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The map label for this gene is nuoL [H]

Identifier: 190571387

GI number: 190571387

Start: 1061720

End: 1063567

Strand: Direct

Name: nuoL [H]

Synonym: WPa_0995

Alternate gene names: 190571387

Gene position: 1061720-1063567 (Clockwise)

Preceding gene: 190571386

Following gene: 190571388

Centisome position: 71.62

GC content: 35.06

Gene sequence:

>1848_bases
ATGATGGATATACTGAAATTAATAGTATTTTTGCCACTCTTTGGTTCGCTGTTTGCAGCACTTTTTAGAAAAAGTCAGTT
AGTTACAACGGCAGGGATTGGAATATCTGCAGTTTTATCTTGGTATGTTTTTCTCACCTTCTCTGAAAATTATCACTTGA
GTTTATTTCCTTTATTTTCATTAAGTGTATTAAAAGTAAATTGGGCAATTAGTGTGGATGCTCTCTCATCCTTAATGCTG
ATTGTTATTACCACCGTTTCGCTGGTAGTGCATCTCTATTCTATCGGTTATATGGAGCATGATAAGGGGAAGTCGAGGTT
TTTTTCTTACCTATCGCTGTTCACATTTTGTATGATTGTGCTGGTTGTAAGCGATAATTTCGTGCAGCTTTTTTTTGGCT
GGGAAGGGGTTGGCCTATGTTCTTATTTACTCATAGGATTTTGGTTCCAAAAATATTCTGCAAATAATGCAGCAATTAAA
GCATTTGTTGTGAATAGGGTAGGAGACTTTGCACTATTGATTGGAACCTTTCTTATTTATTATACATTTCACTCTTTGAA
TTTTACTGAAGTTTTTGACACAACTGATCTTCTTGGCACGCAGAACATTAGGGCATTCTGCTGTGAATTCAAAGTAACTC
ATATAATATGCATATTACTTTTTATTGGCTGTATGGGTAAATCTGCACAGCTTGGTTTACATGTTTGGTTGCCAGATGCA
ATGGAAGGGCCAACCCCTGTTTCTGCACTCATTCACGCAGCAACGATGGTAACAGCAGGTATATTTTTAGTAGCAAAATG
TTCTCCATTATTTGAGCTATCAAATGTGGCACGAGAATTAATAGTTATTGTTGGGGCACTTACTGCTTTCTTTGCAGCTA
CGGTTGCGATTACTCAGAACGATATAAAAAAAATAATTGCTTATTCAACCTGCAGTCAACTTGGTTATATGTTCATGGCA
TGTGGGCTTTCTGCTTACAATGTTGCTATTTTTCATTTAATGACACACGCTTTTTTTAAAGCTCTACTATTTCTTGGTGC
TGGCAATGTGATTCATGCAATGCATCATGAGCAAAACATTCAGAAAATGGGAAATTGCTGGAAGAAAATCCCTTGCACTT
ATACTCTCATGTGGATTGGATCTCTTGCGCTTTCTGGAATATTTCCATTTGCAGGTTTTTACTCAAAGGATTTGATAATT
GAACATGCTTATAGCACGGATAGCTTTGCTTTTGTAATAAGCTTAGTTGTTGCATTCTTCACAGCGTTTTACTCTTGGAG
GTTATTGCTTCTTGTGTTCCACAGCCAAAAACAAAGTAAAATTAATATACATGAGGCACCAAAGATTATGCTTATACCAT
TACTGATACTCGCTTTTGGATCAGTATTTTCTGGAATATGGGGAGCAAATATTTTGAACATAACTAGTAATGCGTTTTGG
AAATCAAGTTTAGTAGTTATTGATGAGCATGGAGTGCGTAATTTCTTTATAAAATTGCTACCAACCTTGGCGAGCCTAAG
TGGAATAGCACTTGCGTACCTAATTTACCAATATCAAGTAATTAGGCAAATTAAGAGTAAATTTTTACTTAAGTTTTTGC
AGAATAAATGGTACTTTGATGAGGTGTATGAGTTTGTTATCATTGCACCGATAAGGTTTATGTCTAGGCTTCTATGGAAA
TTTGATGTTAAGGTTATTGATTCATTTGGGCCAAATGGTGTTGTAAGGTTGGTTAATGAATGTTCAAAAAGTTCTATAAA
GTTGCAGACTGGTTATATATTTGATTATGCATTTATTATGTTTGTTACTCTAATAATCGGTGCTTTATATATTATTGGAA
TTAAATAG

Upstream 100 bases:

>100_bases
CTGTTGCGGCAGCAGAGTCAGGAGTTGGGCTTGCAATATTGGTTGTATATTATAGAAGCCGTGGCAATATAGATGTTGAA
CAAGCAAATTTAATGAAAGA

Downstream 100 bases:

>100_bases
AAGGTGTTGTTACTTAGTATATTCTTGCTTCCACTGATAGGAGCGTTGATTTTATCCTCGATCAGGATTAATCATCAATC
TATACACCTAAAATTCCTTG

Product: NADH dehydrogenase I, L subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MMDILKLIVFLPLFGSLFAALFRKSQLVTTAGIGISAVLSWYVFLTFSENYHLSLFPLFSLSVLKVNWAISVDALSSLML
IVITTVSLVVHLYSIGYMEHDKGKSRFFSYLSLFTFCMIVLVVSDNFVQLFFGWEGVGLCSYLLIGFWFQKYSANNAAIK
AFVVNRVGDFALLIGTFLIYYTFHSLNFTEVFDTTDLLGTQNIRAFCCEFKVTHIICILLFIGCMGKSAQLGLHVWLPDA
MEGPTPVSALIHAATMVTAGIFLVAKCSPLFELSNVARELIVIVGALTAFFAATVAITQNDIKKIIAYSTCSQLGYMFMA
CGLSAYNVAIFHLMTHAFFKALLFLGAGNVIHAMHHEQNIQKMGNCWKKIPCTYTLMWIGSLALSGIFPFAGFYSKDLII
EHAYSTDSFAFVISLVVAFFTAFYSWRLLLLVFHSQKQSKINIHEAPKIMLIPLLILAFGSVFSGIWGANILNITSNAFW
KSSLVVIDEHGVRNFFIKLLPTLASLSGIALAYLIYQYQVIRQIKSKFLLKFLQNKWYFDEVYEFVIIAPIRFMSRLLWK
FDVKVIDSFGPNGVVRLVNECSKSSIKLQTGYIFDYAFIMFVTLIIGALYIIGIK

Sequences:

>Translated_615_residues
MMDILKLIVFLPLFGSLFAALFRKSQLVTTAGIGISAVLSWYVFLTFSENYHLSLFPLFSLSVLKVNWAISVDALSSLML
IVITTVSLVVHLYSIGYMEHDKGKSRFFSYLSLFTFCMIVLVVSDNFVQLFFGWEGVGLCSYLLIGFWFQKYSANNAAIK
AFVVNRVGDFALLIGTFLIYYTFHSLNFTEVFDTTDLLGTQNIRAFCCEFKVTHIICILLFIGCMGKSAQLGLHVWLPDA
MEGPTPVSALIHAATMVTAGIFLVAKCSPLFELSNVARELIVIVGALTAFFAATVAITQNDIKKIIAYSTCSQLGYMFMA
CGLSAYNVAIFHLMTHAFFKALLFLGAGNVIHAMHHEQNIQKMGNCWKKIPCTYTLMWIGSLALSGIFPFAGFYSKDLII
EHAYSTDSFAFVISLVVAFFTAFYSWRLLLLVFHSQKQSKINIHEAPKIMLIPLLILAFGSVFSGIWGANILNITSNAFW
KSSLVVIDEHGVRNFFIKLLPTLASLSGIALAYLIYQYQVIRQIKSKFLLKFLQNKWYFDEVYEFVIIAPIRFMSRLLWK
FDVKVIDSFGPNGVVRLVNECSKSSIKLQTGYIFDYAFIMFVTLIIGALYIIGIK
>Mature_615_residues
MMDILKLIVFLPLFGSLFAALFRKSQLVTTAGIGISAVLSWYVFLTFSENYHLSLFPLFSLSVLKVNWAISVDALSSLML
IVITTVSLVVHLYSIGYMEHDKGKSRFFSYLSLFTFCMIVLVVSDNFVQLFFGWEGVGLCSYLLIGFWFQKYSANNAAIK
AFVVNRVGDFALLIGTFLIYYTFHSLNFTEVFDTTDLLGTQNIRAFCCEFKVTHIICILLFIGCMGKSAQLGLHVWLPDA
MEGPTPVSALIHAATMVTAGIFLVAKCSPLFELSNVARELIVIVGALTAFFAATVAITQNDIKKIIAYSTCSQLGYMFMA
CGLSAYNVAIFHLMTHAFFKALLFLGAGNVIHAMHHEQNIQKMGNCWKKIPCTYTLMWIGSLALSGIFPFAGFYSKDLII
EHAYSTDSFAFVISLVVAFFTAFYSWRLLLLVFHSQKQSKINIHEAPKIMLIPLLILAFGSVFSGIWGANILNITSNAFW
KSSLVVIDEHGVRNFFIKLLPTLASLSGIALAYLIYQYQVIRQIKSKFLLKFLQNKWYFDEVYEFVIIAPIRFMSRLLWK
FDVKVIDSFGPNGVVRLVNECSKSSIKLQTGYIFDYAFIMFVTLIIGALYIIGIK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=405, Percent_Identity=42.4691358024691, Blast_Score=302, Evalue=8e-82,
Organism=Escherichia coli, GI1788614, Length=569, Percent_Identity=38.6643233743409, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1788829, Length=340, Percent_Identity=28.5294117647059, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1788827, Length=352, Percent_Identity=30.1136363636364, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788831, Length=363, Percent_Identity=28.9256198347107, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788613, Length=425, Percent_Identity=24.4705882352941, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI2367154, Length=376, Percent_Identity=22.3404255319149, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693160, Length=264, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 69144; Mature: 69144

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDILKLIVFLPLFGSLFAALFRKSQLVTTAGIGISAVLSWYVFLTFSENYHLSLFPLFS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHEEECCCCCEEEEHHHH
LSVLKVNWAISVDALSSLMLIVITTVSLVVHLYSIGYMEHDKGKSRFFSYLSLFTFCMIV
EEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LVVSDNFVQLFFGWEGVGLCSYLLIGFWFQKYSANNAAIKAFVVNRVGDFALLIGTFLIY
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
YTFHSLNFTEVFDTTDLLGTQNIRAFCCEFKVTHIICILLFIGCMGKSAQLGLHVWLPDA
HHHHCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
MEGPTPVSALIHAATMVTAGIFLVAKCSPLFELSNVARELIVIVGALTAFFAATVAITQN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKKIIAYSTCSQLGYMFMACGLSAYNVAIFHLMTHAFFKALLFLGAGNVIHAMHHEQNI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QKMGNCWKKIPCTYTLMWIGSLALSGIFPFAGFYSKDLIIEHAYSTDSFAFVISLVVAFF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHHHH
TAFYSWRLLLLVFHSQKQSKINIHEAPKIMLIPLLILAFGSVFSGIWGANILNITSNAFW
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCC
KSSLVVIDEHGVRNFFIKLLPTLASLSGIALAYLIYQYQVIRQIKSKFLLKFLQNKWYFD
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EVYEFVIIAPIRFMSRLLWKFDVKVIDSFGPNGVVRLVNECSKSSIKLQTGYIFDYAFIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHH
FVTLIIGALYIIGIK
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MMDILKLIVFLPLFGSLFAALFRKSQLVTTAGIGISAVLSWYVFLTFSENYHLSLFPLFS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHEEECCCCCEEEEHHHH
LSVLKVNWAISVDALSSLMLIVITTVSLVVHLYSIGYMEHDKGKSRFFSYLSLFTFCMIV
EEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LVVSDNFVQLFFGWEGVGLCSYLLIGFWFQKYSANNAAIKAFVVNRVGDFALLIGTFLIY
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
YTFHSLNFTEVFDTTDLLGTQNIRAFCCEFKVTHIICILLFIGCMGKSAQLGLHVWLPDA
HHHHCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
MEGPTPVSALIHAATMVTAGIFLVAKCSPLFELSNVARELIVIVGALTAFFAATVAITQN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKKIIAYSTCSQLGYMFMACGLSAYNVAIFHLMTHAFFKALLFLGAGNVIHAMHHEQNI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QKMGNCWKKIPCTYTLMWIGSLALSGIFPFAGFYSKDLIIEHAYSTDSFAFVISLVVAFF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHHHH
TAFYSWRLLLLVFHSQKQSKINIHEAPKIMLIPLLILAFGSVFSGIWGANILNITSNAFW
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCC
KSSLVVIDEHGVRNFFIKLLPTLASLSGIALAYLIYQYQVIRQIKSKFLLKFLQNKWYFD
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EVYEFVIIAPIRFMSRLLWKFDVKVIDSFGPNGVVRLVNECSKSSIKLQTGYIFDYAFIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHH
FVTLIIGALYIIGIK
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA