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The map label for this gene is hemH [H]

Identifier: 189183423

GI number: 189183423

Start: 542061

End: 543095

Strand: Direct

Name: hemH [H]

Synonym: OTT_0516

Alternate gene names: 189183423

Gene position: 542061-543095 (Clockwise)

Preceding gene: 189183422

Following gene: 189183424

Centisome position: 26.98

GC content: 27.05

Gene sequence:

>1035_bases
GTGAGTAACGAAAAAAAGATAGCAATAGTTCTACTAAACCTTGGAGGACCAGATAAAATTGAATCTGTTAAACAGTTTTT
GTTTAATTTGTTTTATGATAAACATATAGTTCAACTTCCTAATCCATTTAGATTCTTAGTCGCTAAAATAATAGCATCAG
TAAGAAACAAGTCTTCACAAAAAATTTATAATAAAATTGGAGGTAAATCTCCAATTTTATTTCAAACAACTTTACAAGCT
GAAGCACTAAGAATTAAGCTAAAAAATAAGTTACTTCATCCATATAAGATTTTTATAGCTATGCGTTATTGGAATCCATT
GATTCACGAAATAGTTTCACAAATAAAAGAATATCAACCAAGCAAAGTTATATTGTTACCACTATATCCTCAGTTTTCTA
CTAGTACTACATTATCTGCAATAGAGGAATTTAAAAATAGTTTATTAAAGAATAAATTTAGTTGTTTAGTTAAAACTGTT
TGTTGCTATCCAGTTAACAAAGGATTAGTAAATGGATACTCAAGTATAATAAAAAACTGCACTAATGATTTTTCTAATAC
TGTTTTGTTGTTTTCTGCACATGGACTACCAAAAAAATTTATTACTCAAGGAGATCCATATCAGTGGCAAATTGAAAATT
CAGTAAAGTCAATTATTAAAAAACTAAATGTAAAAGGATTACATTGGAAAATATCTTACCAAAGTAAAATAGGACCATTA
AAATGGCTAGAGCCTGATACGAAATCTGAAATTATTTGTGCAGCTAAAAGTAAAAAAAATATTATAATTGTACCTATAAG
TTTTGTATCTGAACATGTAGAAACTTTAGTTGAGCTTGATATAGATTACTCTAGTATTGCTAAACATTATGGAGTTAGTT
ATTGCAGAGCTGAAACTGTAGGCGTAAATGATTTATTCATAAATGGAATAGCAGATATAATACTAAAAGCTATTAATAGT
AATGATGACGTTATTTCAGGAAATTGTGATAAAATATGCCCACAAAAATTTATACAGTGTATATATAAAAGATAG

Upstream 100 bases:

>100_bases
AACAATAGATTTATTTTTAATTTAGGTCATGGTATTCTACCAGAAACTCCAATAAAAAATGTTGAGTTAATAGTTAAACT
AGTAAAAAACTACCATTCAA

Downstream 100 bases:

>100_bases
GTAACAAAATGCAAAACTATTATGATTATTTTAAATCTATACATATTATATCAGTAATTTTCTGGATGGCTGGAATGTTA
TATCTTCCTAGATTATATGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSNEKKIAIVLLNLGGPDKIESVKQFLFNLFYDKHIVQLPNPFRFLVAKIIASVRNKSSQKIYNKIGGKSPILFQTTLQA
EALRIKLKNKLLHPYKIFIAMRYWNPLIHEIVSQIKEYQPSKVILLPLYPQFSTSTTLSAIEEFKNSLLKNKFSCLVKTV
CCYPVNKGLVNGYSSIIKNCTNDFSNTVLLFSAHGLPKKFITQGDPYQWQIENSVKSIIKKLNVKGLHWKISYQSKIGPL
KWLEPDTKSEIICAAKSKKNIIIVPISFVSEHVETLVELDIDYSSIAKHYGVSYCRAETVGVNDLFINGIADIILKAINS
NDDVISGNCDKICPQKFIQCIYKR

Sequences:

>Translated_344_residues
MSNEKKIAIVLLNLGGPDKIESVKQFLFNLFYDKHIVQLPNPFRFLVAKIIASVRNKSSQKIYNKIGGKSPILFQTTLQA
EALRIKLKNKLLHPYKIFIAMRYWNPLIHEIVSQIKEYQPSKVILLPLYPQFSTSTTLSAIEEFKNSLLKNKFSCLVKTV
CCYPVNKGLVNGYSSIIKNCTNDFSNTVLLFSAHGLPKKFITQGDPYQWQIENSVKSIIKKLNVKGLHWKISYQSKIGPL
KWLEPDTKSEIICAAKSKKNIIIVPISFVSEHVETLVELDIDYSSIAKHYGVSYCRAETVGVNDLFINGIADIILKAINS
NDDVISGNCDKICPQKFIQCIYKR
>Mature_343_residues
SNEKKIAIVLLNLGGPDKIESVKQFLFNLFYDKHIVQLPNPFRFLVAKIIASVRNKSSQKIYNKIGGKSPILFQTTLQAE
ALRIKLKNKLLHPYKIFIAMRYWNPLIHEIVSQIKEYQPSKVILLPLYPQFSTSTTLSAIEEFKNSLLKNKFSCLVKTVC
CYPVNKGLVNGYSSIIKNCTNDFSNTVLLFSAHGLPKKFITQGDPYQWQIENSVKSIIKKLNVKGLHWKISYQSKIGPLK
WLEPDTKSEIICAAKSKKNIIIVPISFVSEHVETLVELDIDYSSIAKHYGVSYCRAETVGVNDLFINGIADIILKAINSN
DDVISGNCDKICPQKFIQCIYKR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=332, Percent_Identity=35.5421686746988, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI60499021, Length=332, Percent_Identity=35.5421686746988, Blast_Score=175, Evalue=7e-44,
Organism=Escherichia coli, GI1786681, Length=284, Percent_Identity=24.6478873239437, Blast_Score=91, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=32.7327327327327, Blast_Score=169, Evalue=7e-43,
Organism=Drosophila melanogaster, GI17864156, Length=337, Percent_Identity=33.8278931750742, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=31.8007662835249, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45552018, Length=143, Percent_Identity=39.8601398601399, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39065; Mature: 38934

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEKKIAIVLLNLGGPDKIESVKQFLFNLFYDKHIVQLPNPFRFLVAKIIASVRNKSSQ
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHCCHHH
KIYNKIGGKSPILFQTTLQAEALRIKLKNKLLHPYKIFIAMRYWNPLIHEIVSQIKEYQP
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCC
SKVILLPLYPQFSTSTTLSAIEEFKNSLLKNKFSCLVKTVCCYPVNKGLVNGYSSIIKNC
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TNDFSNTVLLFSAHGLPKKFITQGDPYQWQIENSVKSIIKKLNVKGLHWKISYQSKIGPL
HHHCCCEEEEEECCCCCHHHCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEEECCCCCCC
KWLEPDTKSEIICAAKSKKNIIIVPISFVSEHVETLVELDIDYSSIAKHYGVSYCRAETV
CCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCC
GVNDLFINGIADIILKAINSNDDVISGNCDKICPQKFIQCIYKR
CCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNEKKIAIVLLNLGGPDKIESVKQFLFNLFYDKHIVQLPNPFRFLVAKIIASVRNKSSQ
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHCCHHH
KIYNKIGGKSPILFQTTLQAEALRIKLKNKLLHPYKIFIAMRYWNPLIHEIVSQIKEYQP
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHCCC
SKVILLPLYPQFSTSTTLSAIEEFKNSLLKNKFSCLVKTVCCYPVNKGLVNGYSSIIKNC
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TNDFSNTVLLFSAHGLPKKFITQGDPYQWQIENSVKSIIKKLNVKGLHWKISYQSKIGPL
HHHCCCEEEEEECCCCCHHHCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEEECCCCCCC
KWLEPDTKSEIICAAKSKKNIIIVPISFVSEHVETLVELDIDYSSIAKHYGVSYCRAETV
CCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCC
GVNDLFINGIADIILKAINSNDDVISGNCDKICPQKFIQCIYKR
CCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA