Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 18977778

GI number: 18977778

Start: 1320418

End: 1321755

Strand: Direct

Name: thrC [H]

Synonym: PF1406

Alternate gene names: 18977778

Gene position: 1320418-1321755 (Clockwise)

Preceding gene: 18977777

Following gene: 18977779

Centisome position: 69.2

GC content: 38.12

Gene sequence:

>1338_bases
ATGAAATGTCCGAAATGCGGGAGAGAGTGGACTACTTTTATTCCCCCCTTTTGTACTTGTGGGGCTGAACTTGAAATTAG
CTATGACTACTCTAAAGTAGATGTTAGAAAGTGGAAGAACAGACTTTCTTCTGTATGGAAATATCGAGAGCTTCTTCCCC
CTGTAAAGAGAATGATTACACTGCGAGAGGGTGGAACTCCGTTAATAAAGGCAAGAATTTCAGAAAAAATTGGGATAGAT
GTGTATATTAAGGATGAAACTAGAAATCCCACAGGTTCATTTAGGGATAGACTAGCTACAGTTGCCATTTCTTATGGTTT
ACCTTATGCATCCAACGGATTTATTGTAGCTAGTGATGGAAATGCTGCAGTTTCAGTTGCAGCTTATGCTGCAAGAGCTG
AAAAGGAAGCGTTTGTAGTAATCCCAAGGAAAGTTGACAGGGGGAAGTTAATACAGATGATGGCCTTTGGGGCCAAAATC
ATTAGATTTGGGGAAAGTGTTGACGAGGCAATAGAGTATGCAAGGGAAATAGCAAAGCTCAATGGCCTTTATAACGTCAC
GCCAGAAGATAATATTATTGGACTTGAAGGTCAAAAAACAATAGCCTTTGAACTTTGGGAAGAGCTAAATCCCACCCACG
TAGTAGTTCCAACTGGTAGTGGAAGTTATATTTATTCAATTTACAAGGGATTTAAGGAGTTAATGGAAATCGGGGTTCTT
GAGGAAATTCCTAATTTGATAGCCGTTCAAACTGATAAATGCAATCCTATAGCATCTGAAGTTCTGGGAACAAAGAAGAA
ATGCACAGAAACAAAAGCTCTCGGCTTGTACGTTAAAAATCCAGTTATGAAAAACAAGGCAGTTAAAGCTATAAAAGAAA
GCAAAGGTACTGCAGTAATTGTAAATGAGGAAGAAATCATGAGAGGAGAAAAATTACTTGCAAGTGAGGGCATTTATGCA
GAATTATCCTCAGCCGTAGTCATGCCGGCTTTGCTAAAGCTTAAAGAAAATGGGTTTATAGAAAAAGGAGACAAAGTTGT
ACTAGTAGTTACAGGTTCTGGTTTAAAAACTGGAGAAGGTGGAAAAGAGAAATTTTCAATTGGACCAACTAAAATTGAGA
TACTTAGGCTGTTGAAAGAAAGAGAAATGTATGCATATGAGATCTGGAGCTTACTTGGGAAACCTCTAAAGTACCAAGCA
GTCCATCAGCACATTAAGGAGTTACTTGAATTGGGATTAGTTGAACAGGCATATAGAAAGGGAAAGAGGGTATATTACAA
GATAACTGAAAAAGGATTGAGAATTCTACAAAACTTCGAAGACCTAGAGAACATTTAA

Upstream 100 bases:

>100_bases
CCTCAAAAATGTTTGGATTTAGCTACGAGCATTCACAAGAAGTTTGGACTCTCCACTAGGGCTCCAAACAATCTCGACAC
CATTCGACTGAGGTGATGCC

Downstream 100 bases:

>100_bases
AATCGTTACTTCTTAAGGTAATTTGGTGAAAGCATGAGGATAGTGTTTGACATAGGAGGGTCTGTCTTGGTTCCAGAGAA
TCCTGATATAGACTTCATAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKCPKCGREWTTFIPPFCTCGAELEISYDYSKVDVRKWKNRLSSVWKYRELLPPVKRMITLREGGTPLIKARISEKIGID
VYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVASDGNAAVSVAAYAARAEKEAFVVIPRKVDRGKLIQMMAFGAKI
IRFGESVDEAIEYAREIAKLNGLYNVTPEDNIIGLEGQKTIAFELWEELNPTHVVVPTGSGSYIYSIYKGFKELMEIGVL
EEIPNLIAVQTDKCNPIASEVLGTKKKCTETKALGLYVKNPVMKNKAVKAIKESKGTAVIVNEEEIMRGEKLLASEGIYA
ELSSAVVMPALLKLKENGFIEKGDKVVLVVTGSGLKTGEGGKEKFSIGPTKIEILRLLKEREMYAYEIWSLLGKPLKYQA
VHQHIKELLELGLVEQAYRKGKRVYYKITEKGLRILQNFEDLENI

