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The map label for this gene is pth

Identifier: 193212908

GI number: 193212908

Start: 1374215

End: 1374787

Strand: Direct

Name: pth

Synonym: Cpar_1258

Alternate gene names: 193212908

Gene position: 1374215-1374787 (Clockwise)

Preceding gene: 193212907

Following gene: 193212912

Centisome position: 60.03

GC content: 58.29

Gene sequence:

>573_bases
ATGAAACTCATCATCGGACTCGGTAATCCGGAACCCCGCTACGACGGCACCCGCCACAACGTCGGCTTCGAGGTCGTGGA
TCGGCTTGCATCGTCATTCCAGGCGCCGTTCAAGGCGGGCAAAGGTAAATACCACGAAGCCAAATGCAGCCACCGCGGAG
AGTCGCTGCTGCTCGTCAGGCCGACGACCTACATGAACCACTCCGGCCAGGCAGTCATGGCGGCCATGCAGTTCTACAAA
GTCAAGAGACAGGACATGCTCGTCATCTGCGACGACCTGAACCTCCCGGTCGGCACCATCCGCTTGCGCGCCAAAGGCTC
GGACGGTGGACAGAACGGCCTGAAGCACATTATCCAGCAAATGGGCACCAACGAATTTTCCCGCTTGCGAATCGGCATCC
GCAAGGGCGACATGCCCCCCGGCTCGTTTTCATCATTCGTGCTTGGGAAATTCGATGAGGAGGAGAGAAAAGTGATCGAC
CGCGTAGTCGAAACCAGCGCCGATGCCGTGCTCGACTTCGCACTCAACGGCATCGAACACGCGATGACCCAGTTCAACAA
AACGGTTGCCTGA

Upstream 100 bases:

>100_bases
TTGATTAATCGCGACGGTTTCGTACCATACGGCGGTCTTCCTCTACGGAAGGCCGCCGTTTTCTTTTGCATGACACTGCT
CGATCGACAAGCACGCTACC

Downstream 100 bases:

>100_bases
ACACAGGAAGACCGACTCCCCTGCCATTCACCACAGGGCAGACGACAGCAGAATCAGACACACAACAGCTTAACAGACCG
CCAGTTCCAGAGATGGAGTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKLIIGLGNPEPRYDGTRHNVGFEVVDRLASSFQAPFKAGKGKYHEAKCSHRGESLLLVRPTTYMNHSGQAVMAAMQFYK
VKRQDMLVICDDLNLPVGTIRLRAKGSDGGQNGLKHIIQQMGTNEFSRLRIGIRKGDMPPGSFSSFVLGKFDEEERKVID
RVVETSADAVLDFALNGIEHAMTQFNKTVA

Sequences:

>Translated_190_residues
MKLIIGLGNPEPRYDGTRHNVGFEVVDRLASSFQAPFKAGKGKYHEAKCSHRGESLLLVRPTTYMNHSGQAVMAAMQFYK
VKRQDMLVICDDLNLPVGTIRLRAKGSDGGQNGLKHIIQQMGTNEFSRLRIGIRKGDMPPGSFSSFVLGKFDEEERKVID
RVVETSADAVLDFALNGIEHAMTQFNKTVA
>Mature_190_residues
MKLIIGLGNPEPRYDGTRHNVGFEVVDRLASSFQAPFKAGKGKYHEAKCSHRGESLLLVRPTTYMNHSGQAVMAAMQFYK
VKRQDMLVICDDLNLPVGTIRLRAKGSDGGQNGLKHIIQQMGTNEFSRLRIGIRKGDMPPGSFSSFVLGKFDEEERKVID
RVVETSADAVLDFALNGIEHAMTQFNKTVA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=173, Percent_Identity=29.4797687861272, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=38.4210526315789, Blast_Score=110, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=31.6939890710383, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CHLP8 (B3QP08)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998861.1
- GeneID:   6420190
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1258
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21085; Mature: 21085

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIIGLGNPEPRYDGTRHNVGFEVVDRLASSFQAPFKAGKGKYHEAKCSHRGESLLLVR
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHCCCCCEEEEEC
PTTYMNHSGQAVMAAMQFYKVKRQDMLVICDDLNLPVGTIRLRAKGSDGGQNGLKHIIQQ
CCHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGTNEFSRLRIGIRKGDMPPGSFSSFVLGKFDEEERKVIDRVVETSADAVLDFALNGIEH
HCCCCHHHEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AMTQFNKTVA
HHHHHHHCCC
>Mature Secondary Structure
MKLIIGLGNPEPRYDGTRHNVGFEVVDRLASSFQAPFKAGKGKYHEAKCSHRGESLLLVR
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHCCCCCEEEEEC
PTTYMNHSGQAVMAAMQFYKVKRQDMLVICDDLNLPVGTIRLRAKGSDGGQNGLKHIIQQ
CCHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGTNEFSRLRIGIRKGDMPPGSFSSFVLGKFDEEERKVIDRVVETSADAVLDFALNGIEH
HCCCCHHHEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AMTQFNKTVA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA