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The map label for this gene is hisQ [H]

Identifier: 189352291

GI number: 189352291

Start: 339799

End: 340488

Strand: Direct

Name: hisQ [H]

Synonym: BMULJ_03510

Alternate gene names: 189352291

Gene position: 339799-340488 (Clockwise)

Preceding gene: 189352290

Following gene: 189352292

Centisome position: 13.74

GC content: 64.49

Gene sequence:

>690_bases
ATGATTTTCCAGGGATTTGGCCCGCTGCTGTGGGCCGGTACGGTCGAGACCGTGAAGCTCGCGGTGCTGTCGCTCGCCGC
TTCGCTGCTGCTCGGCCTCGCGGGCGCGGCCGCCAAACTGTCGACGAACCGCGTGCTGCGCGCAGTCGGCACGTTCTATA
CGACGCTGATCCGCGCGGTGCCCGACCTCGTGCTGATGCTGCTGCTGTTCTACGGGATCCAGATCCTGCTGAACAACGTG
ACCGACCTGCTCGGCTGGCAACAGATCGACATCGATCCGTTCTTCGCCGGCGTCGTGACGCTCGGCTTCATCTACGGCGC
CTACTTCACCGAAACGTTCCGCGGCGCGTTCCTCGCGGTGCCGCGCGGTCAGCTCGAAGCCGGCTTCGCATACGGAATGG
GTGGCTGGCGCGTGTTTCGGCGCATCCTGTTCCCGCAGATGATGCGCTTTGCGCTGCCGGGCATCGGCAACAACTGGCAG
GTGCTCGTGAAGGCGACCGCGCTCGTGTCGATCATCGGCCTCGCGGATGTCGTGAAGGCGTCGCAGGACGCCGGCAAGAG
CACGCTCGATTTCTTCTTCTTCACGCTCGCGGCCGGTGCGATCTATCTCGCGATCACGACGGTGTCGAACGTCGTGCTGC
ACCACCTCGAGAAGCGTTATTCGGTCGGCGTCCGGAGGCTTGCACTGTGA

Upstream 100 bases:

>100_bases
GAAGAAGTATTTCGCGTTCGACGTCTACGGCGGCTGACGCCGCGGCGGCGCGCGCGGCACACGGCCTCGCGCGCCGCCTG
TCTTTCCGGATGGAACCGAC

Downstream 100 bases:

>100_bases
TCGAACTCGTCAGCCAGTACTGGCAGAACTATCTCTATACCGACGGCTACCGCTTCACCGGCCTCGCGATCACGCTGTGG
CTGCTCGTCGTGTCGATCGT

Product: polar amino acid transport system permease protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MIFQGFGPLLWAGTVETVKLAVLSLAASLLLGLAGAAAKLSTNRVLRAVGTFYTTLIRAVPDLVLMLLLFYGIQILLNNV
TDLLGWQQIDIDPFFAGVVTLGFIYGAYFTETFRGAFLAVPRGQLEAGFAYGMGGWRVFRRILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKASQDAGKSTLDFFFFTLAAGAIYLAITTVSNVVLHHLEKRYSVGVRRLAL

Sequences:

>Translated_229_residues
MIFQGFGPLLWAGTVETVKLAVLSLAASLLLGLAGAAAKLSTNRVLRAVGTFYTTLIRAVPDLVLMLLLFYGIQILLNNV
TDLLGWQQIDIDPFFAGVVTLGFIYGAYFTETFRGAFLAVPRGQLEAGFAYGMGGWRVFRRILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKASQDAGKSTLDFFFFTLAAGAIYLAITTVSNVVLHHLEKRYSVGVRRLAL
>Mature_229_residues
MIFQGFGPLLWAGTVETVKLAVLSLAASLLLGLAGAAAKLSTNRVLRAVGTFYTTLIRAVPDLVLMLLLFYGIQILLNNV
TDLLGWQQIDIDPFFAGVVTLGFIYGAYFTETFRGAFLAVPRGQLEAGFAYGMGGWRVFRRILFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKASQDAGKSTLDFFFFTLAAGAIYLAITTVSNVVLHHLEKRYSVGVRRLAL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=222, Percent_Identity=61.7117117117117, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1787087, Length=223, Percent_Identity=36.7713004484305, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787030, Length=215, Percent_Identity=31.1627906976744, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788226, Length=219, Percent_Identity=29.6803652968037, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788645, Length=238, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786873, Length=213, Percent_Identity=28.6384976525822, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786874, Length=186, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082239, Length=220, Percent_Identity=26.8181818181818, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787086, Length=219, Percent_Identity=28.310502283105, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24913; Mature: 24913

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQGFGPLLWAGTVETVKLAVLSLAASLLLGLAGAAAKLSTNRVLRAVGTFYTTLIRAV
CCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLVLMLLLFYGIQILLNNVTDLLGWQQIDIDPFFAGVVTLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGFAYGMGGWRVFRRILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQDAGKSTLDFFFFTLAAGAIYLAITTVSNVVLHHLEKRYSVGVRRLAL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFQGFGPLLWAGTVETVKLAVLSLAASLLLGLAGAAAKLSTNRVLRAVGTFYTTLIRAV
CCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLVLMLLLFYGIQILLNNVTDLLGWQQIDIDPFFAGVVTLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGFAYGMGGWRVFRRILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQDAGKSTLDFFFFTLAAGAIYLAITTVSNVVLHHLEKRYSVGVRRLAL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]