Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 189499158

GI number: 189499158

Start: 165416

End: 167395

Strand: Reverse

Name: thrS

Synonym: Cphamn1_0172

Alternate gene names: 189499158

Gene position: 167395-165416 (Counterclockwise)

Preceding gene: 189499159

Following gene: 189499157

Centisome position: 6.12

GC content: 50.1

Gene sequence:

>1980_bases
ATGTCCGAAAACATAGATGTACAGGCAACTGTAACCGTTACCTTTCCCGATGGCAGGAATATGTCTATTCCGTCCGGGTC
TTCAGGTTACGATATCGCACAATCAATAGGGCACAGCCTCGCCAGGGAGGCTCTCGCGATACGTATCAACGGTGAACTTG
CTGATCTTGGAACCGCGGTCACCGATGACGCCACAGTTGAAATCATCACCTTTGATCATCCGGGTGCAACAGGCAAACAC
ATATTCTGGCACAGCGCCAGCCATATCATGGCTCAGGCTATCGAAGAGCTTTTTCCCGGCACGAAGTTCGGCGCCGGACC
GGCTGTTGAGCAGGGCTTCTATTACGATATTGCCTCTGAACACCGTTTCAATGAAGAAGATCTGCAAAAGATAGAGCAGC
AAATGCTTGACATTTCTAAACGCAGCATCGACATCAGGCGTGAAGAGATGCCCCGAGAAAAAGCCATAGCGTTCTTTTCT
GAATCCAGAAAAGATCCCTACAAGGTGGAGATTCTTCAGGACACACTCAAAGAGGCCGATTCAGTGTCGATATACCATCA
GGGAGCGTTTGCCGATCTCTGCAGCGGCCCTCACCTGCCGAACACCTCAAAGCTGAAAGCCGTCAAACTGACAAATATTT
CAGCATCTTTCTGGAGAGGAGACTCTTCCCGCGAAAGCATGCAGAGAATCTACGGGATAGCGTTTCCTTCCGCCAAACTC
CTGAAACAGCATCTCGCCCGGTTAGAGGAAGCCAAAAAACGGGATCATAGAAAACTGGGGGCTGAACTTGAGCTTTTTAT
GCTCTCTCAGGATGTCGGCAGCGGCTTGCCGATCTGGCTGCCCAAAGGGGCGATCATTCGCAGCGAGCTCGAGGCTTTTC
TGAAAGAAGAGCAGAGAAAACGCGGCTATGTTCCTGTCTATACTCCACATATCGGCAATATCGACCTGTACAAACGTTCG
GGTCACTATCCCTACTACAGCGACTCACAGTTTCCTCCTCTTACCTACAAGGATGACCTGGGAAGAGAGGAACAGTACCT
GCTCAAACCGATGAACTGTCCTCACCATCACCTTATTTACAGTTCACAATTGCGCAGCTACCGTGATTTGCCAATCCGTA
TGGCGGAATTCGGTACGGTATACCGCCATGAACAGTCAGGTGAACTGAACGGTCTGATCAGGGCGAGAGGCTTTACACAG
GACGATTCGCATATATACTGCCGACCAGACCAGCTGGTTGATGAAATCTGCGCTGCCATAGACCTGACCAAATTTGTCTT
TACCACACTTGGCTTCGATGATATAGAGGTTCGCCTCTCCCTGCATGACCCGGAGAACCAGGGGAAATACGGCGGAACCG
AGGAGGTCTGGAAACAGGCGGAAAAGGATGTCAGGGAGGCTGCTGACCGTATGGAGATCAACTATGTTATCGGTATCGGC
GAAGCCAGCTTTTACGGACCGAAAATTGATTTCATTGTACGCGACGCCCTGGGAAGAAAATGGCAGCTCGGCACTGTCCA
GGTTGATTACGTCATGCCTGAACGGTTTGATCTTTCCTATATCGGCAGTGATGGAAAACCGCACCGTCCGGTCATTATTC
ACCGAGCACCGTTTGGTTCGATGGAACGCTTTATCGGAGTTCTCATTGAACATACCGCAGGTAACTTCCCGTTATGGCTT
GCTCCTGTTCAGGTAGCTGTTCTGCCGATTACCGAGGAGGTTCACGCCTATGCGGAAAGGGTTCACCAGATGCTGATTGA
CAATGGCATTCGGGCAGATCTCGATATCCGCAGCGAGAAAATCGGCAAAAAAATACGTGAAGCAGAGGTCGGCAAAATCC
CGTATATGGTTATCATCGGCCAGAAGGAAGCTGACTCGGAAGAGATTTCATTGAGACGTCACCGTAAAGGGGATCAAGGC
TCATTGACGCTTCAGGCACTCAAAGATATGTTAGTAAAGGAAGTCCGAAACAAATCCTGA

Upstream 100 bases:

>100_bases
ACAAACTGACAAAAAGCGGCTGGACGATTCTGAAATCAGTCAGGAAGTATTGTTTTCGACATACTTCTTAGGCGAGTTTT
TATAGAGAGAGACAGTATTC

Downstream 100 bases:

>100_bases
CCGCACAGCGGGCAAAACATCTGCGTCAGATAACATAAATCACGACTGTATGAGAAAAAAAAGAAGCGCTCCTCAAAAAC
CAAAAGTAACGTATCGAGTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MSENIDVQATVTVTFPDGRNMSIPSGSSGYDIAQSIGHSLAREALAIRINGELADLGTAVTDDATVEIITFDHPGATGKH
IFWHSASHIMAQAIEELFPGTKFGAGPAVEQGFYYDIASEHRFNEEDLQKIEQQMLDISKRSIDIRREEMPREKAIAFFS
ESRKDPYKVEILQDTLKEADSVSIYHQGAFADLCSGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSAKL
LKQHLARLEEAKKRDHRKLGAELELFMLSQDVGSGLPIWLPKGAIIRSELEAFLKEEQRKRGYVPVYTPHIGNIDLYKRS
GHYPYYSDSQFPPLTYKDDLGREEQYLLKPMNCPHHHLIYSSQLRSYRDLPIRMAEFGTVYRHEQSGELNGLIRARGFTQ
DDSHIYCRPDQLVDEICAAIDLTKFVFTTLGFDDIEVRLSLHDPENQGKYGGTEEVWKQAEKDVREAADRMEINYVIGIG
EASFYGPKIDFIVRDALGRKWQLGTVQVDYVMPERFDLSYIGSDGKPHRPVIIHRAPFGSMERFIGVLIEHTAGNFPLWL
APVQVAVLPITEEVHAYAERVHQMLIDNGIRADLDIRSEKIGKKIREAEVGKIPYMVIIGQKEADSEEISLRRHRKGDQG
SLTLQALKDMLVKEVRNKS

Sequences:

>Translated_659_residues
MSENIDVQATVTVTFPDGRNMSIPSGSSGYDIAQSIGHSLAREALAIRINGELADLGTAVTDDATVEIITFDHPGATGKH
IFWHSASHIMAQAIEELFPGTKFGAGPAVEQGFYYDIASEHRFNEEDLQKIEQQMLDISKRSIDIRREEMPREKAIAFFS
ESRKDPYKVEILQDTLKEADSVSIYHQGAFADLCSGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSAKL
LKQHLARLEEAKKRDHRKLGAELELFMLSQDVGSGLPIWLPKGAIIRSELEAFLKEEQRKRGYVPVYTPHIGNIDLYKRS
GHYPYYSDSQFPPLTYKDDLGREEQYLLKPMNCPHHHLIYSSQLRSYRDLPIRMAEFGTVYRHEQSGELNGLIRARGFTQ
DDSHIYCRPDQLVDEICAAIDLTKFVFTTLGFDDIEVRLSLHDPENQGKYGGTEEVWKQAEKDVREAADRMEINYVIGIG
EASFYGPKIDFIVRDALGRKWQLGTVQVDYVMPERFDLSYIGSDGKPHRPVIIHRAPFGSMERFIGVLIEHTAGNFPLWL
APVQVAVLPITEEVHAYAERVHQMLIDNGIRADLDIRSEKIGKKIREAEVGKIPYMVIIGQKEADSEEISLRRHRKGDQG
SLTLQALKDMLVKEVRNKS
>Mature_658_residues
SENIDVQATVTVTFPDGRNMSIPSGSSGYDIAQSIGHSLAREALAIRINGELADLGTAVTDDATVEIITFDHPGATGKHI
FWHSASHIMAQAIEELFPGTKFGAGPAVEQGFYYDIASEHRFNEEDLQKIEQQMLDISKRSIDIRREEMPREKAIAFFSE
SRKDPYKVEILQDTLKEADSVSIYHQGAFADLCSGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSAKLL
KQHLARLEEAKKRDHRKLGAELELFMLSQDVGSGLPIWLPKGAIIRSELEAFLKEEQRKRGYVPVYTPHIGNIDLYKRSG
HYPYYSDSQFPPLTYKDDLGREEQYLLKPMNCPHHHLIYSSQLRSYRDLPIRMAEFGTVYRHEQSGELNGLIRARGFTQD
DSHIYCRPDQLVDEICAAIDLTKFVFTTLGFDDIEVRLSLHDPENQGKYGGTEEVWKQAEKDVREAADRMEINYVIGIGE
ASFYGPKIDFIVRDALGRKWQLGTVQVDYVMPERFDLSYIGSDGKPHRPVIIHRAPFGSMERFIGVLIEHTAGNFPLWLA
PVQVAVLPITEEVHAYAERVHQMLIDNGIRADLDIRSEKIGKKIREAEVGKIPYMVIIGQKEADSEEISLRRHRKGDQGS
LTLQALKDMLVKEVRNKS

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=654, Percent_Identity=37.3088685015291, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=650, Percent_Identity=36.3076923076923, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=638, Percent_Identity=36.3636363636364, Blast_Score=417, Evalue=1e-116,
Organism=Escherichia coli, GI1788013, Length=648, Percent_Identity=40.1234567901235, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71984192, Length=643, Percent_Identity=35.7698289269051, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71984184, Length=643, Percent_Identity=35.7698289269051, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322112, Length=643, Percent_Identity=36.3919129082426, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=418, Percent_Identity=33.7320574162679, Blast_Score=247, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24583842, Length=646, Percent_Identity=38.2352941176471, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI28574141, Length=646, Percent_Identity=38.2352941176471, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24583839, Length=646, Percent_Identity=38.2352941176471, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLPB (B3EKG9)

Other databases:

- EMBL:   CP001101
- RefSeq:   YP_001958628.1
- ProteinModelPortal:   B3EKG9
- SMR:   B3EKG9
- GeneID:   6373826
- GenomeReviews:   CP001101_GR
- KEGG:   cpb:Cphamn1_0172
- HOGENOM:   HBG352811
- OMA:   GRKWQLG
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74647; Mature: 74515

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENIDVQATVTVTFPDGRNMSIPSGSSGYDIAQSIGHSLAREALAIRINGELADLGTAV
CCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHCCCEE
TDDATVEIITFDHPGATGKHIFWHSASHIMAQAIEELFPGTKFGAGPAVEQGFYYDIASE
CCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
HRFNEEDLQKIEQQMLDISKRSIDIRREEMPREKAIAFFSESRKDPYKVEILQDTLKEAD
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCC
SVSIYHQGAFADLCSGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSAKL
CEEEEECCCHHHHHCCCCCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCCHHH
LKQHLARLEEAKKRDHRKLGAELELFMLSQDVGSGLPIWLPKGAIIRSELEAFLKEEQRK
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
RGYVPVYTPHIGNIDLYKRSGHYPYYSDSQFPPLTYKDDLGREEQYLLKPMNCPHHHLIY
CCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHEEE
SSQLRSYRDLPIRMAEFGTVYRHEQSGELNGLIRARGFTQDDSHIYCRPDQLVDEICAAI
HHHHHHHCCCCEEHHHHCHHHEECCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHH
DLTKFVFTTLGFDDIEVRLSLHDPENQGKYGGTEEVWKQAEKDVREAADRMEINYVIGIG
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEC
EASFYGPKIDFIVRDALGRKWQLGTVQVDYVMPERFDLSYIGSDGKPHRPVIIHRAPFGS
CCCCCCCCCCEEEHHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCH
MERFIGVLIEHTAGNFPLWLAPVQVAVLPITEEVHAYAERVHQMLIDNGIRADLDIRSEK
HHHHHHHHHHHCCCCCCEEEECEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
IGKKIREAEVGKIPYMVIIGQKEADSEEISLRRHRKGDQGSLTLQALKDMLVKEVRNKS
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SENIDVQATVTVTFPDGRNMSIPSGSSGYDIAQSIGHSLAREALAIRINGELADLGTAV
CCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHCCCEE
TDDATVEIITFDHPGATGKHIFWHSASHIMAQAIEELFPGTKFGAGPAVEQGFYYDIASE
CCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
HRFNEEDLQKIEQQMLDISKRSIDIRREEMPREKAIAFFSESRKDPYKVEILQDTLKEAD
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCC
SVSIYHQGAFADLCSGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSAKL
CEEEEECCCHHHHHCCCCCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCCHHH
LKQHLARLEEAKKRDHRKLGAELELFMLSQDVGSGLPIWLPKGAIIRSELEAFLKEEQRK
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
RGYVPVYTPHIGNIDLYKRSGHYPYYSDSQFPPLTYKDDLGREEQYLLKPMNCPHHHLIY
CCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHEEE
SSQLRSYRDLPIRMAEFGTVYRHEQSGELNGLIRARGFTQDDSHIYCRPDQLVDEICAAI
HHHHHHHCCCCEEHHHHCHHHEECCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHH
DLTKFVFTTLGFDDIEVRLSLHDPENQGKYGGTEEVWKQAEKDVREAADRMEINYVIGIG
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEC
EASFYGPKIDFIVRDALGRKWQLGTVQVDYVMPERFDLSYIGSDGKPHRPVIIHRAPFGS
CCCCCCCCCCEEEHHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCH
MERFIGVLIEHTAGNFPLWLAPVQVAVLPITEEVHAYAERVHQMLIDNGIRADLDIRSEK
HHHHHHHHHHHCCCCCCEEEECEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
IGKKIREAEVGKIPYMVIIGQKEADSEEISLRRHRKGDQGSLTLQALKDMLVKEVRNKS
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA