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The map label for this gene is hemF [H]

Identifier: 190571359

GI number: 190571359

Start: 1032356

End: 1033180

Strand: Reverse

Name: hemF [H]

Synonym: WPa_0965

Alternate gene names: 190571359

Gene position: 1033180-1032356 (Counterclockwise)

Preceding gene: 190571363

Following gene: 190571358

Centisome position: 69.69

GC content: 36.61

Gene sequence:

>825_bases
ATGGAAAAACAAAAGACACAAGCATTTGAATGGTTCTGCGCACTGAGAAACAAGATCACCGAATCTTTCTTATCAATTGA
GGTACAGTCATTCACACAACCAAAAATCGAAAAAAGAAAGTGGAACCGACCAGGTGGAGGAAGTGGTGAATCTACAATTA
TCTTTGGTAATATTTTTGAAAAAGTTGGAATAAACGTTTCAAGAGTATACGGAAAGCTCGAAGACTCAGCCATTAATGAA
ATTTCTGGTGCAAGTGAAAGCAATGGAGAGTTTTGGGCAAGCGGTATATCTTTAGTGTCTCACATGCAATCTCCCCTTAT
CCCTGCAGCACATATGAACACAAGATTGATATATACCTCAAAACAATGGTTTGGTGGAGGAATGGACTTTACTCCAATTT
ATAAGGATGAGGGAGATTGCAAGTATATTCACGAATCAATTAAAGCAACTTGCGATGAGTTCAACATCGAATATTATCCG
AAATTTAAAAAGCAATGTGATGATTACTTTTTTTTACAACATAGAAAAGAGCCACGTGGTATTGGTGGAATTTTTTATGA
CAATCTAACTTCTGGCAACTGGAAAAACGATTTTGAGTTCACAAAAGCAGTAGGTGAAGCCTTTTTAGAAATTTACTTAC
ACATCATACACAAACATATGCAAAAATCTTGGACAAAAGAACAACGAGAAGAACAATTGATAAAACGTGGCAGATATGTG
GAGTTCAATCTTCTTTATGATCGTGGTACAAGGTTTGGTTTAATGACTAATGGTAACCCCGATGCAATTATGATGTCGAT
GCCTCCTCTTGTTAAGTGGGTGTGA

Upstream 100 bases:

>100_bases
ATAGATTTATTAACATCCTTGATGAGTAGTTACTATCCCAATCTAATTAAGTCCTGTAAATATAGAGTACAATAATATTA
ATAAGCCAACAGAAGGCATT

Downstream 100 bases:

>100_bases
AAAGCGATTATTAATATAAAATAAATCGTTATAGTTTAAGATTGTACCACATATGGTGAGCTTTTGTATAGAGGGGTACA
ATCATGGGTATAAGTAGATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MEKQKTQAFEWFCALRNKITESFLSIEVQSFTQPKIEKRKWNRPGGGSGESTIIFGNIFEKVGINVSRVYGKLEDSAINE
ISGASESNGEFWASGISLVSHMQSPLIPAAHMNTRLIYTSKQWFGGGMDFTPIYKDEGDCKYIHESIKATCDEFNIEYYP
KFKKQCDDYFFLQHRKEPRGIGGIFYDNLTSGNWKNDFEFTKAVGEAFLEIYLHIIHKHMQKSWTKEQREEQLIKRGRYV
EFNLLYDRGTRFGLMTNGNPDAIMMSMPPLVKWV

Sequences:

>Translated_274_residues
MEKQKTQAFEWFCALRNKITESFLSIEVQSFTQPKIEKRKWNRPGGGSGESTIIFGNIFEKVGINVSRVYGKLEDSAINE
ISGASESNGEFWASGISLVSHMQSPLIPAAHMNTRLIYTSKQWFGGGMDFTPIYKDEGDCKYIHESIKATCDEFNIEYYP
KFKKQCDDYFFLQHRKEPRGIGGIFYDNLTSGNWKNDFEFTKAVGEAFLEIYLHIIHKHMQKSWTKEQREEQLIKRGRYV
EFNLLYDRGTRFGLMTNGNPDAIMMSMPPLVKWV
>Mature_274_residues
MEKQKTQAFEWFCALRNKITESFLSIEVQSFTQPKIEKRKWNRPGGGSGESTIIFGNIFEKVGINVSRVYGKLEDSAINE
ISGASESNGEFWASGISLVSHMQSPLIPAAHMNTRLIYTSKQWFGGGMDFTPIYKDEGDCKYIHESIKATCDEFNIEYYP
KFKKQCDDYFFLQHRKEPRGIGGIFYDNLTSGNWKNDFEFTKAVGEAFLEIYLHIIHKHMQKSWTKEQREEQLIKRGRYV
EFNLLYDRGTRFGLMTNGNPDAIMMSMPPLVKWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=248, Percent_Identity=40.3225806451613, Blast_Score=198, Evalue=4e-51,
Organism=Escherichia coli, GI1788777, Length=284, Percent_Identity=37.6760563380282, Blast_Score=213, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320249, Length=282, Percent_Identity=37.9432624113475, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17864388, Length=262, Percent_Identity=40.8396946564886, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 31758; Mature: 31758

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQKTQAFEWFCALRNKITESFLSIEVQSFTQPKIEKRKWNRPGGGSGESTIIFGNIFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEHHHHH
KVGINVSRVYGKLEDSAINEISGASESNGEFWASGISLVSHMQSPLIPAAHMNTRLIYTS
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
KQWFGGGMDFTPIYKDEGDCKYIHESIKATCDEFNIEYYPKFKKQCDDYFFLQHRKEPRG
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCHHHCCCHHHHHHCCCCCCC
IGGIFYDNLTSGNWKNDFEFTKAVGEAFLEIYLHIIHKHMQKSWTKEQREEQLIKRGRYV
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
EFNLLYDRGTRFGLMTNGNPDAIMMSMPPLVKWV
EEEEEEECCCEEEEEECCCCCEEEEECCCHHHCC
>Mature Secondary Structure
MEKQKTQAFEWFCALRNKITESFLSIEVQSFTQPKIEKRKWNRPGGGSGESTIIFGNIFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEHHHHH
KVGINVSRVYGKLEDSAINEISGASESNGEFWASGISLVSHMQSPLIPAAHMNTRLIYTS
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
KQWFGGGMDFTPIYKDEGDCKYIHESIKATCDEFNIEYYPKFKKQCDDYFFLQHRKEPRG
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCHHHCCCHHHHHHCCCCCCC
IGGIFYDNLTSGNWKNDFEFTKAVGEAFLEIYLHIIHKHMQKSWTKEQREEQLIKRGRYV
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
EFNLLYDRGTRFGLMTNGNPDAIMMSMPPLVKWV
EEEEEEECCCEEEEEECCCCCEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA