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The map label for this gene is map [H]

Identifier: 189183280

GI number: 189183280

Start: 384838

End: 385644

Strand: Direct

Name: map [H]

Synonym: OTT_0373

Alternate gene names: 189183280

Gene position: 384838-385644 (Clockwise)

Preceding gene: 189183279

Following gene: 189183281

Centisome position: 19.16

GC content: 32.59

Gene sequence:

>807_bases
ATGGTTAATGATATGCGATTGGTTCAACAACAAAGTGATTTTCTAGAAAAAATGCGAGCTGCTAGCAAGATTGCAGCATC
TACTTTAGAAATGATTGAAAAATATGTTCAGCCAGGAGTAACGAGTAATCTGTTAAATAAAATTTGCCACGATTACATTA
TCTCGCATGGAGCAGTTCCAGCTCCTTTAGGATATAAAGGGTTTCCAAAATCAATATGTACATCAGTTAATCATGTAATC
TGTCATGGTATACCTAATGATAAAGTGCTAAAAAATGGAGATATACTAAATATTGATATATCATTAAGTAAAGATGGCGT
TTTTGCGGATACTTGTAAAATGTATTTTGTAGGTCAGCCATCAGTAATGGCGAAAAGGATAGTTCAATGTGCACAAGAAT
GTTTATATTATGGTATCAATCAGGTAAAGGCTAATGCAAGTATAAGAAATATTGGTAGAGTTATTCAGAATAATGCTAAA
AAATATGGTTACTCCGTAGTAAGAGATTTTTGTGGACATGGTATTGGCAAAATGTTACATCAGGATCCACAAATTTTGCA
TTATGATGATGCAAGTTGTGAAGATCAATATATGAAAGTAGGTATGACGTTTACTATTGAGCCTATGATTAATGTTGGTA
AACCTTATGCAACAATTTTATCTGATGGCTGGACTGCAGTTACTAAAGATCGTTCTTTATCAGCACAATATGAACATACA
TTATTAGTAGCAGATGCTGGAGTTGAAATTTTGACTTTACGCAGTGAGGAAGATCTTAGTTATATTAATAGTTTTACAAA
AGTATGA

Upstream 100 bases:

>100_bases
CAATACAAGGTTATCTATAAATTGTAATTTTTGTGAATGATAATGATTTGGTGTACTGGTTTTTAGTTTCAGTTTTGCTA
ATTTAGCAATTCTTGATTGA

Downstream 100 bases:

>100_bases
CTTTATTTAACTAGTAAACATAGTATTAACCTATTATTATACTTAGACTAGATATATTACATTGATTCTACAAAGTTAGC
AATTTGTTATAATAAACGTA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MVNDMRLVQQQSDFLEKMRAASKIAASTLEMIEKYVQPGVTSNLLNKICHDYIISHGAVPAPLGYKGFPKSICTSVNHVI
CHGIPNDKVLKNGDILNIDISLSKDGVFADTCKMYFVGQPSVMAKRIVQCAQECLYYGINQVKANASIRNIGRVIQNNAK
KYGYSVVRDFCGHGIGKMLHQDPQILHYDDASCEDQYMKVGMTFTIEPMINVGKPYATILSDGWTAVTKDRSLSAQYEHT
LLVADAGVEILTLRSEEDLSYINSFTKV

Sequences:

>Translated_268_residues
MVNDMRLVQQQSDFLEKMRAASKIAASTLEMIEKYVQPGVTSNLLNKICHDYIISHGAVPAPLGYKGFPKSICTSVNHVI
CHGIPNDKVLKNGDILNIDISLSKDGVFADTCKMYFVGQPSVMAKRIVQCAQECLYYGINQVKANASIRNIGRVIQNNAK
KYGYSVVRDFCGHGIGKMLHQDPQILHYDDASCEDQYMKVGMTFTIEPMINVGKPYATILSDGWTAVTKDRSLSAQYEHT
LLVADAGVEILTLRSEEDLSYINSFTKV
>Mature_268_residues
MVNDMRLVQQQSDFLEKMRAASKIAASTLEMIEKYVQPGVTSNLLNKICHDYIISHGAVPAPLGYKGFPKSICTSVNHVI
CHGIPNDKVLKNGDILNIDISLSKDGVFADTCKMYFVGQPSVMAKRIVQCAQECLYYGINQVKANASIRNIGRVIQNNAK
KYGYSVVRDFCGHGIGKMLHQDPQILHYDDASCEDQYMKVGMTFTIEPMINVGKPYATILSDGWTAVTKDRSLSAQYEHT
LLVADAGVEILTLRSEEDLSYINSFTKV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=243, Percent_Identity=44.8559670781893, Blast_Score=217, Evalue=7e-57,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=39.5161290322581, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=53.1746031746032, Blast_Score=286, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71996291, Length=240, Percent_Identity=42.9166666666667, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=43.9516129032258, Blast_Score=214, Evalue=9e-57,
Organism=Drosophila melanogaster, GI21355531, Length=244, Percent_Identity=43.4426229508197, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24583427, Length=238, Percent_Identity=37.8151260504202, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29768; Mature: 29768

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNDMRLVQQQSDFLEKMRAASKIAASTLEMIEKYVQPGVTSNLLNKICHDYIISHGAVP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
APLGYKGFPKSICTSVNHVICHGIPNDKVLKNGDILNIDISLSKDGVFADTCKMYFVGQP
CCCCCCCCCHHHHHHHHHEEECCCCCCCEECCCCEEEEEEEECCCCCCHHHEEEEEECCC
SVMAKRIVQCAQECLYYGINQVKANASIRNIGRVIQNNAKKYGYSVVRDFCGHGIGKMLH
HHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
QDPQILHYDDASCEDQYMKVGMTFTIEPMINVGKPYATILSDGWTAVTKDRSLSAQYEHT
CCCCEEEECCCCCHHHHHHCCCEEEECCHHHCCCCHHHHHCCCCEEEECCCCCCCCCCEE
LLVADAGVEILTLRSEEDLSYINSFTKV
EEEEECCEEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MVNDMRLVQQQSDFLEKMRAASKIAASTLEMIEKYVQPGVTSNLLNKICHDYIISHGAVP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
APLGYKGFPKSICTSVNHVICHGIPNDKVLKNGDILNIDISLSKDGVFADTCKMYFVGQP
CCCCCCCCCHHHHHHHHHEEECCCCCCCEECCCCEEEEEEEECCCCCCHHHEEEEEECCC
SVMAKRIVQCAQECLYYGINQVKANASIRNIGRVIQNNAKKYGYSVVRDFCGHGIGKMLH
HHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
QDPQILHYDDASCEDQYMKVGMTFTIEPMINVGKPYATILSDGWTAVTKDRSLSAQYEHT
CCCCEEEECCCCCHHHHHHCCCEEEECCHHHCCCCHHHHHCCCCEEEECCCCCCCCCCEE
LLVADAGVEILTLRSEEDLSYINSFTKV
EEEEECCEEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]