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The map label for this gene is map [H]

Identifier: 192288823

GI number: 192288823

Start: 417363

End: 418187

Strand: Reverse

Name: map [H]

Synonym: Rpal_0392

Alternate gene names: 192288823

Gene position: 418187-417363 (Counterclockwise)

Preceding gene: 192288825

Following gene: 192288821

Centisome position: 7.28

GC content: 65.33

Gene sequence:

>825_bases
ATGAGCTACGTCGACGCCACCGAAACCGCCCAGCGCAAGACCGGGCAGATCAAGCTGCACGGCCCCGCCGGCTTCGCCGG
TATGCGCAAGGCTGGCCAAGTGGTGGCGCGCTGCCTCGACGAACTCGTCGACATCGTCAAGCCGGGGGTTCCGACCTCGC
GGATCGACGATTTTGTTCGCGACTTCGCCTTCAGCAACGGCGCCTATCCGGCGACGCTGATGTACCGCGGCTACCGCTAC
TCGACCTGCACCTCGCTCAACCACGTGGTCTGCCACGGCATGCCGGGCGACCGGCCGCTGAAGGAAGGCGACATCGTCAA
TGTCGACGTGACCATGATCGTCGACGGCTGGTACGGCGATTCCAGCCGGATGTATCCGGTCGGCCCGATCGCCCGCAAAG
CCGAGCGGCTGATCGACGTCACCTACGAGTCGCTGTTGCGCGGCATCGCGGCCGTCAAACCGGGCGCCACCACCGGCGAC
ATCGGCCATGCCATCCAGAGCTTCGTCGAACCGCAGCAGATGAGCGTGGTGCGCGACTTCTGCGGCCACGGCCTCGGCCG
GCTGTTCCACGACGAGCCGAACATCATTCACGTCGGCAGCCCGGGGCAGGGTGCGGTGCTGAAGCCCGGCATGTTCTTCA
CCATCGAGCCGATGATCAATCTCGGCAAACCCTATGTGAAGATCCTGTCCGACGGCTGGACCGCGGTGACCCGCGACCGC
TCTCTGTCGGCGCAGTTCGAACACTCGATCGGCGTCACCGAAGACGGCTGCGAAATCTTCACCGCCTCTCCCAAGGGCCT
CGACAAGCCGCCGTTCCAGAGCTGA

Upstream 100 bases:

>100_bases
CATGTCCGGCCGGCGACCCAGACGGCCGGCGCCCGCGCTTGCTGCATCGGGCCGCGGTCACTAGATTGGGCTCAAATCAC
CCTTAAACAGACTGGTCCGC

Downstream 100 bases:

>100_bases
GCGCCTCCATCGGCCAGCCGCCGTAGCGTCGGCAAAGCCCCCCTACGCCGGACCTACGCTGAAGAGTTCACTCAGTGCTC
GCGTCGCCCTCACCCATTGA

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSYVDATETAQRKTGQIKLHGPAGFAGMRKAGQVVARCLDELVDIVKPGVPTSRIDDFVRDFAFSNGAYPATLMYRGYRY
STCTSLNHVVCHGMPGDRPLKEGDIVNVDVTMIVDGWYGDSSRMYPVGPIARKAERLIDVTYESLLRGIAAVKPGATTGD
IGHAIQSFVEPQQMSVVRDFCGHGLGRLFHDEPNIIHVGSPGQGAVLKPGMFFTIEPMINLGKPYVKILSDGWTAVTRDR
SLSAQFEHSIGVTEDGCEIFTASPKGLDKPPFQS

Sequences:

>Translated_274_residues
MSYVDATETAQRKTGQIKLHGPAGFAGMRKAGQVVARCLDELVDIVKPGVPTSRIDDFVRDFAFSNGAYPATLMYRGYRY
STCTSLNHVVCHGMPGDRPLKEGDIVNVDVTMIVDGWYGDSSRMYPVGPIARKAERLIDVTYESLLRGIAAVKPGATTGD
IGHAIQSFVEPQQMSVVRDFCGHGLGRLFHDEPNIIHVGSPGQGAVLKPGMFFTIEPMINLGKPYVKILSDGWTAVTRDR
SLSAQFEHSIGVTEDGCEIFTASPKGLDKPPFQS
>Mature_273_residues
SYVDATETAQRKTGQIKLHGPAGFAGMRKAGQVVARCLDELVDIVKPGVPTSRIDDFVRDFAFSNGAYPATLMYRGYRYS
TCTSLNHVVCHGMPGDRPLKEGDIVNVDVTMIVDGWYGDSSRMYPVGPIARKAERLIDVTYESLLRGIAAVKPGATTGDI
GHAIQSFVEPQQMSVVRDFCGHGLGRLFHDEPNIIHVGSPGQGAVLKPGMFFTIEPMINLGKPYVKILSDGWTAVTRDRS
LSAQFEHSIGVTEDGCEIFTASPKGLDKPPFQS

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=273, Percent_Identity=43.2234432234432, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI40385867, Length=238, Percent_Identity=38.2352941176471, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=50.2024291497976, Blast_Score=248, Evalue=2e-67,
Organism=Escherichia coli, GI1789275, Length=259, Percent_Identity=23.1660231660232, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=259, Percent_Identity=40.9266409266409, Blast_Score=198, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323273, Length=260, Percent_Identity=40.3846153846154, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355531, Length=266, Percent_Identity=42.1052631578947, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24583427, Length=236, Percent_Identity=39.8305084745763, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29808; Mature: 29677

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVDATETAQRKTGQIKLHGPAGFAGMRKAGQVVARCLDELVDIVKPGVPTSRIDDFVR
CCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DFAFSNGAYPATLMYRGYRYSTCTSLNHVVCHGMPGDRPLKEGDIVNVDVTMIVDGWYGD
HHHHCCCCCCEEEEECCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYPVGPIARKAERLIDVTYESLLRGIAAVKPGATTGDIGHAIQSFVEPQQMSVVRDF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
CGHGLGRLFHDEPNIIHVGSPGQGAVLKPGMFFTIEPMINLGKPYVKILSDGWTAVTRDR
HHCHHHHHCCCCCCEEEECCCCCCCEECCCEEEEECCHHHCCCHHHHHHHCCCEEEECCC
SLSAQFEHSIGVTEDGCEIFTASPKGLDKPPFQS
CCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SYVDATETAQRKTGQIKLHGPAGFAGMRKAGQVVARCLDELVDIVKPGVPTSRIDDFVR
CCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DFAFSNGAYPATLMYRGYRYSTCTSLNHVVCHGMPGDRPLKEGDIVNVDVTMIVDGWYGD
HHHHCCCCCCEEEEECCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYPVGPIARKAERLIDVTYESLLRGIAAVKPGATTGDIGHAIQSFVEPQQMSVVRDF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
CGHGLGRLFHDEPNIIHVGSPGQGAVLKPGMFFTIEPMINLGKPYVKILSDGWTAVTRDR
HHCHHHHHCCCCCCEEEECCCCCCCEECCCEEEEECCHHHCCCHHHHHHHCCCEEEECCC
SLSAQFEHSIGVTEDGCEIFTASPKGLDKPPFQS
CCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]