Click here to switch to the map view.

The map label for this gene is hldD [H]

Identifier: 193212913

GI number: 193212913

Start: 1378296

End: 1379291

Strand: Direct

Name: hldD [H]

Synonym: Cpar_1263

Alternate gene names: 193212913

Gene position: 1378296-1379291 (Clockwise)

Preceding gene: 193212912

Following gene: 193212914

Centisome position: 60.21

GC content: 56.12

Gene sequence:

>996_bases
ATGATCATCATTACCGGCGGCGCCGGATTCATCGGCAGCGCCATGCTCTGGGAGCTGAACCGTCATGGTCTTAACGATGT
ACTGATCGTCGATGACCTTGGGCTTGCATCCGAAGGAAAATGGCTCAATCTCAGAGGCCTTCGCTACGCCGACTTCGTCC
ACAAAGACGACCTCCCCGTCCTCTTACAGCATAACCAGCTTCCAGACATCGAGGCGATCATCCACATGGGCGCCATCAGC
TCCACAACAGAGCAGGATGCCGGCTTGCTCATGCGCAACAACTACGAGTATTCAAAGTTGCTGGCATCATGGTGCGCCGA
CAAAGGCGTGCGATTTATCTACGCATCGAGCGCCGCGACCTTCGGCGACGGCTCGGCGGGATACACCGATGGCACTGAAC
CGCTCGACCGACTGAGGCCGCTGAACATGTACGGCTACTCCAAGCATCTCTTCGACTGCTGGGCGCACCGCAACGGCATC
CTCGACAAGGCGGCCGGCCTGAAATTCTATAATGTTTACGGCCCGAACGAGTACCACAAAGAGGATATGACCAGCGTGGT
CTTCAAGGCCTTCAACCAGATTCGCGAACACGGGACGGTCAAGCTCTTCCGGTCGCATCATCCGGATTTTGCGGACGGAG
AGCAGATGCGCGACTTCGTCTACGTGAAAGATTGCACCCGCATCATGCACTGGCTGCTGGAAACTCCTGCGGCGGCAGGA
CTGTTCAATGTGGGAACCGGTCAGGCGCGTAGTTTCAAAGACCTTGTAACGGCAACGTTCGACGCGCTGGAGCAACCGGT
CAACATCGAGTTTATCGACATGCCCGAAACCATTCGGGAAAAATACCAGTACTACACCTGCGCCGATTGCGGCAATCTCA
GGCAAGCCGGATTTACCGAGCCAATGACTTCGCTTGAAGATGGCGTGCGCGATTATGTCCGCAACCACCTGAACACCGCT
TCACCGCATCTGGAAAACCGTCGGTCGACAGAATAA

Upstream 100 bases:

>100_bases
TATCCCAGCGCAAGACCGGTTTCTCCAGCGAACCGGTCTTTTGCTTTTACAGGCCAACAGGCGTATATTTTTTTGTGCAC
AACCATTTTGACCCTTTTTC

Downstream 100 bases:

>100_bases
AACAAGGAAAACCTTGACTGAAAAAACAATCGAATTCGAAGGCATCGAGCCGGTCATTATTTTCGGGCCATACGACAGCT
ATCTGAAAAAAGTCCGTGAA

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MIIITGGAGFIGSAMLWELNRHGLNDVLIVDDLGLASEGKWLNLRGLRYADFVHKDDLPVLLQHNQLPDIEAIIHMGAIS
STTEQDAGLLMRNNYEYSKLLASWCADKGVRFIYASSAATFGDGSAGYTDGTEPLDRLRPLNMYGYSKHLFDCWAHRNGI
LDKAAGLKFYNVYGPNEYHKEDMTSVVFKAFNQIREHGTVKLFRSHHPDFADGEQMRDFVYVKDCTRIMHWLLETPAAAG
LFNVGTGQARSFKDLVTATFDALEQPVNIEFIDMPETIREKYQYYTCADCGNLRQAGFTEPMTSLEDGVRDYVRNHLNTA
SPHLENRRSTE

Sequences:

>Translated_331_residues
MIIITGGAGFIGSAMLWELNRHGLNDVLIVDDLGLASEGKWLNLRGLRYADFVHKDDLPVLLQHNQLPDIEAIIHMGAIS
STTEQDAGLLMRNNYEYSKLLASWCADKGVRFIYASSAATFGDGSAGYTDGTEPLDRLRPLNMYGYSKHLFDCWAHRNGI
LDKAAGLKFYNVYGPNEYHKEDMTSVVFKAFNQIREHGTVKLFRSHHPDFADGEQMRDFVYVKDCTRIMHWLLETPAAAG
LFNVGTGQARSFKDLVTATFDALEQPVNIEFIDMPETIREKYQYYTCADCGNLRQAGFTEPMTSLEDGVRDYVRNHLNTA
SPHLENRRSTE
>Mature_331_residues
MIIITGGAGFIGSAMLWELNRHGLNDVLIVDDLGLASEGKWLNLRGLRYADFVHKDDLPVLLQHNQLPDIEAIIHMGAIS
STTEQDAGLLMRNNYEYSKLLASWCADKGVRFIYASSAATFGDGSAGYTDGTEPLDRLRPLNMYGYSKHLFDCWAHRNGI
LDKAAGLKFYNVYGPNEYHKEDMTSVVFKAFNQIREHGTVKLFRSHHPDFADGEQMRDFVYVKDCTRIMHWLLETPAAAG
LFNVGTGQARSFKDLVTATFDALEQPVNIEFIDMPETIREKYQYYTCADCGNLRQAGFTEPMTSLEDGVRDYVRNHLNTA
SPHLENRRSTE

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=318, Percent_Identity=41.8238993710692, Blast_Score=230, Evalue=8e-62,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37393; Mature: 37393

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIITGGAGFIGSAMLWELNRHGLNDVLIVDDLGLASEGKWLNLRGLRYADFVHKDDLPV
CEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHCCCCCCE
LLQHNQLPDIEAIIHMGAISSTTEQDAGLLMRNNYEYSKLLASWCADKGVRFIYASSAAT
EEECCCCCCHHHHHHHCCCCCCCCHHCCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCC
FGDGSAGYTDGTEPLDRLRPLNMYGYSKHLFDCWAHRNGILDKAAGLKFYNVYGPNEYHK
CCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEECCCCHHHH
EDMTSVVFKAFNQIREHGTVKLFRSHHPDFADGEQMRDFVYVKDCTRIMHWLLETPAAAG
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCC
LFNVGTGQARSFKDLVTATFDALEQPVNIEFIDMPETIREKYQYYTCADCGNLRQAGFTE
EEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCEEEECCCCCCCCCCCCC
PMTSLEDGVRDYVRNHLNTASPHLENRRSTE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIIITGGAGFIGSAMLWELNRHGLNDVLIVDDLGLASEGKWLNLRGLRYADFVHKDDLPV
CEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHCCCCCCE
LLQHNQLPDIEAIIHMGAISSTTEQDAGLLMRNNYEYSKLLASWCADKGVRFIYASSAAT
EEECCCCCCHHHHHHHCCCCCCCCHHCCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCC
FGDGSAGYTDGTEPLDRLRPLNMYGYSKHLFDCWAHRNGILDKAAGLKFYNVYGPNEYHK
CCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEECCCCHHHH
EDMTSVVFKAFNQIREHGTVKLFRSHHPDFADGEQMRDFVYVKDCTRIMHWLLETPAAAG
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCC
LFNVGTGQARSFKDLVTATFDALEQPVNIEFIDMPETIREKYQYYTCADCGNLRQAGFTE
EEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCEEEECCCCCCCCCCCCC
PMTSLEDGVRDYVRNHLNTASPHLENRRSTE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA