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The map label for this gene is pqqL [C]

Identifier: 190570921

GI number: 190570921

Start: 538446

End: 539774

Strand: Direct

Name: pqqL [C]

Synonym: WPa_0501

Alternate gene names: 190570921

Gene position: 538446-539774 (Clockwise)

Preceding gene: 190570920

Following gene: 190570922

Centisome position: 36.32

GC content: 33.56

Gene sequence:

>1329_bases
ATGCTTCGCAAATTCTTTAGTTTTTTTATACTATCTGTGTTTTTTTTCATTTGTCCGATTTCTTTGGAAGCTGAAATCAT
AAAGCATGCTAAGCTCAGTAACGGATTGGATGTTTATGTAGTACCTAATCACCGAATTCCAGCTGTTTTTCATGCAATAA
TATATAAAGTTGGGGGAATGGATGACCCAATTGGCAAAGCAGGATTGGCTCACTACTTTGAACACTTAATGTTTGAAACT
ACAGGAAAATTTAAAGACATAGAATCCACTTTGGGCAGCATTGGGGCCCAATTTAATGCTTTTACCACTAAAGAATACAC
CTGCTACTACGAATTAGTTCTCAAAAAAGATTTACCACTAGCAATGGAAATTGAAGCAGATAGAATGGGCAATTTTGATG
TTACTCAAGACAAAATAGATAGAGAAAAAAATATCGTATTAGAAGAAAGAAAGATGAGATTTGATAATAATCCTGAAGCT
TTACTATGGGAGGAAATGAACAGTGCATTTTATCGTAATGGTTATGGTAGGTCTGTTATTGGTTGGGAGAGCGATATTAA
AACTTACAATCAAGATGACATAACAAGGTTTCATGATAACTATTATCATCCAGGTAATGCTATACTGCTCGTTGTTGGTG
ATGTAGAATTTGAAGAAGTAGTGGGATTAGCAAAGGAAAAATATGGTGCAATTAAAGCTGAGCCTGTAGTGAAGCATTAT
CCGAACCAAGATTCAATACATAATGCAGATATATCGGTAATTTTAGAAAGCACTGAAGTAAAAGAGCCAGTTTTATACTT
TCGCTATAGTGTTCCTTTATTTGAGCAAATAAGTGAAACTTTTCCTGTTGATTTGGCAGTTGATGTTTTGGGGAATGGCA
AGTCTAGTAAGCTATATAAAGATTTAGTTCTAGATAAGAATGTAGCAGTAGAAGTGTTTGCTTATTATAATAGCTTAGCT
TTTAGTAATGGTTACATTGAGATTCGGGTAACTCCAAAAAGCGGGGTGAATTTGGATGCTGTTGCAAGAGAGTTAGAAAA
TTCTATTAATCACTTTAACTCTGAAGGAATAACAAGTGAAGAGTTGCAAAGTACAAAGTCTAAATACAAAGCAGCACAGC
TTGATAATCTATCTGATTTAACTAATATAGCAATGTTTTATATACCACGTCTAGCACTAGGTATTCCACTTGATGAAATA
GACATTTCATATAGCAAAATTAATGATGTCAATCTAGAGGATGTAAATAATAAAGTTCACGCTATCTTTTCTACTAATAA
ATTAGTTGGTCGTTTGCTACCAAAAGGAGGTAATAATGAAGATAAGTAA

Upstream 100 bases:

>100_bases
AATTTAGCAGATCTATCTATAGTTTGTGGAATGTGTACATTGTTATATAAGTGGTATATATATGATAGGTCTATCTCTAA
GCAAAATGAGGAATGAAATA

Downstream 100 bases:

>100_bases
ATATGTATTTCTATTTTTTTTCTGTCTAGGCTTTAATTTGCAAGCAAGCAGTCACTTAAATATAGAGGAGGTTACTACTA
ATAAAGGATTTAAGTTTTTA

Product: protease, insulinase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLRKFFSFFILSVFFFICPISLEAEIIKHAKLSNGLDVYVVPNHRIPAVFHAIIYKVGGMDDPIGKAGLAHYFEHLMFET
TGKFKDIESTLGSIGAQFNAFTTKEYTCYYELVLKKDLPLAMEIEADRMGNFDVTQDKIDREKNIVLEERKMRFDNNPEA
LLWEEMNSAFYRNGYGRSVIGWESDIKTYNQDDITRFHDNYYHPGNAILLVVGDVEFEEVVGLAKEKYGAIKAEPVVKHY
PNQDSIHNADISVILESTEVKEPVLYFRYSVPLFEQISETFPVDLAVDVLGNGKSSKLYKDLVLDKNVAVEVFAYYNSLA
FSNGYIEIRVTPKSGVNLDAVARELENSINHFNSEGITSEELQSTKSKYKAAQLDNLSDLTNIAMFYIPRLALGIPLDEI
DISYSKINDVNLEDVNNKVHAIFSTNKLVGRLLPKGGNNEDK

Sequences:

>Translated_442_residues
MLRKFFSFFILSVFFFICPISLEAEIIKHAKLSNGLDVYVVPNHRIPAVFHAIIYKVGGMDDPIGKAGLAHYFEHLMFET
TGKFKDIESTLGSIGAQFNAFTTKEYTCYYELVLKKDLPLAMEIEADRMGNFDVTQDKIDREKNIVLEERKMRFDNNPEA
LLWEEMNSAFYRNGYGRSVIGWESDIKTYNQDDITRFHDNYYHPGNAILLVVGDVEFEEVVGLAKEKYGAIKAEPVVKHY
PNQDSIHNADISVILESTEVKEPVLYFRYSVPLFEQISETFPVDLAVDVLGNGKSSKLYKDLVLDKNVAVEVFAYYNSLA
FSNGYIEIRVTPKSGVNLDAVARELENSINHFNSEGITSEELQSTKSKYKAAQLDNLSDLTNIAMFYIPRLALGIPLDEI
DISYSKINDVNLEDVNNKVHAIFSTNKLVGRLLPKGGNNEDK
>Mature_442_residues
MLRKFFSFFILSVFFFICPISLEAEIIKHAKLSNGLDVYVVPNHRIPAVFHAIIYKVGGMDDPIGKAGLAHYFEHLMFET
TGKFKDIESTLGSIGAQFNAFTTKEYTCYYELVLKKDLPLAMEIEADRMGNFDVTQDKIDREKNIVLEERKMRFDNNPEA
LLWEEMNSAFYRNGYGRSVIGWESDIKTYNQDDITRFHDNYYHPGNAILLVVGDVEFEEVVGLAKEKYGAIKAEPVVKHY
PNQDSIHNADISVILESTEVKEPVLYFRYSVPLFEQISETFPVDLAVDVLGNGKSSKLYKDLVLDKNVAVEVFAYYNSLA
FSNGYIEIRVTPKSGVNLDAVARELENSINHFNSEGITSEELQSTKSKYKAAQLDNLSDLTNIAMFYIPRLALGIPLDEI
DISYSKINDVNLEDVNNKVHAIFSTNKLVGRLLPKGGNNEDK

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=165, Percent_Identity=31.5151515151515, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI46593007, Length=202, Percent_Identity=26.2376237623762, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787770, Length=363, Percent_Identity=23.6914600550964, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=167, Percent_Identity=25.748502994012, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=389, Percent_Identity=24.4215938303342, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357875, Length=169, Percent_Identity=28.9940828402367, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646943, Length=169, Percent_Identity=28.9940828402367, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 50149; Mature: 50149

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKFFSFFILSVFFFICPISLEAEIIKHAKLSNGLDVYVVPNHRIPAVFHAIIYKVGGM
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
DDPIGKAGLAHYFEHLMFETTGKFKDIESTLGSIGAQFNAFTTKEYTCYYELVLKKDLPL
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCEEEEEEEEECCCCCE
AMEIEADRMGNFDVTQDKIDREKNIVLEERKMRFDNNPEALLWEEMNSAFYRNGYGRSVI
EEEEECCCCCCCCCCHHHHCCHHCEEEHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCEE
GWESDIKTYNQDDITRFHDNYYHPGNAILLVVGDVEFEEVVGLAKEKYGAIKAEPVVKHY
CCCHHCCCCCCHHHHHHHCCEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHC
PNQDSIHNADISVILESTEVKEPVLYFRYSVPLFEQISETFPVDLAVDVLGNGKSSKLYK
CCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCCCHHHHH
DLVLDKNVAVEVFAYYNSLAFSNGYIEIRVTPKSGVNLDAVARELENSINHFNSEGITSE
HHHHCCCCCEEEEEHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ELQSTKSKYKAAQLDNLSDLTNIAMFYIPRLALGIPLDEIDISYSKINDVNLEDVNNKVH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCCCCHHHCCCEEE
AIFSTNKLVGRLLPKGGNNEDK
EEEECHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLRKFFSFFILSVFFFICPISLEAEIIKHAKLSNGLDVYVVPNHRIPAVFHAIIYKVGGM
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
DDPIGKAGLAHYFEHLMFETTGKFKDIESTLGSIGAQFNAFTTKEYTCYYELVLKKDLPL
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCEEEEEEEEECCCCCE
AMEIEADRMGNFDVTQDKIDREKNIVLEERKMRFDNNPEALLWEEMNSAFYRNGYGRSVI
EEEEECCCCCCCCCCHHHHCCHHCEEEHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCEE
GWESDIKTYNQDDITRFHDNYYHPGNAILLVVGDVEFEEVVGLAKEKYGAIKAEPVVKHY
CCCHHCCCCCCHHHHHHHCCEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHC
PNQDSIHNADISVILESTEVKEPVLYFRYSVPLFEQISETFPVDLAVDVLGNGKSSKLYK
CCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCCCHHHHH
DLVLDKNVAVEVFAYYNSLAFSNGYIEIRVTPKSGVNLDAVARELENSINHFNSEGITSE
HHHHCCCCCEEEEEHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ELQSTKSKYKAAQLDNLSDLTNIAMFYIPRLALGIPLDEIDISYSKINDVNLEDVNNKVH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCCCCHHHCCCEEE
AIFSTNKLVGRLLPKGGNNEDK
EEEECHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]