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The map label for this gene is adk

Identifier: 190571566

GI number: 190571566

Start: 1263496

End: 1264137

Strand: Direct

Name: adk

Synonym: WPa_1186

Alternate gene names: 190571566

Gene position: 1263496-1264137 (Clockwise)

Preceding gene: 190571565

Following gene: 190571567

Centisome position: 85.23

GC content: 29.75

Gene sequence:

>642_bases
GTGATTATTACAATTTTTGGTCCTCCTGGCTCTGGTAAGGGTACTCAGTCCAGTTTGTTAATAGCAAAGTATAATTTTAA
ATTAGTTTCAGTAGGAGATTTATTAAGGAATATTATATCTAGTGAGAGTAAATTAGGTAAAGGAATAAAGGATACTGTTG
AATCTGGTAATTTAATTCAAGATGAAGTTATATGTAAATTATTGTGTGACCAGCTTGCATTAATAGATGGTGATTTTTTG
TTAGATGGTTTTCCAAGAAATTTAAATCAAGCTCATTTTTTAACTCAAGTTTTGCAAAAAAGATGCAATAGGGATGTTGA
TCTTGTAATTGAGTTGCAGCTTGACGATAATATTGCAATTGATAGATTAAAAGATCGTCTTACTTGTTTGGATTGTAAAA
GTATATATAGTATATCTTCTTTTAAGAATACTACTTGTGCTAAATGTAAAAGTACGAGATTGGAGAAGAGAATTGATGAT
GCTAATATGCTTGCAATTAATAAGAGGATAAGAGAATATCATTCTCAGATAGAGGGTTTGCGCGAGTATTATAAGGACAA
GTTGTTAACAATTAACGCTAATTTGAGTGTTGATAGAGTAATGCAAGAGATTGAAAGTAAAATTTCTTGTAATTTGATTT
GA

Upstream 100 bases:

>100_bases
ACGTTATTACTGATACTATTATGCAAGTACAATCTTATGTTTTTTCAAATAGGTACGATAGTTGGATAAAGAAATATGAG
TCTAAAACAAGGAGACTAAA

Downstream 100 bases:

>100_bases
CTATAAGTTGTTTTATGGTATAAATTAAGAGTTATTATTAATAAAGTATCGAGGTATCAGTGGCACGTATTGCAGGCATA
AATGTTCCAGTGAAGAAGTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MIITIFGPPGSGKGTQSSLLIAKYNFKLVSVGDLLRNIISSESKLGKGIKDTVESGNLIQDEVICKLLCDQLALIDGDFL
LDGFPRNLNQAHFLTQVLQKRCNRDVDLVIELQLDDNIAIDRLKDRLTCLDCKSIYSISSFKNTTCAKCKSTRLEKRIDD
ANMLAINKRIREYHSQIEGLREYYKDKLLTINANLSVDRVMQEIESKISCNLI

Sequences:

>Translated_213_residues
MIITIFGPPGSGKGTQSSLLIAKYNFKLVSVGDLLRNIISSESKLGKGIKDTVESGNLIQDEVICKLLCDQLALIDGDFL
LDGFPRNLNQAHFLTQVLQKRCNRDVDLVIELQLDDNIAIDRLKDRLTCLDCKSIYSISSFKNTTCAKCKSTRLEKRIDD
ANMLAINKRIREYHSQIEGLREYYKDKLLTINANLSVDRVMQEIESKISCNLI
>Mature_213_residues
MIITIFGPPGSGKGTQSSLLIAKYNFKLVSVGDLLRNIISSESKLGKGIKDTVESGNLIQDEVICKLLCDQLALIDGDFL
LDGFPRNLNQAHFLTQVLQKRCNRDVDLVIELQLDDNIAIDRLKDRLTCLDCKSIYSISSFKNTTCAKCKSTRLEKRIDD
ANMLAINKRIREYHSQIEGLREYYKDKLLTINANLSVDRVMQEIESKISCNLI

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=35.2112676056338, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=35.2112676056338, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=33.8709677419355, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI310110345, Length=186, Percent_Identity=31.7204301075269, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI53832003, Length=186, Percent_Identity=31.7204301075269, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI8051579, Length=186, Percent_Identity=31.7204301075269, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI53832001, Length=186, Percent_Identity=31.7204301075269, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI28144897, Length=205, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=27.8846153846154, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=27.6995305164319, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=34.0425531914894, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=33.8028169014084, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=30.5825242718447, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=32.2751322751323, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=33.1550802139037, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322828, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI22026816, Length=185, Percent_Identity=37.8378378378378, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=29.7674418604651, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647141, Length=215, Percent_Identity=29.7674418604651, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=31.2169312169312, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=31.2169312169312, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_WOLPP (B3CN46)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975924.1
- EnsemblBacteria:   EBWOLT00000000825
- GeneID:   6384975
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_1186
- GeneTree:   EBGT00050000030902
- HOGENOM:   HBG630208
- OMA:   GILYQRK
- ProtClustDB:   CLSK739935
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 24045; Mature: 24045

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITIFGPPGSGKGTQSSLLIAKYNFKLVSVGDLLRNIISSESKLGKGIKDTVESGNLIQ
CEEEEECCCCCCCCCCCEEEEEEECEEEEEHHHHHHHHHHCHHHHCCCHHHHHHCCCCHH
DEVICKLLCDQLALIDGDFLLDGFPRNLNQAHFLTQVLQKRCNRDVDLVIELQLDDNIAI
HHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHH
DRLKDRLTCLDCKSIYSISSFKNTTCAKCKSTRLEKRIDDANMLAINKRIREYHSQIEGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
REYYKDKLLTINANLSVDRVMQEIESKISCNLI
HHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIITIFGPPGSGKGTQSSLLIAKYNFKLVSVGDLLRNIISSESKLGKGIKDTVESGNLIQ
CEEEEECCCCCCCCCCCEEEEEEECEEEEEHHHHHHHHHHCHHHHCCCHHHHHHCCCCHH
DEVICKLLCDQLALIDGDFLLDGFPRNLNQAHFLTQVLQKRCNRDVDLVIELQLDDNIAI
HHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHH
DRLKDRLTCLDCKSIYSISSFKNTTCAKCKSTRLEKRIDDANMLAINKRIREYHSQIEGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
REYYKDKLLTINANLSVDRVMQEIESKISCNLI
HHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA