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The map label for this gene is serS

Identifier: 190570965

GI number: 190570965

Start: 590375

End: 591655

Strand: Reverse

Name: serS

Synonym: WPa_0551

Alternate gene names: 190570965

Gene position: 591655-590375 (Counterclockwise)

Preceding gene: 190570968

Following gene: 190570964

Centisome position: 39.91

GC content: 34.74

Gene sequence:

>1281_bases
ATGCATGATATAGAACATATACGCAAAAACCCTAAAGGATTTGAAAAAGCAATAAAAAGCAGAGGGGTGAAAGAATTTAC
TGCAAAAGAAATATTAGAGATAGACCATAAAAAAAGATCACTGACTACTAAATTGCAAGCTTTAAATAAGCAACGAAACG
AGGTCACGGAAGAAATAAAGAGGCTTAAAATGAACAAAAGCCCATGTGAAGAACAAGTAAAGTTATCAAAAAGCATCACA
AGTGAGATAGAGACAATCAGCCTCAAGGAGCAAACAGAAAAAAATAAGTTAGTGGATATTTTATCTAACTTACCAAATAT
TTCTGCACAAAATGTACCAATAGGTGAAGATGAGAGCTCCAACGTAGAAATCAGAAAATATGGAAAGAAAAGAAAATTTG
ATTTTACACCAAAATTTCATTATGAACTCGGAGAAAGGTTAGGCTTGATGGATTTTGAACAAGCAGCAAAAATTTCTGGA
TCAAGGTTTACAATACTAAAAGGACAGTTAGCTAAGCTTGGACGAGCATTAATAAATTTTATGCTGGAAACACATGTTAA
TGAATTTGCCTATACTGAGGTGTATCACCCAGCCCTGGTGAAAAACGAGGCGATGTATAACGTTGGTCAGCTACCAAAAT
TTTCTGATGACTCATATTTAACTACCGATAAATTAAGATTAATTCCCACAAGTGAAGTAGTTTTAACAAATTTAGTTGCT
GACAAAATAATAGAAGAAAAAGAACTGCCTATTCGGTTTACTGCATATTCAGAATGTTTTCGTAAAGAAGCTGGCAGTGC
AGGACGAGATACAAGAGGTATGATAAGGCAACACCAATTTGGTAAAGTGGAGTTGGTAAGCATCACAACTGAAGACCAGT
CAAAAGACGAGCTTGAACGTATGACAAATGCTGCTGAGGAAATATTAAAAAAATTAGAACTACCGTATAGAATAATGCTG
CTTTGTAGTGGTGATATGGGCTTTGCTGCACAAAAGACTTATGATATAGAGGTATGGTTACCTGAGCAAAATAAGTACAG
AGAAATATCAAGCTGCTCAAATTGCGGTACGTTCCAGGCAAGAAGAATGAATACTAAATACTTCTTAGAAACTGACAGAA
AAACAAAAAAATACGTTCACACTTTAAACGGCTCAGCTTTAGCCATAGGAAGAACAATTGTTGCCATAATGGAGAATTAT
CAAAATTCCGATGGGTCAGTTACAATACCAAACGTGTTGCAAAGATACATGAGTAATGATACTGTTATAAGCAAACAATA
A

Upstream 100 bases:

>100_bases
CAAATTATGAAGGTAAAATCAATATTAGCATTTATATGTAAAAATATTGAGCATTCAAAGCTTTTGAAGTAGAGTAATGA
TGTTAGTAATAGCACAACAT

Downstream 100 bases:

>100_bases
TTTTGACATATAGAAAAGCGAGGAAATAAAGATGAAGGTTCTGGTTATAGGTTCTGGTGGGCGTGAGCATGCTTTACTTT
GGGCTTTAAAGAAGTCTCCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHDIEHIRKNPKGFEKAIKSRGVKEFTAKEILEIDHKKRSLTTKLQALNKQRNEVTEEIKRLKMNKSPCEEQVKLSKSIT
SEIETISLKEQTEKNKLVDILSNLPNISAQNVPIGEDESSNVEIRKYGKKRKFDFTPKFHYELGERLGLMDFEQAAKISG
SRFTILKGQLAKLGRALINFMLETHVNEFAYTEVYHPALVKNEAMYNVGQLPKFSDDSYLTTDKLRLIPTSEVVLTNLVA
DKIIEEKELPIRFTAYSECFRKEAGSAGRDTRGMIRQHQFGKVELVSITTEDQSKDELERMTNAAEEILKKLELPYRIML
LCSGDMGFAAQKTYDIEVWLPEQNKYREISSCSNCGTFQARRMNTKYFLETDRKTKKYVHTLNGSALAIGRTIVAIMENY
QNSDGSVTIPNVLQRYMSNDTVISKQ

Sequences:

>Translated_426_residues
MHDIEHIRKNPKGFEKAIKSRGVKEFTAKEILEIDHKKRSLTTKLQALNKQRNEVTEEIKRLKMNKSPCEEQVKLSKSIT
SEIETISLKEQTEKNKLVDILSNLPNISAQNVPIGEDESSNVEIRKYGKKRKFDFTPKFHYELGERLGLMDFEQAAKISG
SRFTILKGQLAKLGRALINFMLETHVNEFAYTEVYHPALVKNEAMYNVGQLPKFSDDSYLTTDKLRLIPTSEVVLTNLVA
DKIIEEKELPIRFTAYSECFRKEAGSAGRDTRGMIRQHQFGKVELVSITTEDQSKDELERMTNAAEEILKKLELPYRIML
LCSGDMGFAAQKTYDIEVWLPEQNKYREISSCSNCGTFQARRMNTKYFLETDRKTKKYVHTLNGSALAIGRTIVAIMENY
QNSDGSVTIPNVLQRYMSNDTVISKQ
>Mature_426_residues
MHDIEHIRKNPKGFEKAIKSRGVKEFTAKEILEIDHKKRSLTTKLQALNKQRNEVTEEIKRLKMNKSPCEEQVKLSKSIT
SEIETISLKEQTEKNKLVDILSNLPNISAQNVPIGEDESSNVEIRKYGKKRKFDFTPKFHYELGERLGLMDFEQAAKISG
SRFTILKGQLAKLGRALINFMLETHVNEFAYTEVYHPALVKNEAMYNVGQLPKFSDDSYLTTDKLRLIPTSEVVLTNLVA
DKIIEEKELPIRFTAYSECFRKEAGSAGRDTRGMIRQHQFGKVELVSITTEDQSKDELERMTNAAEEILKKLELPYRIML
LCSGDMGFAAQKTYDIEVWLPEQNKYREISSCSNCGTFQARRMNTKYFLETDRKTKKYVHTLNGSALAIGRTIVAIMENY
QNSDGSVTIPNVLQRYMSNDTVISKQ

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI225579074, Length=442, Percent_Identity=28.7330316742081, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI8923421, Length=440, Percent_Identity=28.8636363636364, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI16306548, Length=337, Percent_Identity=35.6083086053413, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=44.4964871194379, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539260, Length=469, Percent_Identity=29.8507462686567, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=329, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=435, Percent_Identity=32.4137931034483, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=415, Percent_Identity=31.566265060241, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24581334, Length=386, Percent_Identity=32.6424870466321, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=359, Percent_Identity=31.7548746518106, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24649556, Length=409, Percent_Identity=22.2493887530562, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_WOLPP (B3CQ06)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975323.1
- EnsemblBacteria:   EBWOLT00000001092
- GeneID:   6384580
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0551
- GeneTree:   EBGT00050000031206
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48877; Mature: 48877

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIEHIRKNPKGFEKAIKSRGVKEFTAKEILEIDHKKRSLTTKLQALNKQRNEVTEEIK
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKMNKSPCEEQVKLSKSITSEIETISLKEQTEKNKLVDILSNLPNISAQNVPIGEDESS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIRKYGKKRKFDFTPKFHYELGERLGLMDFEQAAKISGSRFTILKGQLAKLGRALINF
CCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
MLETHVNEFAYTEVYHPALVKNEAMYNVGQLPKFSDDSYLTTDKLRLIPTSEVVLTNLVA
HHHHHHHHHHHHHHHCHHHHCCCHHHCCCCCCCCCCCCEEEECCEEECCCHHHHHHHHHH
DKIIEEKELPIRFTAYSECFRKEAGSAGRDTRGMIRQHQFGKVELVSITTEDQSKDELER
HHHHHHCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
MTNAAEEILKKLELPYRIMLLCSGDMGFAAQKTYDIEVWLPEQNKYREISSCSNCGTFQA
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHCCCCCCCHH
RRMNTKYFLETDRKTKKYVHTLNGSALAIGRTIVAIMENYQNSDGSVTIPNVLQRYMSND
HHCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCC
TVISKQ
CEECCC
>Mature Secondary Structure
MHDIEHIRKNPKGFEKAIKSRGVKEFTAKEILEIDHKKRSLTTKLQALNKQRNEVTEEIK
CCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKMNKSPCEEQVKLSKSITSEIETISLKEQTEKNKLVDILSNLPNISAQNVPIGEDESS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIRKYGKKRKFDFTPKFHYELGERLGLMDFEQAAKISGSRFTILKGQLAKLGRALINF
CCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
MLETHVNEFAYTEVYHPALVKNEAMYNVGQLPKFSDDSYLTTDKLRLIPTSEVVLTNLVA
HHHHHHHHHHHHHHHCHHHHCCCHHHCCCCCCCCCCCCEEEECCEEECCCHHHHHHHHHH
DKIIEEKELPIRFTAYSECFRKEAGSAGRDTRGMIRQHQFGKVELVSITTEDQSKDELER
HHHHHHCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
MTNAAEEILKKLELPYRIMLLCSGDMGFAAQKTYDIEVWLPEQNKYREISSCSNCGTFQA
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHCCCCCCCHH
RRMNTKYFLETDRKTKKYVHTLNGSALAIGRTIVAIMENYQNSDGSVTIPNVLQRYMSND
HHCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCC
TVISKQ
CEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA