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The map label for this gene is pepQ [H]

Identifier: 190571049

GI number: 190571049

Start: 702813

End: 704609

Strand: Reverse

Name: pepQ [H]

Synonym: WPa_0642

Alternate gene names: 190571049

Gene position: 704609-702813 (Counterclockwise)

Preceding gene: 190571050

Following gene: 190571048

Centisome position: 47.53

GC content: 34.39

Gene sequence:

>1797_bases
ATGTCAAAAATCGAAGAATTTCGCTCTTTTATGCACGAAATAAATGTTGATACATTTATGTTGAATACTAAAGACGAGTA
TTTAAATGAATATTCAAAAGAGTTAGCAGAGTTATGTGGCTTCACGGGAACAAATGGGCTACTTATCGTTACAAAGAGTA
ATAAGTGCCCATTTTTTACAGATGGACGCTATATCACACAAGCTCGCAGTCAGCTCGATCAGGGCAGTTTTCGAGTATAT
AATATACAAGAAGAGGATCCACACAAATGGGTAAAAGCAAACTTAACATTGACTACCTCACTGGGTTACTATCCGCAATA
TTTTACTATGAAGGACATAAGAAAATATGAAGGCATTTGTAAACTAGTACCATACTTAATTAAAAAAGATAGTAGTCATA
AAGCACAAACAATAGTCTCACATGTATCTGGTGAGAGTGGTAAGGATAAATGTGAAAGAGTAGCTAAAAACATAGAGGCT
GAAGCAGTGCTTCTGACTGATCCAAATTCAATTTCGTGGTTATTAAATTTAAGAAATGAAAGTTCTGAATATACTCCTTG
TATATTGGGTCGTGCTATATTGTATAAAAATGCCAATGTTGATTTATTTATTCAAGATAAAGAACATTCAACTATAGAAG
CAAATTTTGATAACCATATAAATGTTTTTGATATTAGTGAGCTAGAAAATTCACTACATAAGTTAAATTTGGTGGTGATA
GATCCAAGCACGACTCCAATGAGCATTATGAATGCAATAGATCCCTTGTATAACCATTATTTAAATGAAAAATCAGCTTC
GGTGTCATTCCAGTGCTTGACCAGAAATAAAAAAGCATGGATCCCAGTGTCAAGAACTGGGATGACAATAAGTAATGAAA
GAGGTCTAATAGAAAATAAGCAGATAATTGAGAAGGAGGATCCTTGTTTGATTCACAAAGCAGTAAAAAATCAAACTGAA
ATAACTGGAGCTATAAGTGCGCACATCAAAGATGGAGTAGCAGTTATAAATTTTCTATATTGGCTTGAAAACAATATTGA
CAGTGAAATTACTGAGCTTGAAGCTGAAGAAAAAGTTTTAGAATACAGAAAAGAGCAGAATTTGTTTAAGCAACCGAGTT
TTCCAACAATTTCAGCATTCAACGAGAATGGAGCAATCATTCATTACCGTGCAAGCAATAAGACAAATAAAGTCATTCAA
GAAGATGGGCTGTATTTAATTGATTCTGGTGGTCAGTACCTTGATGGCACAACCGATGTTACAAGAACTATAGCAATTGG
TAGTCCAACCAATGAGCAACGAGCTCACTACACAATAGTATTAAAAGCTCACATTGCGATAGCAAGTGCGGTCTTTCCTT
CTGGCACTACTGGTGGAGAATTGGACATATTAGCGCGTATACATTTATGGAAATTTGGAATGGATTACATGCACGGTACA
GGACATGGAGTAGGAAGTTACCTTTCGGTACACGAAGGACCGCAAGCAATATCAAGAGGAAATAAAGTGGAACTCATTCC
AGGCATGATACTTTCTAACGAGCCTGGTTATTATATTCCAGGAAAGTATGGAATAAGAATTGAGAATCTGATGTATATTG
AAAGGCGAGAAAACGTCTTTTTAAGCTTTAAACAATTGACCTCTGTTCCTTATGATAAAAAGCTAATAGATATACAAATG
CTTACTGAAGATGAAGTTAAATGGATAAATAGCTATCACCAATTTGTTTATAAAAATATAGAAAATGGCATAAAAGATAA
GGAATGGTTAAAGAGAGTATGTGAACCTTTAAAATAG

Upstream 100 bases:

>100_bases
ATTGCGAAGCAAATACAAGGTATCACTCCAGCAGCGATAGTTAGCATATTAGTGTACCTTAGGAATAAGAAAACGAAAAT
AGCTGCTAATTCTGCGTAAC

Downstream 100 bases:

>100_bases
TTAATTTATCATTTAATCAAGTATTAATATAGTTGTTCTTGTATTGTTTTTAATTAAAAACAATATATAATATTAGTTTC
AAATAGGTGTAATTATGACA

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSKIEEFRSFMHEINVDTFMLNTKDEYLNEYSKELAELCGFTGTNGLLIVTKSNKCPFFTDGRYITQARSQLDQGSFRVY
NIQEEDPHKWVKANLTLTTSLGYYPQYFTMKDIRKYEGICKLVPYLIKKDSSHKAQTIVSHVSGESGKDKCERVAKNIEA
EAVLLTDPNSISWLLNLRNESSEYTPCILGRAILYKNANVDLFIQDKEHSTIEANFDNHINVFDISELENSLHKLNLVVI
DPSTTPMSIMNAIDPLYNHYLNEKSASVSFQCLTRNKKAWIPVSRTGMTISNERGLIENKQIIEKEDPCLIHKAVKNQTE
ITGAISAHIKDGVAVINFLYWLENNIDSEITELEAEEKVLEYRKEQNLFKQPSFPTISAFNENGAIIHYRASNKTNKVIQ
EDGLYLIDSGGQYLDGTTDVTRTIAIGSPTNEQRAHYTIVLKAHIAIASAVFPSGTTGGELDILARIHLWKFGMDYMHGT
GHGVGSYLSVHEGPQAISRGNKVELIPGMILSNEPGYYIPGKYGIRIENLMYIERRENVFLSFKQLTSVPYDKKLIDIQM
LTEDEVKWINSYHQFVYKNIENGIKDKEWLKRVCEPLK

Sequences:

>Translated_598_residues
MSKIEEFRSFMHEINVDTFMLNTKDEYLNEYSKELAELCGFTGTNGLLIVTKSNKCPFFTDGRYITQARSQLDQGSFRVY
NIQEEDPHKWVKANLTLTTSLGYYPQYFTMKDIRKYEGICKLVPYLIKKDSSHKAQTIVSHVSGESGKDKCERVAKNIEA
EAVLLTDPNSISWLLNLRNESSEYTPCILGRAILYKNANVDLFIQDKEHSTIEANFDNHINVFDISELENSLHKLNLVVI
DPSTTPMSIMNAIDPLYNHYLNEKSASVSFQCLTRNKKAWIPVSRTGMTISNERGLIENKQIIEKEDPCLIHKAVKNQTE
ITGAISAHIKDGVAVINFLYWLENNIDSEITELEAEEKVLEYRKEQNLFKQPSFPTISAFNENGAIIHYRASNKTNKVIQ
EDGLYLIDSGGQYLDGTTDVTRTIAIGSPTNEQRAHYTIVLKAHIAIASAVFPSGTTGGELDILARIHLWKFGMDYMHGT
GHGVGSYLSVHEGPQAISRGNKVELIPGMILSNEPGYYIPGKYGIRIENLMYIERRENVFLSFKQLTSVPYDKKLIDIQM
LTEDEVKWINSYHQFVYKNIENGIKDKEWLKRVCEPLK
>Mature_597_residues
SKIEEFRSFMHEINVDTFMLNTKDEYLNEYSKELAELCGFTGTNGLLIVTKSNKCPFFTDGRYITQARSQLDQGSFRVYN
IQEEDPHKWVKANLTLTTSLGYYPQYFTMKDIRKYEGICKLVPYLIKKDSSHKAQTIVSHVSGESGKDKCERVAKNIEAE
AVLLTDPNSISWLLNLRNESSEYTPCILGRAILYKNANVDLFIQDKEHSTIEANFDNHINVFDISELENSLHKLNLVVID
PSTTPMSIMNAIDPLYNHYLNEKSASVSFQCLTRNKKAWIPVSRTGMTISNERGLIENKQIIEKEDPCLIHKAVKNQTEI
TGAISAHIKDGVAVINFLYWLENNIDSEITELEAEEKVLEYRKEQNLFKQPSFPTISAFNENGAIIHYRASNKTNKVIQE
DGLYLIDSGGQYLDGTTDVTRTIAIGSPTNEQRAHYTIVLKAHIAIASAVFPSGTTGGELDILARIHLWKFGMDYMHGTG
HGVGSYLSVHEGPQAISRGNKVELIPGMILSNEPGYYIPGKYGIRIENLMYIERRENVFLSFKQLTSVPYDKKLIDIQML
TEDEVKWINSYHQFVYKNIENGIKDKEWLKRVCEPLK

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=618, Percent_Identity=32.2006472491909, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI93141226, Length=645, Percent_Identity=27.2868217054264, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI264681565, Length=618, Percent_Identity=30.42071197411, Blast_Score=256, Evalue=4e-68,
Organism=Escherichia coli, GI1788728, Length=189, Percent_Identity=34.3915343915344, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17509539, Length=655, Percent_Identity=30.8396946564885, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI25149105, Length=620, Percent_Identity=25.6451612903226, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322999, Length=678, Percent_Identity=30.8259587020649, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI17137632, Length=619, Percent_Identity=32.6332794830372, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI161078230, Length=630, Percent_Identity=27.4603174603175, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21357287, Length=630, Percent_Identity=27.4603174603175, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 68135; Mature: 68004

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIEEFRSFMHEINVDTFMLNTKDEYLNEYSKELAELCGFTGTNGLLIVTKSNKCPFFT
CCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEE
DGRYITQARSQLDQGSFRVYNIQEEDPHKWVKANLTLTTSLGYYPQYFTMKDIRKYEGIC
CCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
KLVPYLIKKDSSHKAQTIVSHVSGESGKDKCERVAKNIEAEAVLLTDPNSISWLLNLRNE
HHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCC
SSEYTPCILGRAILYKNANVDLFIQDKEHSTIEANFDNHINVFDISELENSLHKLNLVVI
CCCCCHHHHCHHHEEECCCEEEEEECCCCCEEEECCCCCEEEEEHHHHHCCHHEEEEEEE
DPSTTPMSIMNAIDPLYNHYLNEKSASVSFQCLTRNKKAWIPVSRTGMTISNERGLIENK
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEECCCCCCCCCC
QIIEKEDPCLIHKAVKNQTEITGAISAHIKDGVAVINFLYWLENNIDSEITELEAEEKVL
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EYRKEQNLFKQPSFPTISAFNENGAIIHYRASNKTNKVIQEDGLYLIDSGGQYLDGTTDV
HHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHCCEEEEECCCCCCCCCCCC
TRTIAIGSPTNEQRAHYTIVLKAHIAIASAVFPSGTTGGELDILARIHLWKFGMDYMHGT
EEEEEECCCCCCCCCEEEEEEEEEEHHHHHHCCCCCCCCCEEEEEEEHHHHHCHHHHCCC
GHGVGSYLSVHEGPQAISRGNKVELIPGMILSNEPGYYIPGKYGIRIENLMYIERRENVF
CCCCCCEEEECCCHHHHHCCCEEEEECCEEECCCCCEEECCCCCEEEEEEEEEEECCCEE
LSFKQLTSVPYDKKLIDIQMLTEDEVKWINSYHQFVYKNIENGIKDKEWLKRVCEPLK
EEHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SKIEEFRSFMHEINVDTFMLNTKDEYLNEYSKELAELCGFTGTNGLLIVTKSNKCPFFT
CHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEE
DGRYITQARSQLDQGSFRVYNIQEEDPHKWVKANLTLTTSLGYYPQYFTMKDIRKYEGIC
CCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
KLVPYLIKKDSSHKAQTIVSHVSGESGKDKCERVAKNIEAEAVLLTDPNSISWLLNLRNE
HHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCC
SSEYTPCILGRAILYKNANVDLFIQDKEHSTIEANFDNHINVFDISELENSLHKLNLVVI
CCCCCHHHHCHHHEEECCCEEEEEECCCCCEEEECCCCCEEEEEHHHHHCCHHEEEEEEE
DPSTTPMSIMNAIDPLYNHYLNEKSASVSFQCLTRNKKAWIPVSRTGMTISNERGLIENK
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEECCCCCCCCCC
QIIEKEDPCLIHKAVKNQTEITGAISAHIKDGVAVINFLYWLENNIDSEITELEAEEKVL
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EYRKEQNLFKQPSFPTISAFNENGAIIHYRASNKTNKVIQEDGLYLIDSGGQYLDGTTDV
HHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHCCEEEEECCCCCCCCCCCC
TRTIAIGSPTNEQRAHYTIVLKAHIAIASAVFPSGTTGGELDILARIHLWKFGMDYMHGT
EEEEEECCCCCCCCCEEEEEEEEEEHHHHHHCCCCCCCCCEEEEEEEHHHHHCHHHHCCC
GHGVGSYLSVHEGPQAISRGNKVELIPGMILSNEPGYYIPGKYGIRIENLMYIERRENVF
CCCCCCEEEECCCHHHHHCCCEEEEECCEEECCCCCEEECCCCCEEEEEEEEEEECCCEE
LSFKQLTSVPYDKKLIDIQMLTEDEVKWINSYHQFVYKNIENGIKDKEWLKRVCEPLK
EEHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]