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The map label for this gene is nuoF [H]

Identifier: 190571396

GI number: 190571396

Start: 1070983

End: 1072236

Strand: Direct

Name: nuoF [H]

Synonym: WPa_1004

Alternate gene names: 190571396

Gene position: 1070983-1072236 (Clockwise)

Preceding gene: 190571392

Following gene: 190571401

Centisome position: 72.24

GC content: 38.44

Gene sequence:

>1254_bases
ATGCTAAAAGAACAGGATAAAATATTCATAAACTTAAATGGTAAAGAAACACCACTACTTGAAGGTGCAAAAAAACGTGG
TAGTTGGCAAAAAACAAAGGAATTACTGGATTTAGGATCAGAAAAAATCATTGATGAAGTAAAGAAATCTGGCTTGAGAG
GTCGAGGGGGTGCAGGATTTTCTACTGGCCTTAAGTGGAGCTTTATGCCTAAAAATCCTTTAAAAGCGTATTTAGTAGTC
AATGCAGATGAGTCAGAACCTGGTACGTGTAAAGATAGAGATATATTACGATATGAGCCACATAAGTTACTTGAGGGAAT
TCTTCTAGCTGGCAGAGCGATCAGCGCATCAGTTGCATATATTTATATCAGGGGTGAATTTTATAATGAATATTTAGTTC
TAAAAAAGGCACTTGAGGAAGCCTATAAAGAAAACTTAATTGGAAAAAATGCCTGCAAATCAGGTTATGATCTTGATGTG
TTTATCCATAGGGGTGCAGGAGCTTACATATGTGGGGAAGAAACAGCTCAACTCGAATCCATTGAAGGAAAAAAGGGCTT
TCCTCGCATGAAACCTCCATTTCCTGCAGGTGTTGGACTTTTTGGTTGTCCAACTACAATAAACAATGTTGAAACTATAG
CCATGGTTCCAGATATTCTAAATCGCGGAGGAGAGTGGTTTGCATCTCTTGGTAAACCAAATAATACTGGCACTAAGGTC
TTTTGCATTTCAGGGCATGTAAATAATCCATGTAATGTTGAAGAAGAGCTCGGAATTTCACTGCGTGAATTAATTGAAAA
ATACGCAGGTGGAGTGAGAGGAGGTTGGGATAATTTACTTGCTGTAATACCTGGTGGGTCTTCAGTCCCACTAATTCCAA
AATCTATATGTGATACTATTGAAATGGATTTTGATTCATTAAGGGCTGCACAATCAGGGCTTGGTACTGCTGCTGTAATA
GTGATGGATAAATCAACTGACATAATAGCTGCAATAGAAAGATTATCACATTTCTATATGCATGAGTCCTGCGGACAATG
TACACCATGCCGTGAAGGCACTGGATGGATGTGGAGGATTATGAGAAGAATGGTAGCAGGAAATATTAAACCTGGTGAAG
TAGATAAGCTACTTGACCTTACAACTCAAATAGAAGGGCATACAATTTGTGCACTTGGCGATGCTGCAGCTTGGCCAGTT
CAAGGATTAATCAGACATTTTCGTCATATAATTGAAGAGAGGATAGTAACTTAA

Upstream 100 bases:

>100_bases
AAAATAAAATGATCCCGTAGCTCAGCCGGTAGAGCAACTGACTTTTAATCAGTGGGTCACGCGTTCGAATCGCGTCGGGA
TCACTTAGAATCTTAAAAGC

Downstream 100 bases:

>100_bases
CTTATACTTTTAAATGATTTTACTACTTAGCAGCTAAAGTTAAAGAATATTGATTTCCTTCCCTTTTAGGTGCTAATTCT
ACTTTTGCAATATCTTCAGC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLKEQDKIFINLNGKETPLLEGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGFSTGLKWSFMPKNPLKAYLVV
NADESEPGTCKDRDILRYEPHKLLEGILLAGRAISASVAYIYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDV
FIHRGAGAYICGEETAQLESIEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKV
FCISGHVNNPCNVEEELGISLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTIEMDFDSLRAAQSGLGTAAVI
VMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRIMRRMVAGNIKPGEVDKLLDLTTQIEGHTICALGDAAAWPV
QGLIRHFRHIIEERIVT

Sequences:

>Translated_417_residues
MLKEQDKIFINLNGKETPLLEGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGFSTGLKWSFMPKNPLKAYLVV
NADESEPGTCKDRDILRYEPHKLLEGILLAGRAISASVAYIYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDV
FIHRGAGAYICGEETAQLESIEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKV
FCISGHVNNPCNVEEELGISLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTIEMDFDSLRAAQSGLGTAAVI
VMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRIMRRMVAGNIKPGEVDKLLDLTTQIEGHTICALGDAAAWPV
QGLIRHFRHIIEERIVT
>Mature_417_residues
MLKEQDKIFINLNGKETPLLEGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGFSTGLKWSFMPKNPLKAYLVV
NADESEPGTCKDRDILRYEPHKLLEGILLAGRAISASVAYIYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDV
FIHRGAGAYICGEETAQLESIEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKV
FCISGHVNNPCNVEEELGISLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTIEMDFDSLRAAQSGLGTAAVI
VMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRIMRRMVAGNIKPGEVDKLLDLTTQIEGHTICALGDAAAWPV
QGLIRHFRHIIEERIVT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=416, Percent_Identity=68.0288461538462, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI260656005, Length=416, Percent_Identity=68.0288461538462, Blast_Score=592, Evalue=1e-169,
Organism=Escherichia coli, GI1788620, Length=400, Percent_Identity=43, Blast_Score=325, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=417, Percent_Identity=64.9880095923261, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI19920794, Length=416, Percent_Identity=66.5865384615385, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI45550452, Length=416, Percent_Identity=62.2596153846154, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24653819, Length=419, Percent_Identity=48.9260143198091, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24653817, Length=419, Percent_Identity=45.1073985680191, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45804; Mature: 45804

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEQDKIFINLNGKETPLLEGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGF
CCCCCCEEEEEECCCCCCHHHCHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGLKWSFMPKNPLKAYLVVNADESEPGTCKDRDILRYEPHKLLEGILLAGRAISASVAY
CCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHCCCEEECEEEE
IYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDVFIHRGAGAYICGEETAQLES
EEEEECHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCEEEECCCHHHHHH
IEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHCCCHHHHHCCCCCCCCCEE
FCISGHVNNPCNVEEELGISLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTI
EEEECCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
EMDFDSLRAAQSGLGTAAVIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRI
HCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MRRMVAGNIKPGEVDKLLDLTTQIEGHTICALGDAAAWPVQGLIRHFRHIIEERIVT
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKEQDKIFINLNGKETPLLEGAKKRGSWQKTKELLDLGSEKIIDEVKKSGLRGRGGAGF
CCCCCCEEEEEECCCCCCHHHCHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGLKWSFMPKNPLKAYLVVNADESEPGTCKDRDILRYEPHKLLEGILLAGRAISASVAY
CCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHCCCEEECEEEE
IYIRGEFYNEYLVLKKALEEAYKENLIGKNACKSGYDLDVFIHRGAGAYICGEETAQLES
EEEEECHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCEEEECCCHHHHHH
IEGKKGFPRMKPPFPAGVGLFGCPTTINNVETIAMVPDILNRGGEWFASLGKPNNTGTKV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHCCCHHHHHCCCCCCCCCEE
FCISGHVNNPCNVEEELGISLRELIEKYAGGVRGGWDNLLAVIPGGSSVPLIPKSICDTI
EEEECCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
EMDFDSLRAAQSGLGTAAVIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWRI
HCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MRRMVAGNIKPGEVDKLLDLTTQIEGHTICALGDAAAWPVQGLIRHFRHIIEERIVT
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA