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The map label for this gene is ribB [H]

Identifier: 190571575

GI number: 190571575

Start: 1269498

End: 1270142

Strand: Direct

Name: ribB [H]

Synonym: WPa_1195

Alternate gene names: 190571575

Gene position: 1269498-1270142 (Clockwise)

Preceding gene: 190571574

Following gene: 190571576

Centisome position: 85.63

GC content: 35.81

Gene sequence:

>645_bases
ATGGTACAAGTAACTTATCCTTCAATTAGTCTACCTGGTATTTCTTCTGTGGAAGATGTATTGAGGGATGCTAGTTCTGG
TAAATTATTCATTTTAGTTGACGATGAAAACAGAGAGAATGAAGGTGATCTGATTGTATTAGCTGAGAAATTAGAGCCAG
AACATGTGGCTTTTATGGTTAGATACGGTACAGGGATTGTTTGCTTAGCAATGACTAAAGTTCACATGAAAAGGTTAGGC
CTTAGTTTCATGGAAAAAAAAAATGTTGGTGAAAATCATACTGCTTTTACTACATCAATTGATGCACGTTATGGTATTAC
TACGGGTGTTTCAGCTGAGGATAGAACAAAAACTATACATGTTGCTATTGATAAAAATAGAACTCAGGATGACATTATAA
CTCCCGGTCATATTTTTCCTGTGATTGCACATGAGGGTGGAGTAGAGCAACGTGCTGGTCATACTGAAGCAAGTGTTGAG
ATAGCTAAGTTAGTGGGATGTAATCATTCTGCAGTTATTTGTGAATTAGTGAATGATGATGGCTCTATGATGCGCTTACC
CCAGTTGCTTGAATTTGCTGAACAACATAATATTAAGTTAACTACCATTGATAAACTTATCAGTTACGTTCAAAATTTAA
ACTAG

Upstream 100 bases:

>100_bases
TAGTGCTTTAATTGGCAAAAAAGTTGGTGAGTATGTGGAAGTGATAGTGCCAAATGGAGAGAAATTGTATAAAATAGTTA
AGATTGAGTTTAAGTAAATC

Downstream 100 bases:

>100_bases
CGTTTATAGATTCGTATAGTTTAAGTGTTAAAATATAAAATTCCTCAAAGTTATACAAACAAGGAATTTCCATGTCTAAG
CTTTTTGTTTTACTATTTTT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MVQVTYPSISLPGISSVEDVLRDASSGKLFILVDDENRENEGDLIVLAEKLEPEHVAFMVRYGTGIVCLAMTKVHMKRLG
LSFMEKKNVGENHTAFTTSIDARYGITTGVSAEDRTKTIHVAIDKNRTQDDIITPGHIFPVIAHEGGVEQRAGHTEASVE
IAKLVGCNHSAVICELVNDDGSMMRLPQLLEFAEQHNIKLTTIDKLISYVQNLN

Sequences:

>Translated_214_residues
MVQVTYPSISLPGISSVEDVLRDASSGKLFILVDDENRENEGDLIVLAEKLEPEHVAFMVRYGTGIVCLAMTKVHMKRLG
LSFMEKKNVGENHTAFTTSIDARYGITTGVSAEDRTKTIHVAIDKNRTQDDIITPGHIFPVIAHEGGVEQRAGHTEASVE
IAKLVGCNHSAVICELVNDDGSMMRLPQLLEFAEQHNIKLTTIDKLISYVQNLN
>Mature_214_residues
MVQVTYPSISLPGISSVEDVLRDASSGKLFILVDDENRENEGDLIVLAEKLEPEHVAFMVRYGTGIVCLAMTKVHMKRLG
LSFMEKKNVGENHTAFTTSIDARYGITTGVSAEDRTKTIHVAIDKNRTQDDIITPGHIFPVIAHEGGVEQRAGHTEASVE
IAKLVGCNHSAVICELVNDDGSMMRLPQLLEFAEQHNIKLTTIDKLISYVQNLN

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=211, Percent_Identity=43.6018957345972, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=192, Percent_Identity=43.75, Blast_Score=154, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 23571; Mature: 23571

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQVTYPSISLPGISSVEDVLRDASSGKLFILVDDENRENEGDLIVLAEKLEPEHVAFMV
CEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEE
RYGTGIVCLAMTKVHMKRLGLSFMEKKNVGENHTAFTTSIDARYGITTGVSAEDRTKTIH
ECCCCEEEEHHHHHHHHHHCHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCEEEE
VAIDKNRTQDDIITPGHIFPVIAHEGGVEQRAGHTEASVEIAKLVGCNHSAVICELVNDD
EEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHEEEEHHHCCCCCEEEEEEECCC
GSMMRLPQLLEFAEQHNIKLTTIDKLISYVQNLN
CCEEHHHHHHHHHHHCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MVQVTYPSISLPGISSVEDVLRDASSGKLFILVDDENRENEGDLIVLAEKLEPEHVAFMV
CEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEE
RYGTGIVCLAMTKVHMKRLGLSFMEKKNVGENHTAFTTSIDARYGITTGVSAEDRTKTIH
ECCCCEEEEHHHHHHHHHHCHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCEEEE
VAIDKNRTQDDIITPGHIFPVIAHEGGVEQRAGHTEASVEIAKLVGCNHSAVICELVNDD
EEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHEEEEHHHCCCCCEEEEEEECCC
GSMMRLPQLLEFAEQHNIKLTTIDKLISYVQNLN
CCEEHHHHHHHHHHHCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]