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The map label for this gene is ttuC [H]

Identifier: 189352272

GI number: 189352272

Start: 317511

End: 318593

Strand: Direct

Name: ttuC [H]

Synonym: BMULJ_03491

Alternate gene names: 189352272

Gene position: 317511-318593 (Clockwise)

Preceding gene: 189352270

Following gene: 189352273

Centisome position: 12.84

GC content: 68.24

Gene sequence:

>1083_bases
ATGAAGACGTACCGTATCGCGACCATTCCCGGCGACGGCATCGGGAAGGAAGTCGTGCCGGCCGGCAAGCAGGTGCTCGA
GGCGCTGGCCCGCGGCAGCGACCGCTTCGCGTTCGAGTTCGAGGATTTCGACTGGGGCGCGGACTACTACCGGCGGCACG
GCGCGATGATGCCGGCCGACGGCCTCGACGCGCTGCGCGGCAAGGACGCGATCCTGTTCGGCTCGGCCGGCGACCCGGAT
GTGCCCGACCACGTGACGCTGTGGGGGCTGCGGCTGAAGATTTGCCAGGGCTTCGATCAGTACGCGAACGTGCGGCCGAC
GCGCATCCTGCCCGGCATCGACGCACCGCTGAAACGCTGCGGCCCGGACGACCTGAACTGGGTGATCGTGCGCGAGAACT
CGGAAGGCGAGTACGCGGGTGTCGGCGGCCGCGTGCATCAGGGCCATCCGATCGAGGCTGCGACCGACGTGTCGATCCTC
ACGCGTGTCGGCGTCGAGCGAATCATGCGCTTTGCGTTCCGGCTTGCGCAATCGCGTCCGCGCAAGCTGCTGACGGTCAT
CACGAAGAGCAACGCGCAGCGTCACGCGATGGTGATGTGGGACGAGATCGCGAAGCAGGTCGCGCAGGAGTTTCCGGACG
TGACGTGGGACAAGGAACTCGTCGATGCGGCGACGGCGCGGATGGTCAATCGTCCGGCCTCGCTGGACACGATCGTCGCG
ACGAACCTGCATGCGGACATCCTCAGCGATCTCGCGGCCGCGCTCGCCGGCAGCCTCGGCATCGCGCCGACCGGCAACAT
CGATCCCGAACGCCGCTATCCGTCGATGTTCGAACCGATCCACGGCTCCGCGTTCGACATCATGGGCAAGGGGCTCGCGA
ATCCGGTCGGCACGTTCTGGTCGGTCGTGATGCTGCTCGAGCATCTCGGCGAGACCGAGGCGGCCGCGCGCGTGATGCGC
GCGATCGAAGCCGTGACGGCCGATCCGTCGCTGCATACGCGCGACCTCGGCGGCCATGCGACGACCGCGCAGGTGACGGC
GGCTGTCTGCGAGCACGTCGCGCACGCGGCCGTGACGGCCTGA

Upstream 100 bases:

>100_bases
TTCGTGAACGGAAGTTAAAGATGCTTTGAGTCTAGCACCGGTTCCTGCACTGTCGGTTCGGTAAAGTGGCCGTACGCTCA
CGATCAATCGAGGTATTCGC

Downstream 100 bases:

>100_bases
CGGCGGGCGTCCCTGCGGGCTCTCCTACCGGCGTCCCGTTTCACGCCAATCGATTCGATCTGCCTACGACTCGCGCAACC
GACGCGAGCGGGGCGCCGAT

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKTYRIATIPGDGIGKEVVPAGKQVLEALARGSDRFAFEFEDFDWGADYYRRHGAMMPADGLDALRGKDAILFGSAGDPD
VPDHVTLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCGPDDLNWVIVRENSEGEYAGVGGRVHQGHPIEAATDVSIL
TRVGVERIMRFAFRLAQSRPRKLLTVITKSNAQRHAMVMWDEIAKQVAQEFPDVTWDKELVDAATARMVNRPASLDTIVA
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSVVMLLEHLGETEAAARVMR
AIEAVTADPSLHTRDLGGHATTAQVTAAVCEHVAHAAVTA

Sequences:

>Translated_360_residues
MKTYRIATIPGDGIGKEVVPAGKQVLEALARGSDRFAFEFEDFDWGADYYRRHGAMMPADGLDALRGKDAILFGSAGDPD
VPDHVTLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCGPDDLNWVIVRENSEGEYAGVGGRVHQGHPIEAATDVSIL
TRVGVERIMRFAFRLAQSRPRKLLTVITKSNAQRHAMVMWDEIAKQVAQEFPDVTWDKELVDAATARMVNRPASLDTIVA
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSVVMLLEHLGETEAAARVMR
AIEAVTADPSLHTRDLGGHATTAQVTAAVCEHVAHAAVTA
>Mature_360_residues
MKTYRIATIPGDGIGKEVVPAGKQVLEALARGSDRFAFEFEDFDWGADYYRRHGAMMPADGLDALRGKDAILFGSAGDPD
VPDHVTLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCGPDDLNWVIVRENSEGEYAGVGGRVHQGHPIEAATDVSIL
TRVGVERIMRFAFRLAQSRPRKLLTVITKSNAQRHAMVMWDEIAKQVAQEFPDVTWDKELVDAATARMVNRPASLDTIVA
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSVVMLLEHLGETEAAARVMR
AIEAVTADPSLHTRDLGGHATTAQVTAAVCEHVAHAAVTA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=348, Percent_Identity=32.183908045977, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4758582, Length=352, Percent_Identity=28.4090909090909, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI28178821, Length=353, Percent_Identity=26.0623229461756, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI28178816, Length=355, Percent_Identity=26.1971830985915, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI28178838, Length=323, Percent_Identity=28.1733746130031, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI28178819, Length=198, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788101, Length=358, Percent_Identity=49.7206703910614, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87081683, Length=332, Percent_Identity=34.9397590361446, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1787381, Length=363, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=351, Percent_Identity=32.4786324786325, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=27.7620396600567, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25144293, Length=362, Percent_Identity=27.3480662983425, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=355, Percent_Identity=25.3521126760563, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322097, Length=362, Percent_Identity=36.7403314917127, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324709, Length=354, Percent_Identity=32.4858757062147, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=355, Percent_Identity=28.4507042253521, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319830, Length=366, Percent_Identity=29.7814207650273, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24643268, Length=352, Percent_Identity=32.1022727272727, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24643270, Length=348, Percent_Identity=31.6091954022989, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24661184, Length=354, Percent_Identity=28.8135593220339, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI281362242, Length=347, Percent_Identity=28.8184438040346, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648872, Length=347, Percent_Identity=28.8184438040346, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161078635, Length=354, Percent_Identity=25.1412429378531, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078637, Length=354, Percent_Identity=25.1412429378531, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078633, Length=354, Percent_Identity=25.1412429378531, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24650122, Length=354, Percent_Identity=25.1412429378531, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161078639, Length=351, Percent_Identity=25.3561253561254, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI20130355, Length=351, Percent_Identity=25.3561253561254, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39035; Mature: 39035

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYRIATIPGDGIGKEVVPAGKQVLEALARGSDRFAFEFEDFDWGADYYRRHGAMMPAD
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCC
GLDALRGKDAILFGSAGDPDVPDHVTLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRC
CHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCCCEECCCCCHHHHHC
GPDDLNWVIVRENSEGEYAGVGGRVHQGHPIEAATDVSILTRVGVERIMRFAFRLAQSRP
CCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKLLTVITKSNAQRHAMVMWDEIAKQVAQEFPDVTWDKELVDAATARMVNRPASLDTIVA
HHEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCCCCCHHHHHHCCCCCHHHHHH
SVVMLLEHLGETEAAARVMRAIEAVTADPSLHTRDLGGHATTAQVTAAVCEHVAHAAVTA
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTYRIATIPGDGIGKEVVPAGKQVLEALARGSDRFAFEFEDFDWGADYYRRHGAMMPAD
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCC
GLDALRGKDAILFGSAGDPDVPDHVTLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRC
CHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCCCEECCCCCHHHHHC
GPDDLNWVIVRENSEGEYAGVGGRVHQGHPIEAATDVSILTRVGVERIMRFAFRLAQSRP
CCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RKLLTVITKSNAQRHAMVMWDEIAKQVAQEFPDVTWDKELVDAATARMVNRPASLDTIVA
HHEEHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCCCCCHHHHHHCCCCCHHHHHH
SVVMLLEHLGETEAAARVMRAIEAVTADPSLHTRDLGGHATTAQVTAAVCEHVAHAAVTA
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]