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The map label for this gene is trx

Identifier: 189026142

GI number: 189026142

Start: 997618

End: 997935

Strand: Reverse

Name: trx

Synonym: TPASS_0919

Alternate gene names: 189026142

Gene position: 997935-997618 (Counterclockwise)

Preceding gene: 189026145

Following gene: 189026125

Centisome position: 87.58

GC content: 49.06

Gene sequence:

>318_bases
ATGGCATTACTTGACATAAGTAGCGGGAACGTCCGCAAGACTATCGAGACCAACCCTCTGGTCATTGTGGACTTCTGGGC
TCCCTGGTGCGGTTCGTGCAAAATGCTCGGTCCTGTTCTGGAGGAGGTAGAAAGCGAAGTCGGCAGCGGTGTTGTTATTG
GAAAACTGAATGTCGATGACGACCAAGATCTCGCCGTTGAGTTCAATGTGGCGAGCATCCCCACGCTTATTGTTTTTAAA
GACGGGAAAGAAGTCGATCGTTCCATAGGCTTCGTTGATAAGTCAAAAATTCTCACGCTCATCCAGAAGAACGCCTAA

Upstream 100 bases:

>100_bases
ACGTTTGGACTATGGTGCAGAGGATAGGAAAAGATGCAACTGTACACTCCTGCGCCTATCTGGTACCCTCTGGCATAGTT
TTTACCTAAGGAGCATTTCA

Downstream 100 bases:

>100_bases
GGATATTTCTTTCGTACGGAGTGTGCTACCAGCTCATCAGCAAAGCGATGCAGCCGGTGCCTAGGGGAACAGTTATATTG
TCGTAGTCTTTGCAGGGGAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDDDQDLAVEFNVASIPTLIVFK
DGKEVDRSIGFVDKSKILTLIQKNA

Sequences:

>Translated_105_residues
MALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDDDQDLAVEFNVASIPTLIVFK
DGKEVDRSIGFVDKSKILTLIQKNA
>Mature_104_residues
ALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDDDQDLAVEFNVASIPTLIVFKD
GKEVDRSIGFVDKSKILTLIQKNA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=91, Percent_Identity=37.3626373626374, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-16,
Organism=Escherichia coli, GI1788936, Length=75, Percent_Identity=41.3333333333333, Blast_Score=74, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=35.8695652173913, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=77, Percent_Identity=35.0649350649351, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=91, Percent_Identity=36.2637362637363, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=87, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=101, Percent_Identity=31.6831683168317, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=101, Percent_Identity=31.6831683168317, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=101, Percent_Identity=31.6831683168317, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=49.2957746478873, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=38.3838383838384, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319806, Length=91, Percent_Identity=29.6703296703297, Blast_Score=63, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=36.7088607594937, Blast_Score=60, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=38.6363636363636, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17648013, Length=77, Percent_Identity=40.2597402597403, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=77, Percent_Identity=40.2597402597403, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=35.8695652173913, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=38.3720930232558, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21358065, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_TREPA (O83889)

Other databases:

- EMBL:   AE000520
- PIR:   D71265
- RefSeq:   NP_219354.1
- ProteinModelPortal:   O83889
- SMR:   O83889
- GeneID:   2611310
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0919
- NMPDR:   fig|243276.1.peg.913
- TIGR:   TP_0919
- HOGENOM:   HBG493509
- OMA:   FAFYKNG
- ProtClustDB:   CLSK2300333
- BioCyc:   TPAL243276:TP_0919-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11391; Mature: 11260

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDD
CEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
DQDLAVEFNVASIPTLIVFKDGKEVDRSIGFVDKSKILTLIQKNA
CCCEEEEEECCCCCEEEEEECCCHHHHHCCCCCCHHEEEEEECCC
>Mature Secondary Structure 
ALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDD
EEEECCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
DQDLAVEFNVASIPTLIVFKDGKEVDRSIGFVDKSKILTLIQKNA
CCCEEEEEECCCCCEEEEEECCCHHHHHCCCCCCHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876