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The map label for this gene is yggV [C]

Identifier: 188586563

GI number: 188586563

Start: 2058982

End: 2059587

Strand: Reverse

Name: yggV [C]

Synonym: Nther_1950

Alternate gene names: 188586563

Gene position: 2059587-2058982 (Counterclockwise)

Preceding gene: 188586564

Following gene: 188586562

Centisome position: 65.06

GC content: 37.79

Gene sequence:

>606_bases
ATGAAACTTGTACTCGCCTCAGGTAATCAGGGAAAACTTAACGAATTAAAAGCATTACTTAGCAAACAGCCAGTTGAAAT
TTATTCTATGTCGGATTTTAATAATATAAAAGAAGCCCAAGAAACTGGAAAAACCTTTGCGGAAAATGCCATTATTAAGG
CGCAAAATGTAGCTGATTCAACAGGATACTTATCCCTAGCCGATGATTCAGGTCTAGAAGTAGACGCTTTAGATGGTGCG
CCAGGAGTCTACTCTGCACGTTATGCAGGTGAAAACGCCTGTGATCAAGACAATAATAACAAATTATTGCGATCATTAAA
GGATATACCTTATAAACAACGTACTGCTCGTTTTAAATGTGTAATTGCCATTGCTTACCCTGATACTCCACCTGTAACAT
TCACTGGCACCTGTGAAGGATATATTTTAAGGGAACCTAAAGGAGATAGAGGTTTTGGATATGATCCTTTATTTTATCAT
CCTGATATGGGAAAAACATTTGGCGAACTCTACCAGGAAGAAAAAAGTTCTATCAGTCATCGTGGTAAAGCCCTGGAAAA
ATTAGTTGCCAACTTCCAAGATGTTATGAGTCTAATGGAGGGATAA

Upstream 100 bases:

>100_bases
TGTTAAGCTATGCTGAGAAAGGAATGCATGCTTTAATGGAAGTACAAAGTCAAGCTTTATCAGAAATCTATCCACCTCCT
GCCAAGAAAGGATGATTATC

Downstream 100 bases:

>100_bases
TAATGATATTACCAGAAAAAGAGAAGATAAAACTAGCAGTAATCAGTGATACCCATGGGAAGATTGATGATGTCGTTCAA
AGTATATCTAAAAACGAACC

Product: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MKLVLASGNQGKLNELKALLSKQPVEIYSMSDFNNIKEAQETGKTFAENAIIKAQNVADSTGYLSLADDSGLEVDALDGA
PGVYSARYAGENACDQDNNNKLLRSLKDIPYKQRTARFKCVIAIAYPDTPPVTFTGTCEGYILREPKGDRGFGYDPLFYH
PDMGKTFGELYQEEKSSISHRGKALEKLVANFQDVMSLMEG

Sequences:

>Translated_201_residues
MKLVLASGNQGKLNELKALLSKQPVEIYSMSDFNNIKEAQETGKTFAENAIIKAQNVADSTGYLSLADDSGLEVDALDGA
PGVYSARYAGENACDQDNNNKLLRSLKDIPYKQRTARFKCVIAIAYPDTPPVTFTGTCEGYILREPKGDRGFGYDPLFYH
PDMGKTFGELYQEEKSSISHRGKALEKLVANFQDVMSLMEG
>Mature_201_residues
MKLVLASGNQGKLNELKALLSKQPVEIYSMSDFNNIKEAQETGKTFAENAIIKAQNVADSTGYLSLADDSGLEVDALDGA
PGVYSARYAGENACDQDNNNKLLRSLKDIPYKQRTARFKCVIAIAYPDTPPVTFTGTCEGYILREPKGDRGFGYDPLFYH
PDMGKTFGELYQEEKSSISHRGKALEKLVANFQDVMSLMEG

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Escherichia coli, GI1789324, Length=190, Percent_Identity=52.6315789473684, Blast_Score=194, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556833, Length=195, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19920712, Length=192, Percent_Identity=29.6875, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_NATTJ (B2A6I7)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918108.1
- ProteinModelPortal:   B2A6I7
- SMR:   B2A6I7
- GeneID:   6315857
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1950
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 22136; Mature: 22136

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLASGNQGKLNELKALLSKQPVEIYSMSDFNNIKEAQETGKTFAENAIIKAQNVADS
CEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCC
TGYLSLADDSGLEVDALDGAPGVYSARYAGENACDQDNNNKLLRSLKDIPYKQRTARFKC
CCEEEECCCCCCEEEECCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHCCCHHCCCEEEE
VIAIAYPDTPPVTFTGTCEGYILREPKGDRGFGYDPLFYHPDMGKTFGELYQEEKSSISH
EEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
RGKALEKLVANFQDVMSLMEG
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLVLASGNQGKLNELKALLSKQPVEIYSMSDFNNIKEAQETGKTFAENAIIKAQNVADS
CEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCC
TGYLSLADDSGLEVDALDGAPGVYSARYAGENACDQDNNNKLLRSLKDIPYKQRTARFKC
CCEEEECCCCCCEEEECCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHCCCHHCCCEEEE
VIAIAYPDTPPVTFTGTCEGYILREPKGDRGFGYDPLFYHPDMGKTFGELYQEEKSSISH
EEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
RGKALEKLVANFQDVMSLMEG
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA