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The map label for this gene is 18977777

Identifier: 18977777

GI number: 18977777

Start: 1318458

End: 1320413

Strand: Direct

Name: 18977777

Synonym: PF1405

Alternate gene names: NA

Gene position: 1318458-1320413 (Clockwise)

Preceding gene: 18977776

Following gene: 18977778

Centisome position: 69.09

GC content: 40.39

Gene sequence:

>1956_bases
GTGACAATTTTGATTAAAAGGGAAACCATGGTTGAAGAAATTCTTAAGGAGATAAGAGAAAAGGTAGCTCAAAAAATACC
AAAAGAAGCAAAAATAACCGAAATAGAATTTGAAGGGCCAGAATTAGTCATTTACGTTAAAAATCCTGAGGTTGTAATGA
AAGATGGGGAGCTTATAAAAGAGCTGGCGAAAATTCTAAAGAAGAGGATAAGTATTAGACCAGATCCAGATGTTTTGTTA
CCTCCTGAAGAGGCTGAGAAGTTAATTCTGGAAATTGTTCCAAAAGAGGCTGAAATTACGAATATTTCTTTTGATCCATC
CGTAGGAGAAGTTCTAATTGAGGCAAAGAAACCTGGGTTAGTAATTGGAAAAAATGGTGAAACTCTTAGACTAATCACCG
AAAAAGTAAGGTGGGCCCCCAAAGTTGTCAGAACGCCTCCACTTCAGAGCCAGACTATCTACCTAATCAGACAAATTCTT
CAAACTGAAAGTAAGGATAGAAGAAAGTTCCTGAGGCAAGTTGGGAGAAATATCTACAGAAAGCCCGAATATAAAAGCAG
GTGGATTAGAATAACTGGACTTGGAGGATTTAGAGAAGTAGGTAGAAGTGCACTATTAGTACAAACTGATGAAAGTTTCG
TGTTGGTTGATTTTGGAATTAACGTTGCTGCCTTAAATGATCCATATAAGGCATTTCCACACTTTGACGCTCCAGAGTTT
CAATATGTATTGAAAGAGGGCTTACTGGATGCAATAGTCATTACTCACGCTCATCTTGACCACAGTGGAATGCTTCCATA
CTTATTCAGATACAATTTATTCGATGGGCCAATATACACAACTCCTCCTACTAGGGATTTAATGGTGTTACTCCAAAAGG
ATTTTGTGGAGATTCAACAGAGCAATGGACAGGAGCCATTATACAAGCCTAAAGACATAAAGGAAGTCATTAAGCACACA
ATAACCTTAGATTATGGGGAAGTTAGAGATATATCTCCCGACGTGAGGCTAACACTCCACAATGCTGGCCACATTTTAGG
CTCAGCAATCGTTCACTTGCACATAGGGAATGGGTTGCATAACATTGCAGTTACTGGAGACTTTAAATTCATTCCAACAA
GATTATTAGAGCCAGCAAGTTACAGATTCCCAAGACTTGAAACTCTAGTCATGGAATCAACGTACGGTGGAGCTAATGAT
ATTCAAATGCCCAGGGAAGAAGCGGAGAAGAGGTTGATAGAAGTCATTCACCAGACCATAAGGAGGGGAGGAAAAGTCCT
AATTCCAGCAATGGCAGTGGGGAGGGCTCAAGAAATAATGATGGTGCTAGAGGAGTACGCAAGAGTCGGAGGCATTGATG
TCCCAATATATCTCGATGGAATGATTTGGGAAGCTACAGCAATTCATACTGCGTATCCCGAATATTTAAGCAAAACACTG
AGGGAACAAATTTTCAAGGAAGACTACAACCCATTCTTAAGTGAAATCTTTCATCCAGTGGCCAATTCGAAAGAGAGGCA
GGACATTATTGATAGCAATGAGCCCGCAATAATCATAGCCTCTTCTGGTATGTTAGTTGGAGGACCAAGCGTAGAATATT
TCAAGCAGTTGGCCTCTGATAAGAGAAACTCAATCATCTTCGTAAGTTATCAAGCTGAAGGAACACTTGGAAGACAGGTG
CAGAGTGGAGTTAGAGAGATTCCAATGATAGGAGAAAGTGGAAGAACAGAGGTCATAAAAGTGAACATGGAGGTTCATAC
AATTGATGGATTCTCGGGTCATGCTGACAGAAAAGAACTAATGAATTACGTAGCTAAGGTTAGACCAAGACCCGAGAGGG
TAATTACAGTTCATGGGGAGCCTCAAAAATGTTTGGATTTAGCTACGAGCATTCACAAGAAGTTTGGACTCTCCACTAGG
GCTCCAAACAATCTCGACACCATTCGACTGAGGTGA

Upstream 100 bases:

>100_bases
GTTCACAGGAGATGGATTGCTCGTTGTAACGATAACAAAAGACGGATACAAAGAATACAGAGGAGCAGAACTAGAAAAAA
TGTTAAAGTAGTCCAAGGAG

Downstream 100 bases:

>100_bases
TGCCATGAAATGTCCGAAATGCGGGAGAGAGTGGACTACTTTTATTCCCCCCTTTTGTACTTGTGGGGCTGAACTTGAAA
TTAGCTATGACTACTCTAAA

Product: cleavage and polyadenylation specifity factor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MTILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIKELAKILKKRISIRPDPDVLL
PPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGLVIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQIL
QTESKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEF
QYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQSNGQEPLYKPKDIKEVIKHT
ITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLHNIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGAND
IQMPREEAEKRLIEVIHQTIRRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTL
REQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASDKRNSIIFVSYQAEGTLGRQV
QSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKELMNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTR
APNNLDTIRLR

Sequences:

>Translated_651_residues
MTILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIKELAKILKKRISIRPDPDVLL
PPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGLVIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQIL
QTESKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEF
QYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQSNGQEPLYKPKDIKEVIKHT
ITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLHNIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGAND
IQMPREEAEKRLIEVIHQTIRRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTL
REQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASDKRNSIIFVSYQAEGTLGRQV
QSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKELMNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTR
APNNLDTIRLR
>Mature_650_residues
TILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIKELAKILKKRISIRPDPDVLLP
PEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGLVIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQILQ
TESKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEFQ
YVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQSNGQEPLYKPKDIKEVIKHTI
TLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLHNIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGANDI
QMPREEAEKRLIEVIHQTIRRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTLR
EQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASDKRNSIIFVSYQAEGTLGRQVQ
SGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKELMNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTRA
PNNLDTIRLR

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33300633, Length=468, Percent_Identity=30.982905982906, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI7706427, Length=457, Percent_Identity=30.1969365426696, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI34101288, Length=378, Percent_Identity=22.7513227513227, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564696, Length=468, Percent_Identity=29.9145299145299, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566029, Length=477, Percent_Identity=29.1404612159329, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17559452, Length=431, Percent_Identity=23.8979118329466, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323307, Length=470, Percent_Identity=29.1489361702128, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21358523, Length=466, Percent_Identity=30.0429184549356, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24648013, Length=459, Percent_Identity=29.4117647058824, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21358013, Length=399, Percent_Identity=24.0601503759398, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 73876; Mature: 73745

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIK
CEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCEEECCCHHHH
ELAKILKKRISIRPDPDVLLPPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHEEEEECCCCE
VIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQILQTESKDRRKFLRQVGRNIYR
EECCCCCEEHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
KPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEF
CCCCCCCEEEEEECCCHHHHCCCEEEEEECCCEEEEEECCEEEEECCCHHHCCCCCCHHH
QYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQ
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHEEECCCCCEECCCCCHHHHHHHHHHHHHHHH
SNGQEPLYKPKDIKEVIKHTITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLH
CCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCHHHHEEEEEEEECCCCE
NIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGANDIQMPREEAEKRLIEVIHQTI
EEEEECCCEECHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTL
HCCCCEEEEHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHHHHHHHHHHHH
REQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASD
HHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECCEEECCCCHHHHHHHHCC
KRNSIIFVSYQAEGTLGRQVQSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKEL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHH
MNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTRAPNNLDTIRLR
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
TILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIK
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCEEECCCHHHH
ELAKILKKRISIRPDPDVLLPPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGL
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHEEEEECCCCE
VIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQILQTESKDRRKFLRQVGRNIYR
EECCCCCEEHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
KPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEF
CCCCCCCEEEEEECCCHHHHCCCEEEEEECCCEEEEEECCEEEEECCCHHHCCCCCCHHH
QYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQ
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHEEECCCCCEECCCCCHHHHHHHHHHHHHHHH
SNGQEPLYKPKDIKEVIKHTITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLH
CCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCHHHHEEEEEEEECCCCE
NIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGANDIQMPREEAEKRLIEVIHQTI
EEEEECCCEECHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTL
HCCCCEEEEHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCEEEEHHHHHHHHHHHHHHHH
REQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASD
HHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEECCEEECCCCHHHHHHHHCC
KRNSIIFVSYQAEGTLGRQVQSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKEL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHH
MNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTRAPNNLDTIRLR
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]