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The map label for this gene is clpP [H]

Identifier: 189183283

GI number: 189183283

Start: 387626

End: 388246

Strand: Direct

Name: clpP [H]

Synonym: OTT_0376

Alternate gene names: 189183283

Gene position: 387626-388246 (Clockwise)

Preceding gene: 189183281

Following gene: 189183284

Centisome position: 19.29

GC content: 36.39

Gene sequence:

>621_bases
ATGAATAATAATCAAACCTCTTTATATGTACCTATGGTTGTCGAACAAACTAATCGTGGGGAGCGAGCTTATGACATCTA
CTCTAGATTACTTAAAGAGAGAATTGTATTTGTTTGTGGTGAAATAGAGGATCATATGGCAAATTTGGTTGTAGCGCAAT
TATTGTTTCTTGAAGCTGAATCACCTGATAAAAAGATTTTTATGTATATTAATTCCCCAGGTGGGGCAGTAACTGCAGGC
ATGGCTATATATGACACAATGCAATATATTAAGTCGCCTGTATTAACATTATGCCTTGGACAAGCATGTTCAATGGGATC
ATTGCTACTTGCAGCAGGCCAGAAGAGTATGCGTCATTGTTTGCCTAATAGCAGAATCATGATTCATCAGCCATCAGGCG
GATTTCGAGGGCAGGCTACAGATATTCAAATTCATGCACAGGAAATACTTAAAATGAAAAAGATTATTAATAACTTGTAT
GTTCATCATACTAATCAACCATTACAGGTAATAGAGGAAAGTATGGAACGTGATAACTTTATGGATCCAGTAGCAGCAAA
AGAGTTTGGATTAGTTGACCATATAACTACAGAACGTGCTCAAGTAGCAGAAAGAAAATAA

Upstream 100 bases:

>100_bases
CATCAGCCCTTGACAATCACGCGCATTATGTAAAAATTGCTAATACTTATTTAGCTAAAATTTATCTATAATAATTTTCA
ATACAAATTAAGGATATTTT

Downstream 100 bases:

>100_bases
ACATTTATCGTTCCAGCAAGTTAGATTTTTCATCTTTATAGTGCACTGTAGATGTTTTATGCGTTTGATACCTCTAACCT
GTATCAAACGTAAAAGGAGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MNNNQTSLYVPMVVEQTNRGERAYDIYSRLLKERIVFVCGEIEDHMANLVVAQLLFLEAESPDKKIFMYINSPGGAVTAG
MAIYDTMQYIKSPVLTLCLGQACSMGSLLLAAGQKSMRHCLPNSRIMIHQPSGGFRGQATDIQIHAQEILKMKKIINNLY
VHHTNQPLQVIEESMERDNFMDPVAAKEFGLVDHITTERAQVAERK

Sequences:

>Translated_206_residues
MNNNQTSLYVPMVVEQTNRGERAYDIYSRLLKERIVFVCGEIEDHMANLVVAQLLFLEAESPDKKIFMYINSPGGAVTAG
MAIYDTMQYIKSPVLTLCLGQACSMGSLLLAAGQKSMRHCLPNSRIMIHQPSGGFRGQATDIQIHAQEILKMKKIINNLY
VHHTNQPLQVIEESMERDNFMDPVAAKEFGLVDHITTERAQVAERK
>Mature_206_residues
MNNNQTSLYVPMVVEQTNRGERAYDIYSRLLKERIVFVCGEIEDHMANLVVAQLLFLEAESPDKKIFMYINSPGGAVTAG
MAIYDTMQYIKSPVLTLCLGQACSMGSLLLAAGQKSMRHCLPNSRIMIHQPSGGFRGQATDIQIHAQEILKMKKIINNLY
VHHTNQPLQVIEESMERDNFMDPVAAKEFGLVDHITTERAQVAERK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=67.1794871794872, Blast_Score=276, Evalue=1e-74,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=65.2631578947368, Blast_Score=273, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=55.440414507772, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI20129427, Length=186, Percent_Identity=63.4408602150538, Blast_Score=258, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23185; Mature: 23185

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNQTSLYVPMVVEQTNRGERAYDIYSRLLKERIVFVCGEIEDHMANLVVAQLLFLEAE
CCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SPDKKIFMYINSPGGAVTAGMAIYDTMQYIKSPVLTLCLGQACSMGSLLLAAGQKSMRHC
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHH
LPNSRIMIHQPSGGFRGQATDIQIHAQEILKMKKIINNLYVHHTNQPLQVIEESMERDNF
CCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCC
MDPVAAKEFGLVDHITTERAQVAERK
CCCHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNNQTSLYVPMVVEQTNRGERAYDIYSRLLKERIVFVCGEIEDHMANLVVAQLLFLEAE
CCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SPDKKIFMYINSPGGAVTAGMAIYDTMQYIKSPVLTLCLGQACSMGSLLLAAGQKSMRHC
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHH
LPNSRIMIHQPSGGFRGQATDIQIHAQEILKMKKIINNLYVHHTNQPLQVIEESMERDNF
CCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCC
MDPVAAKEFGLVDHITTERAQVAERK
CCCHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA