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The map label for this gene is merA [H]

Identifier: 189352125

GI number: 189352125

Start: 150769

End: 152133

Strand: Direct

Name: merA [H]

Synonym: BMULJ_03343

Alternate gene names: 189352125

Gene position: 150769-152133 (Clockwise)

Preceding gene: 189352124

Following gene: 189352127

Centisome position: 6.1

GC content: 66.52

Gene sequence:

>1365_bases
ATGGCAGACGTCAAACGGGTTGATTTCCTGTTTCTGGGCGGCGGCAAGGGCGGCAAGTCGCTCGCGATGGACATGGCCCG
TCGAGGCAAGCGCGTCGCGGTGATCGAGCGCGGGATGATCGGCGGCTCGTGCATCAACGTCGCGTGCATTCCGAGCAAGG
CGTTGATTCACCACGCGCGCTCGATGCATGCATGGCGCGAAGCGGCGAAACGGCACGAGGTGACCGCCGACATGGCGGCC
GTGTCGACGTATGTGGCGTCGGTCGTGAACGGCATGGTCGACGTCAACCGTCGCGCATTTGAGCAGTCGGGGCTCGAACT
GATGATCGGAACCGGCCGGTTCGTCGCGCCGCGAACGATTGCCGTGCGCACGGACGACGGCGCAGAAGCGATCTACGAGG
GCGAGAACGTCTACATCAACACCGGCACGGTCGCGGCGATCCCCGACGTCCCGGGCCTGCGCGACGCGCAGCCGCTCACG
CACGTCGAGGCACTGCGCCTGACGACGCTTCCCCGGCATCTGATCGTGATCGGCGGCGGCTATATCGGCCTCGAAATGGC
ACAGGCCTTTCGGCGTCTCGGCAGCGCGGTCACGCTCGTTACCGATACGCCGCGTGTCGCGATGCGCGAGGACGAGGATG
TCGGTACGGTCATTCAGCAGGCGCTCGCCGACGATGGCATTCAGTTGATGCTCGCGGCGAAGCTCGTCGACGTGCAGGGT
AAAAGCGGCGAGCGCGTGACAGTGAGGCTGGCCGACGGCAGCGTCGTCGAAGGCTCGGACCTGCTCGTTGCGACCGGCCG
CAAGCCGCAGACGGACGGCATCGGGCTGGAGCGCGCCGGCGTCGAGACGGACGCGCGCGGGTTCATCAAGGTCGACCCGC
AGCTCGCGACGACCGCCGAGCGCACGTGGGCGATCGGCGAAGTCGCCGGTACGCCGATGTTTACGCATGCTTCGTTCGAC
GACTATCGCGTGCTCAAGGCCGGTATCGAAGGGCGGCCGGCGAGTACCGCGGGGCGGATCATCCCGTACGCGCTATTCAT
CGATCCGGAGCTCGGCCGTATCGGCCTGAACGAAGCCGATGCAAAGGCGCGCGATATCGAGGTCCGCGTCGCGAAGCTGC
CGATGGCGTCCGTGCCGAGGGCACGCACCGACGGAAAGACGCGCGGCTTCATGAAGGCGCTGGTGCGGCCGGACACGGGC
GCGATTCTGGGCTTCACGATGGTCGGCACGGGCGCGGGCGACGTGACGACCGCGGTGCAAATGGCGATGCTCGGCGGATT
GCCGTATACGGCGGTGCGTGACGCGATCATCGGTCATCCTATCGTTTCGGAAGGGCTGAATCTGTTGTTCGCGACGTTGG
GGTGA

Upstream 100 bases:

>100_bases
GAGCGCCCATCGATGCAACGGCCGGCCGCGACATCGCCGAGACGAGCGGCGAGCCGGCTTCACTCATTTCGAGTCGAACC
AATAGAATCTGGAGAGCAGA

Downstream 100 bases:

>100_bases
GGACGGGGAGCTGCCTGCACGTGCGGCGCCAAGACGGCGAGTTCTTCCATGAGTCGGGCGTTCGGTGAGCGCGTCTGGCG
GATGCCCGTCTATTCCGCCG

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MADVKRVDFLFLGGGKGGKSLAMDMARRGKRVAVIERGMIGGSCINVACIPSKALIHHARSMHAWREAAKRHEVTADMAA
VSTYVASVVNGMVDVNRRAFEQSGLELMIGTGRFVAPRTIAVRTDDGAEAIYEGENVYINTGTVAAIPDVPGLRDAQPLT
HVEALRLTTLPRHLIVIGGGYIGLEMAQAFRRLGSAVTLVTDTPRVAMREDEDVGTVIQQALADDGIQLMLAAKLVDVQG
KSGERVTVRLADGSVVEGSDLLVATGRKPQTDGIGLERAGVETDARGFIKVDPQLATTAERTWAIGEVAGTPMFTHASFD
DYRVLKAGIEGRPASTAGRIIPYALFIDPELGRIGLNEADAKARDIEVRVAKLPMASVPRARTDGKTRGFMKALVRPDTG
AILGFTMVGTGAGDVTTAVQMAMLGGLPYTAVRDAIIGHPIVSEGLNLLFATLG

Sequences:

>Translated_454_residues
MADVKRVDFLFLGGGKGGKSLAMDMARRGKRVAVIERGMIGGSCINVACIPSKALIHHARSMHAWREAAKRHEVTADMAA
VSTYVASVVNGMVDVNRRAFEQSGLELMIGTGRFVAPRTIAVRTDDGAEAIYEGENVYINTGTVAAIPDVPGLRDAQPLT
HVEALRLTTLPRHLIVIGGGYIGLEMAQAFRRLGSAVTLVTDTPRVAMREDEDVGTVIQQALADDGIQLMLAAKLVDVQG
KSGERVTVRLADGSVVEGSDLLVATGRKPQTDGIGLERAGVETDARGFIKVDPQLATTAERTWAIGEVAGTPMFTHASFD
DYRVLKAGIEGRPASTAGRIIPYALFIDPELGRIGLNEADAKARDIEVRVAKLPMASVPRARTDGKTRGFMKALVRPDTG
AILGFTMVGTGAGDVTTAVQMAMLGGLPYTAVRDAIIGHPIVSEGLNLLFATLG
>Mature_453_residues
ADVKRVDFLFLGGGKGGKSLAMDMARRGKRVAVIERGMIGGSCINVACIPSKALIHHARSMHAWREAAKRHEVTADMAAV
STYVASVVNGMVDVNRRAFEQSGLELMIGTGRFVAPRTIAVRTDDGAEAIYEGENVYINTGTVAAIPDVPGLRDAQPLTH
VEALRLTTLPRHLIVIGGGYIGLEMAQAFRRLGSAVTLVTDTPRVAMREDEDVGTVIQQALADDGIQLMLAAKLVDVQGK
SGERVTVRLADGSVVEGSDLLVATGRKPQTDGIGLERAGVETDARGFIKVDPQLATTAERTWAIGEVAGTPMFTHASFDD
YRVLKAGIEGRPASTAGRIIPYALFIDPELGRIGLNEADAKARDIEVRVAKLPMASVPRARTDGKTRGFMKALVRPDTGA
ILGFTMVGTGAGDVTTAVQMAMLGGLPYTAVRDAIIGHPIVSEGLNLLFATLG

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=453, Percent_Identity=28.476821192053, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=26.7241379310345, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI148277065, Length=466, Percent_Identity=25.3218884120172, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI33519430, Length=466, Percent_Identity=25.3218884120172, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI33519428, Length=466, Percent_Identity=25.3218884120172, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI33519426, Length=466, Percent_Identity=25.3218884120172, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI148277071, Length=466, Percent_Identity=25.3218884120172, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI291045266, Length=442, Percent_Identity=24.6606334841629, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=25.4817987152034, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI291045268, Length=463, Percent_Identity=23.5421166306695, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=34.5982142857143, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=29.4247787610619, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=26.8817204301075, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=26.3761467889908, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.0672451193059, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=24.5322245322245, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=412, Percent_Identity=26.9417475728155, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=412, Percent_Identity=26.9417475728155, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=26.3374485596708, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=221, Percent_Identity=27.6018099547511, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=480, Percent_Identity=28.75, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=23.175965665236, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=24.2489270386266, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=30, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=25.2100840336134, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=25.2100840336134, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=25.1559251559252, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=25.5144032921811, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48119; Mature: 47988

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVKRVDFLFLGGGKGGKSLAMDMARRGKRVAVIERGMIGGSCINVACIPSKALIHHAR
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHH
SMHAWREAAKRHEVTADMAAVSTYVASVVNGMVDVNRRAFEQSGLELMIGTGRFVAPRTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCEEE
AVRTDDGAEAIYEGENVYINTGTVAAIPDVPGLRDAQPLTHVEALRLTTLPRHLIVIGGG
EEEECCCCCCEECCCEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCC
YIGLEMAQAFRRLGSAVTLVTDTPRVAMREDEDVGTVIQQALADDGIQLMLAAKLVDVQG
HHHHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEEEEEEEEECCC
KSGERVTVRLADGSVVEGSDLLVATGRKPQTDGIGLERAGVETDARGFIKVDPQLATTAE
CCCCEEEEEEECCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHCHH
RTWAIGEVAGTPMFTHASFDDYRVLKAGIEGRPASTAGRIIPYALFIDPELGRIGLNEAD
HHEEEHHHCCCCEEEECCCCCHHHEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC
AKARDIEVRVAKLPMASVPRARTDGKTRGFMKALVRPDTGAILGFTMVGTGAGDVTTAVQ
CCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHH
MAMLGGLPYTAVRDAIIGHPIVSEGLNLLFATLG
HHHHCCCCHHHHHHHHHCCCHHHHCHHEEEEECC
>Mature Secondary Structure 
ADVKRVDFLFLGGGKGGKSLAMDMARRGKRVAVIERGMIGGSCINVACIPSKALIHHAR
CCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHH
SMHAWREAAKRHEVTADMAAVSTYVASVVNGMVDVNRRAFEQSGLELMIGTGRFVAPRTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCEEE
AVRTDDGAEAIYEGENVYINTGTVAAIPDVPGLRDAQPLTHVEALRLTTLPRHLIVIGGG
EEEECCCCCCEECCCEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCC
YIGLEMAQAFRRLGSAVTLVTDTPRVAMREDEDVGTVIQQALADDGIQLMLAAKLVDVQG
HHHHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEEEEEEEEECCC
KSGERVTVRLADGSVVEGSDLLVATGRKPQTDGIGLERAGVETDARGFIKVDPQLATTAE
CCCCEEEEEEECCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHCHH
RTWAIGEVAGTPMFTHASFDDYRVLKAGIEGRPASTAGRIIPYALFIDPELGRIGLNEAD
HHEEEHHHCCCCEEEECCCCCHHHEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC
AKARDIEVRVAKLPMASVPRARTDGKTRGFMKALVRPDTGAILGFTMVGTGAGDVTTAVQ
CCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHH
MAMLGGLPYTAVRDAIIGHPIVSEGLNLLFATLG
HHHHCCCCHHHHHHHHHCCCHHHHCHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]