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The map label for this gene is fadH [H]

Identifier: 192288834

GI number: 192288834

Start: 431221

End: 432057

Strand: Reverse

Name: fadH [H]

Synonym: Rpal_0403

Alternate gene names: 192288834

Gene position: 432057-431221 (Counterclockwise)

Preceding gene: 192288836

Following gene: 192288833

Centisome position: 7.52

GC content: 68.22

Gene sequence:

>837_bases
ATGTTCGAGGCTGGACTGCTCGCGAACAGACGGATTCTGATTACCGGCGGCGGTTCCGGACTCGGCGCCGCGATGGCGGC
ACGCTTTGCCGAACTCGGTGCGTCGCTGGTGCTGTGCGGGCGGCGTGCCGAGGTGCTGCAAGAGACCGCGGAGCAACTTC
GGTCACACGGCAGCCAAGTCGACACCATCGTTTGCGACGTGCGCGATCCGCAAGCGGTCGAAGCCATGCTCGACGAGATC
TGGCGCGTTGCGCCGCTCGACGTACTGGTCAACAACGCCGCTGCGACCTTCATCGCACAGACCGAACGCCTGTCGGCGCG
TGCCGCCGACGCGATCCTGGCGCCGACGCTGCACGGCGCGATGTACTGCACGCTCGGCGCCGGCCGGCGCTGGATCGACG
GCGAACATGCGGGCGTCGTGCTCAGCATCCTGTCGACCTCGACGATCACCGGCCGCGCCTTTACAGTGCCGTCCGCAATG
GCCAAGTCGGCGGTGCTGGCGATGACCAAGAGCCTCGCGGTCGAATGGGGACCGAAGCAGATCCGGTTGGTGGCCATCGC
GCCGGGTGCATTTCCGACCGCGGGTGCGACCGCGCAGCTGAGGCCCGACGGCCGCTCCGCCGATCCGGCGGACCGGGTGC
CACTCGGCCGCGTCGGTCGCCACGCCGAACTCGCCAATCTCGCCAGCTTCCTGATCTCCGATCAGGCCGGCTACATCACC
GGCGAGATGGTGGTGCAGGACGGCGGTACCCATCTGCGCAGCTCCGGCGCCGAAGACCTGCTGCAATGGAACGATCAGCA
ATGGTCCGCGCATCGGGCCGGGCGCGCCAAATCCTGA

Upstream 100 bases:

>100_bases
TCGAAAGATGATGGATGCCCGGATTAAGTCCGGGCCTGACGCTGCATGTGGGACTAATTCCGCACGAATTCCGCTTCGCG
GTTAATCAAGGAGGCGCGCG

Downstream 100 bases:

>100_bases
CGGTACGCCAGCTACATGCCGAGGCCGGATCGGCGGTGAGCAACGCCGGCTGACGGCTTTCCAGAATCGACCGGCCCGGT
TATTCCGGGCGTCGTGACCA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MFEAGLLANRRILITGGGSGLGAAMAARFAELGASLVLCGRRAEVLQETAEQLRSHGSQVDTIVCDVRDPQAVEAMLDEI
WRVAPLDVLVNNAAATFIAQTERLSARAADAILAPTLHGAMYCTLGAGRRWIDGEHAGVVLSILSTSTITGRAFTVPSAM
AKSAVLAMTKSLAVEWGPKQIRLVAIAPGAFPTAGATAQLRPDGRSADPADRVPLGRVGRHAELANLASFLISDQAGYIT
GEMVVQDGGTHLRSSGAEDLLQWNDQQWSAHRAGRAKS

Sequences:

>Translated_278_residues
MFEAGLLANRRILITGGGSGLGAAMAARFAELGASLVLCGRRAEVLQETAEQLRSHGSQVDTIVCDVRDPQAVEAMLDEI
WRVAPLDVLVNNAAATFIAQTERLSARAADAILAPTLHGAMYCTLGAGRRWIDGEHAGVVLSILSTSTITGRAFTVPSAM
AKSAVLAMTKSLAVEWGPKQIRLVAIAPGAFPTAGATAQLRPDGRSADPADRVPLGRVGRHAELANLASFLISDQAGYIT
GEMVVQDGGTHLRSSGAEDLLQWNDQQWSAHRAGRAKS
>Mature_278_residues
MFEAGLLANRRILITGGGSGLGAAMAARFAELGASLVLCGRRAEVLQETAEQLRSHGSQVDTIVCDVRDPQAVEAMLDEI
WRVAPLDVLVNNAAATFIAQTERLSARAADAILAPTLHGAMYCTLGAGRRWIDGEHAGVVLSILSTSTITGRAFTVPSAM
AKSAVLAMTKSLAVEWGPKQIRLVAIAPGAFPTAGATAQLRPDGRSADPADRVPLGRVGRHAELANLASFLISDQAGYIT
GEMVVQDGGTHLRSSGAEDLLQWNDQQWSAHRAGRAKS

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=244, Percent_Identity=42.6229508196721, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=29.7709923664122, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI10190704, Length=257, Percent_Identity=33.852140077821, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=28.5140562248996, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=28.0487804878049, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=27.3092369477912, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=31.7391304347826, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=27.0916334661355, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=31.3008130081301, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=31.2741312741313, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=28.2786885245902, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=30.2904564315353, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=30.2040816326531, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=27.2, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=27.6150627615063, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=28.8065843621399, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367365, Length=257, Percent_Identity=24.9027237354086, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=27.2030651340996, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=274, Percent_Identity=38.3211678832117, Blast_Score=170, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17561272, Length=256, Percent_Identity=39.84375, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17536651, Length=275, Percent_Identity=36.3636363636364, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=25.8426966292135, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=277, Percent_Identity=27.0758122743682, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=31.7460317460317, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=28, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.1044776119403, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=26, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=243, Percent_Identity=25.1028806584362, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=25.0950570342205, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=24.4979919678715, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=25.5813953488372, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=256, Percent_Identity=24.609375, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=26.1224489795918, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=26.0536398467433, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355319, Length=266, Percent_Identity=28.1954887218045, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=31.3492063492063, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.8880308880309, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=28.1124497991968, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357041, Length=261, Percent_Identity=29.1187739463602, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 29230; Mature: 29230

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEAGLLANRRILITGGGSGLGAAMAARFAELGASLVLCGRRAEVLQETAEQLRSHGSQV
CCCCCEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCEE
DTIVCDVRDPQAVEAMLDEIWRVAPLDVLVNNAAATFIAQTERLSARAADAILAPTLHGA
EEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
MYCTLGAGRRWIDGEHAGVVLSILSTSTITGRAFTVPSAMAKSAVLAMTKSLAVEWGPKQ
EEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHEEECCCE
IRLVAIAPGAFPTAGATAQLRPDGRSADPADRVPLGRVGRHAELANLASFLISDQAGYIT
EEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
GEMVVQDGGTHLRSSGAEDLLQWNDQQWSAHRAGRAKS
EEEEEECCCCHHHCCCHHHHHHCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MFEAGLLANRRILITGGGSGLGAAMAARFAELGASLVLCGRRAEVLQETAEQLRSHGSQV
CCCCCEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCEE
DTIVCDVRDPQAVEAMLDEIWRVAPLDVLVNNAAATFIAQTERLSARAADAILAPTLHGA
EEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
MYCTLGAGRRWIDGEHAGVVLSILSTSTITGRAFTVPSAMAKSAVLAMTKSLAVEWGPKQ
EEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHEEECCCE
IRLVAIAPGAFPTAGATAQLRPDGRSADPADRVPLGRVGRHAELANLASFLISDQAGYIT
EEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
GEMVVQDGGTHLRSSGAEDLLQWNDQQWSAHRAGRAKS
EEEEEECCCCHHHCCCHHHHHHCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]