Sequences:

>Translated_445_residues
MKCPKCGREWTTFIPPFCTCGAELEISYDYSKVDVRKWKNRLSSVWKYRELLPPVKRMITLREGGTPLIKARISEKIGID
VYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVASDGNAAVSVAAYAARAEKEAFVVIPRKVDRGKLIQMMAFGAKI
IRFGESVDEAIEYAREIAKLNGLYNVTPEDNIIGLEGQKTIAFELWEELNPTHVVVPTGSGSYIYSIYKGFKELMEIGVL
EEIPNLIAVQTDKCNPIASEVLGTKKKCTETKALGLYVKNPVMKNKAVKAIKESKGTAVIVNEEEIMRGEKLLASEGIYA
ELSSAVVMPALLKLKENGFIEKGDKVVLVVTGSGLKTGEGGKEKFSIGPTKIEILRLLKEREMYAYEIWSLLGKPLKYQA
VHQHIKELLELGLVEQAYRKGKRVYYKITEKGLRILQNFEDLENI
>Mature_445_residues
MKCPKCGREWTTFIPPFCTCGAELEISYDYSKVDVRKWKNRLSSVWKYRELLPPVKRMITLREGGTPLIKARISEKIGID
VYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVASDGNAAVSVAAYAARAEKEAFVVIPRKVDRGKLIQMMAFGAKI
IRFGESVDEAIEYAREIAKLNGLYNVTPEDNIIGLEGQKTIAFELWEELNPTHVVVPTGSGSYIYSIYKGFKELMEIGVL
EEIPNLIAVQTDKCNPIASEVLGTKKKCTETKALGLYVKNPVMKNKAVKAIKESKGTAVIVNEEEIMRGEKLLASEGIYA
ELSSAVVMPALLKLKENGFIEKGDKVVLVVTGSGLKTGEGGKEKFSIGPTKIEILRLLKEREMYAYEIWSLLGKPLKYQA
VHQHIKELLELGLVEQAYRKGKRVYYKITEKGLRILQNFEDLENI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790207, Length=218, Percent_Identity=29.3577981651376, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=301, Percent_Identity=26.9102990033223, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 49777; Mature: 49777

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCPKCGREWTTFIPPFCTCGAELEISYDYSKVDVRKWKNRLSSVWKYRELLPPVKRMIT
CCCCCCCCCCHHCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHEE
LREGGTPLIKARISEKIGIDVYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVASDG
CCCCCCCEEHEEHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
NAAVSVAAYAARAEKEAFVVIPRKVDRGKLIQMMAFGAKIIRFGESVDEAIEYAREIAKL
CCEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NGLYNVTPEDNIIGLEGQKTIAFELWEELNPTHVVVPTGSGSYIYSIYKGFKELMEIGVL
CCCEECCCCCCEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
EEIPNLIAVQTDKCNPIASEVLGTKKKCTETKALGLYVKNPVMKNKAVKAIKESKGTAVI
HHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEE
VNEEEIMRGEKLLASEGIYAELSSAVVMPALLKLKENGFIEKGDKVVLVVTGSGLKTGEG
ECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCC
GKEKFSIGPTKIEILRLLKEREMYAYEIWSLLGKPLKYQAVHQHIKELLELGLVEQAYRK
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GKRVYYKITEKGLRILQNFEDLENI
CCEEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKCPKCGREWTTFIPPFCTCGAELEISYDYSKVDVRKWKNRLSSVWKYRELLPPVKRMIT
CCCCCCCCCCHHCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHEE
LREGGTPLIKARISEKIGIDVYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVASDG
CCCCCCCEEHEEHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
NAAVSVAAYAARAEKEAFVVIPRKVDRGKLIQMMAFGAKIIRFGESVDEAIEYAREIAKL
CCEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NGLYNVTPEDNIIGLEGQKTIAFELWEELNPTHVVVPTGSGSYIYSIYKGFKELMEIGVL
CCCEECCCCCCEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
EEIPNLIAVQTDKCNPIASEVLGTKKKCTETKALGLYVKNPVMKNKAVKAIKESKGTAVI
HHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEE
VNEEEIMRGEKLLASEGIYAELSSAVVMPALLKLKENGFIEKGDKVVLVVTGSGLKTGEG
ECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCCC
GKEKFSIGPTKIEILRLLKEREMYAYEIWSLLGKPLKYQAVHQHIKELLELGLVEQAYRK
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GKRVYYKITEKGLRILQNFEDLENI
CCEEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]