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The map label for this gene is htrA [H]

Identifier: 190571439

GI number: 190571439

Start: 1122041

End: 1123504

Strand: Reverse

Name: htrA [H]

Synonym: WPa_1052

Alternate gene names: 190571439

Gene position: 1123504-1122041 (Counterclockwise)

Preceding gene: 190571440

Following gene: 190571438

Centisome position: 75.79

GC content: 33.2

Gene sequence:

>1464_bases
ATGAAAAGTAAAGCATTTATTTTATCTATATTTGCATATTTTTTAATTTCATTTGCTTCATATGCTAATCTGTTTGCAAA
AACAGTTGCAGATCCTGTATGTAGTTGTAATAAAGGGCTTGCTGATATAGTGGAAGAACTTATTCCCGCAGTTGTAAATA
TTTCAAGTGAGCAAATAGTTAAGCAAGAAAATAACAGTAGAACTAAAATTCCCTTTACGCCAAGAAATAATTTCTTTGAT
GACTTTAGAGAATTTTTCGAGCATTTTGATCAATTTTTCGATAGAGCTCCTAGCATTAATAGAGAAGTGACGTTACTTGG
GTCTGGATTTATTATAGATAAAAGTGGAACCATAGTAACCAACTATCACGTTATTAAAAATGCCCAAGATATTACAGTTA
CTATGAACGATAATACTTATTTCAAAGCAGAAGTTTTAGGCTATGATGCAAAAACTGATCTTGCTGTGCTTAAGATTAAT
TCTGATAAAGATCTTCCTTTTGTTGAATTTGGTAATTCTGATAAAGCAAGAGTTGGTGATACAGTTATTGCAATAGGCAA
CCCTTTTGGTTTAGGTGGCTCTGTAAGTACAGGAATTGTGTCTGCAAGATCTAGAGACATTAGTATTGGTACTATGAATG
AATTTATTCAAACTGATGCTGCAATTAATAGAGGTAACTCAGGGGGACCACTATTTCATCTAAATGGAAAAGTTATAGGC
ATTAATACTGCTATTTATTCCCCATCTGAATCTGGCGGTAACGTGGGTATAGGCTTTGCTATACCATCTAATCTAGCTAT
TTCAATTATTGACACATTAAAAAGTGGTAAAAAAATAAAACATGGTTGGCTTGGCGTGCAAGTTCAGCCTATAACAAAAG
AATTTGCTGAATCCTTGGGTTTAAAAGATATCAAAGGTGCATTAGTTGCAAGCGTAGTAAAGGGCAGTCCTGCAGAGAAA
GGAGGAATCAAAGTAGGTGATATACTATTAGAGTTTGACGGCAAAAAAATTGATAGAATGACGCAATTACCTCATATGGT
TTCACGAACTGAGCCCGGAAAGAAAGTACAGGTTAAGTTACTTAGAAAAGGTAAAGAAGTCAATATCAAGGTTGCAATCG
AGGAATCTACAAATGATGATTCAGGTAATAATCAAGAAGAAAATAAATCAACATCTAGTTATATAAGTGGTTTAACCGTT
TCAAATTTGCCAAAAGAACTAAAAAACAATGCACCCACAAAGGGTGTAGTAGTTACTAGTGTAGATAGTAGTAGTAATTC
TACACTACGTGTTATTAAGAAAGGTGATATAATTATTCAACTAGATGGAATCGATATTGAAAATACTAATGATTTTCAAA
AACAAATTGATTCAGCAGTAAAAAAAGACGGCAAAGATTCAGTAATGCTGCTTATTTACCGCAACGGCAATCAATTTTTC
ACCTCAATCAAATTGAAGAAGTAG

Upstream 100 bases:

>100_bases
GAAAGCTTACAGTAAATCATTTGCTGAGGGTAATACTAAATTTGTGCTTTCACCAAATAATAATTTCTTAGATATTTTGA
ACAAGGGATGGAAATAGTTT

Downstream 100 bases:

>100_bases
CTATTTATCTAGCTGGTCATGAAAAATTGCTTGACAAATTTAACTAGCTTCTTTATCCTGAGGGTAAGGGTGTTTCTGTA
GATTAATAAAATTTGTCCCT

Product: protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKSKAFILSIFAYFLISFASYANLFAKTVADPVCSCNKGLADIVEELIPAVVNISSEQIVKQENNSRTKIPFTPRNNFFD
DFREFFEHFDQFFDRAPSINREVTLLGSGFIIDKSGTIVTNYHVIKNAQDITVTMNDNTYFKAEVLGYDAKTDLAVLKIN
SDKDLPFVEFGNSDKARVGDTVIAIGNPFGLGGSVSTGIVSARSRDISIGTMNEFIQTDAAINRGNSGGPLFHLNGKVIG
INTAIYSPSESGGNVGIGFAIPSNLAISIIDTLKSGKKIKHGWLGVQVQPITKEFAESLGLKDIKGALVASVVKGSPAEK
GGIKVGDILLEFDGKKIDRMTQLPHMVSRTEPGKKVQVKLLRKGKEVNIKVAIEESTNDDSGNNQEENKSTSSYISGLTV
SNLPKELKNNAPTKGVVVTSVDSSSNSTLRVIKKGDIIIQLDGIDIENTNDFQKQIDSAVKKDGKDSVMLLIYRNGNQFF
TSIKLKK

Sequences:

>Translated_487_residues
MKSKAFILSIFAYFLISFASYANLFAKTVADPVCSCNKGLADIVEELIPAVVNISSEQIVKQENNSRTKIPFTPRNNFFD
DFREFFEHFDQFFDRAPSINREVTLLGSGFIIDKSGTIVTNYHVIKNAQDITVTMNDNTYFKAEVLGYDAKTDLAVLKIN
SDKDLPFVEFGNSDKARVGDTVIAIGNPFGLGGSVSTGIVSARSRDISIGTMNEFIQTDAAINRGNSGGPLFHLNGKVIG
INTAIYSPSESGGNVGIGFAIPSNLAISIIDTLKSGKKIKHGWLGVQVQPITKEFAESLGLKDIKGALVASVVKGSPAEK
GGIKVGDILLEFDGKKIDRMTQLPHMVSRTEPGKKVQVKLLRKGKEVNIKVAIEESTNDDSGNNQEENKSTSSYISGLTV
SNLPKELKNNAPTKGVVVTSVDSSSNSTLRVIKKGDIIIQLDGIDIENTNDFQKQIDSAVKKDGKDSVMLLIYRNGNQFF
TSIKLKK
>Mature_487_residues
MKSKAFILSIFAYFLISFASYANLFAKTVADPVCSCNKGLADIVEELIPAVVNISSEQIVKQENNSRTKIPFTPRNNFFD
DFREFFEHFDQFFDRAPSINREVTLLGSGFIIDKSGTIVTNYHVIKNAQDITVTMNDNTYFKAEVLGYDAKTDLAVLKIN
SDKDLPFVEFGNSDKARVGDTVIAIGNPFGLGGSVSTGIVSARSRDISIGTMNEFIQTDAAINRGNSGGPLFHLNGKVIG
INTAIYSPSESGGNVGIGFAIPSNLAISIIDTLKSGKKIKHGWLGVQVQPITKEFAESLGLKDIKGALVASVVKGSPAEK
GGIKVGDILLEFDGKKIDRMTQLPHMVSRTEPGKKVQVKLLRKGKEVNIKVAIEESTNDDSGNNQEENKSTSSYISGLTV
SNLPKELKNNAPTKGVVVTSVDSSSNSTLRVIKKGDIIIQLDGIDIENTNDFQKQIDSAVKKDGKDSVMLLIYRNGNQFF
TSIKLKK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=316, Percent_Identity=34.4936708860759, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI22129776, Length=332, Percent_Identity=32.5301204819277, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7019477, Length=298, Percent_Identity=33.5570469798658, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI24308541, Length=267, Percent_Identity=35.5805243445693, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1786356, Length=453, Percent_Identity=36.8653421633554, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789629, Length=439, Percent_Identity=38.0410022779043, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=38.0434782608696, Blast_Score=183, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646839, Length=312, Percent_Identity=29.8076923076923, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52935; Mature: 52935

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKAFILSIFAYFLISFASYANLFAKTVADPVCSCNKGLADIVEELIPAVVNISSEQIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
KQENNSRTKIPFTPRNNFFDDFREFFEHFDQFFDRAPSINREVTLLGSGFIIDKSGTIVT
HHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCEEE
NYHVIKNAQDITVTMNDNTYFKAEVLGYDAKTDLAVLKINSDKDLPFVEFGNSDKARVGD
EEEEEECCCEEEEEECCCEEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCC
TVIAIGNPFGLGGSVSTGIVSARSRDISIGTMNEFIQTDAAINRGNSGGPLFHLNGKVIG
EEEEECCCCCCCCCCCCCEEECCCCCEEECHHHHHHHHHHHHCCCCCCCCEEEECCEEEE
INTAIYSPSESGGNVGIGFAIPSNLAISIIDTLKSGKKIKHGWLGVQVQPITKEFAESLG
EEEEEECCCCCCCCEEEEEECCCCCHHHEEHHHHCCCCEECCEEEEEEEHHHHHHHHHCC
LKDIKGALVASVVKGSPAEKGGIKVGDILLEFDGKKIDRMTQLPHMVSRTEPGKKVQVKL
CCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEHEE
LRKGKEVNIKVAIEESTNDDSGNNQEENKSTSSYISGLTVSNLPKELKNNAPTKGVVVTS
ECCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHCCCCCCCEEEEE
VDSSSNSTLRVIKKGDIIIQLDGIDIENTNDFQKQIDSAVKKDGKDSVMLLIYRNGNQFF
ECCCCCCEEEEEEECCEEEEECCEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
TSIKLKK
EEEEECC
>Mature Secondary Structure
MKSKAFILSIFAYFLISFASYANLFAKTVADPVCSCNKGLADIVEELIPAVVNISSEQIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
KQENNSRTKIPFTPRNNFFDDFREFFEHFDQFFDRAPSINREVTLLGSGFIIDKSGTIVT
HHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCEEE
NYHVIKNAQDITVTMNDNTYFKAEVLGYDAKTDLAVLKINSDKDLPFVEFGNSDKARVGD
EEEEEECCCEEEEEECCCEEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCC
TVIAIGNPFGLGGSVSTGIVSARSRDISIGTMNEFIQTDAAINRGNSGGPLFHLNGKVIG
EEEEECCCCCCCCCCCCCEEECCCCCEEECHHHHHHHHHHHHCCCCCCCCEEEECCEEEE
INTAIYSPSESGGNVGIGFAIPSNLAISIIDTLKSGKKIKHGWLGVQVQPITKEFAESLG
EEEEEECCCCCCCCEEEEEECCCCCHHHEEHHHHCCCCEECCEEEEEEEHHHHHHHHHCC
LKDIKGALVASVVKGSPAEKGGIKVGDILLEFDGKKIDRMTQLPHMVSRTEPGKKVQVKL
CCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEHEE
LRKGKEVNIKVAIEESTNDDSGNNQEENKSTSSYISGLTVSNLPKELKNNAPTKGVVVTS
ECCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHCCCCCCCEEEEE
VDSSSNSTLRVIKKGDIIIQLDGIDIENTNDFQKQIDSAVKKDGKDSVMLLIYRNGNQFF
ECCCCCCEEEEEEECCEEEEECCEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
TSIKLKK
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]