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The map label for this gene is gpmA

Identifier: 189025401

GI number: 189025401

Start: 190194

End: 190949

Strand: Direct

Name: gpmA

Synonym: TPASS_0168

Alternate gene names: 189025401

Gene position: 190194-190949 (Clockwise)

Preceding gene: 189025400

Following gene: 189025402

Centisome position: 16.69

GC content: 51.46

Gene sequence:

>756_bases
ATGAAGCTTGTGTTGATCCGTCATGGAGAAAGTGAATGGAACAGGCTGAACCTGTTCACTGGTTGGACAGATGTTCCGCT
TACCCCACGTGGGGAGTCGGAAGCCCAGGAAGGAGGCCGCGTACTGCAAGAAGCGGGGTTTGATTTTGACCTATGCTACA
CTTCTTTCTTGAAACGTGCCATTCGTACGCTCAATTTTGTACTCCAGGCACTGGACCGTGAGTGGTTGCCGGTTCACAAA
AGCTGGAAATTGAACGAGCGGCATTATGGGGATCTACAAGGTTTAAATAAGACAGAGACGGCGCAGAAGTATGGTGAGCA
GCAGGTTAGGGTGTGGCGTCGCTCCTTTGATGTGGCTCCTCCTCCGCTTACTGTAGGGGACGCACGTTGTCCGCATACTC
AAGCCTCCTACCGGGGGGTATGCGCGTCTGGTCGGACGCCAGTACTTCCGTTTACGGAAAGTTTGAAAGATACCGTTGCG
CGTGTGGTGCCGTATTTTGAAGAGGAAATCAAACCGCAGATGATTTCCGGACAGCGTGTGCTTATTGTGGCGCATGGTAA
CTCGTTGCGCGCACTGATGAAGCACATAGAGTCTTTGGATGAGACTCAGATAATGGAAGTAAATTTGCCTACCGGTGTAC
CGCTTGTCTATGAGTTCGAGGCGGATTTTACCCTGTGTGGGAAGCGTTTTTTAGGTAATGAGGCGGATGTTGCAGCGAGG
GCGCAGGCTGTGGCTGATCAGGGTAAGAGTAACTAA

Upstream 100 bases:

>100_bases
GACGATGTGCCAGGTGTATGATCTTTTTGTATGGGGTGAGGATGCGCCTTTTGTCAGATAAAAGGGGATGTGCAAAACGT
ATTGTTGAGAGGAGAGGGCC

Downstream 100 bases:

>100_bases
CTAAACCTGCGTGTCGTATCCTCTGGTCGTATGTATGATTGTAAGGCTCCGCTTCAAGCTGGGGCGGAGCGTCCTGCTTT
GTGGCTTGACTTCGGGCTCT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHK
SWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVA
RVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAAR
AQAVADQGKSN

Sequences:

>Translated_251_residues
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHK
SWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVA
RVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAAR
AQAVADQGKSN
>Mature_251_residues
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHK
SWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVA
RVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAAR
AQAVADQGKSN

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=252, Percent_Identity=50.7936507936508, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI4505753, Length=250, Percent_Identity=54, Blast_Score=264, Evalue=5e-71,
Organism=Homo sapiens, GI71274132, Length=250, Percent_Identity=52.4, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4502445, Length=255, Percent_Identity=43.921568627451, Blast_Score=227, Evalue=6e-60,
Organism=Homo sapiens, GI40353764, Length=255, Percent_Identity=43.921568627451, Blast_Score=227, Evalue=6e-60,
Organism=Homo sapiens, GI310129614, Length=163, Percent_Identity=55.2147239263804, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786970, Length=249, Percent_Identity=57.0281124497992, Blast_Score=285, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322697, Length=251, Percent_Identity=47.808764940239, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324516, Length=294, Percent_Identity=27.891156462585, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320183, Length=298, Percent_Identity=27.8523489932886, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324857, Length=232, Percent_Identity=26.2931034482759, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85725270, Length=251, Percent_Identity=48.605577689243, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI85725272, Length=251, Percent_Identity=48.605577689243, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24650981, Length=251, Percent_Identity=48.605577689243, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24646216, Length=253, Percent_Identity=45.0592885375494, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI28571817, Length=228, Percent_Identity=37.280701754386, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24648979, Length=228, Percent_Identity=37.280701754386, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI28571815, Length=228, Percent_Identity=37.280701754386, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_TREPA (P96121)

Other databases:

- EMBL:   U55214
- EMBL:   AE000520
- PIR:   E71357
- RefSeq:   NP_218607.1
- ProteinModelPortal:   P96121
- SMR:   P96121
- IntAct:   P96121
- GeneID:   2611142
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0168
- NMPDR:   fig|243276.1.peg.166
- TIGR:   TP_0168
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   TPAL243276:TP_0168-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28359; Mature: 28359

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 8-8 ACT_SITE 185-185

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRA
CEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IRTLNFVLQALDREWLPVHKSWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVARVVPYFEEEIKPQMISGQRV
CCCCCCCCCCCCCCHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEE
LIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAAR
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHH
AQAVADQGKSN
HHHHHHCCCCC
>Mature Secondary Structure
MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRA
CEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IRTLNFVLQALDREWLPVHKSWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVARVVPYFEEEIKPQMISGQRV
CCCCCCCCCCCCCCHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCEE
LIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAAR
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCHHHHHH
AQAVADQGKSN
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9332349; 9665876