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The map label for this gene is pepQ [H]

Identifier: 189184846

GI number: 189184846

Start: 1972696

End: 1974468

Strand: Reverse

Name: pepQ [H]

Synonym: OTT_1939

Alternate gene names: 189184846

Gene position: 1974468-1972696 (Counterclockwise)

Preceding gene: 189184847

Following gene: 189184843

Centisome position: 98.28

GC content: 30.17

Gene sequence:

>1773_bases
ATGAAGCATAATGAACAAAGGTTGAAGCAATTAAGGCAAAAATTTTTAGAATTTGGTATCAGTGGATACATTATTCCTTC
CAGTAATGAATATCAAAGTGAATGTGCTCCGAAATATGCTAGAAGATTGGAGTATATTACCGGATTTTCTGGATCATATG
GAATAGCCATAATTACATTAAATAAGGCTATATTATTTACTGATGGTAGATATTTAATTCAAGCAAGTAACCAAGTTGAT
TTGGAGCAATTTCAAATTATGAATATCAAAGATATTTTGACAACAGATTGGTGTAGTATTATTTCAAGTGATACAGATAC
GATTATAGGTTATGATCCTTATCTTTTTAATTTACGTTCAATTAACTACTTTCAGCAGTTAAAATTAAAGACTATATCAC
CAAATTTAATTGACTTGATCTGGAATAACCAGCCTTCTAAACCATCAACTAATGCTTGGATTTACTCAATAGACTATGCA
GGACAAACAATTCAGGATAAAATTTCTAAGTTATTTATTGAGCTTAAAAATAAAAATGTTGATGGATATTTTATTACTGA
TTCTACATCAATATGCTGGTTGCTTAATCTTAGGGCATATGATACCGAATTTACACCTTTAATGCTATCATACGCTTACC
TAGATTCTAAGAATCAATCAGTGTATCTTTTTACAAATTTAGAACGTTTGAATCAATCAGTAAAGCAACACCTTAATCAA
GGATATCAAACTATTAAATTATATTCAGAAACTGATATTAATGTTATATTGAAGCAGATTACAAATAAAATTCTTGTTAG
TGAAAGCTGTCCTATAGGCTTTTTATCAGCAATTAACAACAAACAAGTTGTTAAGCAGCAACATGATTTGTGTTCAACAA
TGAAAGCTTGTAAAAATCAAGTTGAAATTGCTACTGCTAAGCAATGCCATATCAATGATGCAGTAGCAGTATGCGAATTT
TTTGCTTGGTTAGATAATATAGTTACTCAACATAAGCTTGAATCAATAAATATTACCGAATACAGTTTAAGCAAAATGCT
TACTAGTTTTCGTAAAAAACAGCCAAATTATATTTGTAATAGCTTTGATAGCATATGTGGCTTTAATGAAAATAGTGCTA
TTATACATTATCAACCAACAGATCAATCTGCAAAGTTAATCAAAGGCAATGGAATTCTATTAGTAGATTCTGGAGGACAA
TATCTCGGCGGTACTACTGATATTACTCGTACAATAGTAATTGGACAAGCAACTCAGTTACAAAAGGAGAGGTATACTTT
GATTCTAAAAGGACATATATCTTTACTAAACAGTGTTTTCCCTTGTGGAACAGTAGGAAGTAATCTAGATGTTATTGCTA
GAAGAAATTTATGGCATCATGGCCTTGATTATCCTCATGGTACTGGACATGGAGTTAGTAATTGTCTTAGTGTTCACGAA
GGCCCTCAATATATTGGACAATATAATAACGATGTAGCATTAGCTGAAGGTATGATACTTTCAAATGAACCAGGGTACTA
TGAAGAAGGTAACTATGGTATTAGAATAGAAAATCTTATGTTTGTTAAAAATTCAAAATATGAAGGATTTTTAGAATTTG
AGACCTTAACGCTTATTCCATATTGCAGTGATCTTATTTTAACCTCACTACTAACTAACGAAGAAAAAGAATATATTCAT
CATTATTATCAAAGAATAAATAATCAAGTAAAGCCACTTCTTAGTGATAAAGCAAAAATTTGGCTTGAAAAGCATGTAAG
TATGAATATTTGA

Upstream 100 bases:

>100_bases
TGGTAGTAGGTAACAAAGCTGGAAACAAGCTACAGAAAGCTCAGCAACTAGGAATCAAAATTATTAATGAAGAAGAATGG
ATCAAAATGGTTAATGAATT

Downstream 100 bases:

>100_bases
GAACATTGTTTAACTAAATATTAGGTAGTGTAACAAACATCTAATCTTATAATAAAAGCATAAGTTTGATAAATTGATAC
ATCAGAGAGTAGCAAGAAAG

Product: aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIMNIKDILTTDWCSIISSDTDTIIGYDPYLFNLRSINYFQQLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNLRAYDTEFTPLMLSYAYLDSKNQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKQITNKILVSESCPIGFLSAINNKQVVKQQHDLCSTMKACKNQVEIATAKQCHINDAVAVCEF
FAWLDNIVTQHKLESINITEYSLSKMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTDQSAKLIKGNGILLVDSGGQ
YLGGTTDITRTIVIGQATQLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQYIGQYNNDVALAEGMILSNEPGYYEEGNYGIRIENLMFVKNSKYEGFLEFETLTLIPYCSDLILTSLLTNEEKEYIH
HYYQRINNQVKPLLSDKAKIWLEKHVSMNI

Sequences:

>Translated_590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIMNIKDILTTDWCSIISSDTDTIIGYDPYLFNLRSINYFQQLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNLRAYDTEFTPLMLSYAYLDSKNQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKQITNKILVSESCPIGFLSAINNKQVVKQQHDLCSTMKACKNQVEIATAKQCHINDAVAVCEF
FAWLDNIVTQHKLESINITEYSLSKMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTDQSAKLIKGNGILLVDSGGQ
YLGGTTDITRTIVIGQATQLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQYIGQYNNDVALAEGMILSNEPGYYEEGNYGIRIENLMFVKNSKYEGFLEFETLTLIPYCSDLILTSLLTNEEKEYIH
HYYQRINNQVKPLLSDKAKIWLEKHVSMNI
>Mature_590_residues
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITLNKAILFTDGRYLIQASNQVD
LEQFQIMNIKDILTTDWCSIISSDTDTIIGYDPYLFNLRSINYFQQLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYA
GQTIQDKISKLFIELKNKNVDGYFITDSTSICWLLNLRAYDTEFTPLMLSYAYLDSKNQSVYLFTNLERLNQSVKQHLNQ
GYQTIKLYSETDINVILKQITNKILVSESCPIGFLSAINNKQVVKQQHDLCSTMKACKNQVEIATAKQCHINDAVAVCEF
FAWLDNIVTQHKLESINITEYSLSKMLTSFRKKQPNYICNSFDSICGFNENSAIIHYQPTDQSAKLIKGNGILLVDSGGQ
YLGGTTDITRTIVIGQATQLQKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
GPQYIGQYNNDVALAEGMILSNEPGYYEEGNYGIRIENLMFVKNSKYEGFLEFETLTLIPYCSDLILTSLLTNEEKEYIH
HYYQRINNQVKPLLSDKAKIWLEKHVSMNI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=598, Percent_Identity=35.61872909699, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI93141226, Length=613, Percent_Identity=33.278955954323, Blast_Score=332, Evalue=9e-91,
Organism=Homo sapiens, GI264681565, Length=598, Percent_Identity=34.4481605351171, Blast_Score=322, Evalue=6e-88,
Organism=Escherichia coli, GI1788728, Length=199, Percent_Identity=26.6331658291457, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=589, Percent_Identity=32.427843803056, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI25149105, Length=595, Percent_Identity=28.4033613445378, Blast_Score=228, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322999, Length=647, Percent_Identity=33.3848531684699, Blast_Score=327, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17137632, Length=616, Percent_Identity=33.7662337662338, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI161078230, Length=603, Percent_Identity=28.1923714759536, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21357287, Length=603, Percent_Identity=28.1923714759536, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67353; Mature: 67353

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NKAILFTDGRYLIQASNQVDLEQFQIMNIKDILTTDWCSIISSDTDTIIGYDPYLFNLRS
CEEEEEECCEEEEEECCCCCHHHHEECCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEC
INYFQQLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYAGQTIQDKISKLFIELKNKNV
CCHHHHEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEECCCC
DGYFITDSTSICWLLNLRAYDTEFTPLMLSYAYLDSKNQSVYLFTNLERLNQSVKQHLNQ
CEEEEECCCCEEEEEEEEECCCCCCHHHEEEEEECCCCCEEEEEECHHHHHHHHHHHHHC
GYQTIKLYSETDINVILKQITNKILVSESCPIGFLSAINNKQVVKQQHDLCSTMKACKNQ
CCEEEEEECCCCHHHHHHHHHHHEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
VEIATAKQCHINDAVAVCEFFAWLDNIVTQHKLESINITEYSLSKMLTSFRKKQPNYICN
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHH
SFDSICGFNENSAIIHYQPTDQSAKLIKGNGILLVDSGGQYLGGTTDITRTIVIGQATQL
CHHHHCCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCCCCCCCCCCEEEEEECCHHHH
QKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
CCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHCC
GPQYIGQYNNDVALAEGMILSNEPGYYEEGNYGIRIENLMFVKNSKYEGFLEFETLTLIP
CHHHHCCCCCCEEEECCEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEEEECH
YCSDLILTSLLTNEEKEYIHHYYQRINNQVKPLLSDKAKIWLEKHVSMNI
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHCCHHHHHEECCCCCCC
>Mature Secondary Structure
MKHNEQRLKQLRQKFLEFGISGYIIPSSNEYQSECAPKYARRLEYITGFSGSYGIAIITL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NKAILFTDGRYLIQASNQVDLEQFQIMNIKDILTTDWCSIISSDTDTIIGYDPYLFNLRS
CEEEEEECCEEEEEECCCCCHHHHEECCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEC
INYFQQLKLKTISPNLIDLIWNNQPSKPSTNAWIYSIDYAGQTIQDKISKLFIELKNKNV
CCHHHHEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEECCCC
DGYFITDSTSICWLLNLRAYDTEFTPLMLSYAYLDSKNQSVYLFTNLERLNQSVKQHLNQ
CEEEEECCCCEEEEEEEEECCCCCCHHHEEEEEECCCCCEEEEEECHHHHHHHHHHHHHC
GYQTIKLYSETDINVILKQITNKILVSESCPIGFLSAINNKQVVKQQHDLCSTMKACKNQ
CCEEEEEECCCCHHHHHHHHHHHEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
VEIATAKQCHINDAVAVCEFFAWLDNIVTQHKLESINITEYSLSKMLTSFRKKQPNYICN
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHH
SFDSICGFNENSAIIHYQPTDQSAKLIKGNGILLVDSGGQYLGGTTDITRTIVIGQATQL
CHHHHCCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCCCCCCCCCCEEEEEECCHHHH
QKERYTLILKGHISLLNSVFPCGTVGSNLDVIARRNLWHHGLDYPHGTGHGVSNCLSVHE
CCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHCC
GPQYIGQYNNDVALAEGMILSNEPGYYEEGNYGIRIENLMFVKNSKYEGFLEFETLTLIP
CHHHHCCCCCCEEEECCEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEEEECH
YCSDLILTSLLTNEEKEYIHHYYQRINNQVKPLLSDKAKIWLEKHVSMNI
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHCCHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]