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The map label for this gene is hisM [H]

Identifier: 189352292

GI number: 189352292

Start: 340485

End: 341198

Strand: Direct

Name: hisM [H]

Synonym: BMULJ_03511

Alternate gene names: 189352292

Gene position: 340485-341198 (Clockwise)

Preceding gene: 189352291

Following gene: 189352293

Centisome position: 13.77

GC content: 64.57

Gene sequence:

>714_bases
GTGATCGAACTCGTCAGCCAGTACTGGCAGAACTATCTCTATACCGACGGCTACCGCTTCACCGGCCTCGCGATCACGCT
GTGGCTGCTCGTCGTGTCGATCGTGCTCGGCTTCGCGCTCGCCGTGCCGCTCGCGATCGCGCGCGCCTCGTCGAATCGCT
GGATCTCGGGGCCCGTCTGGCTCTACACCTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTGCTGATGTGCTACACG
GGCATCTACAGCCTGCAGGTCGTGCACGACCACGTGCTGCTCGATGCGTTCTTCCGCAACGCGATGAACTGCACGCTGCT
CGCGTTCGTGCTGAACGAGGCCGCGTACGCGACCGAAATCTTTGCAGGCGCGATCAAGGCGACGCCGTCCGGCGAGATCG
AGGCCGGCATGGCGTACGGCATGTCGCGCTTCAAGCTCTATACGCGCGTGATCCTGCCGTCCGCGCTGCGCCGTTCGCTG
CCGAGCTACAGCAACGAAGTGATCCTGATGCTGCACGCGACGACGCTCGCGTTCACCGCGACCGTGCCCGACATCCTGAA
AGTCACGCGCGACGTGAACTCGGCGACCTACATGTCGTTCCAGGCGTACGGGATCGCGGCCGTGATCTATGCCGTCGTCG
TGTTCGCGCTGATCTGGGCATTCCGCAAGCTCGAGGCGCGCTGGCTCGCGTACCTGTCGCCGCGCAGCCATTGA

Upstream 100 bases:

>100_bases
TCGCGGCCGGTGCGATCTATCTCGCGATCACGACGGTGTCGAACGTCGTGCTGCACCACCTCGAGAAGCGTTATTCGGTC
GGCGTCCGGAGGCTTGCACT

Downstream 100 bases:

>100_bases
CACGTTCACGCATTCGAAAGGAAACACACGCATGTACAAGCTCATCGTCGAGGACCTGCACAAGAAGTTCGGCGACAACG
AAGTCCTGAAGGGCGTCACG

Product: polar amino acid transport system permease protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELVSQYWQNYLYTDGYRFTGLAITLWLLVVSIVLGFALAVPLAIARASSNRWISGPVWLYTYVFRGTPLYVQLLMCYT
GIYSLQVVHDHVLLDAFFRNAMNCTLLAFVLNEAAYATEIFAGAIKATPSGEIEAGMAYGMSRFKLYTRVILPSALRRSL
PSYSNEVILMLHATTLAFTATVPDILKVTRDVNSATYMSFQAYGIAAVIYAVVVFALIWAFRKLEARWLAYLSPRSH

Sequences:

>Translated_237_residues
MIELVSQYWQNYLYTDGYRFTGLAITLWLLVVSIVLGFALAVPLAIARASSNRWISGPVWLYTYVFRGTPLYVQLLMCYT
GIYSLQVVHDHVLLDAFFRNAMNCTLLAFVLNEAAYATEIFAGAIKATPSGEIEAGMAYGMSRFKLYTRVILPSALRRSL
PSYSNEVILMLHATTLAFTATVPDILKVTRDVNSATYMSFQAYGIAAVIYAVVVFALIWAFRKLEARWLAYLSPRSH
>Mature_237_residues
MIELVSQYWQNYLYTDGYRFTGLAITLWLLVVSIVLGFALAVPLAIARASSNRWISGPVWLYTYVFRGTPLYVQLLMCYT
GIYSLQVVHDHVLLDAFFRNAMNCTLLAFVLNEAAYATEIFAGAIKATPSGEIEAGMAYGMSRFKLYTRVILPSALRRSL
PSYSNEVILMLHATTLAFTATVPDILKVTRDVNSATYMSFQAYGIAAVIYAVVVFALIWAFRKLEARWLAYLSPRSH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=61.4406779661017, Blast_Score=311, Evalue=2e-86,
Organism=Escherichia coli, GI1787086, Length=213, Percent_Identity=35.2112676056338, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787030, Length=207, Percent_Identity=29.4685990338164, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788226, Length=196, Percent_Identity=32.1428571428571, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788646, Length=199, Percent_Identity=30.1507537688442, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787087, Length=218, Percent_Identity=27.0642201834862, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786873, Length=215, Percent_Identity=24.6511627906977, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786874, Length=220, Percent_Identity=26.8181818181818, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI87082239, Length=215, Percent_Identity=26.046511627907, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26646; Mature: 26646

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELVSQYWQNYLYTDGYRFTGLAITLWLLVVSIVLGFALAVPLAIARASSNRWISGPVW
CHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LYTYVFRGTPLYVQLLMCYTGIYSLQVVHDHVLLDAFFRNAMNCTLLAFVLNEAAYATEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAGAIKATPSGEIEAGMAYGMSRFKLYTRVILPSALRRSLPSYSNEVILMLHATTLAFTA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
TVPDILKVTRDVNSATYMSFQAYGIAAVIYAVVVFALIWAFRKLEARWLAYLSPRSH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIELVSQYWQNYLYTDGYRFTGLAITLWLLVVSIVLGFALAVPLAIARASSNRWISGPVW
CHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LYTYVFRGTPLYVQLLMCYTGIYSLQVVHDHVLLDAFFRNAMNCTLLAFVLNEAAYATEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAGAIKATPSGEIEAGMAYGMSRFKLYTRVILPSALRRSLPSYSNEVILMLHATTLAFTA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
TVPDILKVTRDVNSATYMSFQAYGIAAVIYAVVVFALIWAFRKLEARWLAYLSPRSH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]