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The map label for this gene is hgdC [H]

Identifier: 188586388

GI number: 188586388

Start: 1840045

End: 1840836

Strand: Reverse

Name: hgdC [H]

Synonym: Nther_1773

Alternate gene names: 188586388

Gene position: 1840836-1840045 (Counterclockwise)

Preceding gene: 188586389

Following gene: 188586387

Centisome position: 58.15

GC content: 39.27

Gene sequence:

>792_bases
ATGTCAATAGCAGCAGGAATAGATATTGGATCTTTATCAACTGAAGTCGTTATTGTTCAGAATAATCAAATTACATCACA
AGTGATTTCAGCAACAGGGTCAAACAGTAAAAAGGCTAGTGAAGAGTCATTTAACAAAGCCCTTGATAAAGCGGGAGTAC
AAAAAGAAGAGGTAGGTTACATAGTTAGTACCGGTTACGGAAGAGTAGCTACTCCTTTTGCCGATAAACAGATTACTGAA
ATAACTTGTCATGCCAAGGGGATGTACTATTTAAACCCTGATATGAGGACAGTTATTGATATTGGTGGTCAAGACAGTAA
AGCGATAAAATTAGCTCCTGATGGGACTGTTGAGGACTTCATTATGAATGATAAATGTGCGGCCGGAACTGGCAGATTTC
TAGAAGTCATGGCCAGTGCCTTGGAAGTAGAACTTGAAGAATTTGTAGATATTGGTAAACGACAGGGAGAACAAGTACCA
GTCACCAGTATGTGTACTGTTTTTGCAGAATCAGAAGTGGTTTCTTTAATTGGTCAAGGATATGCCAAAGAAAAAATTAT
TCGAGGATTGATAGATTCTATAGGTGAACGCACAGAAACCATGGCAGATCGAGTCCAGATAGAACCACCTATAGCTATGA
GTGGTGGAGTTGCAAAAAATAAGGCCGTAGTGACAGCCCTTGAAAATAGATCTGGGGAAAATATATTTGTGCCTAAAGAA
CCGCAAACTGTAGGAGCTTTAGGAGCTGCCTTATTAGCTGAACAATTTATAGCAAAAAGTCGAGCGAATTAG

Upstream 100 bases:

>100_bases
ATATTATTATAAGTTAAAAAGTGATCGGCTTGCCATTAAGGTAGGCCGATTACTTGTAATAAATTATTTAAATTATAGTT
AAATCAAAGGAGGGGAGTTT

Downstream 100 bases:

>100_bases
TCTTTGCTTAATAATATAAGAGATTAGACAAATATATGGATGGGAGTGGTTCGGTGAGCAAAGAAACCCAAAAAGTCGCC
TGGTTATGTACTTACATACC

Product: CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSIAAGIDIGSLSTEVVIVQNNQITSQVISATGSNSKKASEESFNKALDKAGVQKEEVGYIVSTGYGRVATPFADKQITE
ITCHAKGMYYLNPDMRTVIDIGGQDSKAIKLAPDGTVEDFIMNDKCAAGTGRFLEVMASALEVELEEFVDIGKRQGEQVP
VTSMCTVFAESEVVSLIGQGYAKEKIIRGLIDSIGERTETMADRVQIEPPIAMSGGVAKNKAVVTALENRSGENIFVPKE
PQTVGALGAALLAEQFIAKSRAN

Sequences:

>Translated_263_residues
MSIAAGIDIGSLSTEVVIVQNNQITSQVISATGSNSKKASEESFNKALDKAGVQKEEVGYIVSTGYGRVATPFADKQITE
ITCHAKGMYYLNPDMRTVIDIGGQDSKAIKLAPDGTVEDFIMNDKCAAGTGRFLEVMASALEVELEEFVDIGKRQGEQVP
VTSMCTVFAESEVVSLIGQGYAKEKIIRGLIDSIGERTETMADRVQIEPPIAMSGGVAKNKAVVTALENRSGENIFVPKE
PQTVGALGAALLAEQFIAKSRAN
>Mature_262_residues
SIAAGIDIGSLSTEVVIVQNNQITSQVISATGSNSKKASEESFNKALDKAGVQKEEVGYIVSTGYGRVATPFADKQITEI
TCHAKGMYYLNPDMRTVIDIGGQDSKAIKLAPDGTVEDFIMNDKCAAGTGRFLEVMASALEVELEEFVDIGKRQGEQVPV
TSMCTVFAESEVVSLIGQGYAKEKIIRGLIDSIGERTETMADRVQIEPPIAMSGGVAKNKAVVTALENRSGENIFVPKEP
QTVGALGAALLAEQFIAKSRAN

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=255, Percent_Identity=40, Blast_Score=184, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 27983; Mature: 27852

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAAGIDIGSLSTEVVIVQNNQITSQVISATGSNSKKASEESFNKALDKAGVQKEEVGY
CCEECCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCE
IVSTGYGRVATPFADKQITEITCHAKGMYYLNPDMRTVIDIGGQDSKAIKLAPDGTVEDF
EEECCCCCEECCCCCCCEEEEEEEECCEEEECCCCEEEEEECCCCCCEEEECCCCCHHHH
IMNDKCAAGTGRFLEVMASALEVELEEFVDIGKRQGEQVPVTSMCTVFAESEVVSLIGQG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
YAKEKIIRGLIDSIGERTETMADRVQIEPPIAMSGGVAKNKAVVTALENRSGENIFVPKE
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCC
PQTVGALGAALLAEQFIAKSRAN
CCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIAAGIDIGSLSTEVVIVQNNQITSQVISATGSNSKKASEESFNKALDKAGVQKEEVGY
CEECCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCE
IVSTGYGRVATPFADKQITEITCHAKGMYYLNPDMRTVIDIGGQDSKAIKLAPDGTVEDF
EEECCCCCEECCCCCCCEEEEEEEECCEEEECCCCEEEEEECCCCCCEEEECCCCCHHHH
IMNDKCAAGTGRFLEVMASALEVELEEFVDIGKRQGEQVPVTSMCTVFAESEVVSLIGQG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
YAKEKIIRGLIDSIGERTETMADRVQIEPPIAMSGGVAKNKAVVTALENRSGENIFVPKE
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCC
PQTVGALGAALLAEQFIAKSRAN
CCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]