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The map label for this gene is dxs [H]

Identifier: 193213336

GI number: 193213336

Start: 1856937

End: 1858865

Strand: Direct

Name: dxs [H]

Synonym: Cpar_1696

Alternate gene names: 193213336

Gene position: 1856937-1858865 (Clockwise)

Preceding gene: 193213335

Following gene: 193213340

Centisome position: 81.12

GC content: 61.74

Gene sequence:

>1929_bases
ATGACCGAGGCCCTCTCGTCACCTGTTTCGCAAGGCTATAGCCTGCTTTCGACAATCCATGATCCCGCCGACCTCAAGAA
GCTGAGCATCAGCCAGCTTGAGCAGGTGGCCGCCGAGTGCCGCAGAAAAGTAATCGAGCTGGTGTCGCAGCATGGCGGCC
ATTTCGCTTCCAGCCTCGGCGTGGTCGAGCTGACCGTCGCGCTGCATCACGTCTATCAGAGTCCGACCGACCGGTTCATC
TGGGATGTGGGCCATCAGGCTTACGTGCACAAAATGCTGACCGGACGACTGGAACAGATGGACACCAACCGCCGCTACAA
CGGGCTGGCGGGCTTTCCGAAGCGCAGTGAAAGCGCGCACGACGCTTTCGACACTGGCCACGCCTCGACCTCGATCTCCG
CAGCGGCAGGCATGGCCGTGGCGCGTGACCTGGCCGGGCGGTCGGAAAAGGTGGTTGCGATCATCGGCGACGGCAGCCTG
ACCGGCGGCATGGCCTTCGAGGCGATGAATCACCTCGGCGACGTGAAGTCCGACGTGCTTGTCATCCTGAATGACAACCA
GATGGCGATTTCGCCAAGCACCGGCGGACTGAACAACTACTTGGTAAACCTGCCGCTGAACAAGACCTACAACAAGCTCC
GGAAGTTCGTCTGGGACAGCATTTCCCTGATGCACAACGATATCGGCGAAACGGCCAAAACCGCCGTGCATCGGCTTGAA
GATGGCATCAAGGCGGCCTTCACACCCGGTGCGTACTTCGAAGCGCTCGGCTTCCGCTACTTCGGCCCGATCGACGGGCA
CAACATGGAGCAGCTCACCAAGGCGCTAAGCGAAATGCGTTCGCTGCCGCACCCAAAGCTGCTGCACGTCATCACCAAAA
AGGGCAAAGGGTTCAAGCCCGCCGAGGAGAACCAGCCCAAGTGGCACGCCAGCGCAGGCGGCTTCGACATCGAGACCGGC
GCGAATCTGAAGGCTCCGGGCAAACCCGCGAAGCCGAAGTACCAAGAGGTGTTCGGTGAAGCGCTGGTCGAGCTGGCGCT
GAAAGACCAGACCATCACCGCCATCACCGCCGCCATGCCTAGCGGCACCTCGCTCGACCTGTTCCAGCAGGCGATCCCGT
CGCGCTTTTTCGACGTCGGAATCGCCGAGCAGCACGCTGTCACCTTCTGCGCCGGTCTGGCTCTCGGCGGCTTCAAACCG
GTCTGCGCGATCTACTCGACCTTTCTGCAACGCGGCTACGACCAGCTCATCCACGACGTGGCGCTGCAGAACCTGCACGT
AGTCTTTGCCATCGACCGCGCAGGCCTCGTCGGCGAAGACGGCCCGACGCACCACGGCGCGTTCGACCTGTCGTACCTCA
ACGCCGTACCGAATCTGACGATCATGGCTCCGGGCGACGAGCAGGAGCTGCGCGACATGCTCTACACTGCGCTCTACGAA
GTGAAAGGCCCGGTGGCCATCCGTTACCCGAGAGGCACCGGCACCGGCGCTACGCTGCACAAAGAGTTCACGCCGATTCC
TGTCGGCAAGGGCCGCGTGCTGCGCGAAGGCGACACGGTCGCACTGCTCGGCATCGGCTCAATGAGCCAGAGAGCACTCG
AAACCGCCGAACTGCTCGAAAAAGCCGGGCTGAATCCGCTGGTCTGCGACATGCGTTTCCTCAAGCCGCTTGACACCGAG
ATGATCGACATGGCCGCAGCCAAATGCAAGCACATCGTCACCATCGAAGAAAACAGCATCATCGGCGGCTTCGGCAGCAG
CGTGACGAGCTACCTCAGCCACGCCCATCCCGGCATGAAGAGCATCAGCTTTGGCCTCCCGGACGACTTCGTCACGCACG
GCAGCATGCAAGAGCTGTACAAGGAAGTGGGACTGGACGCGGAGACGCTGGCGGAGAAGATTCAGGAGTTCTGCAAGGTG
GAGGCGTAG

Upstream 100 bases:

>100_bases
TCTGAAAAGAAAATCCTCCCCCCAATCGGAACCATAGAGGAGTTCGGGCGGTTGAAAAAACAAGTACTTTTCTTCCGCCT
GAACTCCAGATTCCGAACCT

Downstream 100 bases:

>100_bases
AGCGTTAAGGAAAAAATCGTGATTTTTGGTAGGGGCAACCCTTGCGGTTGCCCTGATTTATCAGTTTGCACAGAGTTCCG
AGTTCACCCACAAAAGGGCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MTEALSSPVSQGYSLLSTIHDPADLKKLSISQLEQVAAECRRKVIELVSQHGGHFASSLGVVELTVALHHVYQSPTDRFI
WDVGHQAYVHKMLTGRLEQMDTNRRYNGLAGFPKRSESAHDAFDTGHASTSISAAAGMAVARDLAGRSEKVVAIIGDGSL
TGGMAFEAMNHLGDVKSDVLVILNDNQMAISPSTGGLNNYLVNLPLNKTYNKLRKFVWDSISLMHNDIGETAKTAVHRLE
DGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLTKALSEMRSLPHPKLLHVITKKGKGFKPAEENQPKWHASAGGFDIETG
ANLKAPGKPAKPKYQEVFGEALVELALKDQTITAITAAMPSGTSLDLFQQAIPSRFFDVGIAEQHAVTFCAGLALGGFKP
VCAIYSTFLQRGYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNAVPNLTIMAPGDEQELRDMLYTALYE
VKGPVAIRYPRGTGTGATLHKEFTPIPVGKGRVLREGDTVALLGIGSMSQRALETAELLEKAGLNPLVCDMRFLKPLDTE
MIDMAAAKCKHIVTIEENSIIGGFGSSVTSYLSHAHPGMKSISFGLPDDFVTHGSMQELYKEVGLDAETLAEKIQEFCKV
EA

Sequences:

>Translated_642_residues
MTEALSSPVSQGYSLLSTIHDPADLKKLSISQLEQVAAECRRKVIELVSQHGGHFASSLGVVELTVALHHVYQSPTDRFI
WDVGHQAYVHKMLTGRLEQMDTNRRYNGLAGFPKRSESAHDAFDTGHASTSISAAAGMAVARDLAGRSEKVVAIIGDGSL
TGGMAFEAMNHLGDVKSDVLVILNDNQMAISPSTGGLNNYLVNLPLNKTYNKLRKFVWDSISLMHNDIGETAKTAVHRLE
DGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLTKALSEMRSLPHPKLLHVITKKGKGFKPAEENQPKWHASAGGFDIETG
ANLKAPGKPAKPKYQEVFGEALVELALKDQTITAITAAMPSGTSLDLFQQAIPSRFFDVGIAEQHAVTFCAGLALGGFKP
VCAIYSTFLQRGYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNAVPNLTIMAPGDEQELRDMLYTALYE
VKGPVAIRYPRGTGTGATLHKEFTPIPVGKGRVLREGDTVALLGIGSMSQRALETAELLEKAGLNPLVCDMRFLKPLDTE
MIDMAAAKCKHIVTIEENSIIGGFGSSVTSYLSHAHPGMKSISFGLPDDFVTHGSMQELYKEVGLDAETLAEKIQEFCKV
EA
>Mature_641_residues
TEALSSPVSQGYSLLSTIHDPADLKKLSISQLEQVAAECRRKVIELVSQHGGHFASSLGVVELTVALHHVYQSPTDRFIW
DVGHQAYVHKMLTGRLEQMDTNRRYNGLAGFPKRSESAHDAFDTGHASTSISAAAGMAVARDLAGRSEKVVAIIGDGSLT
GGMAFEAMNHLGDVKSDVLVILNDNQMAISPSTGGLNNYLVNLPLNKTYNKLRKFVWDSISLMHNDIGETAKTAVHRLED
GIKAAFTPGAYFEALGFRYFGPIDGHNMEQLTKALSEMRSLPHPKLLHVITKKGKGFKPAEENQPKWHASAGGFDIETGA
NLKAPGKPAKPKYQEVFGEALVELALKDQTITAITAAMPSGTSLDLFQQAIPSRFFDVGIAEQHAVTFCAGLALGGFKPV
CAIYSTFLQRGYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNAVPNLTIMAPGDEQELRDMLYTALYEV
KGPVAIRYPRGTGTGATLHKEFTPIPVGKGRVLREGDTVALLGIGSMSQRALETAELLEKAGLNPLVCDMRFLKPLDTEM
IDMAAAKCKHIVTIEENSIIGGFGSSVTSYLSHAHPGMKSISFGLPDDFVTHGSMQELYKEVGLDAETLAEKIQEFCKVE
A

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=681, Percent_Identity=25.2569750367107, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI4507521, Length=681, Percent_Identity=25.2569750367107, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI133778974, Length=381, Percent_Identity=24.9343832020997, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI225637463, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI225637459, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI225637461, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI156564403, Length=247, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI291084858, Length=239, Percent_Identity=22.1757322175732, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=631, Percent_Identity=47.8605388272583, Blast_Score=581, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17539652, Length=671, Percent_Identity=24.8882265275708, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17538422, Length=230, Percent_Identity=24.7826086956522, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645119, Length=588, Percent_Identity=25.5102040816327, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551847, Length=588, Percent_Identity=25.5102040816327, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550715, Length=588, Percent_Identity=25.5102040816327, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24666278, Length=611, Percent_Identity=25.531914893617, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21358145, Length=244, Percent_Identity=25, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650940, Length=244, Percent_Identity=25, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69525; Mature: 69394

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEALSSPVSQGYSLLSTIHDPADLKKLSISQLEQVAAECRRKVIELVSQHGGHFASSLG
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
VVELTVALHHVYQSPTDRFIWDVGHQAYVHKMLTGRLEQMDTNRRYNGLAGFPKRSESAH
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DAFDTGHASTSISAAAGMAVARDLAGRSEKVVAIIGDGSLTGGMAFEAMNHLGDVKSDVL
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEE
VILNDNQMAISPSTGGLNNYLVNLPLNKTYNKLRKFVWDSISLMHNDIGETAKTAVHRLE
EEECCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLTKALSEMRSLPHPKLLHVITKKGKGFKP
HCHHHHCCCCHHHHHHCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AEENQPKWHASAGGFDIETGANLKAPGKPAKPKYQEVFGEALVELALKDQTITAITAAMP
CCCCCCCEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHEECCC
SGTSLDLFQQAIPSRFFDVGIAEQHAVTFCAGLALGGFKPVCAIYSTFLQRGYDQLIHDV
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNAVPNLTIMAPGDEQELRDMLYTALYE
HHHCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
VKGPVAIRYPRGTGTGATLHKEFTPIPVGKGRVLREGDTVALLGIGSMSQRALETAELLE
HCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHH
KAGLNPLVCDMRFLKPLDTEMIDMAAAKCKHIVTIEENSIIGGFGSSVTSYLSHAHPGMK
HCCCCCEEHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCEECCCHHHHHHHHHHCCCCHH
SISFGLPDDFVTHGSMQELYKEVGLDAETLAEKIQEFCKVEA
HCCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEALSSPVSQGYSLLSTIHDPADLKKLSISQLEQVAAECRRKVIELVSQHGGHFASSLG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
VVELTVALHHVYQSPTDRFIWDVGHQAYVHKMLTGRLEQMDTNRRYNGLAGFPKRSESAH
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DAFDTGHASTSISAAAGMAVARDLAGRSEKVVAIIGDGSLTGGMAFEAMNHLGDVKSDVL
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEE
VILNDNQMAISPSTGGLNNYLVNLPLNKTYNKLRKFVWDSISLMHNDIGETAKTAVHRLE
EEECCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLTKALSEMRSLPHPKLLHVITKKGKGFKP
HCHHHHCCCCHHHHHHCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AEENQPKWHASAGGFDIETGANLKAPGKPAKPKYQEVFGEALVELALKDQTITAITAAMP
CCCCCCCEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHEECCC
SGTSLDLFQQAIPSRFFDVGIAEQHAVTFCAGLALGGFKPVCAIYSTFLQRGYDQLIHDV
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNAVPNLTIMAPGDEQELRDMLYTALYE
HHHCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
VKGPVAIRYPRGTGTGATLHKEFTPIPVGKGRVLREGDTVALLGIGSMSQRALETAELLE
HCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHH
KAGLNPLVCDMRFLKPLDTEMIDMAAAKCKHIVTIEENSIIGGFGSSVTSYLSHAHPGMK
HCCCCCEEHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCEECCCHHHHHHHHHHCCCCHH
SISFGLPDDFVTHGSMQELYKEVGLDAETLAEKIQEFCKVEA
HCCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]