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The map label for this gene is nuoD [H]

Identifier: 190571038

GI number: 190571038

Start: 689115

End: 690287

Strand: Reverse

Name: nuoD [H]

Synonym: WPa_0631

Alternate gene names: 190571038

Gene position: 690287-689115 (Counterclockwise)

Preceding gene: 190571045

Following gene: 190571036

Centisome position: 46.56

GC content: 40.32

Gene sequence:

>1173_bases
ATGCCTGATCTAAAGACAATGATGCTAAATTTTGGTCCTCAGCACCCAGCTGCACATGGGGTGCTACGACTTGTTTTAGA
GATGGATGGTGAAGTGATCGAGAGAGCAGACCCCCATATTGGGCTTTTGCACCGTGGCACTGAAAAATTGATAGAACATA
AAACATATCTTCAAGCTCTGCCTTATTTTGACCGCCTTGATTATGTGTCGCCAATGTCACAAGAGCATGCATATTCGTTG
TGTGTAGAGAAATTGTTGCAATGTGAAATTCCAATTAGAGCAAAATATTTGCGTGTTTTGTTTTGTGAGCTGACAAGAAT
ACTAAATCATTTACTAAATATCTCTTCTCAAGCACTTGATGTTGGGGCGATGACTCCTCTTTTATGGCTCTTTGAAGAGA
GAGAAAAAATACTCGAGTTCTATGAAAGGGCCTCAGGTGCAAGATTTCACGCAGCTTATATAAGGCCAGGTGGACTTGCA
GCAGATATCCCAGAAGGTTTGATTGAAGATATTGCAAAATTTATAGAGCAATTTCCAAAGTATATAGATGATGTTGATGA
ACTTTTAACGGAAAATAGGATATGGAAGCAACGCACTGTAGGAATTAGTGAAATATCAATAAAACAGGCGCTTGATTGGG
GCTTTAGTGGACCAATGCTCCGTGCTGCTGGACTTGCTTGGGACTTGCGAAAAAGCCAGCCATATGAGATATATGATCAG
TTAGATTTTGATATACCTATCGGCCAAAATGGTGACTGTTATGATCGTTATTTAGTAAGAATGGCAGAGATTAGGCAGTC
TGTTAGCTTGGTGAAGCAATGCATAGAGAAAATGCCTGAAGGGCCAATAAAAACTGAAGATAGAAAAATTTCTCCACCGC
CAAGAGCAGAAATGAAAGAATCCATGGAGGCTATGATTCATCATTTTAAGCTTTATTCAGAAGGATATCATGTGCCAGAA
GGTGAGGCTTATGTGGCTGTTGAAGCACCAAAAGGCGAGTTTGGAGTATATATAGTTTCAGATGGTACCAATAGACCTTA
TAGATGTCGAATAAGAGCACCTGGCTTTGCGCATTTACAGGCCTTAGATTTCATGGCAAAAGGACACATGCTTGCTGACA
TTGCAGCAATTATCGGTTCACTCGACATAGTCTTTGGTGAGATTGATAGGTAA

Upstream 100 bases:

>100_bases
GTTTTTCTATTGTAACGATGAGTTATAGCTTGTACAAGAAGCCTATTGACTTTAAGCACATTTTACCCTATACAATTCCA
ATACCTTAAGCTACCAAAGC

Downstream 100 bases:

>100_bases
TTATTGTAAAATAGTAACTCAACTAATGGTCAATACATCCTCTATTAAAAACTGCACAAATTCATTGCCATTCCAGTAAT
TCATAGAGATTTTACCCAAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSL
CVEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLA
ADIPEGLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
LDFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKESMEAMIHHFKLYSEGYHVPE
GEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADIAAIIGSLDIVFGEIDR

Sequences:

>Translated_390_residues
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSL
CVEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLA
ADIPEGLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
LDFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKESMEAMIHHFKLYSEGYHVPE
GEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADIAAIIGSLDIVFGEIDR
>Mature_389_residues
PDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSLC
VEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLAA
DIPEGLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQL
DFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKESMEAMIHHFKLYSEGYHVPEG
EAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADIAAIIGSLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=65.8914728682171, Blast_Score=559, Evalue=1e-159,
Organism=Homo sapiens, GI260898743, Length=381, Percent_Identity=65.3543307086614, Blast_Score=544, Evalue=1e-155,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=40.5194805194805, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=26.9922879177378, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788832, Length=380, Percent_Identity=27.3684210526316, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17555284, Length=388, Percent_Identity=63.1443298969072, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17568379, Length=388, Percent_Identity=63.1443298969072, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=64.9484536082474, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI221459469, Length=387, Percent_Identity=62.7906976744186, Blast_Score=540, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44494; Mature: 44363

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQAL
CCCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYFDRLDYVSPMSQEHAYSLCVEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLAADIPEGLIEDIAKFIEQFPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHC
LDFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SMEAMIHHFKLYSEGYHVPEGEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQ
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHH
ALDFMAKGHMLADIAAIIGSLDIVFGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQAL
CCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYFDRLDYVSPMSQEHAYSLCVEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLAADIPEGLIEDIAKFIEQFPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHC
LDFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SMEAMIHHFKLYSEGYHVPEGEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQ
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHH
ALDFMAKGHMLADIAAIIGSLDIVFGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA