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The map label for this gene is recQ [H]

Identifier: 189352689

GI number: 189352689

Start: 786448

End: 788271

Strand: Reverse

Name: recQ [H]

Synonym: BMULJ_03921

Alternate gene names: 189352689

Gene position: 788271-786448 (Counterclockwise)

Preceding gene: 189352691

Following gene: 189352688

Centisome position: 31.87

GC content: 67.43

Gene sequence:

>1824_bases
ATGACGTTGGATACACGGCTGCGCGACCTGCGCAGGACGATGCGCGAGCGATTCGGGATCGGCCGCCTGCGCGGCGGTCA
GGAGGCGATCATCCGCAGCGTGCTTGCGCGGCGCGATACGCTGGCCACGATGCCTTCCGGCGCCGGCAAGTCGCTCTGCT
ACCAGTTGCCGGCCCTGCATCTGAACGGCGTGACGCTCGTCGTTTCGCCGCTGATCTCGCTGATGAAGGATCAGGCCGAC
AAGCTGCATGCGCTCGGCATCGACTGCTTGCTGTTGAACAGCACGGTCAAGCGCAAGGACGAGCAATCGGCGTTGCAGGC
GTTGCGCGATGGCCGCACGCGGATCGTCTTCGTGACGCCCGAACGACTCGCGCAGCCCGCGTTCGTCGACGTGCTGGCGG
GCGGTACGCGCGTGCCGGTCGAACTCGTCGTCGTGGACGAAGCGCACTGCGTCTCGAAGTGGGGTCACGATTTCCGGCCG
GCCTTTCTCGACATCGCGCATGCCGTCGACACGATCGGCGGCCCGCCCGTCCTGGCGCTGACGGCCACCGCGACGCCCGA
GGTCGTCGACGACATCGTGCACGCACTGCGGCTGCGCAAGCCCACGATCGTGCGTACCGGGACGTACCGGCCCAACCTGC
ACTACCGCGTCGTTCATACGGGCGGCGGCCACGGACGCCGCGAAGCCGCGCGCGCGCTCGAACTCAAGCAGCAGCGCCTG
CTCGATCTGATCGGCGAACTGCAGGGCGCGGGCATCGTCTACGTCGCGACCGTGCGCGACGTGCAACGCGTATGGACGTG
GCTCGCGGCGAGCGGCGAAAGCGTCGCGCGCTACCACGGGCGAATGCCGGCCAGGGAACGCCGTGACGAGCAAGACCGCT
TCATGAACGGCGACGCGCGCCTGATCGTCGCGACGAACGCGTTCGGCATGGGCATCGACAAGCCGGACGTCCGCTTCGTC
ATCCACTACCAGATCCCCGGCAATCTGGACGCGTATTACCAGGAAACCGGGCGCGCCGGGCGCGACGGCGAAGCCGCCGA
CTGCGTGCTGCTGTTCGACCTCAACGATCGCCGCATCCAGCAGTTCTTCCTCGCCGGGAAGTATCCCGATGCCGCACTGG
TATTGCAGGTGTTCGATGCGATCGCGGCAGCGACCGGCGACGCGCAGCAGGAAGCCGCGTCGCCCTCGGCTGGATCGGCA
CGTACGCCGCTGTCGGGGAAAGCGCTCGCGGAAAAGCTGACGGACGTTCCGTCCGGCAAGCTCGACGTCGCGCTCGCGAT
GCTGATCGACGCGCGCATCGTTCAGCGCGACCGCCAGCATCGCTACCGGTTGCGCAAGGACGCGGCGCCGACGCAACTGC
GCGACGCGATTCCGGCGGCCGCAGAGCAATTCCAGCAGATGCGCGAACGCGATCGCAAGGCATTGCAGCAGATGATCGAT
TACGCGCAAAGCGGACGCTGCCGCTGGCGACTGATGCTCGAGTATTACGAGGAAGACACGAAGATCGAACGCTGCGGCAC
TTGCGACAACTGCCTGCATCCGCCGCATGTCGAGCCGCTACCGGAAGCGCATTCGCCGGCCGCGATCGCGCGCCGCCGTG
CCGAGCGCGTGGCCGAGCAGACGCGCGGATGGTCCCGTGGAGAGAAAGCGCGCGTCGCGCGATTCGGTGTGGGCGAGGTC
GTCATGGCGACCGACGAGCAGGTCGCGATCCTGTTTCCCGATGGCAACGTGCGCACGTTCGTTGCGGACCGCGTGCGACA
CGTGCGCGATGCCGAGCCGCGCAATCGCAACGTGCGAAGCACATCGGCACGTGAGGACACATAG

Upstream 100 bases:

>100_bases
GCGCCAGCGCGATCGCTGCATAGCCGGCGTGGTGGCGCGCGCGCCTGCGTGCGGCACGCGCCTTGCGACAGCCTTCCCGC
CTTCACGGACGGGGATGCAG

Downstream 100 bases:

>100_bases
CGCGCCGGCCGGCGGCACGGCGCTTGCGGCTCGCATGCAGGCGAAGGGCGCGGTCGCTTCGTCTTCGTTGTTCGCGCCGT
GCTCGCAAAACGATGGTCAA

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTLDTRLRDLRRTMRERFGIGRLRGGQEAIIRSVLARRDTLATMPSGAGKSLCYQLPALHLNGVTLVVSPLISLMKDQAD
KLHALGIDCLLLNSTVKRKDEQSALQALRDGRTRIVFVTPERLAQPAFVDVLAGGTRVPVELVVVDEAHCVSKWGHDFRP
AFLDIAHAVDTIGGPPVLALTATATPEVVDDIVHALRLRKPTIVRTGTYRPNLHYRVVHTGGGHGRREAARALELKQQRL
LDLIGELQGAGIVYVATVRDVQRVWTWLAASGESVARYHGRMPARERRDEQDRFMNGDARLIVATNAFGMGIDKPDVRFV
IHYQIPGNLDAYYQETGRAGRDGEAADCVLLFDLNDRRIQQFFLAGKYPDAALVLQVFDAIAAATGDAQQEAASPSAGSA
RTPLSGKALAEKLTDVPSGKLDVALAMLIDARIVQRDRQHRYRLRKDAAPTQLRDAIPAAAEQFQQMRERDRKALQQMID
YAQSGRCRWRLMLEYYEEDTKIERCGTCDNCLHPPHVEPLPEAHSPAAIARRRAERVAEQTRGWSRGEKARVARFGVGEV
VMATDEQVAILFPDGNVRTFVADRVRHVRDAEPRNRNVRSTSAREDT

Sequences:

>Translated_607_residues
MTLDTRLRDLRRTMRERFGIGRLRGGQEAIIRSVLARRDTLATMPSGAGKSLCYQLPALHLNGVTLVVSPLISLMKDQAD
KLHALGIDCLLLNSTVKRKDEQSALQALRDGRTRIVFVTPERLAQPAFVDVLAGGTRVPVELVVVDEAHCVSKWGHDFRP
AFLDIAHAVDTIGGPPVLALTATATPEVVDDIVHALRLRKPTIVRTGTYRPNLHYRVVHTGGGHGRREAARALELKQQRL
LDLIGELQGAGIVYVATVRDVQRVWTWLAASGESVARYHGRMPARERRDEQDRFMNGDARLIVATNAFGMGIDKPDVRFV
IHYQIPGNLDAYYQETGRAGRDGEAADCVLLFDLNDRRIQQFFLAGKYPDAALVLQVFDAIAAATGDAQQEAASPSAGSA
RTPLSGKALAEKLTDVPSGKLDVALAMLIDARIVQRDRQHRYRLRKDAAPTQLRDAIPAAAEQFQQMRERDRKALQQMID
YAQSGRCRWRLMLEYYEEDTKIERCGTCDNCLHPPHVEPLPEAHSPAAIARRRAERVAEQTRGWSRGEKARVARFGVGEV
VMATDEQVAILFPDGNVRTFVADRVRHVRDAEPRNRNVRSTSAREDT
>Mature_606_residues
TLDTRLRDLRRTMRERFGIGRLRGGQEAIIRSVLARRDTLATMPSGAGKSLCYQLPALHLNGVTLVVSPLISLMKDQADK
LHALGIDCLLLNSTVKRKDEQSALQALRDGRTRIVFVTPERLAQPAFVDVLAGGTRVPVELVVVDEAHCVSKWGHDFRPA
FLDIAHAVDTIGGPPVLALTATATPEVVDDIVHALRLRKPTIVRTGTYRPNLHYRVVHTGGGHGRREAARALELKQQRLL
DLIGELQGAGIVYVATVRDVQRVWTWLAASGESVARYHGRMPARERRDEQDRFMNGDARLIVATNAFGMGIDKPDVRFVI
HYQIPGNLDAYYQETGRAGRDGEAADCVLLFDLNDRRIQQFFLAGKYPDAALVLQVFDAIAAATGDAQQEAASPSAGSAR
TPLSGKALAEKLTDVPSGKLDVALAMLIDARIVQRDRQHRYRLRKDAAPTQLRDAIPAAAEQFQQMRERDRKALQQMIDY
AQSGRCRWRLMLEYYEEDTKIERCGTCDNCLHPPHVEPLPEAHSPAAIARRRAERVAEQTRGWSRGEKARVARFGVGEVV
MATDEQVAILFPDGNVRTFVADRVRHVRDAEPRNRNVRSTSAREDT

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242943, Length=368, Percent_Identity=39.1304347826087, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI51242947, Length=368, Percent_Identity=39.1304347826087, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI148612816, Length=396, Percent_Identity=37.8787878787879, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI169218196, Length=352, Percent_Identity=38.0681818181818, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI110735439, Length=352, Percent_Identity=38.0681818181818, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557365, Length=369, Percent_Identity=36.3143631436314, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI14591902, Length=352, Percent_Identity=34.0909090909091, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI14591904, Length=352, Percent_Identity=34.0909090909091, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI284005309, Length=438, Percent_Identity=34.0182648401827, Blast_Score=199, Evalue=6e-51,
Organism=Escherichia coli, GI48994977, Length=347, Percent_Identity=43.5158501440922, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082221, Length=349, Percent_Identity=26.9340974212034, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788930, Length=376, Percent_Identity=25.2659574468085, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987993, Length=351, Percent_Identity=39.6011396011396, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71987997, Length=351, Percent_Identity=39.6011396011396, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI25145561, Length=358, Percent_Identity=38.8268156424581, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17552866, Length=351, Percent_Identity=37.6068376068376, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI32564293, Length=353, Percent_Identity=39.0934844192635, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17510309, Length=367, Percent_Identity=25.0681198910082, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510307, Length=367, Percent_Identity=25.0681198910082, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=367, Percent_Identity=25.0681198910082, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=362, Percent_Identity=34.8066298342541, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321360, Length=351, Percent_Identity=23.6467236467236, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324217, Length=338, Percent_Identity=26.9230769230769, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321267, Length=329, Percent_Identity=23.7082066869301, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646066, Length=355, Percent_Identity=38.0281690140845, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24664226, Length=362, Percent_Identity=38.121546961326, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI62472181, Length=366, Percent_Identity=37.7049180327869, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24664230, Length=366, Percent_Identity=37.7049180327869, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI21358123, Length=364, Percent_Identity=34.6153846153846, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI28574962, Length=335, Percent_Identity=25.6716417910448, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67585; Mature: 67454

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDTRLRDLRRTMRERFGIGRLRGGQEAIIRSVLARRDTLATMPSGAGKSLCYQLPALH
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCE
LNGVTLVVSPLISLMKDQADKLHALGIDCLLLNSTVKRKDEQSALQALRDGRTRIVFVTP
ECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHCCCEEEEEECH
ERLAQPAFVDVLAGGTRVPVELVVVDEAHCVSKWGHDFRPAFLDIAHAVDTIGGPPVLAL
HHHCCCHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEE
TATATPEVVDDIVHALRLRKPTIVRTGTYRPNLHYRVVHTGGGHGRREAARALELKQQRL
EECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
LDLIGELQGAGIVYVATVRDVQRVWTWLAASGESVARYHGRMPARERRDEQDRFMNGDAR
HHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHCCCCCE
LIVATNAFGMGIDKPDVRFVIHYQIPGNLDAYYQETGRAGRDGEAADCVLLFDLNDRRIQ
EEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
QFFLAGKYPDAALVLQVFDAIAAATGDAQQEAASPSAGSARTPLSGKALAEKLTDVPSGK
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCH
LDVALAMLIDARIVQRDRQHRYRLRKDAAPTQLRDAIPAAAEQFQQMRERDRKALQQMID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAQSGRCRWRLMLEYYEEDTKIERCGTCDNCLHPPHVEPLPEAHSPAAIARRRAERVAEQ
HHHCCCCEEEHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TRGWSRGEKARVARFGVGEVVMATDEQVAILFPDGNVRTFVADRVRHVRDAEPRNRNVRS
HCCCCCCCHHHHHHCCCCCEEEECCCEEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCC
TSAREDT
CCCCCCC
>Mature Secondary Structure 
TLDTRLRDLRRTMRERFGIGRLRGGQEAIIRSVLARRDTLATMPSGAGKSLCYQLPALH
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCE
LNGVTLVVSPLISLMKDQADKLHALGIDCLLLNSTVKRKDEQSALQALRDGRTRIVFVTP
ECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHCCCEEEEEECH
ERLAQPAFVDVLAGGTRVPVELVVVDEAHCVSKWGHDFRPAFLDIAHAVDTIGGPPVLAL
HHHCCCHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEE
TATATPEVVDDIVHALRLRKPTIVRTGTYRPNLHYRVVHTGGGHGRREAARALELKQQRL
EECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
LDLIGELQGAGIVYVATVRDVQRVWTWLAASGESVARYHGRMPARERRDEQDRFMNGDAR
HHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHCCCCCE
LIVATNAFGMGIDKPDVRFVIHYQIPGNLDAYYQETGRAGRDGEAADCVLLFDLNDRRIQ
EEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
QFFLAGKYPDAALVLQVFDAIAAATGDAQQEAASPSAGSARTPLSGKALAEKLTDVPSGK
HHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCH
LDVALAMLIDARIVQRDRQHRYRLRKDAAPTQLRDAIPAAAEQFQQMRERDRKALQQMID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAQSGRCRWRLMLEYYEEDTKIERCGTCDNCLHPPHVEPLPEAHSPAAIARRRAERVAEQ
HHHCCCCEEEHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TRGWSRGEKARVARFGVGEVVMATDEQVAILFPDGNVRTFVADRVRHVRDAEPRNRNVRS
HCCCCCCCHHHHHHCCCCCEEEECCCEEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCC
TSAREDT
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]