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The map label for this gene is hisC [H]

Identifier: 188586545

GI number: 188586545

Start: 2031049

End: 2032152

Strand: Reverse

Name: hisC [H]

Synonym: Nther_1931

Alternate gene names: 188586545

Gene position: 2032152-2031049 (Counterclockwise)

Preceding gene: 188586546

Following gene: 188586543

Centisome position: 64.2

GC content: 34.24

Gene sequence:

>1104_bases
ATGCTTAAAAGTTTTAGAAAACCCTTGCATAATATGGAACCACATTATATCTCGGAAAATACATTGGAAAAAAAGCGTCG
TGAGTTAGGTCTATCTCACTTTGTTAAACTGGGTTTTAATGAAAATCCTTATGGACCATTTCCTAGTGTAATTTCTGCCA
TGAGACAAGAACTTGAAAATTTAAATAGATATTCCGATGAGAACTTTCTTGAAGTTAAGCGCTTGCTAGCTGAAAAATTT
CAATTAGATATAGGTTTTATTGCCATTTCTCATGGGGCTGAAAATATGCTGCAAACTTTGAGTAAGTGCTTTATTAATGA
AGGGGATGAAGTAATTATCCCAAAAAATTCCTTTAGACTTTATCAAGACTACTCGAAGATCATGGGTGCCCAAATTAAAT
TAACAACTCTAAAGAATTACAAGATTGATTTAGACAAAATTATTAATGAAATAACAGAAAATACTAAGTTAATTTGGTTG
TGTAATCCTAATAATCCCACAGGGACTATTTTTAGCCAGGACGAATTAATTGATTTTTTAAACAAGATTTCTTCAGATAT
TTGGGTTGTTGTAGATGAAGCTTATGCTGAATTTGTAAATGATGATAAATATCCAGATCTTTCCCAAATAATTCAGAATC
GGAAGAATGTTATGTCTGTGAGGACATTTTCAAAGGCCTATGGTTTAGCAGGAGCTAGATTAGGTTATGTACTGGCCAAT
CGTGAAGTTGTTGCCATCATTAATCGAGTAAGCCAACCTTTTAATGCCAACCGAATTGCCCTAGCAGGTGCTAAGGCAGC
GTTGTTGGACAAAGATTACTTTGAATATACTCTTAACGAATTGAAAAATAACAGAAATTATCTGATGAAATCCTTGCATA
ACAGAGGTTTTAATGTTGTGGAATCACATACAAATTTTGTATTTTTTGAAGGGCAGTTTTCAGCGAAACAATTACAAGAA
AGGCTTTTAAAAAGGGGGATTTTCGTTCAAGCAGGTGATGGTTGGGGATATCCTCAGGGAATCAGGGTTACAGTAGGTAC
CTGGGGAGAAATTGAAGCTTTTTTAACTGGTTTAGATCAAGTGCTACAGGACTTGACTACTTAA

Upstream 100 bases:

>100_bases
ACAGAGGAGCAAGAGTCTGAAAAAATTAAAGGTATAATTCAATGGGCACTGAGTTCTAATAAACCCTCGTTAATAGAAAT
AACTCCGGGTGGTGGTGTAG

Downstream 100 bases:

>100_bases
TTAGCGCATTCATCACAAGATCCTTTTAATACCATTTCTCTGTTTGTGATAGTGTATTGAGAATTTGGCGGTTTTATCTT
AGGGATTTCTATTTCGGTAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MLKSFRKPLHNMEPHYISENTLEKKRRELGLSHFVKLGFNENPYGPFPSVISAMRQELENLNRYSDENFLEVKRLLAEKF
QLDIGFIAISHGAENMLQTLSKCFINEGDEVIIPKNSFRLYQDYSKIMGAQIKLTTLKNYKIDLDKIINEITENTKLIWL
CNPNNPTGTIFSQDELIDFLNKISSDIWVVVDEAYAEFVNDDKYPDLSQIIQNRKNVMSVRTFSKAYGLAGARLGYVLAN
REVVAIINRVSQPFNANRIALAGAKAALLDKDYFEYTLNELKNNRNYLMKSLHNRGFNVVESHTNFVFFEGQFSAKQLQE
RLLKRGIFVQAGDGWGYPQGIRVTVGTWGEIEAFLTGLDQVLQDLTT

Sequences:

>Translated_367_residues
MLKSFRKPLHNMEPHYISENTLEKKRRELGLSHFVKLGFNENPYGPFPSVISAMRQELENLNRYSDENFLEVKRLLAEKF
QLDIGFIAISHGAENMLQTLSKCFINEGDEVIIPKNSFRLYQDYSKIMGAQIKLTTLKNYKIDLDKIINEITENTKLIWL
CNPNNPTGTIFSQDELIDFLNKISSDIWVVVDEAYAEFVNDDKYPDLSQIIQNRKNVMSVRTFSKAYGLAGARLGYVLAN
REVVAIINRVSQPFNANRIALAGAKAALLDKDYFEYTLNELKNNRNYLMKSLHNRGFNVVESHTNFVFFEGQFSAKQLQE
RLLKRGIFVQAGDGWGYPQGIRVTVGTWGEIEAFLTGLDQVLQDLTT
>Mature_367_residues
MLKSFRKPLHNMEPHYISENTLEKKRRELGLSHFVKLGFNENPYGPFPSVISAMRQELENLNRYSDENFLEVKRLLAEKF
QLDIGFIAISHGAENMLQTLSKCFINEGDEVIIPKNSFRLYQDYSKIMGAQIKLTTLKNYKIDLDKIINEITENTKLIWL
CNPNNPTGTIFSQDELIDFLNKISSDIWVVVDEAYAEFVNDDKYPDLSQIIQNRKNVMSVRTFSKAYGLAGARLGYVLAN
REVVAIINRVSQPFNANRIALAGAKAALLDKDYFEYTLNELKNNRNYLMKSLHNRGFNVVESHTNFVFFEGQFSAKQLQE
RLLKRGIFVQAGDGWGYPQGIRVTVGTWGEIEAFLTGLDQVLQDLTT

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=268, Percent_Identity=24.6268656716418, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788332, Length=360, Percent_Identity=25, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788722, Length=223, Percent_Identity=26.9058295964126, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786816, Length=284, Percent_Identity=24.2957746478873, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788627, Length=248, Percent_Identity=25.4032258064516, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=222, Percent_Identity=24.7747747747748, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=220, Percent_Identity=27.7272727272727, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=390, Percent_Identity=24.1025641025641, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18859735, Length=323, Percent_Identity=21.671826625387, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42104; Mature: 42104

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSFRKPLHNMEPHYISENTLEKKRRELGLSHFVKLGFNENPYGPFPSVISAMRQELEN
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
LNRYSDENFLEVKRLLAEKFQLDIGFIAISHGAENMLQTLSKCFINEGDEVIIPKNSFRL
HHHCCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
YQDYSKIMGAQIKLTTLKNYKIDLDKIINEITENTKLIWLCNPNNPTGTIFSQDELIDFL
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEECHHHHHHHH
NKISSDIWVVVDEAYAEFVNDDKYPDLSQIIQNRKNVMSVRTFSKAYGLAGARLGYVLAN
HHHCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEC
REVVAIINRVSQPFNANRIALAGAKAALLDKDYFEYTLNELKNNRNYLMKSLHNRGFNVV
CHHHHHHHHHCCCCCCCEEEEECCHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEE
ESHTNFVFFEGQFSAKQLQERLLKRGIFVQAGDGWGYPQGIRVTVGTWGEIEAFLTGLDQ
ECCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHH
VLQDLTT
HHHHHCC
>Mature Secondary Structure
MLKSFRKPLHNMEPHYISENTLEKKRRELGLSHFVKLGFNENPYGPFPSVISAMRQELEN
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
LNRYSDENFLEVKRLLAEKFQLDIGFIAISHGAENMLQTLSKCFINEGDEVIIPKNSFRL
HHHCCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
YQDYSKIMGAQIKLTTLKNYKIDLDKIINEITENTKLIWLCNPNNPTGTIFSQDELIDFL
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEECHHHHHHHH
NKISSDIWVVVDEAYAEFVNDDKYPDLSQIIQNRKNVMSVRTFSKAYGLAGARLGYVLAN
HHHCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEC
REVVAIINRVSQPFNANRIALAGAKAALLDKDYFEYTLNELKNNRNYLMKSLHNRGFNVV
CHHHHHHHHHCCCCCCCEEEEECCHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEE
ESHTNFVFFEGQFSAKQLQERLLKRGIFVQAGDGWGYPQGIRVTVGTWGEIEAFLTGLDQ
ECCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHH
VLQDLTT
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA