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The map label for this gene is proC

Identifier: 189026022

GI number: 189026022

Start: 864674

End: 865465

Strand: Reverse

Name: proC

Synonym: TPASS_0797

Alternate gene names: 189026022

Gene position: 865465-864674 (Counterclockwise)

Preceding gene: 189026023

Following gene: 189026021

Centisome position: 75.95

GC content: 56.69

Gene sequence:

>792_bases
ATGAACGTGGGATTTTTGGGTTTTGGAGCAATGGGACGGGCGCTGGCAGAAGGGTTGGTGCACGCAGGAGCGCTGCAAGC
GGCTCAAGTGTACGCCTGTGCGTTAAATCAGGAAAAGTTGCGTGCGCAGTGTACATCTTTGGGCATAGGTGCCTGCGCGT
CAGTTCAGGAACTGGTACAGAAAAGTGAATGGATTTTTCTTGCAGTCAAACCATCTCAAATCAGCACGGTACTGCGCGAT
CGCCAATCCTTTCAGGGAAAAGTGCTTATTTCCCTTGCGGCGGGTATGTCTTGCGCTGCATACGAGGCATTGTTTGCCGC
GGACCCTCATCAGGGTATCCGTCACCTGTCACTTTTGCCGAACTTACCTTGTCAGGTGGCGCGGGGGGTGATCATTGCAG
AAGCGCGCCACACCCTGCACCACGATGAGCACGCTGCGCTTTTAGCAGTGCTGCGCACAGTTGCACAGGTAGAGGTGGTG
GACACCGCGTACTTTGCGATCGCAGGGGTGATTGCAGGCTGTGCTCCGGCGTTTGCCGCGCAGTTTATAGAAGCGCTCGC
TGACGCAGGGGTGCGCTATGGCCTGGCGCGCGATCAAGCGTACCGGCTTGCGGCACACATGCTTGAAGGGACTGCAGCGC
TCATACAGCACAGTGGTGTACATCCTGCACAACTTAAAGATCGCGTGTGCTCTCCTGCAGGGAGTACTATTCGCGGGGTG
CTTGCGTTAGAGGAGCAGGGATTGCGCCGTGCAGTTATACACGCGGTGCGCGCTGCGCTCAGTTCTTCCTAA

Upstream 100 bases:

>100_bases
GAGGAAGGCCACTGGTAATGCAGCGAGTGAAAGAGGGAACTGTCGGCTAGGAATATTCACAGAGCATTTGGTTTTCCGTG
TCGGATAGGGGGAGCGCAGC

Downstream 100 bases:

>100_bases
GGGGTGGGCAGGGTGCATTGCTTGTTTTTTTTGACTGCTGACAGTACAGTTGCACCCTTGTGAAAAGTTCGTGCGTATAT
TGGCGGATCGGGGTTCTCGT

Product: 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRD
RQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVV
DTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGV
LALEEQGLRRAVIHAVRAALSSS

Sequences:

>Translated_263_residues
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRD
RQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVV
DTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGV
LALEEQGLRRAVIHAVRAALSSS
>Mature_263_residues
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRD
RQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVV
DTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGV
LALEEQGLRRAVIHAVRAALSSS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI198041662, Length=260, Percent_Identity=38.0769230769231, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=35.5805243445693, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=32.8358208955224, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=32.8358208955224, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=35.0943396226415, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=35.5805243445693, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17540664, Length=272, Percent_Identity=30.1470588235294, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=210, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358587, Length=261, Percent_Identity=35.632183908046, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24648116, Length=267, Percent_Identity=34.4569288389513, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=147, Percent_Identity=39.4557823129252, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_TREPA (P27771)

Other databases:

- EMBL:   M73825
- EMBL:   AE000520
- PIR:   D71281
- RefSeq:   NP_219234.1
- ProteinModelPortal:   P27771
- SMR:   P27771
- IntAct:   P27771
- GeneID:   2610812
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0797
- NMPDR:   fig|243276.1.peg.793
- TIGR:   TP_0797
- HOGENOM:   HBG726602
- OMA:   MVAGTGK
- ProtClustDB:   CLSK873814
- BioCyc:   TPAL243276:TP_0797-MONOMER
- BRENDA:   1.5.1.2
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 27645; Mature: 27645

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQ
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHH
KSEWIFLAVKPSQISTVLRDRQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLP
CCCEEEEEECHHHHHHHHHHHHHCCCEEEEEHHCCCHHHHHHHHHHCCHHHHHHHHHHCC
NLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPAFAA
CCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHH
LALEEQGLRRAVIHAVRAALSSS
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQ
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHH
KSEWIFLAVKPSQISTVLRDRQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLP
CCCEEEEEECHHHHHHHHHHHHHCCCEEEEEHHCCCHHHHHHHHHHCCHHHHHHHHHHCC
NLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPAFAA
CCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHH
LALEEQGLRRAVIHAVRAALSSS
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188947; 9665876