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The map label for this gene is lon

Identifier: 189184535

GI number: 189184535

Start: 1654661

End: 1657033

Strand: Reverse

Name: lon

Synonym: OTT_1628

Alternate gene names: 189184535

Gene position: 1657033-1654661 (Counterclockwise)

Preceding gene: 189184537

Following gene: 189184531

Centisome position: 82.48

GC content: 31.65

Gene sequence:

>2373_bases
GTGGCACAAGTTTTAAATGATATTAGCAATCGTGTTTTACCATTATTTCCAATAAGAAACACAGTATTATTTCCTGGGCT
AGTATTGCCTATATTAATTGGCAGAGATGATTCGGTTAAAAATTTGCTAAGATTAGGCAATGATTCTGAGAATCAGCATA
CTATCTTGCTTACTACTCAAAAAAATGCTGATGATATAAAACCTTCAATAAATTCTTTATATAAAATTGGAGTATTGGCA
AAAATAACTGAGCTAGTTCAATTGCCTAATGACAATTATAAAATCTTGATAAAAGTATTAGATCGAGTCAAACTGACAAT
AAGACGCTCGCATGACCTTTTAGTAGCTGAATATGTAATTGTTCCAGATGATGAAATTAATAATGCTGATGAAATAAAAG
ATAAGTTAGCAAATGCAATTGTTCTCTTTAATAAATATATTAGGTTAAGTAAAAAAATTAACCCAGACTTGTTAGTTCAT
GTTTTATCGTACACTAATCAAAGCTATGTAGTTAACGCTTTAGCTGCAAATTTAATTTGCAATGTTGCTAACAAGCAATC
TTTATTAGAAATAACTGATGTTAAACAAAGGATAGAAAGGCTAACTGATCATGTTGCCAAAGAAATCATTATAATGGAAA
CAGATGAATTGATTACTTCGAAGGCGCAGAAAAATCTAGAAAAAATGCAGCGTGATTGCTTTCTTAATGAAAAGATGAAA
ATAATTAAAAACGTTTTAGGAGTAGATGATGAAAAATCTGATATTGCTGAACTGCAAAAGAAAATCGATACTCTTCACCT
TTCAAAAGAAGCTAAAGCTAAAGCGGAAAGTGAGTTAAAAAAATTAAAGATGATGAATCCAATTTCTGCTGAAGCTGCGT
TGACACGTAATTATTTAGATATTCTTCTAGGGTTACCATGGAAAAAAGAAAAAGAAAGTAAGATTAACATTAATATTGAC
AAGGCTTTACAAGATTTGAATGCAGATCATCATGGACTAGAAAAAGTCAAGGAAAGAATAACTGAATATTTAGCAGTACT
GCAAAGGACTAAAAAATCTATAGGAACAATCTTATGTTTTATTGGTCCACCTGGAGTAGGAAAAACATCTTTAGTAAAAT
CTATTGCAGAAGCTACAAAATGTAAATATGCAAAATTTGCTCTAGGTGGAGTGAGAGATGAAGCAGAAATTCGTGGCCAC
AGAAAAACTTATATTGGGGCAATGCCAGGTAAAATTATTTCTTTAATAAAAAGGGAAAATAGTAATAATCTTGTCATATT
ACTAGATGAAATTGATAAGATTTCTAGAGATTCTAGAGGTGATCCAGCATTTGCTTTATTAGAAGTATTAGATCCAGAGC
AAAATAGCCGCTTTCAAGATAATTACCTAGAAGTAGAGTATGATCTTTCAAAAGTACTTTTTATTGCTACTGCTAACAGT
TTTAATTTTCCTATTCCTTTGCGTGATCGTATGGAAATTATTCAAATTCCTGGGTATGTCGAAGGTGAAAAATTAGAAAT
AGCTAAACATCACCTCATTCCTAAACAGATCAAAAATAACGGCTTAAAAAATACTGAAATCAGTTTTTCAGATGAAGCAA
TATTAGAGTTAATAAGATATTATACACGAGAAGCTGGAGTTAGAGGTCTAGAAAGAAAGATCGGAGGAATATGCCGTAAG
GTGCTTAAGAAAATTTTAAGTTCTAAAGATATAAAATCAGAAAGTGTTAGCAAAGAAAATATTAAAGATTATCTTGGATC
TAGGAAATATAAGTATGGGCTTGCTGAAGATGATAATCAAGTAGGCATTACTATTGGATTAGCTTATACTGAAACAGGTG
GGGATTTGATTTGGGTTGAAGCAGTAATGATACCTGGCAAAGGAAAAGTTAAAGCTACAGGTAAGTTAGGTGATGTGATG
AAAGAATCAAGCCAAACTGCATTTAGCTATTTTTGCTCTAGAGCACAAAAATATAATGTAAAGTATGAGCAATATCATAA
GTATGATATTCATATTCATTTTCCTGAAGGAGCTATCCCTAAAGACGGACCTTCTGCAGGTATAGCTATTTTTACTACAA
TAGTTTCCTTAATGACAGGTATACCTGTCAAGCTTTCAGTAGCAATGACTGGTGAAATTACTTTAAGAGGACGAATATTA
CCTATTGGTGGACTAAAAGAAAAGTTAATGGCAGCAAAACGAGGAGGAATTAAAACAGTAATTATTCCAGAAGGAAATAC
TAGTGATTTAGAAGATATACCTAATAGTATTAAAAATGATTTAGATATTATTCCATTATCAGAAGCCGATCAAGTACTAG
ATATTGCTTTGGCTACTACAGTAACCAATTCGCCTGCAGAAACAGCTTGTTAG

Upstream 100 bases:

>100_bases
CTATGCAAAATATTCATACGTAAAATAATTGATTTTAATTATCTGTGTGATTATATAGATTATCATGATATACTAGTAAA
TAAAAATTTAATTATATTTA

Downstream 100 bases:

>100_bases
TATTTGTTAATTTCTCTATAAAATAGAAAGCAAATTAGAATATATCTTTAAAGCCTTTGAATACTACTTAAGTAGTTCTT
TGAGTAATGGAATGGTGATA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLA
KITELVQLPNDNYKILIKVLDRVKLTIRRSHDLLVAEYVIVPDDEINNADEIKDKLANAIVLFNKYIRLSKKINPDLLVH
VLSYTNQSYVVNALAANLICNVANKQSLLEITDVKQRIERLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININID
KALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGH
RKTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEVLDPEQNSRFQDNYLEVEYDLSKVLFIATANS
FNFPIPLRDRMEIIQIPGYVEGEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERKIGGICRK
VLKKILSSKDIKSESVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKVKATGKLGDVM
KESSQTAFSYFCSRAQKYNVKYEQYHKYDIHIHFPEGAIPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKNDLDIIPLSEADQVLDIALATTVTNSPAETAC

Sequences:

>Translated_790_residues
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLA
KITELVQLPNDNYKILIKVLDRVKLTIRRSHDLLVAEYVIVPDDEINNADEIKDKLANAIVLFNKYIRLSKKINPDLLVH
VLSYTNQSYVVNALAANLICNVANKQSLLEITDVKQRIERLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININID
KALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGH
RKTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEVLDPEQNSRFQDNYLEVEYDLSKVLFIATANS
FNFPIPLRDRMEIIQIPGYVEGEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERKIGGICRK
VLKKILSSKDIKSESVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKVKATGKLGDVM
KESSQTAFSYFCSRAQKYNVKYEQYHKYDIHIHFPEGAIPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKNDLDIIPLSEADQVLDIALATTVTNSPAETAC
>Mature_789_residues
AQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLAK
ITELVQLPNDNYKILIKVLDRVKLTIRRSHDLLVAEYVIVPDDEINNADEIKDKLANAIVLFNKYIRLSKKINPDLLVHV
LSYTNQSYVVNALAANLICNVANKQSLLEITDVKQRIERLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMKI
IKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININIDK
ALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHR
KTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEVLDPEQNSRFQDNYLEVEYDLSKVLFIATANSF
NFPIPLRDRMEIIQIPGYVEGEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERKIGGICRKV
LKKILSSKDIKSESVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKVKATGKLGDVMK
ESSQTAFSYFCSRAQKYNVKYEQYHKYDIHIHFPEGAIPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRILP
IGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKNDLDIIPLSEADQVLDIALATTVTNSPAETAC

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=847, Percent_Identity=38.0165289256198, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI21396489, Length=832, Percent_Identity=34.8557692307692, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=49.4845360824742, Blast_Score=740, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=687, Percent_Identity=39.3013100436681, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17556486, Length=529, Percent_Identity=39.6975425330813, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319449, Length=652, Percent_Identity=40.1840490797546, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24666867, Length=636, Percent_Identity=41.1949685534591, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI221513036, Length=636, Percent_Identity=41.1949685534591, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_ORITI (B3CUN9)

Other databases:

- EMBL:   AP008981
- RefSeq:   YP_001938320.1
- MEROPS:   S16.001
- GeneID:   6337849
- GenomeReviews:   AP008981_GR
- KEGG:   ott:OTT_1628
- HOGENOM:   HBG566281
- OMA:   HTFQDHY
- ProtClustDB:   CLSK2538555
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 88223; Mature: 88091

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 685-685 ACT_SITE 728-728

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQ
CHHHHHHHHCCCEEEEECCCHHHCCHHHHHHEECCCHHHHHHHHCCCCCCCCEEEEEEEC
KNADDIKPSINSLYKIGVLAKITELVQLPNDNYKILIKVLDRVKLTIRRSHDLLVAEYVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VPDDEINNADEIKDKLANAIVLFNKYIRLSKKINPDLLVHVLSYTNQSYVVNALAANLIC
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
NVANKQSLLEITDVKQRIERLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
HCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILLGLPWKKEKESKININIDKALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCF
HHHCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHRKTYIGAMPGKIISLIKREN
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHCCC
SNNLVILLDEIDKISRDSRGDPAFALLEVLDPEQNSRFQDNYLEVEYDLSKVLFIATANS
CCCEEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEECCC
FNFPIPLRDRMEIIQIPGYVEGEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRY
CCCCCCCCCCCCEEECCCCCCCCEEHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
YTREAGVRGLERKIGGICRKVLKKILSSKDIKSESVSKENIKDYLGSRKYKYGLAEDDNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCEECCCCCCCCC
VGITIGLAYTETGGDLIWVEAVMIPGKGKVKATGKLGDVMKESSQTAFSYFCSRAQKYNV
EEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYEQYHKYDIHIHFPEGAIPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
CHHHEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEE
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKNDLDIIPLSEADQVLDIALATT
ECCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
VTNSPAETAC
CCCCCCCCCC
>Mature Secondary Structure 
AQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQ
HHHHHHHHCCCEEEEECCCHHHCCHHHHHHEECCCHHHHHHHHCCCCCCCCEEEEEEEC
KNADDIKPSINSLYKIGVLAKITELVQLPNDNYKILIKVLDRVKLTIRRSHDLLVAEYVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VPDDEINNADEIKDKLANAIVLFNKYIRLSKKINPDLLVHVLSYTNQSYVVNALAANLIC
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
NVANKQSLLEITDVKQRIERLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
HCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILLGLPWKKEKESKININIDKALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCF
HHHCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHRKTYIGAMPGKIISLIKREN
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHCCC
SNNLVILLDEIDKISRDSRGDPAFALLEVLDPEQNSRFQDNYLEVEYDLSKVLFIATANS
CCCEEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEECCC
FNFPIPLRDRMEIIQIPGYVEGEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRY
CCCCCCCCCCCCEEECCCCCCCCEEHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
YTREAGVRGLERKIGGICRKVLKKILSSKDIKSESVSKENIKDYLGSRKYKYGLAEDDNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCEECCCCCCCCC
VGITIGLAYTETGGDLIWVEAVMIPGKGKVKATGKLGDVMKESSQTAFSYFCSRAQKYNV
EEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYEQYHKYDIHIHFPEGAIPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
CHHHEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEE
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKNDLDIIPLSEADQVLDIALATT
ECCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
VTNSPAETAC
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA