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The map label for this gene is acnA [H]

Identifier: 189183634

GI number: 189183634

Start: 752263

End: 752604

Strand: Direct

Name: acnA [H]

Synonym: OTT_0727

Alternate gene names: 189183634

Gene position: 752263-752604 (Clockwise)

Preceding gene: 189183628

Following gene: 189183635

Centisome position: 37.44

GC content: 30.99

Gene sequence:

>342_bases
GTGAAATTGAATTTATGCCAGGTAGAATTAATGCAGGATTATACAGGTGTTCCATCATTAGTAGACTTAGGTTCTATGCG
TGATACTGTAGCACATACTGGTGGAGATATAAATAAAATTAATCCGTTAATTCCAATTGATTTGATTATTGATCACTCTA
TACAAGTAGATGTTTATGGTACAAACTATGCTAAACAAAAAAACACTGAATTAAAAATTAAACGCAACATTGAAAGATAT
GAATTTTTAAGATGGAGAGCTAATGCGTTTCAAAATTTTCGTCTTTTTCTACCCGGAACTGGTATTTGTCATCAAGTTAA
CCTAGAATATCTTAGAAAGTAG

Upstream 100 bases:

>100_bases
CTTTTGAAAAATATCTTAAGACACAGCCATAATAATAACAATGTAATAGAAACTATTAACAGTTTTTCAAATTGGATAGC
GAACCCTAAAGCAGTTAAAA

Downstream 100 bases:

>100_bases
TATGGACTTAACAATATTAATGGTCAGCTTTATGCTTATCCTGATACCTTAGTTGGGCTAGATAGTCATACAACTATGGC
TAATGGATTAGGTGCGCTTT

Product: aconitate hydratase

Products: NA

Alternate protein names: Aconitase; Citrate hydro-lyase [H]

Number of amino acids: Translated: 113; Mature: 113

Protein sequence:

>113_residues
MKLNLCQVELMQDYTGVPSLVDLGSMRDTVAHTGGDINKINPLIPIDLIIDHSIQVDVYGTNYAKQKNTELKIKRNIERY
EFLRWRANAFQNFRLFLPGTGICHQVNLEYLRK

Sequences:

>Translated_113_residues
MKLNLCQVELMQDYTGVPSLVDLGSMRDTVAHTGGDINKINPLIPIDLIIDHSIQVDVYGTNYAKQKNTELKIKRNIERY
EFLRWRANAFQNFRLFLPGTGICHQVNLEYLRK
>Mature_113_residues
MKLNLCQVELMQDYTGVPSLVDLGSMRDTVAHTGGDINKINPLIPIDLIIDHSIQVDVYGTNYAKQKNTELKIKRNIERY
EFLRWRANAFQNFRLFLPGTGICHQVNLEYLRK

Specific function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate [H]

COG id: COG1048

COG function: function code C; Aconitase A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aconitase/IPM isomerase family [H]

Homologues:

Organism=Homo sapiens, GI8659555, Length=104, Percent_Identity=55.7692307692308, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787531, Length=104, Percent_Identity=57.6923076923077, Blast_Score=137, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17568399, Length=104, Percent_Identity=53.8461538461538, Blast_Score=128, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24645686, Length=104, Percent_Identity=53.8461538461538, Blast_Score=124, Evalue=8e-30,
Organism=Drosophila melanogaster, GI17137564, Length=104, Percent_Identity=52.8846153846154, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015931
- InterPro:   IPR015937
- InterPro:   IPR001030
- InterPro:   IPR015928
- InterPro:   IPR006249
- InterPro:   IPR015934
- InterPro:   IPR015932
- InterPro:   IPR018136
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00330 Aconitase; PF00694 Aconitase_C [H]

EC number: =4.2.1.3 [H]

Molecular weight: Translated: 13094; Mature: 13094

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNLCQVELMQDYTGVPSLVDLGSMRDTVAHTGGDINKINPLIPIDLIIDHSIQVDVYG
CCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEEC
TNYAKQKNTELKIKRNIERYEFLRWRANAFQNFRLFLPGTGICHQVNLEYLRK
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCEEECCHHHHCC
>Mature Secondary Structure
MKLNLCQVELMQDYTGVPSLVDLGSMRDTVAHTGGDINKINPLIPIDLIIDHSIQVDVYG
CCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEEC
TNYAKQKNTELKIKRNIERYEFLRWRANAFQNFRLFLPGTGICHQVNLEYLRK
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA