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The map label for this gene is kefC [H]

Identifier: 189499080

GI number: 189499080

Start: 78632

End: 80533

Strand: Direct

Name: kefC [H]

Synonym: Cphamn1_0086

Alternate gene names: 189499080

Gene position: 78632-80533 (Clockwise)

Preceding gene: 189499079

Following gene: 189499084

Centisome position: 2.87

GC content: 50.68

Gene sequence:

>1902_bases
ATGCATGAAGGAGGCTTTTTTTTCCAGGCATTTGTCTATCTCACCGCGGCAGTCGTTTCGGTTCCTGTAGCCAAAAAGCT
CGGGCTTGGATCTGTGCTGGGCTATCTGATCGCCGGGATTATCATCGGTCCGTTTGTTCTTGGTCTGATCGGGGAGGAAG
GGCAGAATGTGATGCAGTTCGCGGAGTTCGGGATTATCATGATGCTTTTTCTGATCGGACTCGAGTTGAAGCCCTCTATG
ATCTGGAAGCTGAAAGGTTCTATTTTCGGCATGGGCGGCGCGCAGGTTTTTACTACCGCACTGATCGTGATGGCAATAGC
GATTATGTTCGGGTTGCAGTGGAAGACTTCTCTGGCTCTCGGCCTTGTTCTGGCGTTATCATCGACCGCTATTGTGCTTC
AGACGCTGCATGAAAAAGGGTTGATGAAGACTGACGGCGGGCAGAATTCCTTTTCGGTACTGCTTTTTCAGGATATCGCG
ATTATTCCCATTCTGGCGATGCTTCCCCTGCTCGCAACAGGTCATGCTGCTGTACATGAAGCGCATGGCGAAGGAGCTAC
TCAGGCGTTCCAGGCCTGGATGGACGGGCTGCCGATCTGGGGACAGACTATTGCCGTACTCGGGGTGGTTGCGGGGATTA
TTCTTGCGGGGAGATATCTTGTCAATCCGGCGTTTCGTCTTATTGCACTAACCAGGCTCAGGGAGATGTTTACGGCAGCA
GCCCTGCTTCTTGTCATAGGCATCACCGTACTCATGGGCATGGTTGGTCTCAGTCCGGCCCTTGGCGCGTTCATCGCGGG
CGTTGTTCTCGCTCAGAGCGAATACCGCCATGAACTGGAAACAAATATTGAACCATTCAAGGGCCTGCTTCTGGGGCTTT
TCTTTATTTCCGTGGGGGCATCGATTGATTTTCTTGTCATAGCATCCAATCCTCTGGTTATACTCGAACTGGTTGCTGCG
CTCATAATTCTGAAGTTCCTCATACTTGCTGCCATCGGCAGGGTGTTCAGAATGAGTTTTGACAACATACTTCTTTTTGC
TCTTGCGCTCGCTGAGGGGGGAGAGTTTGCTTTTGTCCTTTTCTCATTCGGTCTCAACAATGGTGTTTTTGAGGCATCGC
TGGTCAATCCGCTTATCGCGGTTGTGGCATTGAGTATGGCTATGACGCCTATGCTCGTTCTGCTGAACGAAAAGCTCATT
CAACCGAGGTTCGGGACAAAAGAGATGCCTGAAAAAGTGCCTGACAGGATTGATAAAAGGAGCCGTGTCATTGTTGCAGG
ATTTGGCAGGGTAGGCAGTGTTGTCGGCAGGTTTATGCAGGCCAATGACGAGGAGGCGACCTATCTTGACGCGGATCCTG
ATAATGTTGAGCTGCTTCGAAAAATGGGTTTGCAGGTGTTTTATGGAGACGCTTCACGCAGCGGTCTTCTGGAGGCTGCA
GGGGCTGCCGAGGCGGAATTGCTTGTTATTGCCGAGGATAACACAGAAAAGGTGGTGGAAATCGCCCGAACAGCACGGAA
ATATTTTCCTCATCTTGAGATAATAGCCCGCGCAAGCGGGTGGGACGATTCCTACGAACTGATCGACATGGGCGTCAGTA
AAATATATCTCGACACTCTTGATTCCGCTTTACGTATCGGTGGTGATGCATTGAGCCGACTGGGACATCGCAAGTATCAC
GTCAGAAGAGCAATGAATACGTTTCGACGGCATGAAGAGAACCACGTGTATGAGCTTGCGGAAATGCGGCATGATAAAAA
GGAACTTATCCGTGCGACCAAACAGAGGATCGAGGATCTCGAACAGCTGATGATGGATGAACGGGAAGAGCTGCACAAGG
ATAAAAACCTCGGTTGGGATACGTCGGGCCATACGAACGACGAACATCTTATGCGCAGTTGA

Upstream 100 bases:

>100_bases
TGTTGAGGATGCTCGCTGATGAATCCTTCGATCCTGCCTCAAGGGACGCTCAGGAGTATCTCAACGAGCGATTCAGTTAA
CCTGTTCAGATCTGTTTTTT

Downstream 100 bases:

>100_bases
AAAGATAGTTGATGTTTTGAAACCAGTTGATGAAGTCAAAGGGAAAAAATCAAAAGTCAAAAGTAAAAGACAAGGAAGCC
TTGAAACACTCGAAATAAAG

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MHEGGFFFQAFVYLTAAVVSVPVAKKLGLGSVLGYLIAGIIIGPFVLGLIGEEGQNVMQFAEFGIIMMLFLIGLELKPSM
IWKLKGSIFGMGGAQVFTTALIVMAIAIMFGLQWKTSLALGLVLALSSTAIVLQTLHEKGLMKTDGGQNSFSVLLFQDIA
IIPILAMLPLLATGHAAVHEAHGEGATQAFQAWMDGLPIWGQTIAVLGVVAGIILAGRYLVNPAFRLIALTRLREMFTAA
ALLLVIGITVLMGMVGLSPALGAFIAGVVLAQSEYRHELETNIEPFKGLLLGLFFISVGASIDFLVIASNPLVILELVAA
LIILKFLILAAIGRVFRMSFDNILLFALALAEGGEFAFVLFSFGLNNGVFEASLVNPLIAVVALSMAMTPMLVLLNEKLI
QPRFGTKEMPEKVPDRIDKRSRVIVAGFGRVGSVVGRFMQANDEEATYLDADPDNVELLRKMGLQVFYGDASRSGLLEAA
GAAEAELLVIAEDNTEKVVEIARTARKYFPHLEIIARASGWDDSYELIDMGVSKIYLDTLDSALRIGGDALSRLGHRKYH
VRRAMNTFRRHEENHVYELAEMRHDKKELIRATKQRIEDLEQLMMDEREELHKDKNLGWDTSGHTNDEHLMRS

Sequences:

>Translated_633_residues
MHEGGFFFQAFVYLTAAVVSVPVAKKLGLGSVLGYLIAGIIIGPFVLGLIGEEGQNVMQFAEFGIIMMLFLIGLELKPSM
IWKLKGSIFGMGGAQVFTTALIVMAIAIMFGLQWKTSLALGLVLALSSTAIVLQTLHEKGLMKTDGGQNSFSVLLFQDIA
IIPILAMLPLLATGHAAVHEAHGEGATQAFQAWMDGLPIWGQTIAVLGVVAGIILAGRYLVNPAFRLIALTRLREMFTAA
ALLLVIGITVLMGMVGLSPALGAFIAGVVLAQSEYRHELETNIEPFKGLLLGLFFISVGASIDFLVIASNPLVILELVAA
LIILKFLILAAIGRVFRMSFDNILLFALALAEGGEFAFVLFSFGLNNGVFEASLVNPLIAVVALSMAMTPMLVLLNEKLI
QPRFGTKEMPEKVPDRIDKRSRVIVAGFGRVGSVVGRFMQANDEEATYLDADPDNVELLRKMGLQVFYGDASRSGLLEAA
GAAEAELLVIAEDNTEKVVEIARTARKYFPHLEIIARASGWDDSYELIDMGVSKIYLDTLDSALRIGGDALSRLGHRKYH
VRRAMNTFRRHEENHVYELAEMRHDKKELIRATKQRIEDLEQLMMDEREELHKDKNLGWDTSGHTNDEHLMRS
>Mature_633_residues
MHEGGFFFQAFVYLTAAVVSVPVAKKLGLGSVLGYLIAGIIIGPFVLGLIGEEGQNVMQFAEFGIIMMLFLIGLELKPSM
IWKLKGSIFGMGGAQVFTTALIVMAIAIMFGLQWKTSLALGLVLALSSTAIVLQTLHEKGLMKTDGGQNSFSVLLFQDIA
IIPILAMLPLLATGHAAVHEAHGEGATQAFQAWMDGLPIWGQTIAVLGVVAGIILAGRYLVNPAFRLIALTRLREMFTAA
ALLLVIGITVLMGMVGLSPALGAFIAGVVLAQSEYRHELETNIEPFKGLLLGLFFISVGASIDFLVIASNPLVILELVAA
LIILKFLILAAIGRVFRMSFDNILLFALALAEGGEFAFVLFSFGLNNGVFEASLVNPLIAVVALSMAMTPMLVLLNEKLI
QPRFGTKEMPEKVPDRIDKRSRVIVAGFGRVGSVVGRFMQANDEEATYLDADPDNVELLRKMGLQVFYGDASRSGLLEAA
GAAEAELLVIAEDNTEKVVEIARTARKYFPHLEIIARASGWDDSYELIDMGVSKIYLDTLDSALRIGGDALSRLGHRKYH
VRRAMNTFRRHEENHVYELAEMRHDKKELIRATKQRIEDLEQLMMDEREELHKDKNLGWDTSGHTNDEHLMRS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=384, Percent_Identity=26.5625, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1786232, Length=623, Percent_Identity=43.1781701444623, Blast_Score=467, Evalue=1e-132,
Organism=Escherichia coli, GI1789749, Length=620, Percent_Identity=41.7741935483871, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1786685, Length=526, Percent_Identity=29.467680608365, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 69242; Mature: 69242

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEGGFFFQAFVYLTAAVVSVPVAKKLGLGSVLGYLIAGIIIGPFVLGLIGEEGQNVMQF
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AEFGIIMMLFLIGLELKPSMIWKLKGSIFGMGGAQVFTTALIVMAIAIMFGLQWKTSLAL
HHHHHHHHHHHHCCCCCCHHHEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GLVLALSSTAIVLQTLHEKGLMKTDGGQNSFSVLLFQDIAIIPILAMLPLLATGHAAVHE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHH
AHGEGATQAFQAWMDGLPIWGQTIAVLGVVAGIILAGRYLVNPAFRLIALTRLREMFTAA
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLLVIGITVLMGMVGLSPALGAFIAGVVLAQSEYRHELETNIEPFKGLLLGLFFISVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SIDFLVIASNPLVILELVAALIILKFLILAAIGRVFRMSFDNILLFALALAEGGEFAFVL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
FSFGLNNGVFEASLVNPLIAVVALSMAMTPMLVLLNEKLIQPRFGTKEMPEKVPDRIDKR
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHCCC
SRVIVAGFGRVGSVVGRFMQANDEEATYLDADPDNVELLRKMGLQVFYGDASRSGLLEAA
CEEEEEECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCEEEECCCCCCCHHHHC
GAAEAELLVIAEDNTEKVVEIARTARKYFPHLEIIARASGWDDSYELIDMGVSKIYLDTL
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHH
DSALRIGGDALSRLGHRKYHVRRAMNTFRRHEENHVYELAEMRHDKKELIRATKQRIEDL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EQLMMDEREELHKDKNLGWDTSGHTNDEHLMRS
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MHEGGFFFQAFVYLTAAVVSVPVAKKLGLGSVLGYLIAGIIIGPFVLGLIGEEGQNVMQF
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AEFGIIMMLFLIGLELKPSMIWKLKGSIFGMGGAQVFTTALIVMAIAIMFGLQWKTSLAL
HHHHHHHHHHHHCCCCCCHHHEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GLVLALSSTAIVLQTLHEKGLMKTDGGQNSFSVLLFQDIAIIPILAMLPLLATGHAAVHE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHH
AHGEGATQAFQAWMDGLPIWGQTIAVLGVVAGIILAGRYLVNPAFRLIALTRLREMFTAA
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLLVIGITVLMGMVGLSPALGAFIAGVVLAQSEYRHELETNIEPFKGLLLGLFFISVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SIDFLVIASNPLVILELVAALIILKFLILAAIGRVFRMSFDNILLFALALAEGGEFAFVL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
FSFGLNNGVFEASLVNPLIAVVALSMAMTPMLVLLNEKLIQPRFGTKEMPEKVPDRIDKR
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHCCC
SRVIVAGFGRVGSVVGRFMQANDEEATYLDADPDNVELLRKMGLQVFYGDASRSGLLEAA
CEEEEEECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCEEEECCCCCCCHHHHC
GAAEAELLVIAEDNTEKVVEIARTARKYFPHLEIIARASGWDDSYELIDMGVSKIYLDTL
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHH
DSALRIGGDALSRLGHRKYHVRRAMNTFRRHEENHVYELAEMRHDKKELIRATKQRIEDL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EQLMMDEREELHKDKNLGWDTSGHTNDEHLMRS
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA