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The map label for this gene is serS [H]

Identifier: 189183335

GI number: 189183335

Start: 444278

End: 445567

Strand: Direct

Name: serS [H]

Synonym: OTT_0428

Alternate gene names: 189183335

Gene position: 444278-445567 (Clockwise)

Preceding gene: 189183334

Following gene: 189183337

Centisome position: 22.11

GC content: 31.32

Gene sequence:

>1290_bases
ATGCTGGACATAAAATGGATTAGAGCAAACCCAGATAAACTTGATGAATCACTAAGCAAACGAGGAATCGATTCAGTATC
TAAATCAATAATACATATTGATTCAGAAAAAAGAACATTAATATCTCTAATTCAGAAATTACAGCATGAAAGAAAAGAAA
AATCTAGTAGTGTAGCACATATTTATGACAAATCAAGTACTGATTTTGAAGAAATACAAAACGATGTTAAGCTGATCAAT
CAAAAGATAACTGAATTAGAAACTTCATTATTGCATCATGAAAAAAGGTTATCTGAGATTATGGATAACCTTCCTAATTT
AGTAGCTGATGATGTACCTTATGGTACTAATAGTGATATGAATAAAGTGCTTAAAGAATGTGGCACAATTCAAAATATCA
AATTCCCAAAACATCATTATGAAATTGGAAAAAATTTAGGAATGATGGATTTTAATACAGCTACTAAGATGTCAGGAAGT
AGGTTTGTAATTTTAAAACATGATCTTGCGAAACTTGAAAGAGCTTTAATCAATTTTATGATTGATGTACATACTACTGA
GTTTAATTTTTTTGAAGTTTCTCCGCCATGCTTAGTTAAGGATCATGCTATGTATAATGTTGGCCAACTACCTAAATTTG
CTGATGCATCATTTGAGACTACAACTGGATATAGATTGATACCTACTGCAGAAGTGCCATTAACTAATATTTTTGCTAAT
ACTACTTTATTAGAAGAAAAATTACCAATAAGATTGGTAGCGTTTACTCCTTGCTTTAGATCAGAAGTAGGAAGCGCTGG
TAAAGACGTTAAAGGTATGTTGCGAATGCATCAATTTGGCAAAGTAGAGCTTTTTACTATCGCTACACCTAAAGAATCAA
ATAGAGAATTTGAGTATCTTACTGCTGCTGCTGAAAAAATTCTAGAGAAATTAGGGTTACCATATAGAGTAGTATTATTA
TGTAGCGGTGATATAGGATTTGCAGCTCATAAAACATATGATCTTGAAGTGTGGTTACCAGCACAAAATTGTTATAGAGA
AATTTCAAGCTGTTCACATTTTAGTTCTTTTCAAGCTAGAAGATCACTAAGTAAATATAGAGAACTTTGCTCTAAAAAAG
TTAATTTTCTACATACAATCAATGGATCCGGACTTGCTGTTGGAAGAACTATAATTGCTATTCTAGAAAATTATCAAAAT
TCAGATGGATCAGTTACAATTCCTGAAAAGCTTAGGAATTACATGGGAGGACAGAAACTGATTACACCTTTAACAGAAAC
AGTATTTTGA

Upstream 100 bases:

>100_bases
ACTCCACCAGATATTCTCAGTCAGTTTGCTCTTGCAACTCCATTGATTTTGTTATATGAGGCTTCTATAATAATATGTAA
AATTTTAAAATTGAGGACAA

Downstream 100 bases:

>100_bases
TTTACTGTAAATTGTCCTTTATTTTAGTTACCATCTTGTATAAATCAGATTTATTATAAAGTTTGTTGCTAGTATCATAA
ATTAAATTTACAATGTCTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLDIKWIRANPDKLDESLSKRGIDSVSKSIIHIDSEKRTLISLIQKLQHERKEKSSSVAHIYDKSSTDFEEIQNDVKLIN
QKITELETSLLHHEKRLSEIMDNLPNLVADDVPYGTNSDMNKVLKECGTIQNIKFPKHHYEIGKNLGMMDFNTATKMSGS
RFVILKHDLAKLERALINFMIDVHTTEFNFFEVSPPCLVKDHAMYNVGQLPKFADASFETTTGYRLIPTAEVPLTNIFAN
TTLLEEKLPIRLVAFTPCFRSEVGSAGKDVKGMLRMHQFGKVELFTIATPKESNREFEYLTAAAEKILEKLGLPYRVVLL
CSGDIGFAAHKTYDLEVWLPAQNCYREISSCSHFSSFQARRSLSKYRELCSKKVNFLHTINGSGLAVGRTIIAILENYQN
SDGSVTIPEKLRNYMGGQKLITPLTETVF

Sequences:

>Translated_429_residues
MLDIKWIRANPDKLDESLSKRGIDSVSKSIIHIDSEKRTLISLIQKLQHERKEKSSSVAHIYDKSSTDFEEIQNDVKLIN
QKITELETSLLHHEKRLSEIMDNLPNLVADDVPYGTNSDMNKVLKECGTIQNIKFPKHHYEIGKNLGMMDFNTATKMSGS
RFVILKHDLAKLERALINFMIDVHTTEFNFFEVSPPCLVKDHAMYNVGQLPKFADASFETTTGYRLIPTAEVPLTNIFAN
TTLLEEKLPIRLVAFTPCFRSEVGSAGKDVKGMLRMHQFGKVELFTIATPKESNREFEYLTAAAEKILEKLGLPYRVVLL
CSGDIGFAAHKTYDLEVWLPAQNCYREISSCSHFSSFQARRSLSKYRELCSKKVNFLHTINGSGLAVGRTIIAILENYQN
SDGSVTIPEKLRNYMGGQKLITPLTETVF
>Mature_429_residues
MLDIKWIRANPDKLDESLSKRGIDSVSKSIIHIDSEKRTLISLIQKLQHERKEKSSSVAHIYDKSSTDFEEIQNDVKLIN
QKITELETSLLHHEKRLSEIMDNLPNLVADDVPYGTNSDMNKVLKECGTIQNIKFPKHHYEIGKNLGMMDFNTATKMSGS
RFVILKHDLAKLERALINFMIDVHTTEFNFFEVSPPCLVKDHAMYNVGQLPKFADASFETTTGYRLIPTAEVPLTNIFAN
TTLLEEKLPIRLVAFTPCFRSEVGSAGKDVKGMLRMHQFGKVELFTIATPKESNREFEYLTAAAEKILEKLGLPYRVVLL
CSGDIGFAAHKTYDLEVWLPAQNCYREISSCSHFSSFQARRSLSKYRELCSKKVNFLHTINGSGLAVGRTIIAILENYQN
SDGSVTIPEKLRNYMGGQKLITPLTETVF

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=363, Percent_Identity=32.5068870523416, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI8923421, Length=442, Percent_Identity=28.9592760180996, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI225579074, Length=445, Percent_Identity=28.5393258426966, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=42.7906976744186, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17539260, Length=354, Percent_Identity=29.6610169491525, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17542084, Length=366, Percent_Identity=28.1420765027322, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321799, Length=407, Percent_Identity=30.2211302211302, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320226, Length=294, Percent_Identity=32.9931972789116, Blast_Score=172, Evalue=7e-44,
Organism=Drosophila melanogaster, GI17737985, Length=353, Percent_Identity=32.0113314447592, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=28.5407725321888, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48619; Mature: 48619

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKWIRANPDKLDESLSKRGIDSVSKSIIHIDSEKRTLISLIQKLQHERKEKSSSVAH
CCEEEEEECCHHHHHHHHHHCCHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCEEE
IYDKSSTDFEEIQNDVKLINQKITELETSLLHHEKRLSEIMDNLPNLVADDVPYGTNSDM
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
NKVLKECGTIQNIKFPKHHYEIGKNLGMMDFNTATKMSGSRFVILKHDLAKLERALINFM
HHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEHHHHHHHHHHHHHH
IDVHTTEFNFFEVSPPCLVKDHAMYNVGQLPKFADASFETTTGYRLIPTAEVPLTNIFAN
HEEEECEEEEEECCCCCEEECCCHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
TTLLEEKLPIRLVAFTPCFRSEVGSAGKDVKGMLRMHQFGKVELFTIATPKESNREFEYL
HHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
TAAAEKILEKLGLPYRVVLLCSGDIGFAAHKTYDLEVWLPAQNCYREISSCSHFSSFQAR
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHH
RSLSKYRELCSKKVNFLHTINGSGLAVGRTIIAILENYQNSDGSVTIPEKLRNYMGGQKL
HHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHCCCCHH
ITPLTETVF
HHHHHHHCC
>Mature Secondary Structure
MLDIKWIRANPDKLDESLSKRGIDSVSKSIIHIDSEKRTLISLIQKLQHERKEKSSSVAH
CCEEEEEECCHHHHHHHHHHCCHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCEEE
IYDKSSTDFEEIQNDVKLINQKITELETSLLHHEKRLSEIMDNLPNLVADDVPYGTNSDM
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
NKVLKECGTIQNIKFPKHHYEIGKNLGMMDFNTATKMSGSRFVILKHDLAKLERALINFM
HHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEHHHHHHHHHHHHHH
IDVHTTEFNFFEVSPPCLVKDHAMYNVGQLPKFADASFETTTGYRLIPTAEVPLTNIFAN
HEEEECEEEEEECCCCCEEECCCHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
TTLLEEKLPIRLVAFTPCFRSEVGSAGKDVKGMLRMHQFGKVELFTIATPKESNREFEYL
HHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
TAAAEKILEKLGLPYRVVLLCSGDIGFAAHKTYDLEVWLPAQNCYREISSCSHFSSFQAR
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHH
RSLSKYRELCSKKVNFLHTINGSGLAVGRTIIAILENYQNSDGSVTIPEKLRNYMGGQKL
HHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHCCCCHH
ITPLTETVF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA