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The map label for this gene is gyrA [H]

Identifier: 189499116

GI number: 189499116

Start: 116456

End: 118942

Strand: Direct

Name: gyrA [H]

Synonym: Cphamn1_0125

Alternate gene names: 189499116

Gene position: 116456-118942 (Clockwise)

Preceding gene: 189499115

Following gene: 189499117

Centisome position: 4.26

GC content: 50.38

Gene sequence:

>2487_bases
ATGCAGCGCGACAAGATTTTACCGATCAGCATAGAAGATGAAATGAGGGACTCCTACCTCGATTATTCCATGTCGGTTAT
CGTCAGCCGCGCGTTGCCCGATGTTCGTGACGGTCTTAAGCCGGTTCACCGCAGGGTGCTGTTCGGTATGCATGAACTTG
GTCTTCAGGCAGGAAAAGGGTATAAAAAATCAGCTCGTGTGGTCGGTGAGGTTCTGGGTAAGTTTCATCCTCATGGAGAC
ACTGCGGTTTACGACAGTCTTGTGCGTATGGTTCAGGATTTTTCCCTGCGCTATCCGCTGATTGACGGACAGGGTAACTT
TGGATCAGTTGACGGGGATTCTCCTGCCGCCATGCGTTATACCGAAGTGCGCATGAAGAACATAGCGGGCGAAATGCTGA
AGGATCTGGAAAAGGAGACTGTGGGCTTCTCGCTGAACTTCGATGATTCGCTTGAAGAACCTACTGTTCTTCCTTCGGCT
ATGCCCAACATGCTTGTTAACGGTGCATCCGGCATTGCTGTCGGAATGGCGACGAATATTCCGCCGCAGAATCTCAGCGA
GGTTGTGAACGGATTGATCGCGATGATCGAAAACCCTGAGATTACTATTGATGAAATCATGGAGCATATTATCGCTCCGG
ACTTCCCTACTGCCGGTATTATCTATGGATATGAGGGCGTAAAGCAGGCCTACCATACCGGTCGGGGCAAGGTTGTTATC
CGTGCTCGTGCGGTTGTCGAGGTGACGCAGAAAAACGGTCGGGAGTCGATCATAGTAACGGAGCTTCCCTACCAGGTCAA
CAAGGTCCGCCTGATCGAAAAGATCGTGGAGCTGATCCACCTGAAAAAAATAGAAGGGATTGCTGATATCCGGGATGAAT
CTGATCGTGACGGTATGCGGCTTGTTATCGAGCTGAAGCGTGACGCTGTTGCCAAAGTGGTGCTCAATCATCTCTACAAG
CATACCCCGATGCAGGATACATTCGGCGTTATTCTGCTTGCTCTTGTTGACGGTGTGCCGAAGGTGCTCAACTTGAAGGA
GATGATGGAGGCGTATCTCAAGCACCGCAATGAGATTGTTCTCCGCAGAACCACCTATGAGCTGGCAGCTGCCGAGAAAA
AGGCTCATATTCTCGAAGGTCTGAAGATCTGTCTCGATAACCTCGATGAAGTGATCTCGACCATTCGCGAGTCTCCTAAC
GCCGGCGTCGCACAGGAAAAGCTGATGGAGAAATTCGGCTTGACCGAGCTACAGTCCAAGGCTGTTCTGGAAATGCGCCT
TCAAAGGCTTACCGGAATGGAACGTGACAAAATCGAAAAGGATTATAACGAGACACTGGCGTTGATCGAGGAGTTGCGTT
TTATTCTCGCAAACCCTGAAAAGCGGATGCAGATTATCAAGGATGAGCTGCTGAAAGTAAAGCAGGTGTATGGCGATGAG
AGACGTACAGAGATCAGGCCGCAGGAGGGAGAGTTTTCCATCGAGGATATGATCGCTCAGGAGGATGTGGTTATTACGAT
CACTCATGAAACCTTTATCAAGCGTTTTCCTGTGTCGGGCTACCGTCGTCAGGCAAGGGGCGGCAAGGGAGTGACAGGCG
CTCAGGCCAGACATGAGGACTTTGTCGAGCATATGTTTGTGGCGTCAACGCACAATTACATCCTTTTCTTCACCAACAAG
GGGAGATGTCACTGGCTGAAGGTATACGAGATACCTGAAGCGGGCAGGGCGGCCAGGGGAAGGTCTCTTGCCAACATTAT
GGAGCTTCAGCCGGGCGAGAAGATCAAGGCATATATCAATGTCAAGACTTTCGACGACCCTCTCTTTATTATAATGGCGA
CAGCGAAGGGTAGTATCAAGAAAACTGAAATTGAGGCTTTTTCCAGGCCTCGCCGAAACGGTATAGCCGCCATAACTATA
GAAGATGGTGACGAACTTATCGATGCCCGCCTGACTGACGGTGAACATGATATTATCCTGGCCAAGAACACAGGTTATGC
GGTGCGTTTTGCGGAGAAAGATGTTCGTCCGATGGGAAGAACTGCGATGGGCGTAAAGGGGATCAGCCTTGATGAGGGAG
AAACATGTATTTCCATGGTTACCTCGAAGCGTCCGGATACTTCCCTGCTCGCGGTGACTGATAACGGGTTCGGTAAGCGA
AGCAAGGTGGAGGATTATCGGTTGACCCGAAGGGGGGCGAAGGGCGTCATTACCCTGAAAGCGCATGAGAAGGTCGGTCA
TCTTGTCGGACTGCTCGATGTCAATGATAGTGACGATCTGATTATTATCACCTCGAACGGTATTGTCAATCGGCAGCATG
TTTCCAATATCCGACTCACCGGTCGCAACACTTCGGGTGTCAGAATTGTCCGCCTGATGCAGGGCGATACGATTTCCGCT
ACCGCGAGAGTGCCGAAAAGTGTTGATGAAGAAGAAAATGAAGCCCTATCCGGTCCTGAGGATCAGATAGAACTTTTTGA
TTCCTGA

Upstream 100 bases:

>100_bases
ATGGCGGATGAGAAATTCTCTCTTCGTCTTCCCTTTAACGGGGTATTCTGTTACATTACGCCCACTACTATACCTACAAT
AATCAGTTATTAGAAAAGAT

Downstream 100 bases:

>100_bases
GGTGAACGTTAACGAGTGAGGATGCAATGGAGAAGAGAAATAAACCGTATATCCAGCACGAGGAGCCGGGATTGAAAAAG
TACTGCGCATGCAGTTTGTC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 828; Mature: 828

Protein sequence:

>828_residues
MQRDKILPISIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGLQAGKGYKKSARVVGEVLGKFHPHGD
TAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKNIAGEMLKDLEKETVGFSLNFDDSLEEPTVLPSA
MPNMLVNGASGIAVGMATNIPPQNLSEVVNGLIAMIENPEITIDEIMEHIIAPDFPTAGIIYGYEGVKQAYHTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELIHLKKIEGIADIRDESDRDGMRLVIELKRDAVAKVVLNHLYK
HTPMQDTFGVILLALVDGVPKVLNLKEMMEAYLKHRNEIVLRRTTYELAAAEKKAHILEGLKICLDNLDEVISTIRESPN
AGVAQEKLMEKFGLTELQSKAVLEMRLQRLTGMERDKIEKDYNETLALIEELRFILANPEKRMQIIKDELLKVKQVYGDE
RRTEIRPQEGEFSIEDMIAQEDVVITITHETFIKRFPVSGYRRQARGGKGVTGAQARHEDFVEHMFVASTHNYILFFTNK
GRCHWLKVYEIPEAGRAARGRSLANIMELQPGEKIKAYINVKTFDDPLFIIMATAKGSIKKTEIEAFSRPRRNGIAAITI
EDGDELIDARLTDGEHDIILAKNTGYAVRFAEKDVRPMGRTAMGVKGISLDEGETCISMVTSKRPDTSLLAVTDNGFGKR
SKVEDYRLTRRGAKGVITLKAHEKVGHLVGLLDVNDSDDLIIITSNGIVNRQHVSNIRLTGRNTSGVRIVRLMQGDTISA
TARVPKSVDEEENEALSGPEDQIELFDS

Sequences:

>Translated_828_residues
MQRDKILPISIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGLQAGKGYKKSARVVGEVLGKFHPHGD
TAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKNIAGEMLKDLEKETVGFSLNFDDSLEEPTVLPSA
MPNMLVNGASGIAVGMATNIPPQNLSEVVNGLIAMIENPEITIDEIMEHIIAPDFPTAGIIYGYEGVKQAYHTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELIHLKKIEGIADIRDESDRDGMRLVIELKRDAVAKVVLNHLYK
HTPMQDTFGVILLALVDGVPKVLNLKEMMEAYLKHRNEIVLRRTTYELAAAEKKAHILEGLKICLDNLDEVISTIRESPN
AGVAQEKLMEKFGLTELQSKAVLEMRLQRLTGMERDKIEKDYNETLALIEELRFILANPEKRMQIIKDELLKVKQVYGDE
RRTEIRPQEGEFSIEDMIAQEDVVITITHETFIKRFPVSGYRRQARGGKGVTGAQARHEDFVEHMFVASTHNYILFFTNK
GRCHWLKVYEIPEAGRAARGRSLANIMELQPGEKIKAYINVKTFDDPLFIIMATAKGSIKKTEIEAFSRPRRNGIAAITI
EDGDELIDARLTDGEHDIILAKNTGYAVRFAEKDVRPMGRTAMGVKGISLDEGETCISMVTSKRPDTSLLAVTDNGFGKR
SKVEDYRLTRRGAKGVITLKAHEKVGHLVGLLDVNDSDDLIIITSNGIVNRQHVSNIRLTGRNTSGVRIVRLMQGDTISA
TARVPKSVDEEENEALSGPEDQIELFDS
>Mature_828_residues
MQRDKILPISIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGLQAGKGYKKSARVVGEVLGKFHPHGD
TAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKNIAGEMLKDLEKETVGFSLNFDDSLEEPTVLPSA
MPNMLVNGASGIAVGMATNIPPQNLSEVVNGLIAMIENPEITIDEIMEHIIAPDFPTAGIIYGYEGVKQAYHTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELIHLKKIEGIADIRDESDRDGMRLVIELKRDAVAKVVLNHLYK
HTPMQDTFGVILLALVDGVPKVLNLKEMMEAYLKHRNEIVLRRTTYELAAAEKKAHILEGLKICLDNLDEVISTIRESPN
AGVAQEKLMEKFGLTELQSKAVLEMRLQRLTGMERDKIEKDYNETLALIEELRFILANPEKRMQIIKDELLKVKQVYGDE
RRTEIRPQEGEFSIEDMIAQEDVVITITHETFIKRFPVSGYRRQARGGKGVTGAQARHEDFVEHMFVASTHNYILFFTNK
GRCHWLKVYEIPEAGRAARGRSLANIMELQPGEKIKAYINVKTFDDPLFIIMATAKGSIKKTEIEAFSRPRRNGIAAITI
EDGDELIDARLTDGEHDIILAKNTGYAVRFAEKDVRPMGRTAMGVKGISLDEGETCISMVTSKRPDTSLLAVTDNGFGKR
SKVEDYRLTRRGAKGVITLKAHEKVGHLVGLLDVNDSDDLIIITSNGIVNRQHVSNIRLTGRNTSGVRIVRLMQGDTISA
TARVPKSVDEEENEALSGPEDQIELFDS

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=25.0783699059561, Blast_Score=75, Evalue=4e-13,
Organism=Homo sapiens, GI19913406, Length=382, Percent_Identity=24.869109947644, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788562, Length=848, Percent_Identity=50.1179245283019, Blast_Score=855, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=697, Percent_Identity=35.8680057388809, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=368, Percent_Identity=23.0978260869565, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=27.8409090909091, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92679; Mature: 92679

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRDKILPISIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGLQAGKG
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YKKSARVVGEVLGKFHPHGDTAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKNIAGEMLKDLEKETVGFSLNFDDSLEEPTVLPSAMPNMLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
PPQNLSEVVNGLIAMIENPEITIDEIMEHIIAPDFPTAGIIYGYEGVKQAYHTGRGKVVI
CHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELIHLKKIEGIADIRDESDRDGMR
EEEEEEHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCE
LVIELKRDAVAKVVLNHLYKHTPMQDTFGVILLALVDGVPKVLNLKEMMEAYLKHRNEIV
EEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCEE
LRRTTYELAAAEKKAHILEGLKICLDNLDEVISTIRESPNAGVAQEKLMEKFGLTELQSK
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
AVLEMRLQRLTGMERDKIEKDYNETLALIEELRFILANPEKRMQIIKDELLKVKQVYGDE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RRTEIRPQEGEFSIEDMIAQEDVVITITHETFIKRFPVSGYRRQARGGKGVTGAQARHED
HHCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHH
FVEHMFVASTHNYILFFTNKGRCHWLKVYEIPEAGRAARGRSLANIMELQPGEKIKAYIN
HHHHHHHEECCCEEEEEECCCCEEEEEEEECCCCCCHHCCCHHHHHHHCCCCCEEEEEEE
VKTFDDPLFIIMATAKGSIKKTEIEAFSRPRRNGIAAITIEDGDELIDARLTDGEHDIIL
EEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEECCCCHHEEEEECCCCCCEEE
AKNTGYAVRFAEKDVRPMGRTAMGVKGISLDEGETCISMVTSKRPDTSLLAVTDNGFGKR
EECCCCEEEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRLTRRGAKGVITLKAHEKVGHLVGLLDVNDSDDLIIITSNGIVNRQHVSNIRLT
CCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEE
GRNTSGVRIVRLMQGDTISATARVPKSVDEEENEALSGPEDQIELFDS
CCCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHCCCCCHHHHEECCC
>Mature Secondary Structure
MQRDKILPISIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMHELGLQAGKG
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YKKSARVVGEVLGKFHPHGDTAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKNIAGEMLKDLEKETVGFSLNFDDSLEEPTVLPSAMPNMLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
PPQNLSEVVNGLIAMIENPEITIDEIMEHIIAPDFPTAGIIYGYEGVKQAYHTGRGKVVI
CHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELIHLKKIEGIADIRDESDRDGMR
EEEEEEHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCE
LVIELKRDAVAKVVLNHLYKHTPMQDTFGVILLALVDGVPKVLNLKEMMEAYLKHRNEIV
EEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCEE
LRRTTYELAAAEKKAHILEGLKICLDNLDEVISTIRESPNAGVAQEKLMEKFGLTELQSK
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
AVLEMRLQRLTGMERDKIEKDYNETLALIEELRFILANPEKRMQIIKDELLKVKQVYGDE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RRTEIRPQEGEFSIEDMIAQEDVVITITHETFIKRFPVSGYRRQARGGKGVTGAQARHED
HHCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHH
FVEHMFVASTHNYILFFTNKGRCHWLKVYEIPEAGRAARGRSLANIMELQPGEKIKAYIN
HHHHHHHEECCCEEEEEECCCCEEEEEEEECCCCCCHHCCCHHHHHHHCCCCCEEEEEEE
VKTFDDPLFIIMATAKGSIKKTEIEAFSRPRRNGIAAITIEDGDELIDARLTDGEHDIIL
EEECCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEECCCCHHEEEEECCCCCCEEE
AKNTGYAVRFAEKDVRPMGRTAMGVKGISLDEGETCISMVTSKRPDTSLLAVTDNGFGKR
EECCCCEEEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRLTRRGAKGVITLKAHEKVGHLVGLLDVNDSDDLIIITSNGIVNRQHVSNIRLT
CCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEE
GRNTSGVRIVRLMQGDTISATARVPKSVDEEENEALSGPEDQIELFDS
CCCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]