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The map label for this gene is tmk

Identifier: 193212981

GI number: 193212981

Start: 1444026

End: 1444679

Strand: Direct

Name: tmk

Synonym: Cpar_1331

Alternate gene names: 193212981

Gene position: 1444026-1444679 (Clockwise)

Preceding gene: 193212980

Following gene: 193212982

Centisome position: 63.08

GC content: 57.65

Gene sequence:

>654_bases
ATGCTTATCACCTTCGAAGGAATCGACGGCGCAGGAAAATCGACCCAGGTCGTCAAGCTGAAACGCCATCTCCAGGAACG
CGGCCGTGAGGTGCTCACCCTGCGCGAGCCGGGCGGGACACCCGTTGCCGAGCAGATTCGGGAGCTGCTGCTCGAAAGCC
ATAACGATATCACCTCGATCGCAGAGTTGCTGCTCTTTTCGGCAAGCCGGGCAGAGCTGATGGAGAAGATCATCGTGCCC
GCACTGGAGGACGGCTGCGACGTCATTCTGGATCGTTTTTTCGATTCGACCACCGCTTACCAGGGCTACGGCCGCGGGCT
GAACCTCGACATGCTCGCAGAAATCAACCGGATCGCCTCGCACGGCATTCGCCCCGACATCACCTTTTACCTCGACCTCA
CGCCTGAAGACGCGCTGTTGAGGAAGTTCTCCGAAAAATCGCTGCCGCTGGCGTTCGAGTCCGAAGAGCTGGACCGCATG
GAGAATTCGGGGCTTGAATTTTACCAGCGTGTCCGGGCCGGTTATCACGCCATTCTGGAAGCTGAACCGCAGCGAATTAT
CATGATCGACGCACTTCTGACGCCACAGGAAATCCACCGGAAAATCCTCTCGGCACTTCAAGCTCTCGAGGTTCCAGAAG
ACGGTAAACGCTAA

Upstream 100 bases:

>100_bases
TCAGGGATTGCGGCCACTGCCCTATGCTTGAATACCCGGAAAAGTTCAGCTCGGCGGTCAAAAATTTTATTTTTGAGGAA
ACACCAGCGCATTAAGACTT

Downstream 100 bases:

>100_bases
GACGGAACCGGAAAAACGTGGGAGCTGTTAGGCATTGGCAGCGACACAAAAAACAAGATTTACTGAATCGTGAAACTCTT
TTTTCGTAAATTTACGTTTC

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MLITFEGIDGAGKSTQVVKLKRHLQERGREVLTLREPGGTPVAEQIRELLLESHNDITSIAELLLFSASRAELMEKIIVP
ALEDGCDVILDRFFDSTTAYQGYGRGLNLDMLAEINRIASHGIRPDITFYLDLTPEDALLRKFSEKSLPLAFESEELDRM
ENSGLEFYQRVRAGYHAILEAEPQRIIMIDALLTPQEIHRKILSALQALEVPEDGKR

Sequences:

>Translated_217_residues
MLITFEGIDGAGKSTQVVKLKRHLQERGREVLTLREPGGTPVAEQIRELLLESHNDITSIAELLLFSASRAELMEKIIVP
ALEDGCDVILDRFFDSTTAYQGYGRGLNLDMLAEINRIASHGIRPDITFYLDLTPEDALLRKFSEKSLPLAFESEELDRM
ENSGLEFYQRVRAGYHAILEAEPQRIIMIDALLTPQEIHRKILSALQALEVPEDGKR
>Mature_217_residues
MLITFEGIDGAGKSTQVVKLKRHLQERGREVLTLREPGGTPVAEQIRELLLESHNDITSIAELLLFSASRAELMEKIIVP
ALEDGCDVILDRFFDSTTAYQGYGRGLNLDMLAEINRIASHGIRPDITFYLDLTPEDALLRKFSEKSLPLAFESEELDRM
ENSGLEFYQRVRAGYHAILEAEPQRIIMIDALLTPQEIHRKILSALQALEVPEDGKR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=194, Percent_Identity=43.298969072165, Blast_Score=126, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHLP8 (B3QP81)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998934.1
- GeneID:   6420267
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1331
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK637698
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24488; Mature: 24488

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITFEGIDGAGKSTQVVKLKRHLQERGREVLTLREPGGTPVAEQIRELLLESHNDITSI
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHH
AELLLFSASRAELMEKIIVPALEDGCDVILDRFFDSTTAYQGYGRGLNLDMLAEINRIAS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHH
HGIRPDITFYLDLTPEDALLRKFSEKSLPLAFESEELDRMENSGLEFYQRVRAGYHAILE
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHHHHC
AEPQRIIMIDALLTPQEIHRKILSALQALEVPEDGKR
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLITFEGIDGAGKSTQVVKLKRHLQERGREVLTLREPGGTPVAEQIRELLLESHNDITSI
CEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHH
AELLLFSASRAELMEKIIVPALEDGCDVILDRFFDSTTAYQGYGRGLNLDMLAEINRIAS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHH
HGIRPDITFYLDLTPEDALLRKFSEKSLPLAFESEELDRMENSGLEFYQRVRAGYHAILE
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHHHHC
AEPQRIIMIDALLTPQEIHRKILSALQALEVPEDGKR
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA