residues
PQWFKSTIDPEDALLQDELKSTCVFPRHIGIIMDGNGRWAKQKGKSRIEGHIAGVDSVQDIVEACSQLGISALTLFTFSI
ENWRRPKPEISALMKLLIKVLKKETPQLCENNIRLEVIGDLNLVSSTVRKTLEETIEQTRNNHELTLTIALSYSGKWDIT
NACRTIAEQVANGTIAPEQIDENLFAANLSTASLPDPELLIRTSGEFRISNFMLWQIAYSEIFFTETYWPDFRRDKLYDA
LREYQNRERRFGQTSEQLKAETLRKQA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=245, Percent_Identity=33.8775510204082, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI45580738, Length=245, Percent_Identity=33.469387755102, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=47.8070175438597, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=37.3271889400922, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI18857969, Length=215, Percent_Identity=35.3488372093023, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30713; Mature: 30582

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQWFKSTIDPEDALLQDELKSTCVFPRHIGIIMDGNGRWAKQKGKSRIEGHIAGVDSVQ
CCCHHHCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCHHHHCHHHHHHHHCCHHHHH
DIVEACSQLGISALTLFTFSIENWRRPKPEISALMKLLIKVLKKETPQLCENNIRLEVIG
HHHHHHHHCCHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEC
DLNLVSSTVRKTLEETIEQTRNNHELTLTIALSYSGKWDITNACRTIAEQVANGTIAPEQ
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHH
IDENLFAANLSTASLPDPELLIRTSGEFRISNFMLWQIAYSEIFFTETYWPDFRRDKLYD
HCCHHHEECCCCCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHEEECCCCCCHHHHHHHH
ALREYQNRERRFGQTSEQLKAETLRKQA
HHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PQWFKSTIDPEDALLQDELKSTCVFPRHIGIIMDGNGRWAKQKGKSRIEGHIAGVDSVQ
CCHHHCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCHHHHCHHHHHHHHCCHHHHH
DIVEACSQLGISALTLFTFSIENWRRPKPEISALMKLLIKVLKKETPQLCENNIRLEVIG
HHHHHHHHCCHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEC
DLNLVSSTVRKTLEETIEQTRNNHELTLTIALSYSGKWDITNACRTIAEQVANGTIAPEQ
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHH
IDENLFAANLSTASLPDPELLIRTSGEFRISNFMLWQIAYSEIFFTETYWPDFRRDKLYD
HCCHHHEECCCCCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHEEECCCCCCHHHHHHHH
ALREYQNRERRFGQTSEQLKAETLRKQA
HHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]