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The map label for this gene is htrA1 [C]

Identifier: 189025998

GI number: 189025998

Start: 842045

End: 843241

Strand: Reverse

Name: htrA1 [C]

Synonym: TPASS_0773

Alternate gene names: 189025998

Gene position: 843241-842045 (Counterclockwise)

Preceding gene: 189026001

Following gene: 189025996

Centisome position: 74.0

GC content: 55.72

Gene sequence:

>1197_bases
GTGCGCAACAAGGTGCGAGTTCTTGCGGTGGTCGCAGCGCTTGCGGCTGCGTGCGCGGTGGGCTTCTTTCTAGGAAGGTG
GTTCGACTTCTCTGCTAGGTCCTCGGTGCTCGAAGCAGCTGATTCCCTCTCCGTTTCTTCTTCGGAAGCGGCCAGCTTTT
CCACGGTTGTTGCAGAGGGGGACCCGTACACCGTCGACGAGCGGCAGAACATCGCCGTTTACCGCAGTGCCAACGAGGCC
GTTGTCAACATTACCACTGAGATGGTAGGGGTTAATTGGTTCTTAGAGCCCGTGCCTCTCGAAGGTGGCTCTGGGTCTGG
CGCTATCATTGACGCCCGCGGGTACGTGCTCACCAATACGCACGTCATCGAGGGTGCGTCTAAAATTTATCTCTCGCTAC
ACGACGGCAGCCAGTACAAGGCAACTGTCGTGGGTGTAGACAGGGAGAATGATCTTGCGGTGCTTAAGTTTGTTTCTCCT
CCTGGAGCACGCTTGACAGTTATCCGCTTCGGTTCTTCGCGCAACTTGGATGTCGGACAAAAGGTGCTTGCCATCGGGAA
TCCCTTTGGACTAGCGCGTACTCTTACCGTCGGGGTTGTTTCTGCTCTCGCGCGTCCCATTCAAAATAAGGGCAGTATCA
TCAGAAATATGATTCAGACGGACGCGGCGATCAATCCTGGGAATTCTGGTGGTCCGCTTCTGGATACCCAGGGGCGCATG
ATAGGCATTAATACCGTTATTTACTCTACATCTGGAAGTTCTTCTGGTGTTGGCTTTGCGGTGCCAGTAGATACCGCAAA
GCGCATAGTGTCCGAGCTAATTCGCTACGGCCGTGTGCGTCGCGGCAAAATCGATGCCGAACTCGTGCAAGTCAACGCAT
CTATTGCTCACTACGCGCAGCTTACAGTAGGCAAGGGATTGCTGGTATCACAGGTCAAGCGGGGAAGCCCCGCTGCACAG
GCAGGACTGCGCGGTGGCACGACGGCCGTACGCTATGGACTGGGACGGAGAGCAGCGGTTATCTACTTGGGGGGAGACGT
CATTACCGCCATCGACAACCAGCCTGTAGCGAATCTGAGCGATTATTACTCGGTGTTGGAGGATAAGAAGCCTGACGACG
AAGTTCGCGTTACAGTACTCCGCGGCAGACGGCAGCATGTGGTAGCCGTGCGGCTCACAGAACGCTCAGATGAGTAG

Upstream 100 bases:

>100_bases
TGCGCGTGGCGCCGTGGGCTATTAGCTCAGCTGGTAGAGCAACGCCCTTTTAAGGCGTGGGTCGATGGTTCGAATCCATC
ATGGCTCAGAGGTGGGATTG

Downstream 100 bases:

>100_bases
CGAGGTCGCGCGCCCCGTGCAGGCTGCCTTTTTCACTGGTTACTTCATGATGCTGCGTGGTCCTCTTTCCTCCTTTTTCC
CCTTCTTTTCCTTTCCCTTG

Product: periplasmic serine protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEGDPYTVDERQNIAVYRSANEA
VVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNTHVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSP
PGARLTVIRFGSSRNLDVGQKVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRM
IGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQLTVGKGLLVSQVKRGSPAAQ
AGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLSDYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE

Sequences:

>Translated_398_residues
MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEGDPYTVDERQNIAVYRSANEA
VVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNTHVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSP
PGARLTVIRFGSSRNLDVGQKVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRM
IGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQLTVGKGLLVSQVKRGSPAAQ
AGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLSDYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE
>Mature_398_residues
MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEGDPYTVDERQNIAVYRSANEA
VVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNTHVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSP
PGARLTVIRFGSSRNLDVGQKVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRM
IGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQLTVGKGLLVSQVKRGSPAAQ
AGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLSDYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=33.695652173913, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24308541, Length=300, Percent_Identity=30.6666666666667, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI7019477, Length=298, Percent_Identity=32.8859060402685, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4506141, Length=304, Percent_Identity=31.25, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789629, Length=295, Percent_Identity=39.3220338983051, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1786356, Length=293, Percent_Identity=37.2013651877133, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1789630, Length=333, Percent_Identity=36.036036036036, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24646839, Length=312, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42187; Mature: 42187

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
DPYTVDERQNIAVYRSANEAVVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNT
CCEEECCCCCEEEEECCCCEEEEEEEEEEEEEEEEEEEECCCCCCCCEEEECCCEEEECC
HVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSPPGARLTVIRFGSSRNLDVGQ
EEECCCEEEEEEEECCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCC
KVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRM
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCE
IGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQ
EEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHEE
LTVGKGLLVSQVKRGSPAAQAGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLS
HHCCCCHHHHHHHCCCCHHHHCCCCCCHHHHCCCCCCEEEEEECCEEEEEECCCCCCCHH
DYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE
HHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
DPYTVDERQNIAVYRSANEAVVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNT
CCEEECCCCCEEEEECCCCEEEEEEEEEEEEEEEEEEEECCCCCCCCEEEECCCEEEECC
HVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSPPGARLTVIRFGSSRNLDVGQ
EEECCCEEEEEEEECCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCC
KVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRM
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCE
IGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQ
EEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHEE
LTVGKGLLVSQVKRGSPAAQAGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLS
HHCCCCHHHHHHHCCCCHHHHCCCCCCHHHHCCCCCCEEEEEECCEEEEEECCCCCCCHH
DYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE
HHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]