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The map label for this gene is lysC [H]

Identifier: 190571299

GI number: 190571299

Start: 968759

End: 969919

Strand: Reverse

Name: lysC [H]

Synonym: WPa_0902

Alternate gene names: 190571299

Gene position: 969919-968759 (Counterclockwise)

Preceding gene: 190571300

Following gene: 190571296

Centisome position: 65.43

GC content: 33.85

Gene sequence:

>1161_bases
ATGAACAAAATAATAATAAAAAAATTTGGTGGTACTTCGCTAACTGACTTAAATCGAGTTGCAAATCTAATAAAAAACGA
TATTGAAAAAGGTTATAATGTAATTGCTGTTGTATCTGCTGCTGCAGGATTCACTGACCAAATGGCTTTTCAAGCCAGGC
AAATTTCAAATTTAAATTGTAGACAAGAGTTATCAGAGTATGATGTCCTGCTTTCAGCAGGAGAACAAATCTCTTGCGGG
TTATTAGCTATCACTCTTCTGTCTGTTGGAGTTAATGCTAAATCATGGCTCGCCTGGCAGTTACCAATTGTAACGGATAA
TTTTTATTCTGAGTCTAAAATAAAAAAGATAAAAATTGACCATGTAAAAAGATCTTTTGCTGAGGGTTATACTGCTGCAA
TCATTGCTGGTTTTCAGGGTATACACGATGATAGAATCACTACTTTTGGTAGAGGAGGATCTGATATCTCAGCAATTGCC
TTTGCTGTAGTCTTTGGTATTAGGACTTGTGAAATTTTTACTGATATTGACGGAATATATACAGCAGACCCAAAAATTGT
TCCAAGGGCACGCAAGCTTAAATCTATCTCTTACAATGAAATATTGGAGATGTCGTCATCTGGTGCTAAAATATTGCATA
ATCGTTCAGTACAACTTGCAATGAAGCATAATATTAAGGTGCAAGTGTTATCCACTTTTGAGGAAGTAGAAGGCACTACA
GTACTACACGAAAAAGATGTACTGGAAAGATACTTAATTACTGGAATAACTTATAGCACTCACGAAGCTCTTGTAACTTT
TACTAACTTTGCAAATACTCTGGATACTTTAAGAGATATAGCAGGAGCAAACGTTAAAGTTGACATGATACATGGGTCAA
GCTTTTTGATTTCTAAATTTGATGTTGATTTAATGACAAAGTTATTGAACAAAAATGAAAATTATGTCGTAAACAATAAT
ATAGCTAAAATTTCAATAATTGGTATTGGTGTTATGTCTAACACTGAAGTGATGTATCGCACACTCAAGGTTTTAAGCGA
AAAAAAGATAGAAATACTTGCTGTCACAATGTCCGAAATCAAGATCAGTATAGTTGTTCAAAAAAAACACGCTGAGGCTT
TAATTAGAGATTTACATACCGAATATGAGCTTGATGTATGA

Upstream 100 bases:

>100_bases
AAGATGAATAATCCTCTATCACTTTAATTAGTGATCAGAAAAACACATTTAATTAAGCAACTATACTCTCTAGAAAGGTG
AAATTGACCTTATTGTAACT

Downstream 100 bases:

>100_bases
CAGCACGCTTGAAATTTATTTACTTGATAATTCAAAAAACTTGAAAGAGCAAAGATAGTTATTGAAATTATCTTGATTTA
CATCGGTTATCCAAGTTTGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNKIIIKKFGGTSLTDLNRVANLIKNDIEKGYNVIAVVSAAAGFTDQMAFQARQISNLNCRQELSEYDVLLSAGEQISCG
LLAITLLSVGVNAKSWLAWQLPIVTDNFYSESKIKKIKIDHVKRSFAEGYTAAIIAGFQGIHDDRITTFGRGGSDISAIA
FAVVFGIRTCEIFTDIDGIYTADPKIVPRARKLKSISYNEILEMSSSGAKILHNRSVQLAMKHNIKVQVLSTFEEVEGTT
VLHEKDVLERYLITGITYSTHEALVTFTNFANTLDTLRDIAGANVKVDMIHGSSFLISKFDVDLMTKLLNKNENYVVNNN
IAKISIIGIGVMSNTEVMYRTLKVLSEKKIEILAVTMSEIKISIVVQKKHAEALIRDLHTEYELDV

Sequences:

>Translated_386_residues
MNKIIIKKFGGTSLTDLNRVANLIKNDIEKGYNVIAVVSAAAGFTDQMAFQARQISNLNCRQELSEYDVLLSAGEQISCG
LLAITLLSVGVNAKSWLAWQLPIVTDNFYSESKIKKIKIDHVKRSFAEGYTAAIIAGFQGIHDDRITTFGRGGSDISAIA
FAVVFGIRTCEIFTDIDGIYTADPKIVPRARKLKSISYNEILEMSSSGAKILHNRSVQLAMKHNIKVQVLSTFEEVEGTT
VLHEKDVLERYLITGITYSTHEALVTFTNFANTLDTLRDIAGANVKVDMIHGSSFLISKFDVDLMTKLLNKNENYVVNNN
IAKISIIGIGVMSNTEVMYRTLKVLSEKKIEILAVTMSEIKISIVVQKKHAEALIRDLHTEYELDV
>Mature_386_residues
MNKIIIKKFGGTSLTDLNRVANLIKNDIEKGYNVIAVVSAAAGFTDQMAFQARQISNLNCRQELSEYDVLLSAGEQISCG
LLAITLLSVGVNAKSWLAWQLPIVTDNFYSESKIKKIKIDHVKRSFAEGYTAAIIAGFQGIHDDRITTFGRGGSDISAIA
FAVVFGIRTCEIFTDIDGIYTADPKIVPRARKLKSISYNEILEMSSSGAKILHNRSVQLAMKHNIKVQVLSTFEEVEGTT
VLHEKDVLERYLITGITYSTHEALVTFTNFANTLDTLRDIAGANVKVDMIHGSSFLISKFDVDLMTKLLNKNENYVVNNN
IAKISIIGIGVMSNTEVMYRTLKVLSEKKIEILAVTMSEIKISIVVQKKHAEALIRDLHTEYELDV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=280, Percent_Identity=27.8571428571429, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790455, Length=452, Percent_Identity=24.7787610619469, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=190, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42817; Mature: 42817

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIIIKKFGGTSLTDLNRVANLIKNDIEKGYNVIAVVSAAAGFTDQMAFQARQISNLNC
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHCCCCH
RQELSEYDVLLSAGEQISCGLLAITLLSVGVNAKSWLAWQLPIVTDNFYSESKIKKIKID
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECEEECCCCCCCHHHEEEHH
HVKRSFAEGYTAAIIAGFQGIHDDRITTFGRGGSDISAIAFAVVFGIRTCEIFTDIDGIY
HHHHHHHCCCCEEEHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCEE
TADPKIVPRARKLKSISYNEILEMSSSGAKILHNRSVQLAMKHNIKVQVLSTFEEVEGTT
ECCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEECCCEEEEEECCCEEEEEEHHHHCCCCE
VLHEKDVLERYLITGITYSTHEALVTFTNFANTLDTLRDIAGANVKVDMIHGSSFLISKF
EEEHHHHHHHHHHHCCEEECCHHHEEHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEECC
DVDLMTKLLNKNENYVVNNNIAKISIIGIGVMSNTEVMYRTLKVLSEKKIEILAVTMSEI
CHHHHHHHHCCCCCEEEECCCEEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEEEEEEE
KISIVVQKKHAEALIRDLHTEYELDV
EEEEEEEHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNKIIIKKFGGTSLTDLNRVANLIKNDIEKGYNVIAVVSAAAGFTDQMAFQARQISNLNC
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHCCCCH
RQELSEYDVLLSAGEQISCGLLAITLLSVGVNAKSWLAWQLPIVTDNFYSESKIKKIKID
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECEEECCCCCCCHHHEEEHH
HVKRSFAEGYTAAIIAGFQGIHDDRITTFGRGGSDISAIAFAVVFGIRTCEIFTDIDGIY
HHHHHHHCCCCEEEHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCEE
TADPKIVPRARKLKSISYNEILEMSSSGAKILHNRSVQLAMKHNIKVQVLSTFEEVEGTT
ECCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEECCCEEEEEECCCEEEEEEHHHHCCCCE
VLHEKDVLERYLITGITYSTHEALVTFTNFANTLDTLRDIAGANVKVDMIHGSSFLISKF
EEEHHHHHHHHHHHCCEEECCHHHEEHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEECC
DVDLMTKLLNKNENYVVNNNIAKISIIGIGVMSNTEVMYRTLKVLSEKKIEILAVTMSEI
CHHHHHHHHCCCCCEEEECCCEEEEEEEEEEECCHHHHHHHHHHHHCCCEEEEEEEEEEE
KISIVVQKKHAEALIRDLHTEYELDV
EEEEEEEHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]