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The map label for this gene is clpP [H]

Identifier: 190570982

GI number: 190570982

Start: 614564

End: 615190

Strand: Direct

Name: clpP [H]

Synonym: WPa_0570

Alternate gene names: 190570982

Gene position: 614564-615190 (Clockwise)

Preceding gene: 190570981

Following gene: 190570983

Centisome position: 41.46

GC content: 34.93

Gene sequence:

>627_bases
ATGACTCTTATACCAATTGTAGTTGAACAAACTAGTCGCGGTGAGCGGGCTTATGACATATATTCAAGGCTAGTAAAAGA
AAGAATAATTTTCGTAACTGGCCCTATTGAAGACAACATGGCCAGCGTAATAGTAGCACAGCTTTTATTTTTAGAATCGG
AAAATCCCGATAAAGACATTTGTATGTATATTAACTCACCAGGTGGTGTTGTAACTGCTGGTTTGTCGATCTACGATACA
ATGCAGTATATAAATCCAGACGTTTCAACTTTGTGTATAGGTCAAGCTGCATCTATGGGTTCTTTGTTGCTTACAGCTGG
TGCGGAGGGTAAACGTTACTCGCTACCTCATTCAAGAATTATGATACATCAGCCATCTGGTGGTTATCATGGGCAAGCAA
CTGATATAGAAATACATGCTAATGAAATTTTGCGAGTTAAGAAAAAATTAAATCAAATTTATGAAAAACATACTGGAAAT
TCACTAAAAAAAATTGAAGAAATGATGGAAAGAGATAAATTCATGGATCCTGAAGAAGCAATGAAAACTGGCTTAATTGA
CAGAGTAATAGCTGAGCGTAAAGATATGAAGATTGAAAATATTAAAGTTAAACAAAAGGTAGTTTAA

Upstream 100 bases:

>100_bases
AGTGACGGATTATATGATAGAAAAAGCTAGTAAAGAAGAACAGATTGTTTCTGTGAAAGAATTAAAGGAATTATTTGATA
ATATTTGATAGGAATAAGGT

Downstream 100 bases:

>100_bases
TGGATAACAATAATGATTTACACTACTGTTCTTTTTGTAACAAGGCACAAAACGAAGTAGATAAATTGATTACTAACTCT
TCAGATGGTTTAAAGGTGTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDICMYINSPGGVVTAGLSIYDT
MQYINPDVSTLCIGQAASMGSLLLTAGAEGKRYSLPHSRIMIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGN
SLKKIEEMMERDKFMDPEEAMKTGLIDRVIAERKDMKIENIKVKQKVV

Sequences:

>Translated_208_residues
MTLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDICMYINSPGGVVTAGLSIYDT
MQYINPDVSTLCIGQAASMGSLLLTAGAEGKRYSLPHSRIMIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGN
SLKKIEEMMERDKFMDPEEAMKTGLIDRVIAERKDMKIENIKVKQKVV
>Mature_207_residues
TLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDICMYINSPGGVVTAGLSIYDTM
QYINPDVSTLCIGQAASMGSLLLTAGAEGKRYSLPHSRIMIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGNS
LKKIEEMMERDKFMDPEEAMKTGLIDRVIAERKDMKIENIKVKQKVV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=66.8421052631579, Blast_Score=267, Evalue=5e-72,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=66.4948453608247, Blast_Score=291, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=57.5268817204301, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=65.2631578947368, Blast_Score=264, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23372; Mature: 23240

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDI
CCEEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEE
CMYINSPGGVVTAGLSIYDTMQYINPDVSTLCIGQAASMGSLLLTAGAEGKRYSLPHSRI
EEEECCCCCEEEECHHHHHHHHHHCCCHHHEECCCCCCCCCEEEECCCCCCEECCCCCEE
MIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGNSLKKIEEMMERDKFMDPEEA
EEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
MKTGLIDRVIAERKDMKIENIKVKQKVV
HHHHHHHHHHHHHHCCEECCEEEHCCCC
>Mature Secondary Structure 
TLIPIVVEQTSRGERAYDIYSRLVKERIIFVTGPIEDNMASVIVAQLLFLESENPDKDI
CEEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEE
CMYINSPGGVVTAGLSIYDTMQYINPDVSTLCIGQAASMGSLLLTAGAEGKRYSLPHSRI
EEEECCCCCEEEECHHHHHHHHHHCCCHHHEECCCCCCCCCEEEECCCCCCEECCCCCEE
MIHQPSGGYHGQATDIEIHANEILRVKKKLNQIYEKHTGNSLKKIEEMMERDKFMDPEEA
EEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
MKTGLIDRVIAERKDMKIENIKVKQKVV
HHHHHHHHHHHHHHCCEECCEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA