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The map label for this gene is ilvB [H]

Identifier: 193213098

GI number: 193213098

Start: 1589656

End: 1591452

Strand: Direct

Name: ilvB [H]

Synonym: Cpar_1453

Alternate gene names: 193213098

Gene position: 1589656-1591452 (Clockwise)

Preceding gene: 193213097

Following gene: 193213099

Centisome position: 69.44

GC content: 53.2

Gene sequence:

>1797_bases
ATGAGAGTTGCCGATTATATAGCACAGCTTATCGCAGAACATGAGCAGACCGCGAAGACCGTTTTTATGGTCTCCGGCGG
CGGAAACATGCACCTGATCGACGCTCTTGGCCGCAACGAAAAGCTCCGTTACGTCTGCAACCATCACGAACAGGCCTGCG
CGATCGCTGCCGAGGGATACTCGCGGGTGTCGAACCAGATTGGCATCGCCTATGTGACCACCGGGCCAGGCGGCACCAAC
GCCATCACCGGCGTGATGGGGGCTTGGGTCGATTCGATTCCCATGCTGATTGTTTCCGGTCAGGTCAAATTCCAGACCAC
CATCGCCTCGCAGCCCGAACTCAACCTTCGGCAACTCGGCGATCAGGAAATCAACATCGTCGATATCGTTCGTCCCATCA
CCAAGTATGCGGTGATGATTACTGACAAGAATTCGATTCGCTTCCACCTCGAAAAAGCGTTGTATGAGGCCAAGCATGGC
AGGCCTGGGCCGGTCTGGATCGACGTGCCGCTCGACATCCAGGGCGCGCAGATCGAGCCGGAATCGCTCGAAGGCTTCGC
GCCGCCCCCCGAACCTGATTATGACCTGAAAATCGACCAGGTCATGACCGCTTTGAAGCGAGCCAAGCGTCCTGTGATAA
TCGCAGGAAACGGCATCGTACTCTCGGGCGCGGTCGGCAAGTTTCGGGCTTTGGCAGAAAAACTCGGCATTCCGGTGCTT
GGCACTTTTGCCCGCTACGACATCGTAAAGGAGTCCGACCCTTGCTATGCGGGCCGGTTCGGAACCCTCGGGCATCGGGC
GGGCAATTTCGCGGTACAAAACAGCGATCTTATCATCGCCATCGGAGCAAGACTTAACGTTCGAGCCATTAGCTATAACT
GGGAATATTTCGGTCGTGAGGCCGAGAAAGTCGTTGTCGATATCGATGAGAACGAACTTAAAAAGCACACGATCAAAGCA
GACATTCCCGTCTGTGCTGATGCGGGCGCGTTCATCAAGGCGTTGTCATGCGCACTTGAAACGCTATCACCGATGCATCA
ACAATGGATGGAGCGGTGTCGCCGTTACCGGGAGACCTTCCCCACCATAATCGAAGAACGCCAGAAAGTCAAAATCAAGG
TGGATTCGTACCATTTCTTCGATGTGCTTTCAGACTGCGCCCCCGACAACGCGGTGTTCGTATTCGGAAACGGCACGGCA
TGCGTCTCTTCTTATCAGAGCTTGCGGCTCAAACAAGGACAGAACATTGTCGTCAACTCGGGCTGTGCCTCGATGGGCTA
TGATCTTCCCGCAGCTATTGGAGCTTGTTATGCTGCGCCAGATCGCCAGATAATCTGCGTTACCGGCGACGGAAGTATGC
AGATGAACATTCAGGAGTTGCAGACCATCGTTCACAATCACCTGCCGATAAAGCTGTTCGTACTGAACAACGAAGGGTAT
ATTTCGATCCGAAACACCCAGCAAGGCTTTTTTAAAGGTCACTTTGTAGGTTGCGAAGCAAGTAGCGGCGTCAGTTGTCC
CGATACCCTGAAAGTGGCCGAGGCCTATGGCCTGAAAAATGGCAGAATCGACAATCACCAAGGGCTTTCCGAGCAGATCA
AAGCTTTTCTCTCAGAAGATGGACCGGTCGTATGCGAAGTCATGCTTGACCCCGGCGAAAAGATGGAACCCAAACTCTCT
TCGGAAGTCAAGTCTGATGGCAGAATCGTCTCCAAACCGCTCGAAGACATGTTCCCGTTTCTCGATCGTGATGTATTCAA
TCAACAGATGATTATCGGAACCATTGATGAAGATTAA

Upstream 100 bases:

>100_bases
TCAGCACTGTTTGCTTCGGAGATTCTTGAGCAAATAAAGAAGATGAAAATCGACAATCAAGTAATTGTTCTTTAAAGTTA
TTTAATCCTTTATTTGAGTT

Downstream 100 bases:

>100_bases
GAAGATTCTGGTTACCGGCGGCACAGGGGGGATCGGATCCTCGATAGTCGCTTGCTTGTCCGCACAGCCTGGCTTTGTCG
TCCACGCTCCCAGCCGGAGC

Product: thiamine pyrophosphate protein TPP binding domain-containing protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MRVADYIAQLIAEHEQTAKTVFMVSGGGNMHLIDALGRNEKLRYVCNHHEQACAIAAEGYSRVSNQIGIAYVTTGPGGTN
AITGVMGAWVDSIPMLIVSGQVKFQTTIASQPELNLRQLGDQEINIVDIVRPITKYAVMITDKNSIRFHLEKALYEAKHG
RPGPVWIDVPLDIQGAQIEPESLEGFAPPPEPDYDLKIDQVMTALKRAKRPVIIAGNGIVLSGAVGKFRALAEKLGIPVL
GTFARYDIVKESDPCYAGRFGTLGHRAGNFAVQNSDLIIAIGARLNVRAISYNWEYFGREAEKVVVDIDENELKKHTIKA
DIPVCADAGAFIKALSCALETLSPMHQQWMERCRRYRETFPTIIEERQKVKIKVDSYHFFDVLSDCAPDNAVFVFGNGTA
CVSSYQSLRLKQGQNIVVNSGCASMGYDLPAAIGACYAAPDRQIICVTGDGSMQMNIQELQTIVHNHLPIKLFVLNNEGY
ISIRNTQQGFFKGHFVGCEASSGVSCPDTLKVAEAYGLKNGRIDNHQGLSEQIKAFLSEDGPVVCEVMLDPGEKMEPKLS
SEVKSDGRIVSKPLEDMFPFLDRDVFNQQMIIGTIDED

Sequences:

>Translated_598_residues
MRVADYIAQLIAEHEQTAKTVFMVSGGGNMHLIDALGRNEKLRYVCNHHEQACAIAAEGYSRVSNQIGIAYVTTGPGGTN
AITGVMGAWVDSIPMLIVSGQVKFQTTIASQPELNLRQLGDQEINIVDIVRPITKYAVMITDKNSIRFHLEKALYEAKHG
RPGPVWIDVPLDIQGAQIEPESLEGFAPPPEPDYDLKIDQVMTALKRAKRPVIIAGNGIVLSGAVGKFRALAEKLGIPVL
GTFARYDIVKESDPCYAGRFGTLGHRAGNFAVQNSDLIIAIGARLNVRAISYNWEYFGREAEKVVVDIDENELKKHTIKA
DIPVCADAGAFIKALSCALETLSPMHQQWMERCRRYRETFPTIIEERQKVKIKVDSYHFFDVLSDCAPDNAVFVFGNGTA
CVSSYQSLRLKQGQNIVVNSGCASMGYDLPAAIGACYAAPDRQIICVTGDGSMQMNIQELQTIVHNHLPIKLFVLNNEGY
ISIRNTQQGFFKGHFVGCEASSGVSCPDTLKVAEAYGLKNGRIDNHQGLSEQIKAFLSEDGPVVCEVMLDPGEKMEPKLS
SEVKSDGRIVSKPLEDMFPFLDRDVFNQQMIIGTIDED
>Mature_598_residues
MRVADYIAQLIAEHEQTAKTVFMVSGGGNMHLIDALGRNEKLRYVCNHHEQACAIAAEGYSRVSNQIGIAYVTTGPGGTN
AITGVMGAWVDSIPMLIVSGQVKFQTTIASQPELNLRQLGDQEINIVDIVRPITKYAVMITDKNSIRFHLEKALYEAKHG
RPGPVWIDVPLDIQGAQIEPESLEGFAPPPEPDYDLKIDQVMTALKRAKRPVIIAGNGIVLSGAVGKFRALAEKLGIPVL
GTFARYDIVKESDPCYAGRFGTLGHRAGNFAVQNSDLIIAIGARLNVRAISYNWEYFGREAEKVVVDIDENELKKHTIKA
DIPVCADAGAFIKALSCALETLSPMHQQWMERCRRYRETFPTIIEERQKVKIKVDSYHFFDVLSDCAPDNAVFVFGNGTA
CVSSYQSLRLKQGQNIVVNSGCASMGYDLPAAIGACYAAPDRQIICVTGDGSMQMNIQELQTIVHNHLPIKLFVLNNEGY
ISIRNTQQGFFKGHFVGCEASSGVSCPDTLKVAEAYGLKNGRIDNHQGLSEQIKAFLSEDGPVVCEVMLDPGEKMEPKLS
SEVKSDGRIVSKPLEDMFPFLDRDVFNQQMIIGTIDED

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=550, Percent_Identity=24.5454545454545, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI93004078, Length=542, Percent_Identity=24.5387453874539, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1790104, Length=556, Percent_Identity=28.9568345323741, Blast_Score=248, Evalue=9e-67,
Organism=Escherichia coli, GI87081685, Length=561, Percent_Identity=29.5900178253119, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI1786717, Length=575, Percent_Identity=26.6086956521739, Blast_Score=202, Evalue=7e-53,
Organism=Escherichia coli, GI1787096, Length=567, Percent_Identity=21.8694885361552, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788716, Length=544, Percent_Identity=22.4264705882353, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17542570, Length=538, Percent_Identity=23.9776951672862, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17531301, Length=520, Percent_Identity=23.8461538461538, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17531299, Length=520, Percent_Identity=23.8461538461538, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323755, Length=563, Percent_Identity=29.8401420959147, Blast_Score=230, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6323073, Length=497, Percent_Identity=23.3400402414487, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320123, Length=497, Percent_Identity=23.943661971831, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321524, Length=497, Percent_Identity=23.5412474849095, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323163, Length=498, Percent_Identity=23.4939759036145, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320816, Length=511, Percent_Identity=23.2876712328767, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320588, Length=523, Percent_Identity=23.3269598470363, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19922626, Length=584, Percent_Identity=24.486301369863, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 65762; Mature: 65762

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVADYIAQLIAEHEQTAKTVFMVSGGGNMHLIDALGRNEKLRYVCNHHEQACAIAAEGY
CCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCCCCHHEEEHHHHH
SRVSNQIGIAYVTTGPGGTNAITGVMGAWVDSIPMLIVSGQVKFQTTIASQPELNLRQLG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCCCCHHHHCC
DQEINIVDIVRPITKYAVMITDKNSIRFHLEKALYEAKHGRPGPVWIDVPLDIQGAQIEP
CCCCCHHHHHHHHHHEEEEEECCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCEECH
ESLEGFAPPPEPDYDLKIDQVMTALKRAKRPVIIAGNGIVLSGAVGKFRALAEKLGIPVL
HHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEECCCEEEECCHHHHHHHHHHCCCCEE
GTFARYDIVKESDPCYAGRFGTLGHRAGNFAVQNSDLIIAIGARLNVRAISYNWEYFGRE
EHHHHHEEECCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEEECHHHHCCC
AEKVVVDIDENELKKHTIKADIPVCADAGAFIKALSCALETLSPMHQQWMERCRRYRETF
CCEEEEECCHHHHHHHEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PTIIEERQKVKIKVDSYHFFDVLSDCAPDNAVFVFGNGTACVSSYQSLRLKQGQNIVVNS
HHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
GCASMGYDLPAAIGACYAAPDRQIICVTGDGSMQMNIQELQTIVHNHLPIKLFVLNNEGY
CCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCE
ISIRNTQQGFFKGHFVGCEASSGVSCPDTLKVAEAYGLKNGRIDNHQGLSEQIKAFLSED
EEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
GPVVCEVMLDPGEKMEPKLSSEVKSDGRIVSKPLEDMFPFLDRDVFNQQMIIGTIDED
CCEEEEEEECCCCCCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure
MRVADYIAQLIAEHEQTAKTVFMVSGGGNMHLIDALGRNEKLRYVCNHHEQACAIAAEGY
CCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCCCCHHEEEHHHHH
SRVSNQIGIAYVTTGPGGTNAITGVMGAWVDSIPMLIVSGQVKFQTTIASQPELNLRQLG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCCCCHHHHCC
DQEINIVDIVRPITKYAVMITDKNSIRFHLEKALYEAKHGRPGPVWIDVPLDIQGAQIEP
CCCCCHHHHHHHHHHEEEEEECCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCEECH
ESLEGFAPPPEPDYDLKIDQVMTALKRAKRPVIIAGNGIVLSGAVGKFRALAEKLGIPVL
HHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEECCCEEEECCHHHHHHHHHHCCCCEE
GTFARYDIVKESDPCYAGRFGTLGHRAGNFAVQNSDLIIAIGARLNVRAISYNWEYFGRE
EHHHHHEEECCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEEECHHHHCCC
AEKVVVDIDENELKKHTIKADIPVCADAGAFIKALSCALETLSPMHQQWMERCRRYRETF
CCEEEEECCHHHHHHHEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PTIIEERQKVKIKVDSYHFFDVLSDCAPDNAVFVFGNGTACVSSYQSLRLKQGQNIVVNS
HHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
GCASMGYDLPAAIGACYAAPDRQIICVTGDGSMQMNIQELQTIVHNHLPIKLFVLNNEGY
CCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCE
ISIRNTQQGFFKGHFVGCEASSGVSCPDTLKVAEAYGLKNGRIDNHQGLSEQIKAFLSED
EEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
GPVVCEVMLDPGEKMEPKLSSEVKSDGRIVSKPLEDMFPFLDRDVFNQQMIIGTIDED
CCEEEEEEECCCCCCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]