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The map label for this gene is f1pep1 [H]

Identifier: 188586580

GI number: 188586580

Start: 2074244

End: 2076256

Strand: Reverse

Name: f1pep1 [H]

Synonym: Nther_1967

Alternate gene names: 188586580

Gene position: 2076256-2074244 (Counterclockwise)

Preceding gene: 188586586

Following gene: 188586579

Centisome position: 65.59

GC content: 35.47

Gene sequence:

>2013_bases
ATGTCTTCTAAAAATTCTCGGATTGTAGTGGAAGATTTTCATGGTACTAAGGTATATGATCCCTACAGGTGGCTAGAGGA
TGAGAAAGCCCCTGAGGTTAAAGAGTGGAGGGAAAGAGAACAGGAACAGACCAAAAATTTTTTAGAAGGTGATTTAAAAA
CTAAAGTTAAACAACGGTTAGAAAAACTGTACAGTTTTCCACAACTATATATTCCTGTAAAAAAAGGACAGCGCTATTTT
TATCAATATCATGATGGCTTGCAAAATCAGCCGGTCTTGTATTTTAGAGAAGCAAATGAGGATAAAGAAAAGCTATTGGT
AGACCCCAATAAATTTAGTGATGACGGTACTACAGCTATAACAGTTTTTTTCCCTAGTGATGACGGTAAATTACTAGCTT
ATTCTCTATCACGAAAAGGAAGTGACTGGCAGGAAATATATATAATAAATGTAGAAACTGGAGAAAAATATCCTGAAACT
ATCCAATATTGCAGATTCACTAATGTAGCATGGTCCAAAGATAATCTGGGTTTTTATTATAGTAGATTTCCAAACCCTGA
AGGGGTTGCAGAAGAAGATCAAAATAAATACAACAAAGTCTATTACCATAAAATTGGCAGAGACCAGTCTAATGATGAGT
TAATTTATGAAGACAATCATGACAAAGAACTGGTATTTAATCCTTTTCTCACTCATGACGGCGAATATATATGCTTGTTC
GTCCGCAAAGGAACAGATCCTCGAAATGGTTTTTATATAAAAAAAGCTGATTCTGAAGATAACTTTACAAAGTTATTCCC
TCAAGGTGAAGCAATGTATAAGCCTATGGGGATAATTGGGAACACTTTTTATTTTTTAAGTGATAAACAAGCACCTAAAG
GAAAGATTATAGCTGTTGATTTAAACAACCAAACCCAGAAAACTGTAATCGCAGAAACAGATAAAATAATCTCCGATGCG
GCTGTAATTAACAATCATCTAGTTTTAGTTTATCAGGATCATGGAAGCCATCTCGTAAATATTTTCAATTTAGACGGAGT
TAAAGTTGATCAGATAACATTAGCTGATTATGCTTCAATTTCTGGGTTGTCGGGGCAGCCTAATGACCCGGAAATGTTTA
TCGCATATAATACATTATTGCGTCCTACGACTATTTTGAGATATACTTTTGATGGTGAATCGGAAATTTATAAAACTCCA
GAAATCTCCTATGAGCTAAGGGATTTTGAAAGTAAGCAAATATTTTATGAGTCGAAAGATGGAACTCAAGTTCCAATGTT
TTTGATATATAAAAAAGGATTGGAATTGAATGGTAATAATCCGGCCTTGATATTTGGCTACGGTGGTTTTAAGATAAGCA
TGAACCCTAGATTTTCGCCCGCTAATATAAAATGGATCGAAGAGGGTGGAATATTTGCTATAGCTTGTATTAGGGGTGGA
AATGAATATGGAGAAGACTGGCACAGACAGGGAATGCTATTGAATAAACAAAATGTATTTGACGACTTTATAGCTGCTGG
GGAATGGTTGATTGACAATAATTATACCCGCAAAGACAAACTAGCTATTACAGGTCGCAGTAATGGTGGCTTATTAGTAG
CTGCATGTATGACCCAACGACCAGATTTATACGGTGCAGTAGTTTGTGGGGTACCAGTTATTGATATGCTGCGATTCCAT
AAGTTTACCATTGGACGCTACTGGATCCCTGAATACGGTGATCCTGATAATGATCCTCAGGCTTTTGAAAATTTATATAG
TTATTCACCTCTCCATAATATATCTAAGGGTGAAGTTTATCCACATACCCTTGTTTTAACTGCTGATACTGATGATAGAG
TTGTCCCAGCTCATGCTTTAAAATTTGTTCGGGCACTTAAGGATAATGCAAAGAATAATCAGGATATTTTCCTAAGAATG
GAGAAAAAAGCTGGTCATGGATTAGGGAAACCTATAGGAAAAAGAATTGAAGAAGATGCTGACTGGTTAAGCTTTTTATT
AAAAGTTCTTTAA

Upstream 100 bases:

>100_bases
AACAGAAAATATAAGTTAGTTAAAAATTTATAGCAGGAAAAATTCAGGAGATATCTAAAGTTGTTAGAAATGGAAATTTT
TAAAAAGGGGAGTTGACTCA

Downstream 100 bases:

>100_bases
AATACGTTCTTTATTAAGTATATTCCTTATTTAAGTATGTCTGAGTTAACTCCCGAACAGTCCACAATGACAACTAACAG
GCAAAATCAAAAATATGAAG

Product: Prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSSKNSRIVVEDFHGTKVYDPYRWLEDEKAPEVKEWREREQEQTKNFLEGDLKTKVKQRLEKLYSFPQLYIPVKKGQRYF
YQYHDGLQNQPVLYFREANEDKEKLLVDPNKFSDDGTTAITVFFPSDDGKLLAYSLSRKGSDWQEIYIINVETGEKYPET
IQYCRFTNVAWSKDNLGFYYSRFPNPEGVAEEDQNKYNKVYYHKIGRDQSNDELIYEDNHDKELVFNPFLTHDGEYICLF
VRKGTDPRNGFYIKKADSEDNFTKLFPQGEAMYKPMGIIGNTFYFLSDKQAPKGKIIAVDLNNQTQKTVIAETDKIISDA
AVINNHLVLVYQDHGSHLVNIFNLDGVKVDQITLADYASISGLSGQPNDPEMFIAYNTLLRPTTILRYTFDGESEIYKTP
EISYELRDFESKQIFYESKDGTQVPMFLIYKKGLELNGNNPALIFGYGGFKISMNPRFSPANIKWIEEGGIFAIACIRGG
NEYGEDWHRQGMLLNKQNVFDDFIAAGEWLIDNNYTRKDKLAITGRSNGGLLVAACMTQRPDLYGAVVCGVPVIDMLRFH
KFTIGRYWIPEYGDPDNDPQAFENLYSYSPLHNISKGEVYPHTLVLTADTDDRVVPAHALKFVRALKDNAKNNQDIFLRM
EKKAGHGLGKPIGKRIEEDADWLSFLLKVL

Sequences:

>Translated_670_residues
MSSKNSRIVVEDFHGTKVYDPYRWLEDEKAPEVKEWREREQEQTKNFLEGDLKTKVKQRLEKLYSFPQLYIPVKKGQRYF
YQYHDGLQNQPVLYFREANEDKEKLLVDPNKFSDDGTTAITVFFPSDDGKLLAYSLSRKGSDWQEIYIINVETGEKYPET
IQYCRFTNVAWSKDNLGFYYSRFPNPEGVAEEDQNKYNKVYYHKIGRDQSNDELIYEDNHDKELVFNPFLTHDGEYICLF
VRKGTDPRNGFYIKKADSEDNFTKLFPQGEAMYKPMGIIGNTFYFLSDKQAPKGKIIAVDLNNQTQKTVIAETDKIISDA
AVINNHLVLVYQDHGSHLVNIFNLDGVKVDQITLADYASISGLSGQPNDPEMFIAYNTLLRPTTILRYTFDGESEIYKTP
EISYELRDFESKQIFYESKDGTQVPMFLIYKKGLELNGNNPALIFGYGGFKISMNPRFSPANIKWIEEGGIFAIACIRGG
NEYGEDWHRQGMLLNKQNVFDDFIAAGEWLIDNNYTRKDKLAITGRSNGGLLVAACMTQRPDLYGAVVCGVPVIDMLRFH
KFTIGRYWIPEYGDPDNDPQAFENLYSYSPLHNISKGEVYPHTLVLTADTDDRVVPAHALKFVRALKDNAKNNQDIFLRM
EKKAGHGLGKPIGKRIEEDADWLSFLLKVL
>Mature_669_residues
SSKNSRIVVEDFHGTKVYDPYRWLEDEKAPEVKEWREREQEQTKNFLEGDLKTKVKQRLEKLYSFPQLYIPVKKGQRYFY
QYHDGLQNQPVLYFREANEDKEKLLVDPNKFSDDGTTAITVFFPSDDGKLLAYSLSRKGSDWQEIYIINVETGEKYPETI
QYCRFTNVAWSKDNLGFYYSRFPNPEGVAEEDQNKYNKVYYHKIGRDQSNDELIYEDNHDKELVFNPFLTHDGEYICLFV
RKGTDPRNGFYIKKADSEDNFTKLFPQGEAMYKPMGIIGNTFYFLSDKQAPKGKIIAVDLNNQTQKTVIAETDKIISDAA
VINNHLVLVYQDHGSHLVNIFNLDGVKVDQITLADYASISGLSGQPNDPEMFIAYNTLLRPTTILRYTFDGESEIYKTPE
ISYELRDFESKQIFYESKDGTQVPMFLIYKKGLELNGNNPALIFGYGGFKISMNPRFSPANIKWIEEGGIFAIACIRGGN
EYGEDWHRQGMLLNKQNVFDDFIAAGEWLIDNNYTRKDKLAITGRSNGGLLVAACMTQRPDLYGAVVCGVPVIDMLRFHK
FTIGRYWIPEYGDPDNDPQAFENLYSYSPLHNISKGEVYPHTLVLTADTDDRVVPAHALKFVRALKDNAKNNQDIFLRME
KKAGHGLGKPIGKRIEEDADWLSFLLKVL

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=691, Percent_Identity=39.2185238784371, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI284172420, Length=327, Percent_Identity=24.4648318042813, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI284172413, Length=327, Percent_Identity=24.4648318042813, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI70778815, Length=327, Percent_Identity=24.4648318042813, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI284172438, Length=327, Percent_Identity=24.4648318042813, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI284172431, Length=327, Percent_Identity=24.4648318042813, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI108860686, Length=224, Percent_Identity=28.125, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI108860692, Length=222, Percent_Identity=27.9279279279279, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1788150, Length=677, Percent_Identity=25.8493353028065, Blast_Score=196, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24583414, Length=694, Percent_Identity=41.64265129683, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221510989, Length=691, Percent_Identity=38.205499276411, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 77144; Mature: 77013

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKNSRIVVEDFHGTKVYDPYRWLEDEKAPEVKEWREREQEQTKNFLEGDLKTKVKQRL
CCCCCCEEEEEECCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EKLYSFPQLYIPVKKGQRYFYQYHDGLQNQPVLYFREANEDKEKLLVDPNKFSDDGTTAI
HHHHCCCEEEEEEECCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCEEE
TVFFPSDDGKLLAYSLSRKGSDWQEIYIINVETGEKYPETIQYCRFTNVAWSKDNLGFYY
EEEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHEECCCEECCCCCCEEE
SRFPNPEGVAEEDQNKYNKVYYHKIGRDQSNDELIYEDNHDKELVFNPFLTHDGEYICLF
ECCCCCCCCCCCCCCHHCEEEEEECCCCCCCCCEEEECCCCCEEEECCEECCCCCEEEEE
VRKGTDPRNGFYIKKADSEDNFTKLFPQGEAMYKPMGIIGNTFYFLSDKQAPKGKIIAVD
EECCCCCCCCEEEEECCCCCCCEEECCCCCHHCCCCCCCCCEEEEEECCCCCCCCEEEEE
LNNQTQKTVIAETDKIISDAAVINNHLVLVYQDHGSHLVNIFNLDGVKVDQITLADYASI
CCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCEEEEEEEEECHHHC
SGLSGQPNDPEMFIAYNTLLRPTTILRYTFDGESEIYKTPEISYELRDFESKQIFYESKD
CCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEECCCCEEEECCCCCCEEEEECCC
GTQVPMFLIYKKGLELNGNNPALIFGYGGFKISMNPRFSPANIKWIEEGGIFAIACIRGG
CCCCCEEEEEECCEEECCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEEEEEEECC
NEYGEDWHRQGMLLNKQNVFDDFIAAGEWLIDNNYTRKDKLAITGRSNGGLLVAACMTQR
CHHCHHHHHCCEEECCHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCEEEEEEECCC
PDLYGAVVCGVPVIDMLRFHKFTIGRYWIPEYGDPDNDPQAFENLYSYSPLHNISKGEVY
CCCEEEEECCCHHHHHHHHHHEECCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
PHTLVLTADTDDRVVPAHALKFVRALKDNAKNNQDIFLRMEKKAGHGLGKPIGKRIEEDA
CEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
DWLSFLLKVL
HHHHHHHHHC
>Mature Secondary Structure 
SSKNSRIVVEDFHGTKVYDPYRWLEDEKAPEVKEWREREQEQTKNFLEGDLKTKVKQRL
CCCCCEEEEEECCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EKLYSFPQLYIPVKKGQRYFYQYHDGLQNQPVLYFREANEDKEKLLVDPNKFSDDGTTAI
HHHHCCCEEEEEEECCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCEEE
TVFFPSDDGKLLAYSLSRKGSDWQEIYIINVETGEKYPETIQYCRFTNVAWSKDNLGFYY
EEEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHEECCCEECCCCCCEEE
SRFPNPEGVAEEDQNKYNKVYYHKIGRDQSNDELIYEDNHDKELVFNPFLTHDGEYICLF
ECCCCCCCCCCCCCCHHCEEEEEECCCCCCCCCEEEECCCCCEEEECCEECCCCCEEEEE
VRKGTDPRNGFYIKKADSEDNFTKLFPQGEAMYKPMGIIGNTFYFLSDKQAPKGKIIAVD
EECCCCCCCCEEEEECCCCCCCEEECCCCCHHCCCCCCCCCEEEEEECCCCCCCCEEEEE
LNNQTQKTVIAETDKIISDAAVINNHLVLVYQDHGSHLVNIFNLDGVKVDQITLADYASI
CCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCEEEEEEEEECHHHC
SGLSGQPNDPEMFIAYNTLLRPTTILRYTFDGESEIYKTPEISYELRDFESKQIFYESKD
CCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEECCCCEEEECCCCCCEEEEECCC
GTQVPMFLIYKKGLELNGNNPALIFGYGGFKISMNPRFSPANIKWIEEGGIFAIACIRGG
CCCCCEEEEEECCEEECCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEEEEEEECC
NEYGEDWHRQGMLLNKQNVFDDFIAAGEWLIDNNYTRKDKLAITGRSNGGLLVAACMTQR
CHHCHHHHHCCEEECCHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCEEEEEEECCC
PDLYGAVVCGVPVIDMLRFHKFTIGRYWIPEYGDPDNDPQAFENLYSYSPLHNISKGEVY
CCCEEEEECCCHHHHHHHHHHEECCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
PHTLVLTADTDDRVVPAHALKFVRALKDNAKNNQDIFLRMEKKAGHGLGKPIGKRIEEDA
CEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
DWLSFLLKVL
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]