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The map label for this gene is qor [C]

Identifier: 189352124

GI number: 189352124

Start: 149663

End: 150670

Strand: Direct

Name: qor [C]

Synonym: BMULJ_03342

Alternate gene names: 189352124

Gene position: 149663-150670 (Clockwise)

Preceding gene: 189352123

Following gene: 189352125

Centisome position: 6.05

GC content: 66.37

Gene sequence:

>1008_bases
ATGAAAGCCATCGTCTATGCAAAGGCCGGCGTGCCGATCGACGATCCGACCGCGCTGTACGACACGGACGTGCCCGTGCC
GGCGCCAGGCCCGCGAGACCTGCTCGTGAAGATCGAGGCGATCGCGGTCAATCCGGTCGATTCGAAGCTGCGGCTCGGCG
TTCAGCCGGCCGGCCCGCGCATCCTCGGCTGGGACGCGGCAGGCACGGTCGAGGCGGTCGGCAGCGACGTCGAACTGTTC
GAGCCGGGCGACAAGGTCTGGTATGCGGGCGACATCGCGCGGCCCGGCAGCTATGCCGAATACGGGCTCGTCGACGAACG
CGTGGCGAGTCGCCGCCCTGCAACGCTCGGCGCTGCCGATGCCGCCGCTCTGCCGTTGACCGCGATCACCGCGTGGGAAC
TGCTGTTCGACCGCCTCAAGGTCGCGGAGCACGGCGGCGCGGGACAGAGCCTGCTCGTGATCGGCGCCGGCGGCGGCGTC
GGCTCGATTCTGGTGCAGTTCGCGCGCAAGCTCACCGCGCTGACCGTGATCGGTACGGCATCGCGGCCTGCCACGCACGC
GTGGGTCGCCGAACTTGGCGCGCACCATGTGATCGACCACGGCAAAGAGTTGCAGCCGCAACTGAATGCGGTCGGCATCG
ACCACGTGGACCACGTGATCAGCCTCACGCATACCGACACGTACTACGCTCAGATCGTCGACGTGCTGAAGCCAGAAGGC
CAGCTCGCGCTGATCGACGATCCCGACACGCTCGATGCAATGCCGCTGAAGCGAAAGTCGATTTCGCTTCATTGGGAATT
CATGTTTACGCGCTCGATGTTCCGCACGCCGGACATGATCCGCCAGCATGCGCTGCTCGAACGCGTCGCGTCGCTGATCG
ACGACGGCGTGCTCAAGAGCACCGTCGGCGAACATCTCGGAAAGATCGACGCGGCCAACCTGCGACGCGCGCACGCGCTG
ATCGAAGCGGGTCGGGCGAAGGGGAAGATCGTGCTGGAGGGGTTTTGA

Upstream 100 bases:

>100_bases
GTGCGCTGTTTCAATATGCGCAGACGTATGTCGCACACGTGACGGAATTCCTGCGCGGCGCGTGAGCGCGCACGCGCTTC
ACCCTTCAAGGAGCCCATCC

Downstream 100 bases:

>100_bases
GCGCCCATCGATGCAACGGCCGGCCGCGACATCGCCGAGACGAGCGGCGAGCCGGCTTCACTCATTTCGAGTCGAACCAA
TAGAATCTGGAGAGCAGAAT

Product: ferredoxin subunit of ring-hydroxylating dioxygenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAIVYAKAGVPIDDPTALYDTDVPVPAPGPRDLLVKIEAIAVNPVDSKLRLGVQPAGPRILGWDAAGTVEAVGSDVELF
EPGDKVWYAGDIARPGSYAEYGLVDERVASRRPATLGAADAAALPLTAITAWELLFDRLKVAEHGGAGQSLLVIGAGGGV
GSILVQFARKLTALTVIGTASRPATHAWVAELGAHHVIDHGKELQPQLNAVGIDHVDHVISLTHTDTYYAQIVDVLKPEG
QLALIDDPDTLDAMPLKRKSISLHWEFMFTRSMFRTPDMIRQHALLERVASLIDDGVLKSTVGEHLGKIDAANLRRAHAL
IEAGRAKGKIVLEGF

Sequences:

>Translated_335_residues
MKAIVYAKAGVPIDDPTALYDTDVPVPAPGPRDLLVKIEAIAVNPVDSKLRLGVQPAGPRILGWDAAGTVEAVGSDVELF
EPGDKVWYAGDIARPGSYAEYGLVDERVASRRPATLGAADAAALPLTAITAWELLFDRLKVAEHGGAGQSLLVIGAGGGV
GSILVQFARKLTALTVIGTASRPATHAWVAELGAHHVIDHGKELQPQLNAVGIDHVDHVISLTHTDTYYAQIVDVLKPEG
QLALIDDPDTLDAMPLKRKSISLHWEFMFTRSMFRTPDMIRQHALLERVASLIDDGVLKSTVGEHLGKIDAANLRRAHAL
IEAGRAKGKIVLEGF
>Mature_335_residues
MKAIVYAKAGVPIDDPTALYDTDVPVPAPGPRDLLVKIEAIAVNPVDSKLRLGVQPAGPRILGWDAAGTVEAVGSDVELF
EPGDKVWYAGDIARPGSYAEYGLVDERVASRRPATLGAADAAALPLTAITAWELLFDRLKVAEHGGAGQSLLVIGAGGGV
GSILVQFARKLTALTVIGTASRPATHAWVAELGAHHVIDHGKELQPQLNAVGIDHVDHVISLTHTDTYYAQIVDVLKPEG
QLALIDDPDTLDAMPLKRKSISLHWEFMFTRSMFRTPDMIRQHALLERVASLIDDGVLKSTVGEHLGKIDAANLRRAHAL
IEAGRAKGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=321, Percent_Identity=27.7258566978193, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13236495, Length=321, Percent_Identity=27.7258566978193, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239676, Length=182, Percent_Identity=36.2637362637363, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI47519420, Length=336, Percent_Identity=27.6785714285714, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI24308257, Length=268, Percent_Identity=26.4925373134328, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI28557745, Length=339, Percent_Identity=27.7286135693215, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI18379349, Length=243, Percent_Identity=30.0411522633745, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790485, Length=324, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=178, Percent_Identity=30.3370786516854, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=271, Percent_Identity=32.4723247232472, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=216, Percent_Identity=31.4814814814815, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35783; Mature: 35783

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVYAKAGVPIDDPTALYDTDVPVPAPGPRDLLVKIEAIAVNPVDSKLRLGVQPAGPR
CCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCHHEECCCCCCCE
ILGWDAAGTVEAVGSDVELFEPGDKVWYAGDIARPGSYAEYGLVDERVASRRPATLGAAD
EEECCCCCCHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
AAALPLTAITAWELLFDRLKVAEHGGAGQSLLVIGAGGGVGSILVQFARKLTALTVIGTA
HHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECC
SRPATHAWVAELGAHHVIDHGKELQPQLNAVGIDHVDHVISLTHTDTYYAQIVDVLKPEG
CCCCHHHHHHHHCCHHHHCCCCCCCCCHHEECCHHHHHEEEEECCCHHHHHHHHHHCCCC
QLALIDDPDTLDAMPLKRKSISLHWEFMFTRSMFRTPDMIRQHALLERVASLIDDGVLKS
CEEEECCCCCCCCCCCCCCEEEEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHH
TVGEHLGKIDAANLRRAHALIEAGRAKGKIVLEGF
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MKAIVYAKAGVPIDDPTALYDTDVPVPAPGPRDLLVKIEAIAVNPVDSKLRLGVQPAGPR
CCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCHHEECCCCCCCE
ILGWDAAGTVEAVGSDVELFEPGDKVWYAGDIARPGSYAEYGLVDERVASRRPATLGAAD
EEECCCCCCHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
AAALPLTAITAWELLFDRLKVAEHGGAGQSLLVIGAGGGVGSILVQFARKLTALTVIGTA
HHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECC
SRPATHAWVAELGAHHVIDHGKELQPQLNAVGIDHVDHVISLTHTDTYYAQIVDVLKPEG
CCCCHHHHHHHHCCHHHHCCCCCCCCCHHEECCHHHHHEEEEECCCHHHHHHHHHHCCCC
QLALIDDPDTLDAMPLKRKSISLHWEFMFTRSMFRTPDMIRQHALLERVASLIDDGVLKS
CEEEECCCCCCCCCCCCCCEEEEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHH
TVGEHLGKIDAANLRRAHALIEAGRAKGKIVLEGF
HHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]