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The map label for this gene is ispD

Identifier: 193212985

GI number: 193212985

Start: 1450461

End: 1451201

Strand: Direct

Name: ispD

Synonym: Cpar_1335

Alternate gene names: 193212985

Gene position: 1450461-1451201 (Clockwise)

Preceding gene: 193212984

Following gene: 193212986

Centisome position: 63.36

GC content: 57.22

Gene sequence:

>741_bases
ATGAAAACCGTTGCAATCATCGCCGCCAGCGGAGTCGGCAAACGCATGAAGCTCGATGGCGGCATGAGCAAGCAGATGAT
CGAAATCGGAGGCCATACGGTCATCTGGCACACCATGAAAGCCTTTCAGGATGCCGAATCGGTCGACGCGGTCTATATCG
CCACCAAATCCGACAGCATCGAACCGTTTAAGCAGCTCGCCCGCGAGAACGGCTTCACGAAGATCCACTCGATCATCGAA
GGCGGAAAAGAACGCCAGGACTCGATCAGAAATTGCATGGATCTGATCGAAGAGGAGATCGAATCATCTGGCGTCATGCC
CGACGCGATCCTGGTACACGACGGCGCACGCCCCTTCATCCAACCGGAAGAGATCGACGAGATCGCAAGGATTTCGGCAG
AGCACGGCGCATGCGTGCCCGCTACAAAGCCCAAGGACACCATCAAATACATCGGACGCACCCCCGAGGTGTTCGGCGAA
ACCCTTGACCGCAGCCGCCTGCTGCAGGTGCAGACCCCGCAGGGATTCACACCAGCGAAACTCATCGAAGCACACCGGAA
AGCCGCCAGCGACGGCGTGTATGCCACCGATGACGCGGCGCTTGTCGAGCGCTACTTCCCCGAGCAGGAGATTCATGTCT
ACGAGATGGGCTACCACAACATCAAGATCACTACGCCCGAAGACGTCCCTGTCGGTGAGGCGATTCTGGCCGGACTCAAA
GCCAGAAAAAGCGAAAATTAA

Upstream 100 bases:

>100_bases
TCGCCGAGCACCGCCTGCTCATGGACGCCTACAAAACCGCACTCAAGAACAACTACCGGTTCCTGGCCTACGGGGACTCA
ATGCTCATCGTCTGAAGACC

Downstream 100 bases:

>100_bases
TTGCTGGCCGACGCTTGTTTTTTGAAAAGCGCCATCGTATATTATCAGCCCCTAAGGTGAGATAGCTCAGTTGGTTAGAG
CACAGGATTCATAACCCTGA

Product: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKTVAIIAASGVGKRMKLDGGMSKQMIEIGGHTVIWHTMKAFQDAESVDAVYIATKSDSIEPFKQLARENGFTKIHSIIE
GGKERQDSIRNCMDLIEEEIESSGVMPDAILVHDGARPFIQPEEIDEIARISAEHGACVPATKPKDTIKYIGRTPEVFGE
TLDRSRLLQVQTPQGFTPAKLIEAHRKAASDGVYATDDAALVERYFPEQEIHVYEMGYHNIKITTPEDVPVGEAILAGLK
ARKSEN

Sequences:

>Translated_246_residues
MKTVAIIAASGVGKRMKLDGGMSKQMIEIGGHTVIWHTMKAFQDAESVDAVYIATKSDSIEPFKQLARENGFTKIHSIIE
GGKERQDSIRNCMDLIEEEIESSGVMPDAILVHDGARPFIQPEEIDEIARISAEHGACVPATKPKDTIKYIGRTPEVFGE
TLDRSRLLQVQTPQGFTPAKLIEAHRKAASDGVYATDDAALVERYFPEQEIHVYEMGYHNIKITTPEDVPVGEAILAGLK
ARKSEN
>Mature_246_residues
MKTVAIIAASGVGKRMKLDGGMSKQMIEIGGHTVIWHTMKAFQDAESVDAVYIATKSDSIEPFKQLARENGFTKIHSIIE
GGKERQDSIRNCMDLIEEEIESSGVMPDAILVHDGARPFIQPEEIDEIARISAEHGACVPATKPKDTIKYIGRTPEVFGE
TLDRSRLLQVQTPQGFTPAKLIEAHRKAASDGVYATDDAALVERYFPEQEIHVYEMGYHNIKITTPEDVPVGEAILAGLK
ARKSEN

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=203, Percent_Identity=25.1231527093596, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789104, Length=241, Percent_Identity=29.045643153527, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_CHLP8 (B3QP85)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998938.1
- GeneID:   6420271
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1335
- HOGENOM:   HBG672839
- OMA:   PSNIKVT
- ProtClustDB:   CLSK637702
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 27118; Mature: 27118

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVAIIAASGVGKRMKLDGGMSKQMIEIGGHTVIWHTMKAFQDAESVDAVYIATKSDSI
CCEEEEEEECCCCCEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHCCCCEEEEEECCCCH
EPFKQLARENGFTKIHSIIEGGKERQDSIRNCMDLIEEEIESSGVMPDAILVHDGARPFI
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
QPEEIDEIARISAEHGACVPATKPKDTIKYIGRTPEVFGETLDRSRLLQVQTPQGFTPAK
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCHHCEEEEECCCCCCHHH
LIEAHRKAASDGVYATDDAALVERYFPEQEIHVYEMGYHNIKITTPEDVPVGEAILAGLK
HHHHHHHHHCCCCEECCHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHH
ARKSEN
HHCCCC
>Mature Secondary Structure
MKTVAIIAASGVGKRMKLDGGMSKQMIEIGGHTVIWHTMKAFQDAESVDAVYIATKSDSI
CCEEEEEEECCCCCEEEECCCCCHHHHHHCCCEEEHHHHHHHHHHCCCCEEEEEECCCCH
EPFKQLARENGFTKIHSIIEGGKERQDSIRNCMDLIEEEIESSGVMPDAILVHDGARPFI
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
QPEEIDEIARISAEHGACVPATKPKDTIKYIGRTPEVFGETLDRSRLLQVQTPQGFTPAK
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCHHCEEEEECCCCCCHHH
LIEAHRKAASDGVYATDDAALVERYFPEQEIHVYEMGYHNIKITTPEDVPVGEAILAGLK
HHHHHHHHHCCCCEECCHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHH
ARKSEN
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA