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The map label for this gene is tyrS [H]

Identifier: 189026058

GI number: 189026058

Start: 902380

End: 903630

Strand: Reverse

Name: tyrS [H]

Synonym: TPASS_0834

Alternate gene names: 189026058

Gene position: 903630-902380 (Counterclockwise)

Preceding gene: 189026059

Following gene: 189026056

Centisome position: 79.3

GC content: 51.88

Gene sequence:

>1251_bases
ATGCGCGGTATAATCGGCTCCATGAATCCTGCGCTTGCGCGTCTTCAGGCGCGTGGTTTTATTAGACAATGTACTGATCT
TTCGGCGCTTTCGGCGCGTATGGATGCAGGCCCACTCACCTTTTATGTCGGTGTAGATCCAACTGGCAGTAGTTTGCACG
TTGGGCACATGCTCCCTATGTTTGCGCTAAAGCATTTGTGTGATGCGGGGCACCGCGGTTGCGTGCTCATCGGTGGAGGT
ACCGCGCGTATTGGGGATCCCTCCGGCAAAACCAGTATGCGCAAGATGCTCGATTATGCAACGCTCGATGCGTACGCGGG
AGCGATAGTTGCGCAGCTGGATCATTTTCTTTCCTTCGATCACAGGCATGTGTTCTATGTGAATAATCGTGATTGGTTGG
CACATTTGAATTACATTGATTTCTTGCGAGAGGTTGGGGCGCATTTTTCTGTAAACAAAATGCTTACCTATGAGGCGTAC
AAGAAACGCCTGGAGACAGGACTTTCCTTTCTTGAATTTAATTATCAGCTATTGCAGAGCTATGATTTTTTAACGCTCAG
TGATCGCTACGCGGTAGAGTTACAAATTGGCGGCGATGATCAATGGGGCAACATTGTTGCCGGGGCGGATTTGGTTCGAA
GAGTGCGCGGAAAAACCGTGCATGGGTTGACCTTTCCGCTCATTACCCGGGCGGATGGGCAAAAAATGGGCAAGACCGAG
CAAGGTGCGCTCTTCTTAGACCCGGCTTTGGTGTCTCCCTATGACTTTTTCCAATACTGGCGAAATACTCCGGATGAAGA
TGTGCGGCGTTTCTTGCTCCTGTTTACCTTTTTGTCTGTGCGCGATGTCGAGGCGATATTGACTCAGGGAATTAATTGTG
CAAAGGAGCTGTTGGCATACGAGGTAACGCGCCTCATGCACGGAACGGCTGTCGCGCAGGTGGCGTTGCAGGGAGCGCGC
GCGGCATTCGGCGGGTGTGGCGATAAGTGTGCATTGCCGACGTTCGAGCTGACACAGTGCACGTTGCAAGTTGGGATCAA
AGTGACTGATTTGTTTGTACAGGTTGGATTGTGTACTACGAAGAGTGATGCACGGCGCTTGATTGCACAAGGAGGAGCTT
TTGTCGGGCTCCAGCGCGTGGCAGATATCGGTGCGGTAATTGACCAGTCAGCGTTGGATTTGGACGGGACGGTAATAGTT
CGCGCGGGGAAAAAACGCGTGGTGCGCATCGTCACTGACGTGCTTGAGTAG

Upstream 100 bases:

>100_bases
TTTTAAAGGAATAGTGACACGCGGGGCGACGGTGGGGGTGCATCAGCGCGTTTTGTCTTTTTCTCGGGACTGAACCGCCT
GCCCTGGATCGGGGTGTGCG

Downstream 100 bases:

>100_bases
TGCGCGGTGTGAATCTGCTATCTGAGGTGATATTGAAAGGGGCAGTCTATCCTGGATTACCCCTTCTGTGTCGTGTCTAC
CGCTTCCTGTTGTGTAGGTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRGIIGSMNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPMFALKHLCDAGHRGCVLIGGG
TARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFDHRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAY
KKRLETGLSFLEFNYQLLQSYDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTE
QGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAYEVTRLMHGTAVAQVALQGAR
AAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTTKSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIV
RAGKKRVVRIVTDVLE

Sequences:

>Translated_416_residues
MRGIIGSMNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPMFALKHLCDAGHRGCVLIGGG
TARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFDHRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAY
KKRLETGLSFLEFNYQLLQSYDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTE
QGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAYEVTRLMHGTAVAQVALQGAR
AAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTTKSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIV
RAGKKRVVRIVTDVLE
>Mature_416_residues
MRGIIGSMNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPMFALKHLCDAGHRGCVLIGGG
TARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFDHRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAY
KKRLETGLSFLEFNYQLLQSYDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTE
QGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAYEVTRLMHGTAVAQVALQGAR
AAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTTKSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIV
RAGKKRVVRIVTDVLE

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=397, Percent_Identity=33.2493702770781, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787925, Length=415, Percent_Identity=40.2409638554217, Blast_Score=313, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI25145802, Length=308, Percent_Identity=36.038961038961, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25145805, Length=205, Percent_Identity=38.0487804878049, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325160, Length=431, Percent_Identity=33.1786542923434, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20130383, Length=402, Percent_Identity=34.8258706467662, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45794; Mature: 45794

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGIIGSMNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHH
FALKHLCDAGHRGCVLIGGGTARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFD
HHHHHHHHCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAYKKRLETGLSFLEFNYQLLQS
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
YDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTE
CCEEEECCCEEEEEEECCCCCCCCEEHHHHHHHHHHCCEECCEEEEEEECCCCCCCCCCC
QGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAY
CCEEEECCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EVTRLMHGTAVAQVALQGARAAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC
KSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIVRAGKKRVVRIVTDVLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCHHHHHHHHHHHC
>Mature Secondary Structure
MRGIIGSMNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHH
FALKHLCDAGHRGCVLIGGGTARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFD
HHHHHHHHCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAYKKRLETGLSFLEFNYQLLQS
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
YDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTE
CCEEEECCCEEEEEEECCCCCCCCEEHHHHHHHHHHCCEECCEEEEEEECCCCCCCCCCC
QGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAY
CCEEEECCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EVTRLMHGTAVAQVALQGARAAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCC
KSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIVRAGKKRVVRIVTDVLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]