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The map label for this gene is sdhA [H]

Identifier: 189184862

GI number: 189184862

Start: 1993097

End: 1994884

Strand: Reverse

Name: sdhA [H]

Synonym: OTT_1955

Alternate gene names: 189184862

Gene position: 1994884-1993097 (Counterclockwise)

Preceding gene: 189184863

Following gene: 189184861

Centisome position: 99.3

GC content: 37.19

Gene sequence:

>1788_bases
GTGAAGGCTTATAAAATTATAAATCATGAATTTGATGTTGTAGTAGTTGGAGCTGGTGGAGCAGGACTAAGGGCTATAGT
TGGTATGGCTGAATCTGGTCTCCGTGCTGCTTGTATTACCAAATTGTTTCCTACTCGTAGTCATACTGTTGCAGCTCAAG
GTGGTATTAGTGCTGCACTAGGTAATATACAACCAGATAAATGGCAATGGCATGCTTATGATACTATTAAAGGATCTGAT
TGGCTTGGAGATCAAGATGCAATTGCTTATATGTGCAAAGAAGCTCCAGCTGCTATTATTGAATTAGAGCATTATGGAGT
CCCATTTTCACGCACAACAGATGGAAAAATTTATCAAAGACCTTTTGGGGGTATGACAACTGAGTTTGGTGATGGTGCGG
CTGCTGTACGAACCTGCGCAGCGGCTGATAGGACTGGTCATGCTATATTACATACTTTATATCAGCAAGCGTTGAAACAT
AAAGCTAAATTTTTCATTGAGTATATAGCTCTTGATTTAATTATGGATAATGGAGCTTGTAAGGGGATAGTTGCTTGGAA
CCTTGACGATGGTACTATTCATTGCTTTAGATCACATATAGTAGTCTTAGCAACTGGAGGGTATGGAAGGGCTTACTTTT
CAGCAACATCAGCCCACAGTTGTACTGGTGATGGAAATGCTATGTGCGCTAGAGCTGGCATAGCTTTACAAGATATGGAA
TTTGTTCAATTTCATCCTACAGGAATTTATGGTGCAGGATGTTTAATCACTGAAGGAGCTAGAGGAGAAGGTGGGTACTT
AGTTAACTCAGAAGGTGAGCGTTTTATGGAAAGATATGCTCCATCAGCCAAAGATCTTGCTTCACGAGATGTAGTTGCAA
GGGCTATGACTATGGAAATCAATGCTGGCCGCGGAGTAGGTATATATAAAGATCATATATTTTTGCATTTAAATCATCTT
GATAGTAAAACGATACAACAAAGGTTACCTGGAATATCTGAAACTGCAATGATCTTTGCTGGAGTTGATGTTACAAAGCA
GCCTATACCAGTAATTCCAACTGTACATTATAATATGGGTGGTATACCAACAAATTATCATGGCCAAGTAGTAACTAAAA
CAGAAAATGGTGATATGGAAATAGTACCTGGATTAATGGCGATTGGAGAAGCTGCTTGCGTATCAGTTCATGGAGCTAAT
AGACTAGGATCCAACTCTCTACTTGATCTAATAATCTTTGGTCGAGCTGCAGCCAATAAAGCAAAAGAAATTATCGCTAT
ATCAACAAAACATCAACCGTTAGGCAATAACATTGTTGATGCTATTATAGAAAGATTTGACCAAACAAGGTTTTTAAATG
GTAATATGCCAATTGCTGAGTTAAGATTAACTATGCAACGTGCTATGCAAAACTATGCTGGAGTATTTCGTAGCTATGAT
AAGTTAACAGAAGGTATGAAAATAATAAAACAAAATTTTAATTCTAGAACAGATATTAAATTAACAGATCATTCACTAAT
TTGGAACACTGATTTAGTTGAGGCAATTGAATTACAAAATTTATTATATCAAGCTGCAATAACTATGTTTTGTGCTGCTA
ACCGTCAAGAAAGCCGAGGAGCCCATGCTCGAGAAGATTACCCTAATAGAGATGATGATAATTGGCTCAAACATACATTA
GCCACAATTGATGAAGAAGGTAACGTAGATATAGATTATAGGAACGTAGTATTAGATCCAAAAGATGATGAAATGATGGC
TATAGTTCCTAAAAAGCGAGTATATTAA

Upstream 100 bases:

>100_bases
TAGTAATAAGTTAAGTTAATATACCAATAAAAGAAATACAGACTTTAAATAGTATATGATGTTTGCAAAATTTGATGTTA
ATTTAATTTTAAAATAAATT

Downstream 100 bases:

>100_bases
CTAGTTATTAGTAAGTAATAAATGAGTTATGCAAATGGTAGAATTTAGATTACCACCAAATTCAAAAGTTAAAGTAGGTA
AGCGCTATGCTGCCAAAGAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAESGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCKEAPAAIIELEHYGVPFSRTTDGKIYQRPFGGMTTEFGDGAAAVRTCAAADRTGHAILHTLYQQALKH
KAKFFIEYIALDLIMDNGACKGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIIAISTKHQPLGNNIVDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRNVVLDPKDDEMMAIVPKKRVY

Sequences:

>Translated_595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAESGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCKEAPAAIIELEHYGVPFSRTTDGKIYQRPFGGMTTEFGDGAAAVRTCAAADRTGHAILHTLYQQALKH
KAKFFIEYIALDLIMDNGACKGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIIAISTKHQPLGNNIVDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRNVVLDPKDDEMMAIVPKKRVY
>Mature_595_residues
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAESGLRAACITKLFPTRSHTVAAQGGISAALGNIQPDKWQWHAYDTIKGSD
WLGDQDAIAYMCKEAPAAIIELEHYGVPFSRTTDGKIYQRPFGGMTTEFGDGAAAVRTCAAADRTGHAILHTLYQQALKH
KAKFFIEYIALDLIMDNGACKGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEINAGRGVGIYKDHIFLHLNHL
DSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMGGIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGAN
RLGSNSLLDLIIFGRAAANKAKEIIAISTKHQPLGNNIVDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRGAHAREDYPNRDDDNWLKHTL
ATIDEEGNVDIDYRNVVLDPKDDEMMAIVPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=605, Percent_Identity=59.1735537190083, Blast_Score=717, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=594, Percent_Identity=53.030303030303, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=39.5147313691508, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1788928, Length=579, Percent_Identity=31.433506044905, Blast_Score=228, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=611, Percent_Identity=61.5384615384615, Blast_Score=743, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=618, Percent_Identity=58.8996763754045, Blast_Score=697, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=63.8190954773869, Blast_Score=782, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=591, Percent_Identity=63.4517766497462, Blast_Score=770, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=59.3137254901961, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=59.3137254901961, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=59.3137254901961, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=55.3921568627451, Blast_Score=676, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65179; Mature: 65179

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAESGLRAACITKLFPTRSHTVAAQGGISAAL
CCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHH
GNIQPDKWQWHAYDTIKGSDWLGDQDAIAYMCKEAPAAIIELEHYGVPFSRTTDGKIYQR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEC
PFGGMTTEFGDGAAAVRTCAAADRTGHAILHTLYQQALKHKAKFFIEYIALDLIMDNGAC
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
KGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
CEEEEEECCCCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCEEECCE
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEI
EEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHEEEEEEE
NAGRGVGIYKDHIFLHLNHLDSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMG
CCCCCCCEEECEEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
GIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGANRLGSNSLLDLIIFGRAAANK
CCCCCCCCEEEEEECCCCEEEECHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCHHHCC
AKEIIAISTKHQPLGNNIVDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRG
HHHHHHHHHHHCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHAREDYPNRDDDNWLKHTLATIDEEGNVDIDYRNVVLDPKDDEMMAIVPKKRVY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKAYKIINHEFDVVVVGAGGAGLRAIVGMAESGLRAACITKLFPTRSHTVAAQGGISAAL
CCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHH
GNIQPDKWQWHAYDTIKGSDWLGDQDAIAYMCKEAPAAIIELEHYGVPFSRTTDGKIYQR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEC
PFGGMTTEFGDGAAAVRTCAAADRTGHAILHTLYQQALKHKAKFFIEYIALDLIMDNGAC
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
KGIVAWNLDDGTIHCFRSHIVVLATGGYGRAYFSATSAHSCTGDGNAMCARAGIALQDME
CEEEEEECCCCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCEEECCE
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVARAMTMEI
EEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHEEEEEEE
NAGRGVGIYKDHIFLHLNHLDSKTIQQRLPGISETAMIFAGVDVTKQPIPVIPTVHYNMG
CCCCCCCEEECEEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
GIPTNYHGQVVTKTENGDMEIVPGLMAIGEAACVSVHGANRLGSNSLLDLIIFGRAAANK
CCCCCCCCEEEEEECCCCEEEECHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCHHHCC
AKEIIAISTKHQPLGNNIVDAIIERFDQTRFLNGNMPIAELRLTMQRAMQNYAGVFRSYD
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KLTEGMKIIKQNFNSRTDIKLTDHSLIWNTDLVEAIELQNLLYQAAITMFCAANRQESRG
HHHHHHHHHHHCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHAREDYPNRDDDNWLKHTLATIDEEGNVDIDYRNVVLDPKDDEMMAIVPKKRVY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA