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The map label for this gene is pyrG

Identifier: 189499118

GI number: 189499118

Start: 119235

End: 120932

Strand: Direct

Name: pyrG

Synonym: Cphamn1_0127

Alternate gene names: 189499118

Gene position: 119235-120932 (Clockwise)

Preceding gene: 189499117

Following gene: 189499119

Centisome position: 4.36

GC content: 50.18

Gene sequence:

>1698_bases
ATGGCACGACCCAAAAACGTAAAGCATATTTTTGTCACAGGCGGGGTTGTATCATCGCTGGGCAAGGGAATACTTTCCGC
TTCTCTCGGTCTTTTGCTGAAGTCGCGCGGTTTGCGTGTGGCTATTCAGAAATACGATCCCTATATCAATGTGGATCCGG
GTACGATGTCTCCCTACCAGCATGGCGAGGTCTATGTGACGGATGACGGCGCCGAGACAGACCTTGATCTCGGACACTAT
GAACGGTTTCTTGACGAGCCTACATCCCAGGCGTCCAACCTCACTATGGGGAGGGTATACAAGGCAGTTATTGACAAGGA
GCGTCAGGGCGAATATCTGGGCGGTACCGTTCAGGTTGTGCCGCATGTGATCGATGAGATCAAGGCGAAAATGAACGAGC
TGGCGAAAAATGCGAATCTTGATGTTCTGATTACCGAAATCGGCGGCACCATAGGTGATATCGAATCGCTTCCTTTTCTT
GAGGCCATGCGGCAGTTGAAGCTTGACCTTGGGACGAAAAATCTGCTGAACATTCATCTGACGCTGGTACCCTACATCAA
GGCGGCATGTGAAATGAAGACCAAGCCGACGCAGCACAGCGTCAAGATGCTTCTTGAGACCGGTATTCAGCCGGATATCC
TTGTCTGTCGCAGTGAAAAGCCTCTTTCACGCGAGATTAAAAACAAGGTTGGCCATTTCTGTAACCTTCATGAAGCAGAC
GTTATCGGACTGAGCGACTGCGAAACCATATACGGCGTGCCGATTATGCTGCTTGATGAGCAGCTTGACAAGCGGGTATT
GAAGAAGCTGGGCATCAAGAAGTTTCAGGACCCTGAGCTTTCCTACTGGACGGAGTTCTGCGATAAGGTGAAGCATCCGG
AGGACGGAGAGGTGACGATTGCTGTATGCGGCAAGTATACCGAATATCCCGATGCCTACAAGTCGATACTCGAGTCTTTT
GTGCATGCAGGGGCGGTCAATAATGTCAAGGTTACCGTGCGCTTCATACGGTCTGAAGACGCTGAAGAAAGCGGTTGCGA
CATAGCAACAGCCATGAAAGATGTTCACGGGCTCCTGGTTGCTCCCGGTTTTGGTGACAGGGGGATAGAAGGAAAGATCA
GTTTTATACGGTATGCGCGTGAAAATAATATTCCTTTTCTGGGAATATGTCTTGGAATGCAGTGTGCCACGATAGAGTTC
GCAAGAAATGTTTGCGGACTTTCCGAGGCTAATTCGACTGAATTCAGTAAACGGTGCCGCCAGCCTGTCATCGATCTGAT
GGAGCATCAGAAAAAGGTTAAGGAGAAAGGCGGAACGATGCGCCTGGGAAGCTATCCCTGTATACTTAAGGAGGATACCA
TAGCCAATAAAGCCTATGGCAAGTTTCTTATCAATGAGCGTCATCGGCATCGTTACGAGTTCAATAACGAGTACCGTGAG
CTGTTAGAGCAAAACGGGATGCTTTTTTCCGGAACCTCCCCCAACGGCGACCTCGTTGAGATTATCGAGATCAGTGGCCA
TCCGTGGTTTGTCGGCGTGCAGTTTCATCCGGAGTACAAGTCAAGGGTTCGTAGCGCACACCCGTTGTTCGTCGGTTTTG
TGGCAGCAGCCAAAGCGTTTGCTTTTGGTGACCGCCAGTTATCCTTCGAGCCTGATACCTTGCCGTTAGGTGAGCCTGAG
CGTACATTGGAGGGCTAA

Upstream 100 bases:

>100_bases
GTGGTTGCGGTTCATCAAAAAATAAACCGTTCTGCGATGGATCACACGAGTTGCTTCAGGAGACCTGATTGATAAATGAA
AGTTAAATTTTGTTACTGAT

Downstream 100 bases:

>100_bases
GAGCGTGAAGTTGTACCGCCCCTGAAACAGGTGTCTGGATTTCACGGGTCAGGCACGGTAATGACTCTGGACTCTATACC
TTCCTGCAAGTGCCGTAGGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MARPKNVKHIFVTGGVVSSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQASNLTMGRVYKAVIDKERQGEYLGGTVQVVPHVIDEIKAKMNELAKNANLDVLITEIGGTIGDIESLPFL
EAMRQLKLDLGTKNLLNIHLTLVPYIKAACEMKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNLHEAD
VIGLSDCETIYGVPIMLLDEQLDKRVLKKLGIKKFQDPELSYWTEFCDKVKHPEDGEVTIAVCGKYTEYPDAYKSILESF
VHAGAVNNVKVTVRFIRSEDAEESGCDIATAMKDVHGLLVAPGFGDRGIEGKISFIRYARENNIPFLGICLGMQCATIEF
ARNVCGLSEANSTEFSKRCRQPVIDLMEHQKKVKEKGGTMRLGSYPCILKEDTIANKAYGKFLINERHRHRYEFNNEYRE
LLEQNGMLFSGTSPNGDLVEIIEISGHPWFVGVQFHPEYKSRVRSAHPLFVGFVAAAKAFAFGDRQLSFEPDTLPLGEPE
RTLEG

Sequences:

>Translated_565_residues
MARPKNVKHIFVTGGVVSSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQASNLTMGRVYKAVIDKERQGEYLGGTVQVVPHVIDEIKAKMNELAKNANLDVLITEIGGTIGDIESLPFL
EAMRQLKLDLGTKNLLNIHLTLVPYIKAACEMKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNLHEAD
VIGLSDCETIYGVPIMLLDEQLDKRVLKKLGIKKFQDPELSYWTEFCDKVKHPEDGEVTIAVCGKYTEYPDAYKSILESF
VHAGAVNNVKVTVRFIRSEDAEESGCDIATAMKDVHGLLVAPGFGDRGIEGKISFIRYARENNIPFLGICLGMQCATIEF
ARNVCGLSEANSTEFSKRCRQPVIDLMEHQKKVKEKGGTMRLGSYPCILKEDTIANKAYGKFLINERHRHRYEFNNEYRE
LLEQNGMLFSGTSPNGDLVEIIEISGHPWFVGVQFHPEYKSRVRSAHPLFVGFVAAAKAFAFGDRQLSFEPDTLPLGEPE
RTLEG
>Mature_564_residues
ARPKNVKHIFVTGGVVSSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYE
RFLDEPTSQASNLTMGRVYKAVIDKERQGEYLGGTVQVVPHVIDEIKAKMNELAKNANLDVLITEIGGTIGDIESLPFLE
AMRQLKLDLGTKNLLNIHLTLVPYIKAACEMKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNLHEADV
IGLSDCETIYGVPIMLLDEQLDKRVLKKLGIKKFQDPELSYWTEFCDKVKHPEDGEVTIAVCGKYTEYPDAYKSILESFV
HAGAVNNVKVTVRFIRSEDAEESGCDIATAMKDVHGLLVAPGFGDRGIEGKISFIRYARENNIPFLGICLGMQCATIEFA
RNVCGLSEANSTEFSKRCRQPVIDLMEHQKKVKEKGGTMRLGSYPCILKEDTIANKAYGKFLINERHRHRYEFNNEYREL
LEQNGMLFSGTSPNGDLVEIIEISGHPWFVGVQFHPEYKSRVRSAHPLFVGFVAAAKAFAFGDRQLSFEPDTLPLGEPER
TLEG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=43.4545454545455, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=44.3636363636364, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=44.3636363636364, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=44.3636363636364, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=51.4760147601476, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25148299, Length=611, Percent_Identity=37.8068739770867, Blast_Score=406, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=40.7079646017699, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=39.4642857142857, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=46.0980036297641, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=44.4444444444444, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLPB (B3EK39)

Other databases:

- EMBL:   CP001101
- RefSeq:   YP_001958588.1
- ProteinModelPortal:   B3EK39
- GeneID:   6373771
- GenomeReviews:   CP001101_GR
- KEGG:   cpb:Cphamn1_0127
- HOGENOM:   HBG597806
- OMA:   NIKIDPY
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 63044; Mature: 62913

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 390-390 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPKNVKHIFVTGGVVSSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQASNLTMGRVYKAVIDKERQGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHCHHHCCCCCCCHHHHH
PHVIDEIKAKMNELAKNANLDVLITEIGGTIGDIESLPFLEAMRQLKLDLGTKNLLNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TLVPYIKAACEMKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNLHEAD
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCC
VIGLSDCETIYGVPIMLLDEQLDKRVLKKLGIKKFQDPELSYWTEFCDKVKHPEDGEVTI
EECCCCCHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
AVCGKYTEYPDAYKSILESFVHAGAVNNVKVTVRFIRSEDAEESGCDIATAMKDVHGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCEEE
APGFGDRGIEGKISFIRYARENNIPFLGICLGMQCATIEFARNVCGLSEANSTEFSKRCR
ECCCCCCCCCCCCCEEEEHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
QPVIDLMEHQKKVKEKGGTMRLGSYPCILKEDTIANKAYGKFLINERHRHRYEFNNEYRE
HHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCHHHHHHHHHCHHHHHHCCCCHHHHH
LLEQNGMLFSGTSPNGDLVEIIEISGHPWFVGVQFHPEYKSRVRSAHPLFVGFVAAAKAF
HHHHCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHH
AFGDRQLSFEPDTLPLGEPERTLEG
HCCCCEECCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
ARPKNVKHIFVTGGVVSSLGKGILSASLGLLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQASNLTMGRVYKAVIDKERQGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHCHHHCCCCCCCHHHHH
PHVIDEIKAKMNELAKNANLDVLITEIGGTIGDIESLPFLEAMRQLKLDLGTKNLLNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TLVPYIKAACEMKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNLHEAD
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCC
VIGLSDCETIYGVPIMLLDEQLDKRVLKKLGIKKFQDPELSYWTEFCDKVKHPEDGEVTI
EECCCCCHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
AVCGKYTEYPDAYKSILESFVHAGAVNNVKVTVRFIRSEDAEESGCDIATAMKDVHGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCEEE
APGFGDRGIEGKISFIRYARENNIPFLGICLGMQCATIEFARNVCGLSEANSTEFSKRCR
ECCCCCCCCCCCCCEEEEHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
QPVIDLMEHQKKVKEKGGTMRLGSYPCILKEDTIANKAYGKFLINERHRHRYEFNNEYRE
HHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCHHHHHHHHHCHHHHHHCCCCHHHHH
LLEQNGMLFSGTSPNGDLVEIIEISGHPWFVGVQFHPEYKSRVRSAHPLFVGFVAAAKAF
HHHHCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHH
AFGDRQLSFEPDTLPLGEPERTLEG
HCCCCEECCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA